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Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients
Abstract
We compared insulin-requiring diabetic outpatients (n = 49) with normal controls (n = 42) for indices of hypothalamic-pituitary-adrenal (HPA) axis activity. Diabetic patients showed significantly elevated 9 a.m. plasma levels of cortisol as well as significantly elevated plasma levels of cortisol and adrenocorticotropic hormone (ACTH) at both 4 p.m. before and 4 p.m. after dexamethasone. Also, there was a significant correlation between postdexamethasone plasma levels of ACTH and duration of diabetes. These results suggest that HPA-axis dysregulation is found among diabetic outpatients. The possible psychiatric implications are discussed.
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Hyperactivity of the HPA axis and hyperinsulinemia are frequently observed in patients with type 1 and type 2 diabetes and in patients with abdominal adiposity.
“Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in association with hyperinsulinemia is frequently found in patients with type 1 and type 2 diabetes mellitus and in subjects with abdominal adiposity.”
From Supraphysiological Hyperinsulinemia Acutely Increases Hypothalamic-Pituitary-Adrenal Secretory Activity in Humans (1999) · cites this paper as [1]
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Metadata
- Authors
- Roy, M., Collier, B., & Roy, A.
- Affiliations
- National Eye Institute (US)
- Corresponding author
- Roy, Monique
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 1990-01
- Volume
- 31
- Issue
- 1
- Pages
- 31-37
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2049915127
- Cited by
- 107
- References
- 26
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 8 · 2012: 2
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- hypothalamic-pituitary-adrenal axis, HPA axis dysregulation, diabetes mellitus, type 1 diabetes, insulin-treated diabetes, cortisol, ACTH, dexamethasone suppression test, diabetes duration, psychiatric implications
- MeSH terms
- Adrenocorticotropic Hormone, Aged, Circadian Rhythm, Depressive Disorder, Dexamethasone, Diabetes Mellitus, Type 1, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System
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