Cited by 107Stress Responses and CortisolAdrenal Hormones and DisordersDiabetes Management and Research

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Hypothalamic-pituitary-adrenal axis dysregulation among diabetic outpatients

Roy, Monique, Collier, Bronwyn, Roy, Alec·1990·Psychiatry Research

Abstract

We compared insulin-requiring diabetic outpatients (n = 49) with normal controls (n = 42) for indices of hypothalamic-pituitary-adrenal (HPA) axis activity. Diabetic patients showed significantly elevated 9 a.m. plasma levels of cortisol as well as significantly elevated plasma levels of cortisol and adrenocorticotropic hormone (ACTH) at both 4 p.m. before and 4 p.m. after dexamethasone. Also, there was a significant correlation between postdexamethasone plasma levels of ACTH and duration of diabetes. These results suggest that HPA-axis dysregulation is found among diabetic outpatients. The possible psychiatric implications are discussed.

Overview

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Registry

Crossref · 10.1016/0165-1781(90)90106-f

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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  • Hyperactivity of the HPA axis and hyperinsulinemia are frequently observed in patients with type 1 and type 2 diabetes and in patients with abdominal adiposity.

    “Hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis in association with hyperinsulinemia is frequently found in patients with type 1 and type 2 diabetes mellitus and in subjects with abdominal adiposity.”

Citations

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Research works printed but not linked: 1

  1. Gold, 1986, The corticotropin releasing factor stimulation test: Implications for the diagnosis and pathophysiology of hypercortisolism in primary affective disor ders and Cushing's disease, New England Journal of Medicine, 314, 1330

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Metadata

Authors
Roy, M., Collier, B., & Roy, A.
Affiliations
National Eye Institute (US)
Corresponding author
Roy, Monique
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
1990-01
Volume
31
Issue
1
Pages
31-37
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2049915127
Cited by
107
References
26
Citations by year
2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 2 · 2013: 8 · 2012: 2
FWCI
0.67
Type
journal article
Language
en
Open access
closed
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
Keywords
hypothalamic-pituitary-adrenal axis, HPA axis dysregulation, diabetes mellitus, type 1 diabetes, insulin-treated diabetes, cortisol, ACTH, dexamethasone suppression test, diabetes duration, psychiatric implications
MeSH terms
Adrenocorticotropic Hormone, Aged, Circadian Rhythm, Depressive Disorder, Dexamethasone, Diabetes Mellitus, Type 1, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System

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