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Cited by 121Autism Spectrum Disorder ResearchT-cell and B-cell ImmunologyTryptophan and brain disorders

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

CD4+ helper T cell depression in autism

Yonk, L.Jeanne, Warren, Reed P., Burger, Roger A., Cole, Phyllis, Odell, J.Dennis, Warren, W.Louise, White, Ellen, Singh, Vijendra K.·1990·Immunology Letters
DOI 10.1016/0165-2478(90)90205-5
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Abstract

CD4+ (helper) T cells are a heterogenous population of lymphocytes including at least two distinct subpopulations. To investigate the possibility that immune abnormalities in some subjects with autism may involve abnormal distributions of CD4+ and/or CD8+ cells, (suppressor) T cells, peripheral blood lymphocytes of 25 autistic subjects were characterized with monoclonal antibodies and flow cytometry. The autistic subjects had a significantly lower percentage and number of CD4+ cells, a lower number of T cells (CD2+ cells) and B cells (CD20+ cells), and a lower percentage and number of total lymphocytes than siblings and normal subjects. The level of blood values for female subjects appeared lower than those for males as compared to normal subjects of the same sex. These results suggest that a decrease in CD4+ cells is associated with autism.

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Crossref · 10.1016/0165-2478(90)90205-5

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Research works printed but not linked: 6

  1. Todd, 1985, 82, 612
  2. Weizman, 1982, Am. J. Psychiatry, 1462
  3. Reinherz, 1979, 76, 4061
  4. Meuer, 1982, 79, 4395
  5. Chess, 1977, J. Aut. Devel. Disord., 7, 79
  6. Morimoto, 1981, J. Clin. Invest., 67, 753, 10.1172/JCI110092 · DOI

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Metadata

Authors
Yonk, L. J., Warren, R. P., Burger, R. A., Cole, P., Odell, J. D., Warren, W. L., White, E., & Singh, V. K.
Affiliations
Utah State University (US)
Corresponding author
Warren, Reed P.
ORCID
Singh, Vijendra K.
Venue
Immunology Letters
Publisher
Elsevier BV
Published
1990-09
Volume
25
Issue
4
Pages
341-345
ISSN
0165-2478 (ISSN-L)
DOI
10.1016/0165-2478(90)90205-5
OpenAlex
W2030658245
Cited by
109
References
11
Citations by year
2026: 2 · 2024: 6 · 2023: 6 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 2 · 2014: 1 · 2013: 2 · 2012: 3
FWCI
0.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Immunology Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh042119-10)
  • National Institute of Mental Health (MH-42119)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
autism spectrum disorder, CD4+ T cells, T helper cells, CD8+ suppressor T cells, peripheral blood lymphocytes, immune abnormalities, CD2+ T cells, B cells, sex differences, lymphocyte count
MeSH terms
Adolescent, Adult, Autistic Disorder, Child, Child, Preschool, Family, Female, Flow Cytometry, Humans, Leukocyte Count, Male, CD4-Positive T-Lymphocytes, T-Lymphocyte Subsets

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