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Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system
Open accessAbstract
Proliferation of central nervous system (CNS) glia in response to peripheral nerve injury occurs without apparent participation of cells of the immune system. It is shown here that following transection of the rat facial nerve there is strongly elevated expression of class I, and to a lesser extent, class II antigens of the major histocompatibility complex (MHC) in the facial nucleus. It is demonstrated by double-immunofluorescence studies that the cells responsible for increased levels of MHC class I antigens are endogenous brain microglia. These findings emphasize the thought that microglia are immunocompetent cells, but, at the same time, raise the possibility for a non-immubological function of MHC antigens under conditions of neural regeneration.
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Citations
Cited by
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Self-citationMicroglia: Intrinsic immuneffector cell of the brain
Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,119
Self-citationImmune proteins in brain development and synaptic plasticity
Boulanger, L. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.001 · Cited by 555
Regulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity
Corriveau, R. A., Huh, G. S., & Shatz, C. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80562-0 · Cited by 548
Role of microglia in CNS inflammation
Graeber, M. B., Li, W., & Rodriguez, M. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.033 · Cited by 392
Metadata
- Authors
- Streit, W. J., Graeber, M. B., & Kreutzberg, G. W.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1989-02
- Volume
- 21
- Issue
- 2-3
- Pages
- 117-123
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2018546126
- Cited by
- 185
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system. https://app.cochat.ai/papers/10.1016/0165-5728(89)90167-7
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- Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1989). Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system. Journal of Neuroimmunology. https://doi.org/10.1016/0165-5728(89)90167-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
