Microglia: a sensor for pathological events in the CNS

Activation of microglial cells by β-amyloid protein and interferon-γ

Meda, L., Cassatella, M. A., Szendrei, G. I., Otvos, L., Baron, P., Villalba, M., Ferrari, D., & Rossi, F. (1995) · Nature · doi:10.1038/374647a0 · Cited by 1,314 · see citing works

Microglia: Intrinsic immuneffector cell of the brain

Gehrmann, J., Matsumoto, Y., & Kreutzberg, G. W. (1995) · Brain Research Reviews · doi:10.1016/0165-0173(94)00015-h · Cited by 1,111 · see citing works

Cytotoxicity of microglia

Banati, R. B., Gehrmann, J., Schubert, P., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440070117 · Cited by 1,020 · see citing works

Functional plasticity of microglia: A review

Streit, W. J., Graeber, M. B., & Kreutzberg, G. W. (1988) · Glia · doi:10.1002/glia.440010502 · Cited by 937 · see citing works

Displacement of synaptic terminals from regenerating motoneurons by microglial cells

Blinzinger, K., & Kreutzberg, G. W. (1968) · Cell and Tissue Research · doi:10.1007/bf00325030 · Cited by 855 · see citing works

Interleukin-1 Stimulation of Astroglial Proliferation After Brain Injury

Giulian, D., & Lachman, L. B. (1985) · Science · doi:10.1126/science.3872478 · Cited by 847 · see citing works

Cellular immune reactivity within the CNS

Wekerle, H., Linington, C., Lassmann, H., & Meyermann, R. (1986) · Trends in Neurosciences · doi:10.1016/0166-2236(86)90077-9 · Cited by 767 · see citing works

The origin and nature of ramified and amoeboid microglia: A historical review and current concepts

Ling, E., & Wong, W.-C. (1993) · Glia · doi:10.1002/glia.440070105 · Cited by 690 · see citing works

Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1

Giulian, D., Vaca, K., & Noonan, C. (1990) · Science · doi:10.1126/science.2148832 · Cited by 651 · see citing works

Antigen presentation and tumor cytotoxicity by interferon‐γ‐treated microglial cells

Frei, K., Siepl, C., Groscurth, P., Bodmer, S., Schwerdel, C., & Fontana, A. (1987) · European Journal of Immunology · doi:10.1002/eji.1830170909 · Cited by 633 · see citing works

Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared

Ford, A. L., Goodsall, A. L., Hickey, W. F., & Sedgwick, J. D. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.9.4309 · Cited by 631 · see citing works

Production of superoxide anions by a CNS macrophage, the microglia

Colton, C. A., & Gilbert, D. L. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80305-8 · Cited by 614 · see citing works

Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: evidence of a role for microglia in cytokine production

Woodroofe, M. N., Sarna, G. S., Wadhwa, M., Hayes, G. M., Loughlin, J., Tinker, A., & Cuzner, M. L. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90110-s · Cited by 580 · see citing works

The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain

Giulian, D., Chen, J., Ingeman, J., George, J., & Noponen, M. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-12-04416.1989 · Cited by 498 · see citing works

Transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte proliferation

Lindholm, D., Ċastrén, E., Kiefer, R., Zafra, F., & Thoenen, H. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.2.395 · Cited by 487 · see citing works

Expression of the histocompatibility glycoprotein HLA-DR in neurological disease

McGeer, P. L., Itagaki, S., & McGeer, E. G. (1988) · Acta Neuropathologica · doi:10.1007/bf00689592 · Cited by 420 · see citing works

Bone Marrow-derived Elements in the Central Nervous System: An Immunohistochemical and Ultrastructural Survey of Rat Chimeras

Hickey, W. F., Vass, K., & Lassmann, H. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199205000-00002 · Cited by 401 · see citing works

Macrophages and inflammation in the central nervous system

Perry, V. H., Andersson, P.-B., & Gordon, S. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90180-t · Cited by 388 · see citing works

Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin

Streit, W. J., & Kreutzberg, G. W. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902680209 · Cited by 387 · see citing works

Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ

Lee, S. C., Dickson, D. W., Liu, W., & Brosnan, C. F. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90229-r · Cited by 354 · see citing works

Microglial cells but not astrocytes undergo mitosis following rat facial nerve axotomy

Graeber, M. B., Tetzlaff, W., Streit, W. J., & Kreutzberg, G. W. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90585-x · Cited by 333 · see citing works

Colony-stimulating factors as promoters of ameboid microglia

Giulian, D., & Ingeman, J. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-12-04707.1988 · Cited by 323 · see citing works

Identity of ED2‐positive perivascular cells in rat brain

Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490220114 · Cited by 280 · see citing works

Microglia in human disease, with an emphasis on acquired immune deficiency syndrome.

Dickson, D. W., Mattiace, L. A., Kure, K., Hutchins, K. D., Lyman, W. D., & Brosnan, C. F. (1991) · PubMed · Cited by 275 · see citing works

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat

Buttini, M., Appel, K., Sauter, A., Gebicke‐Haerter, P. J., & Boddeke, H. W. G. M. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00414-9 · Cited by 243 · see citing works

Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system.

Vass, K., & Lassmann, H. (1990) · Europe PMC (PubMed Central) · Cited by 238 · see citing works

Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages

Kettenmann, H., Hoppe, D., Gottmann, K., Banati, R. B., & Kreutzberg, G. W. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490260303 · Cited by 228 · see citing works

Interleukin‐6 and Transforming Growth Factor‐β1 mRNAs are Induced in Rat Facial Nucleus Following Motoneuron Axotomy

Kiefer, R., Lindholm, D., & Kreutzberg, G. W. (1993) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1993.tb00929.x · Cited by 205 · see citing works

The Costimulatory Molecule B7 is Expressed on Human Microglia in Culture and in Multiple Sclerosis Acute Lesions

Simone, R. D., Giampaolo, A., Giometto, B., Gallo, P., Levi, G., Peschle, C., & Aloisi, F. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199503000-00004 · Cited by 201 · see citing works

Evolution of Neuropathologic Abnormalities Associated with Blood-Brain Barrier Breakdown in Transgenic Mice Expressing lnterleukin-6 in Astrocytes

Brett, F. M., Mizisin, A. P., Powell, H. C., et al. (1995) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199511000-00003 · Cited by 200 · see citing works

Cytotoxic Effect of Brain Macrophages on Developing Neurons

Théry, C., Chamak, B., & Mallat, M. (1991) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1991.tb00050.x · Cited by 190 · see citing works

Endotoxin-induced appearance of immunoreactive interleukin-1β in ramified microglia in rat brain: A light and electron microscopic study

van Dam, A., Bauer, J., Tilders, F. J. H., & BERKENBOSCH, F. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00549-k · Cited by 190 · see citing works

Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system

Streit, W. R., Graeber, M. B., & Kreutzberg, G. W. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90167-7 · Cited by 185 · see citing works

Cholinergic sprouting in the hippocampus: A proposed role for IL-1

Fagan, A. M., & Gage, F. H. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90055-w · Cited by 184 · see citing works

Extracellular ATP activates a cation conductance and a K+ conductance in cultured microglial cells from mouse brain

Walz, W., Ilschner, S., Ohlemeyer, C., Banati, R. B., & Kettenmann, H. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04403.1993 · Cited by 175 · see citing works

Inhibition of Posttraumatic Microglial Proliferation in a Genetic Model of Macrophage Colony‐Stimulating Factor Deficiency in the Mouse

Raivich, G., Moreno-Flores, M. T., Möller, J. C., & Kreutzberg, G. W. (1994) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1994.tb00552.x · Cited by 169 · see citing works

Electrophysiological behavior of microglia

Kettenmann, H., Banati, R. B., & Walz, W. (1993) · Glia · doi:10.1002/glia.440070115 · Cited by 166 · see citing works

IL‐6 Expression in Neurons of Transgenic Mice Causes Reactive Astrocytosis and Increase in Ramified Microglial Cells but no Neuronal Damage

Fattori, E., Lazzaro, D., Musiani, P., Modesti, A., Alonzi, T., & Ciliberto, G. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb01042.x · Cited by 162 · see citing works

Microglial Reaction in the Rat Cerebral Cortex Induced by Cortical Spreading Depression

Gehrmann, J., Mies, G., Bonnekoh, P., Banati, R. B., Iijima, T., Kreutzberg, G. W., & Hossmann, K. (1993) · Brain Pathology · doi:10.1111/j.1750-3639.1993.tb00720.x · Cited by 160 · see citing works

Immune regulation by brain cells in the central nervous system: microglia but not astrocytes present myelin basic protein to encephalitogenic T cells under in vivo-mimicking conditions.

Matsumoto, Y., Ohmori, K., & FUJIWARA, M. T. (1992) · PubMed · Cited by 159 · see citing works

Ultrastructural Location of Major Histocompatibility Complex (MHC) Class II Positive Perivascular Cells in Histologically Normal Human Brain

Graeber, M. B., Streit, W. J., Büringer, D., Sparks, D. L., & Kreutzberg, G. W. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199205000-00009 · Cited by 149 · see citing works

Microglia in the immune surveillance of the brain: Human microglia constitutively express HLA-DR molecules

Gehrmann, J., Banati, R. B., & Kreutzberg, G. W. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90191-z · Cited by 133 · see citing works

Transcription factor NF-κB is activated in microglia during experimental autoimmune encephalomyelitis

Kaltschmidt, C., Kaltschmidt, B., Lannes-Vieira, J., Kreutzberg, G. W., Wekerle, H., Baeuerle, P. A., & Gehrmann, J. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90151-1 · Cited by 133 · see citing works

Increase of macrophage colony‐stimulating factor and granulocyte‐macrophage colony‐stimulating factor receptors in the regenerating rat facial nucleus

Raivich, G., Gehrmann, J., & Kreutzberg, G. W. (1991) · Journal of Neuroscience Research · doi:10.1002/jnr.490300412 · Cited by 133 · see citing works

Early and rapid de novo synthesis of Alzheimer βA4‐Amyloid precursor protein (APP) in activated microglia

Banati, R. B., Gehrmann, J., Czech, C., Mönning, U., Jones, L. L., König, G., Beyreuther, K. T., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440090305 · Cited by 132 · see citing works

Microglia isolated from rat brain secrete a urokinase-type plasminogen activator

Nakajima, K., Tsuzaki, N., Shimojo, M., Hamanoue, M., & Kohsaka, S. (1992) · Brain Research · doi:10.1016/0006-8993(92)90285-h · Cited by 126 · see citing works

Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

Bauer, J., BERKENBOSCH, F., van Dam, A., & Dijkstra, C. D. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90053-2 · Cited by 115 · see citing works

Detection of lysosomal cysteine proteinases in microglia: Flow cytometric measurement and histochemical localization of cathepsin B and L

Banati, R. B., Rothe, G., Valet, G., & Kreutzberg, G. W. (1993) · Glia · doi:10.1002/glia.440070208 · Cited by 111 · see citing works

Modulation of interferon-gamma-induced major histocompatibility complex class II and Fc receptor expression on isolated microglia by transforming growth factor-beta 1, interleukin-4, noradrenaline and glucocorticoids.

Loughlin, J., Woodroofe, M. N., & Cuzner, M. L. (1993) · PubMed · Cited by 95 · see citing works

Production and secretion of plasminogen in cultured rat brain microglia

Nakajima, K., Tsuzaki, N., Nagata, K., Takemoto, N., & Kohsaka, S. (1992) · FEBS Letters · doi:10.1016/0014-5793(92)81270-v · Cited by 95 · see citing works

Expression of transforming growth factor-?1 and interleukin-1? mRNA in rat brain following transient forebrain ischemia

Wie�ner, C., Gehrmann, J., Lindholm, D., T�pper, R., Kreutzberg, G. W., & Hossmann, K. A. (1993) · Acta Neuropathologica · doi:10.1007/bf00228578 · Cited by 94 · see citing works

Neurone-glia interactions in the hypothalamus and pituitary

Theodosis, D. T., & MacVicar, B. A. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10055-2 · Cited by 94 · see citing works

Synaptic Density of Axotomized Hypoglossal Motorneurons Following Pharmacological Blockade of the Microglial Cell Proliferation

Svensson, M. A., & Aldskogius, H. (1993) · Experimental Neurology · doi:10.1006/exnr.1993.1046 · Cited by 93 · see citing works

Local enhancement of major histocompatibility complex (MHC) class I and II expression and cell infiltration in experimental allergic encephalomyelitis around axotomized motor neurons

Mæhlen, J., Olsson, T. P., Zachau, A. C., Klareskog, L., & Kristensson, K. (1989) · Journal of Neuroimmunology · doi:10.1016/0165-5728(89)90031-3 · Cited by 89 · see citing works

CR3/43, a marker for activated human microglia: application to diagnostic neuropathology

Graeber, M. B., Bise, K., & Mehraein, P. (1994) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1994.tb00987.x · Cited by 89 · see citing works

Cytokine expression of macrophages in HIV‐1‐associated vacuolar myelopathy

Tyor, W. R., Glass, J. D., Baumrind, N. L., McArthur, J. C., Griffin, J. W., Becker, P. S., & Griffin, D. E. (1993) · Neurology · doi:10.1212/wnl.43.5.1002 · Cited by 87 · see citing works

Diversity amongst the microglia in growing and regenerating fish CNS: Immunohistochemical characterization using FL. 1, an anti‐macrophage monoclonal antibody

Dowding, A. J., Maggs, A., & Scholes, J. (1991) · Glia · doi:10.1002/glia.440040403 · Cited by 85 · see citing works

Calcitonin gene‐related peptide and ATP induce immediate early gene expression in cultured rat microglial cells

Priller, J., Haas, C. A., Reddington, M., & Kreutzberg, G. W. (1995) · Glia · doi:10.1002/glia.440150408 · Cited by 81 · see citing works

Herpes simplex virus type I infection of the CNS induces major histocompatibility complex antigen expression on rat microglia

Weinstein, D. L., Walker, D. G., Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroscience Research · doi:10.1002/jnr.490260107 · Cited by 77 · see citing works

Spinal cord microglia in experimental allergic neuritis. Evidence for fast and remote activation.

Gehrmann, J., Gold, R., Linington, C., et al. (1992) · PubMed · Cited by 74 · see citing works

Carbachol increases intracellular free calcium in cultured rat microglia

Whittemore, E. R., Korotzer, A. R., Etebari, A., & Cotman, C. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)90297-z · Cited by 59 · see citing works

Characterization and transduction mechanisms of purinoceptors in activated rat microglia

Langosch, J. M., Gebicke‐Haerter, P. J., Nörenberg, W., & Illés, P. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb16169.x · Cited by 58 · see citing works

Formation of microglia-derived brain macrophages is blocked by adriamycin

Graeber, M. B., Streit, W. J., & Kreutzberg, G. W. (1989) · Acta Neuropathologica · doi:10.1007/bf00688171 · Cited by 44 · see citing works

Ueber einen Fall syphilitischer Erkrankung des Centralnervensystems

Buchholz (1899) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf02126943 · Cited by 33 · see citing works

Pathophysiology of glial growth factor receptors

Raivich, G., & Kreutzberg, G. W. (1994) · Glia · doi:10.1002/glia.440110208 · Cited by 33 · see citing works

The transcription factor CREB, but not immediate-early gene encoded proteins, is expressed in activated microglia of lumbar spinal cord following sciatic nerve transection in the rat

Herdegen, T., Fiallos-Estrada, C. E., Schmid, W., et al. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90619-i · Cited by 24 · see citing works

Gradual inhibition of inducible nitric oxide synthase but not of interleukin-1β production in rat microglial cells of endotoxin- treated mixed glial cell cultures

(1996) · Pure Amsterdam UMC · doi:10.1002/(sici)1098-1136(199606)17:2

Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo

Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

ATP mediates rapid microglial response to local brain injury in vivo

Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works

Microglia: Active sensor and versatile effector cells in the normal and pathologic brain

Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676 · see citing works

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.008 · Cited by 2,979 · see citing works

Analysis of Fractalkine Receptor CX₃CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632 · see citing works

Neuroglial activation and neuroinflammation in the brain of patients with autism

Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · see citing works

BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain

Coull, J. A. M., Beggs, S., Boudreau, D., Boivin, D., Tsuda, M., Inoue, K., Gravel, C., Salter, M. W., & De Koninck, Y. (2005) · Nature · doi:10.1038/nature04223 · Cited by 1,965 · see citing works

Microglial physiology: unique stimuli, specialized responses

Ransohoff, R. M., & Perry, V. H. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132528 · Cited by 1,858 · see citing works

Local self-renewal can sustain CNS microglia maintenance and function throughout adult life

Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works

Resting Microglia Directly Monitor the Functional State of Synapses <i>In Vivo</i> and Determine the Fate of Ischemic Terminals

Wake, H., Moorhouse, A. J., Jinno, S., Kohsaka, S., & Nabekura, J. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4363-08.2009 · Cited by 1,619 · see citing works

Onset and Progression in Inherited ALS Determined by Motor Neurons and Microglia

Boillée, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., Kollias, G., & Cleveland, D. W. (2006) · Science · doi:10.1126/science.1123511 · Cited by 1,623 · see citing works

Microglia in neurodegenerative disease

Perry, V. H., Nicoll, J. A. R., & Holmes, C. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.17 · Cited by 1,543 · see citing works

Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism

Block, M. L., & Hong, J.-S. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.06.004 · Cited by 1,557 · see citing works

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

Haynes, S. E., Hollopeter, G., Yang, G., Kurpius, D., Dailey, M. E., Gan, W.-B., & Julius, D. (2006) · Nature Neuroscience · doi:10.1038/nn1805 · Cited by 1,542 · see citing works

Control of microglial neurotoxicity by the fractalkine receptor

Cardona, A. E., Pioro, E. P., Sasse, M. E., Kostenko, V., Cardona, S. M., Dijkstra, I. M., Huang, D., Kidd, G., Dombrowski, S., Dutta, R., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1715 · Cited by 1,531 · see citing works

-Synuclein in Parkinson's Disease

Stefanis, L. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a009399 · Cited by 1,446 · see citing works

In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease

Gerhard, A., Pavese, N., Hotton, G., Turkheimer, F., Es, M., Hammers, A., Eggert, K., Oertel, W., Banati, R. B., & Brooks, D. J. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.08.002 · Cited by 1,200 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs

Olson, J. K., & Miller, S. D. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.3916 · Cited by 1,215 · see citing works

Role for Neuronally Derived Fractalkine in Mediating Interactions between Neurons and CX3CR1-Expressing Microglia

Harrison, J. K., Jiang, Y., Chen, S., Xia, Y., Maciejewski, D., McNamara, R. K., Streit, W. J., Salafranca, M. N., Adhikari, S., Thompson, D. A., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10896 · Cited by 1,176 · see citing works

Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications

Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works

Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works

Role of Pro-Inflammatory Cytokines Released from Microglia in Neurodegenerative Diseases

Smith, J. A., Das, A., Ray, S. K., & Banik, N. L. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.10.004 · Cited by 1,165 · see citing works

Reactive microgliosis

Streit, W. J., Walter, S. A., & Pennell, N. A. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00069-0 · Cited by 1,096 · see citing works

Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention

Liu, B., & Hong, J.-S. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.035048 · Cited by 1,095 · see citing works

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061 · see citing works

Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway

Lehnardt, S., Massillon, L., Follett, P., Jensen, F. E., Ratan, R., Rosenberg, P. A., Volpe, J. J., & Vartanian, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1432609100 · Cited by 1,052 · see citing works

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works

Autophagy and apoptosis dysfunction in neurodegenerative disorders

Ghavami, S., Shojaei, S., Yeganeh, B., Ande, S. R., Jangamreddy, J. R., Mehrpour, M., Christoffersson, J., Chaabane, W., Moghadam, A. R., Kashani, H. H., et al. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.10.004 · Cited by 1,039 · see citing works

Systemic infections and inflammation affect chronic neurodegeneration

Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027 · see citing works

Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

Cunningham, C. L., Martínez-Cerdeño, V., & Noctor, S. C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3441-12.2013 · Cited by 976 · see citing works

The Role of Microglia in the Healthy Brain: Figure 1.

Tremblay, M.-È., Stevens, B., Sierra, A., Wake, H., Bessis, A., & Nimmerjahn, A. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4158-11.2011 · Cited by 992 · see citing works

Overview of General and Discriminating Markers of Differential Microglia Phenotypes

Jurga, A. M., Paleczna, M., & Kuter, K. Z. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00198 · Cited by 1,000 · see citing works

Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia

Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958 · see citing works

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

Hirayama, D., Iida, T., & Nakase, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010092 · Cited by 927 · see citing works

UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

Koizumi, S., Shigemoto-Mogami, Y., Nasu-Tada, K., Shinozaki, Y., Ohsawa, K., Tsuda, M., Joshi, B. V., Jacobson, K. A., Kohsaka, S., & Inoue, K. (2007) · Nature · doi:10.1038/nature05704 · Cited by 802 · see citing works

Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains

Imamura, K., Hishikawa, N., Sawada, M., Nagatsu, T., Yoshida, M., & Hashizume, Y. (2003) · Acta Neuropathologica · doi:10.1007/s00401-003-0766-2 · Cited by 791 · see citing works

Neuronal ‘On’ and ‘Off’ signals control microglia

Biber, K., Neumann, H., Inoue, K., & Boddeke, H. W. G. M. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.08.007 · Cited by 787 · see citing works

Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease

Streit, W. J., Braak, H., Xue, Q.-S., & Bechmann, I. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0556-6 · Cited by 727 · see citing works

Tumor Necrosis Factor-α Induces Neurotoxicity via Glutamate Release from Hemichannels of Activated Microglia in an Autocrine Manner

Takeuchi, H., Jin, S., Wang, J., Zhang, G., Kawanokuchi, J., Kuno, R., Sonobe, Y., Mizuno, T., & Suzumura, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600504200 · Cited by 749 · see citing works

Experimental autoimmune encephalomyelitis repressed by microglial paralysis

Heppner, F. L., Greter, M., Marino, D., Falsig, J., Raivich, G., Hövelmeyer, N., Waisman, A., Rülicke, T., Prinz, M., Priller, J., et al. (2005) · Nature Medicine · doi:10.1038/nm1177 · Cited by 732 · see citing works

TREMs in the immune system and beyond

Colonna, M. (2003) · Nature Reviews Immunology · doi:10.1038/nri1106 · Cited by 701 · see citing works

Sex differences in microglial colonization of the developing rat brain

Schwarz, J. M., Sholar, P. W., & Bilbo, S. D. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07630.x · Cited by 672 · see citing works

Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation

Ledeboer, A., Sloane, E. M., Milligan, E. D., Frank, M. G., Mahony, J. H., Maier, S. F., & Watkins, L. R. (2005) · Pain · doi:10.1016/j.pain.2005.02.009 · Cited by 677 · see citing works

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine · doi:10.1038/nm1201-1356 · Cited by 637 · see citing works

Changing face of microglia

Graeber, M. B. (2010) · Science · doi:10.1126/science.1190929 · Cited by 608 · see citing works

The “quad‐partite” synapse: Microglia‐synapse interactions in the developing and mature CNS

Schafer, D. P., Lehrman, E. K., & Stevens, B. (2013) · Glia · doi:10.1002/glia.22389 · Cited by 570 · see citing works

Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses

Frank, M. G., Baratta, M. V., Sprunger, D. B., Watkins, L. R., & Maier, S. F. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.03.005 · Cited by 578 · see citing works

Microglial cell dysregulation in brain aging and neurodegeneration

von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556 · see citing works

The impact of microglial activation on blood-brain barrier in brain diseases

da Fonseca, A. C. C., Matias, D., Garcia, C., Amaral, R., Geraldo, L. H., Freitas, C., & Lima, F. R. S. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00362 · Cited by 572 · see citing works

Extracellular ATP or ADP Induce Chemotaxis of Cultured Microglia through G_i/o-Coupled P2Y Receptors

Honda, S., Sasaki, Y., Ohsawa, K., Imai, Y., Nakamura, Y., Inoue, K., & Kohsaka, S. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01975.2001 · Cited by 561 · see citing works

The Indispensable Roles of Microglia and Astrocytes during Brain Development

Reemst, K., Noctor, S. C., Lucassen, P. J., & Hol, E. M. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00566 · Cited by 516 · see citing works

Microglia activation in retinal degeneration

Langmann, T. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0207114 · Cited by 496 · see citing works

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

Edison, P., Archer, H. A., Gerhard, A., Hinz, R., Pavese, N., Turkheimer, F. E., Hammers, A., Tai, Y. F., Fox, N., Kennedy, A., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.08.001 · Cited by 513 · see citing works

Synuclein activates microglia in a model of Parkinson's disease

Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474 · see citing works

Modulation of inflammation in brain: A matter of fat

Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460 · see citing works

The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

Ramirez, A. I., de Hoz, R., Salobrar-Garcia, E., Salazar, J. J., Rojas, B., Ajoy, D., López-Cuenca, I., Rojas, P., Triviño, A., & Ramírez, J. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00214 · Cited by 466 · see citing works

Microglial activation in presymptomatic Huntington's disease gene carriers

Tai, Y. F., Pavese, N., Gerhard, A., Tabrizi, S. J., Barker, R. A., Brooks, D. J., & Piccini, P. (2007) · Brain · doi:10.1093/brain/awm044 · Cited by 440 · see citing works

Neuroinflammatory processes in Alzheimer’s disease

Heneka, M. T., O’Banion, M. K., Terwel, D., & Kummer, M. P. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0438-z · Cited by 433 · see citing works

Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis

Mandrekar, S., Jiang, Q., Lee, C. Y. D., Koenigsknecht-Talboo, J., Holtzman, D. M., & Landreth, G. E. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.5572-08.2009 · Cited by 415 · see citing works

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

Sastre, M., Klockgether, T., & Heneka, M. T. (2006) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2005.11.014 · Cited by 426 · see citing works

The Stressed CNS: When Glucocorticoids Aggravate Inflammation

Sorrells, S. F., Caso, J. R., Munhoz, C. D., & Sapolsky, R. M. (2009) · Neuron · doi:10.1016/j.neuron.2009.09.032 · Cited by 425 · see citing works

The role of microglia in central nervous system immunity and glioma immunology

Yang, I., Han, S. J., Kaur, G., Crane, C., & Parsa, A. T. (2010) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2009.05.006 · Cited by 410 · see citing works

Emerging role of the cannabinoid receptor CB ₂ in immune regulation: therapeutic prospects for neuroinflammation

Cabral, G. A., & Griffin-Thomas, L. (2009) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399409000957 · Cited by 408 · see citing works

Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β

Michelucci, A., Heurtaux, T., Grandbarbe, L., Morga, E., & Heuschling, P. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.02.003 · Cited by 411 · see citing works

Cellular responses following retinal injuries and therapeutic approaches for neurodegenerative diseases

Cuenca, N., Fernández-Sánchez, L., Campello, L., Maneu, V., De la Villa, P., Lax, P., & Pinilla, I. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.07.001 · Cited by 401 · see citing works

Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation

Riazi, K., Galic, M. A., Kuzmiski, J. B., Ho, W., Sharkey, K. A., & Pittman, Q. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806682105 · Cited by 400 · see citing works

Microglial senescence: does the brain's immune system have an expiration date?

Streit, W. J. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.07.001 · Cited by 397 · see citing works

Methamphetamine causes microglial activation in the brains of human abusers

Sekine, Y., Ouchi, Y., Sugihara, G., Takei, N., Yoshikawa, E., Nakamura, K., Iwata, Y., Tsuchiya, K. J., Suda, S., Suzuki, K., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1179-08.2008 · Cited by 381 · see citing works

Neuroinflammation and regulation of glial glutamate uptake in neurological disorders

Tilleux, S., & Hermans, E. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21325 · Cited by 381 · see citing works

Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia

Deleo, J. A., Tanga, F. Y., & Tawfik, V. L. (2004) · The Neuroscientist · doi:10.1177/1073858403259950 · Cited by 371 · see citing works

Critical role of TLR4 response in the activation of microglia induced by ethanol

Fernandez-Lizarbe, S., Pascual, M., & Guerri, C. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803590 · Cited by 373 · see citing works

Microglia: activation and their significance in the central nervous system

Nakajima, K., & Kohsaka, S. (2001) · Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a002969 · Cited by 371 · see citing works

HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration

Gao, H.-M., Zhou, H., Zhang, F., Wilson, B. C., Kam, W., & Hong, J.-S. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3732-10.2011 · Cited by 369 · see citing works

Microglia: Agents of the CNS Pro-Inflammatory Response

Rodríguez-Gómez, J. A., Kavanagh, E., Engskog-Vlachos, P., Engskog, M. K. R., Herrera, A. J., Espinosa-Oliva, A. M., Joseph, B., Hajji, N., Venero, J. L., & Burguillos, M. A. (2020) · Cells · doi:10.3390/cells9071717 · Cited by 365 · see citing works

Imaging robust microglial activation after lipopolysaccharide administration in humans with PET

Sandiego, C. M., Gallezot, J.-D., Pittman, B., Nabulsi, N., Lim, K., Lin, S.-F., Matuskey, D., Lee, J.-Y., O’Connor, K. C., Huang, Y., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511003112 · Cited by 356 · see citing works

Microglia in ALS: The Good, The Bad, and The Resting

Henkel, J. S., Beers, D. R., Zhao, W., & Appel, S. H. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9171-5 · Cited by 353 · see citing works

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

Koprich, J. B., Reske-Nielsen, C., Mithal, P., & Isacson, O. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-8 · Cited by 355 · see citing works

Genetic and non-genetic vulnerability factors in schizophrenia: the basis of the “Two hit hypothesis.”

Bayer, T. A., Falkai, P., & Maier, W. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00039-4 · Cited by 346 · see citing works

Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia

Schmid, C. D., Sautkulis, L. N., Danielson, P. E., Cooper, J., Hasel, K. W., Hilbush, B. S., Sutcliffe, J. G., & Carson, M. J. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01243.x · Cited by 351 · see citing works

Naloxone Protects Rat Dopaminergic Neurons against Inflammatory Damage through Inhibition of Microglia Activation and Superoxide Generation

Liu, B., Du, L., & Hong, J.-S. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39275-4 · Cited by 347 · see citing works

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson’s disease

Pott Godoy, M. C., Tarelli, R., Ferrari, C. C., Sarchi, M. I., & Pitossi, F. J. (2008) · Brain · doi:10.1093/brain/awn101 · Cited by 335 · see citing works

Microglial Dynamics and Role in the Healthy and Diseased Brain: A Paradigm of Functional Plasticity

Gomez-Nicola, D., & Perry, V. H. (2015) · The Neuroscientist · doi:10.1177/1073858414530512 · Cited by 340 · see citing works

Toll-like receptors in the pathogenesis of neuroinflammation

Kumar, V. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.03.012 · Cited by 331 · see citing works

mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging

Frank, M. G., Barrientos, R. M., Biedenkapp, J. C., Rudy, J. W., Watkins, L. R., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.013 · Cited by 327 · see citing works

Evidence for activation of microglia in patients with psychiatric illnesses

Bayer, T. A., Buslei, R., Havas, L., & Falkai, P. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00545-5 · Cited by 323 · see citing works

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Chen, Z., Jalabi, W., Hu, W., Park, H.-J., Gale, J. T., Kidd, G. J., Bernatowicz, R., Gossman, Z. C., Chen, J. T., Dutta, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5486 · Cited by 319 · see citing works

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, J. P. E., Vafeiadou, K., Williams, R. J., & Vauzour, D. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.016 · Cited by 315 · see citing works

Control of glial immune function by neurons

Neumann, H. (2001) · Glia · doi:10.1002/glia.1108 · Cited by 319 · see citing works

An inflammatory review of Parkinson's disease

Orr, C. F., Rowe, D. B., & Halliday, G. M. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00127-2 · Cited by 309 · see citing works

Comprehensive characterization and failure modes of tungsten microwire arrays in chronic neural implants

Prasad, A., Xue, Q.-S., Sankar, V., Nishida, T., Shaw, G., Streit, W. J., & Sanchez, J. C. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/5/056015 · Cited by 298 · see citing works

Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus

Battista, D., Ferrari, C. C., Gage, F. H., & Pitossi, F. J. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04539.x · Cited by 306 · see citing works

Cerebrospinal Fluid and Serum Markers of Inflammation in Autism

Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., & Heyes, M. P. (2005) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2005.03.014 · Cited by 300 · see citing works

Predominant phagocytic activity of resident microglia over hematogenous macrophages following transient focal cerebral ischemia: an investigation using green fluorescent protein transgenic bone marrow chimeric mice

Schilling, M., Besselmann, M., Müller, M., Strecker, J. K., Ringelstein, E. B., & Kiefer, R. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.08.004 · Cited by 288 · see citing works

Microglia actions in Alzheimer's disease

Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291 · see citing works

Blockade of TREM‐2 exacerbates experimental autoimmune encephalomyelitis

Piccio, L., Buonsanti, C., Mariani, M., Cella, M., Gilfillan, S., Cross, A. H., Colonna, M., & Panina‐Bordignon, P. (2007) · European Journal of Immunology · doi:10.1002/eji.200636837 · Cited by 284 · see citing works

Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation

Greter, M., Lelios, I., & Croxford, A. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00249 · Cited by 273 · see citing works

Cellular senescence and the aging brain

Chinta, S. J., Woods, G., Rane, A., Demaria, M., Campisi, J., & Andersen, J. K. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.018 · Cited by 282 · see citing works

Neuroprotective function for ramified microglia in hippocampal excitotoxicity

Vinet, J., van Weering, H. R., Heinrich, A., Kälin, R. E., Wegner, A., Brouwer, N., Heppner, F. L., van Rooijen, N., Boddeke, H. W., & Biber, K. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-27 · Cited by 274 · see citing works

Alzheimer’s Disease Research Using Human Microglia

Lue, L., Beach, T. G., & Walker, D. G. (2019) · Cells · doi:10.3390/cells8080838 · Cited by 26 · see citing works

Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019

Shir, D., & Day, G. S. (2022) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001033 · Cited by 13 · see citing works

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112 · see citing works

Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice

Jung, H., Lee, H., Kim, D., Cheong, E., Hyun, Y., Yu, J., & Um, J. W. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s362006 · Cited by 31 · see citing works

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Voet, S., Mc Guire, C., Hagemeyer, N., Martens, A., Schroeder, A., Wieghofer, P., Daems, C., Staszewski, O., Vande Walle, L., Jordao, M. J. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04376-5 · Cited by 227 · see citing works