Cited by 555Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Immune proteins in brain development and synaptic plasticity

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Boulanger, Lisa M.·2009·Neuron

Abstract

Many proteins first identified in the immune system are also expressed in the developing and adult nervous system. Unexpectedly, recent studies reveal that a number of these proteins, in addition to their immunological roles, are essential for the establishment, function, and modification of synaptic connections. These include proinflammatory cytokines (e.g., TNFalpha, IL-6), proteins of the innate immune system (e.g., complement C1q and C3, pentraxins, Dscam), members of the major histocompatibility complex class I (MHCI) family, and MHCI-binding immunoreceptors and their components (e.g., PIRB, Ly49, DAP12, CD3zeta). Understanding how these proteins function in neurons will clarify the molecular basis of fundamental events in brain development and plasticity and may add a new dimension to our understanding of neural-immune interactions in health and disease.

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Crossref · 10.1016/j.neuron.2009.09.001

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  • During normal brain development, microglia engulf synapses and sculpt synaptic connections via a role for complement.

    “During normal brain development, mounting evidence indicates that microglia engulf synapses and sculpt synaptic connections via a novel role for complement, a component of the innate immune system that enhances the clearance of microbes or damaged cells by phagocytes (Boulanger, 2009; Stephan et al., 2012; Chung et al., 2015).”

    From Microglia in Alzheimer’s disease (2018) · cites this paper as Boulanger, 2009

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Authors
Boulanger, L. M.
Affiliations
Princeton University (US)
Corresponding author
Boulanger, Lisa M.
Venue
Neuron
Publisher
Elsevier BV
Published
2009-10
Volume
64
Issue
1
Pages
93-109
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2091389527
Cited by
555
References
116
Citations by year
2026: 20 · 2025: 18 · 2024: 36 · 2023: 34 · 2022: 21 · 2021: 33 · 2020: 28 · 2019: 31 · 2018: 40 · 2017: 36 · 2016: 34 · 2015: 31 · 2014: 35 · 2013: 43 · 2012: 42
FWCI
3.01
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
immune proteins, brain development, synaptic plasticity, inflammatory cytokines, TNF-α, interleukin-6, C1q, complement C3, pentraxins, Dscam, MHC class I, immunoreceptors, PirB, Ly49, DAP12, CD3zeta, neuroimmune interactions
MeSH terms
Animals, Brain, Humans, Neuronal Plasticity, Neurons, Synapses, Neuroimmunomodulation, Signal Transduction

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