CoChat
Sign Up
Cited by 2,070Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Drugs of abuse: anatomy, pharmacology and function of reward pathways

Koob, George F.·1992·Trends in Pharmacological Sciences
DOI 10.1016/0165-6147(92)90060-j
Open this paper in CoChat — free account

Abstract

Drugs of abuse are very powerful reinforcers, and even in conditions of limited access (where the organism is not dependent) these drugs will motivate high rates of operant responding. This presumed hedonic property and the drugs' neuropharmacological specificity provide a means of studying the neuropharmacology and neuroanatomy of brain reward. Three major brain systems appear to be involved in drug reward--dopamine, opioid and GABA. Evidence suggests a midbrain-forebrain-extrapyramidal circuit with its focus in the nucleus accumbens. Data implicating dopamine and opioid systems in indirect sympathomimetic and opiate reward include critical elements in both the nucleus accumbens and ventral tegmental areas. Ethanol reward appears to depend on an interaction with the GABAA receptor complex but may also involve common elements such as dopamine and opioid peptides in this midbrain-forebrain-extrapyramidal circuit. These results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.

Overview

Integrity signals

Registry

Crossref · 10.1016/0165-6147(92)90060-j

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 73 references

Research works printed but not linked: 21

  1. Dahlström, 1964, Acta Physiol. Scand., 232, 1
  2. Weiss, F. et al.Ann. NY Acad. Sci. (in press).
  3. Pfeffer, 1985, Alcohol Drug Res., 6, 37
  4. Rassnick, S., Pulvirenti, L. and Koob, G. F. Psychopharmacology (in press).
  5. Samson, 1988, Alcohol. Clin. Exp. Res., 12, 581
  6. Imperato, 1986, J. Pharmacol. Exp. Ther., 239, 221
  7. Bodnar, 1990, Crit. Rev. Neurobiol., 6, 39
  8. West, 1989, Soc. Neurosri. Abstr., 15, 20.8
  9. Koob, 1984, J. Pharmacol. Exp. Ther., 229, 481
  10. Goldberg, 1971, J. Pharmacol. Exp. Ther., 176, 464
  11. Di Chiara, 1988, J. Pharmacol. Exp. Ther., 244, 1067
  12. Di Chiara, 1988, 85, 5274
  13. Shippenberg, T. S., Spanagel, R. and Herz, A.Ann. NY Acad. Sci. (in press).
  14. Givens, 1990, J. Pharmacol. Exp. Ther., 254, 528
  15. Sepinwall, 1978, Vol. 13, 345
  16. Koob, G. F. and Britton, K. T. in Pharmacology and Neuropharmacology (Vol. 2) Alcohol and Alcoholisms (Begleiter, H. and Kissin, B., eds), Oxford University Press (in press).
  17. Frye, 1982, J. Pharmacol. Exp. Ther., 223, 750
  18. Suzdak, 1986, 83, 4071
  19. Rassnick, S. et al.Ann. NY Acad. Sci. (in press).
  20. Deitrich, 1989, Pharmacol. Rev., 41, 489
  21. Pickens, 1981, J. Pharmacol. Exp. Ther., 216, 205

Cited by

Sorted by citations

Items 1,001–1,004 of 1,004

Related

See all

Metadata

Authors
Koob, G. F.
Affiliations
Scripps Research Institute (US)
Corresponding author
Koob, George F.
Venue
Trends in Pharmacological Sciences
Publisher
Elsevier BV
Published
1992-01
Volume
13
Issue
5
Pages
177-184
ISSN
0165-6147 (ISSN-L)
DOI
10.1016/0165-6147(92)90060-j
OpenAlex
W2001865657
Cited by
2,070
References
73
Citations by year
2026: 7 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 17 · 2021: 28 · 2020: 30 · 2019: 28 · 2018: 46 · 2017: 42 · 2016: 43 · 2015: 37 · 2014: 58 · 2013: 53 · 2012: 53
FWCI
6.53
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Trends in Pharmacological Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (AA-08459)
  • National Institute on Drug Abuse (DA04043, DA04398, R01DA004398, R01DA004043)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
drugs of abuse, brain reward system, dopamine, opioid system, GABA, nucleus accumbens, ventral tegmental area, ethanol reward, opioid reward, operant responding
MeSH terms
Animals, Brain, Humans, Reward, Illicit Drugs, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review