Cited by 2,070Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.

Drugs of abuse: anatomy, pharmacology and function of reward pathways

Koob, George F.·1992·Trends in Pharmacological Sciences

DOI 10.1016/0165-6147(92)90060-j

Open this paper in CoChat — free account

Abstract

Drugs of abuse are very powerful reinforcers, and even in conditions of limited access (where the organism is not dependent) these drugs will motivate high rates of operant responding. This presumed hedonic property and the drugs' neuropharmacological specificity provide a means of studying the neuropharmacology and neuroanatomy of brain reward. Three major brain systems appear to be involved in drug reward--dopamine, opioid and GABA. Evidence suggests a midbrain-forebrain-extrapyramidal circuit with its focus in the nucleus accumbens. Data implicating dopamine and opioid systems in indirect sympathomimetic and opiate reward include critical elements in both the nucleus accumbens and ventral tegmental areas. Ethanol reward appears to depend on an interaction with the GABAA receptor complex but may also involve common elements such as dopamine and opioid peptides in this midbrain-forebrain-extrapyramidal circuit. These results suggest that brain reward systems have a multidetermined neuropharmacological basis that may involve some common neuroanatomical elements.

Integrity signals

Registry

Crossref · 10.1016/0165-6147(92)90060-j

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Handbook of Psychopharmacology
Iversen, L. L., Iversen, S. D., & Snyder, S. H. (1988) · Springer eBooks · doi:10.1007/978-1-4613-0933-8 · Cited by 2,756
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
Self-citation
Brain Dopamine and Reward
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968
An opponent-process theory of motivation. I. Temporal dynamics of affect
Solomon, R. L., & Corbit, J. D. (1974) · Psychological Review · doi:10.1037/h0036128 · Cited by 1,704
New perspectives in basal forebrain organization of special relevance for neuropsychiatric disorders: The striatopallidal, amygdaloid, and corticopetal components of substantia innominata
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217
Catecholamine innervation of the basal forebrain IV. Topography of the dopamine projection to the basal forebrain and neostriatum
Fallon, J. H., & Moore, R. Y. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800310 · Cited by 1,190
Mesocorticolimbic dopaminergic network: functional and regulatory roles
Moal, M. L., & Simon, H. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.155 · Cited by 1,108
Opposite effects of mu and kappa opiate agonists on dopamine release in the nucleus accumbens and in the dorsal caudate of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24578-5 · Cited by 916

Show all 73 references

Research works printed but not linked: 21

Dahlström, 1964, Acta Physiol. Scand., 232, 1
Weiss, F. et al.Ann. NY Acad. Sci. (in press).
Pfeffer, 1985, Alcohol Drug Res., 6, 37
Rassnick, S., Pulvirenti, L. and Koob, G. F. Psychopharmacology (in press).
Samson, 1988, Alcohol. Clin. Exp. Res., 12, 581
Imperato, 1986, J. Pharmacol. Exp. Ther., 239, 221
Bodnar, 1990, Crit. Rev. Neurobiol., 6, 39
West, 1989, Soc. Neurosri. Abstr., 15, 20.8
Koob, 1984, J. Pharmacol. Exp. Ther., 229, 481
Goldberg, 1971, J. Pharmacol. Exp. Ther., 176, 464
Di Chiara, 1988, J. Pharmacol. Exp. Ther., 244, 1067
Di Chiara, 1988, 85, 5274
Shippenberg, T. S., Spanagel, R. and Herz, A.Ann. NY Acad. Sci. (in press).
Givens, 1990, J. Pharmacol. Exp. Ther., 254, 528
Sepinwall, 1978, Vol. 13, 345
Koob, G. F. and Britton, K. T. in Pharmacology and Neuropharmacology (Vol. 2) Alcohol and Alcoholisms (Begleiter, H. and Kissin, B., eds), Oxford University Press (in press).
Frye, 1982, J. Pharmacol. Exp. Ther., 223, 750
Suzdak, 1986, 83, 4071
Rassnick, S. et al.Ann. NY Acad. Sci. (in press).
Deitrich, 1989, Pharmacol. Rev., 41, 489
Pickens, 1981, J. Pharmacol. Exp. Ther., 216, 205

Sorted by citations

Items 601–700 of 1,004

Effects of dopamine and serotonin-releasing agents on methamphetamine discrimination and self-administration in rats
Munzar, P., Baumann, M. H., Shoaib, M. C., & Goldberg, S. R. (1999) · Psychopharmacology · doi:10.1007/s002130050836 · Cited by 71
Reinforcing Effects of Nicotinic Compounds Intravenous Self-administration in Drug-Naive Mice
Rasmussen, T. (1998) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00003-3 · Cited by 71
Addiction Is a Brain Disease, and It Matters
Leshner, A. I. (2003) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.1.2.190 · Cited by 70
Cocaine-induced hyperactivity and sensitization are dependent on GSK3
Miller, J. S., Tallarida, R. J., & Unterwald, E. M. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.03.006 · Cited by 70
Differential Effects of Cocaine on Dopamine Neuron Firing in Awake and Anesthetized Rats
Koulchitsky, S., Backer, B. D., Quertemont, É., Charlier, C., & Seutin, V. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.339 · Cited by 70
Hippocampal and amygdaloid interactions in the nucleus accumbens
Groenewegen, H. J., Mulder, A. B., Beijer, A. V. J., Wright, C. I., Lopes, F. H. D. S., & Pennartz, C. M. A. (1999) · Psychobiology · doi:10.3758/bf03332111 · Cited by 70
Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice
McGeehan, A., Janak, P. H., & Olive, M. F. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1733-2 · Cited by 70
Modulation of Blood Pressure and Obesity With the Dopamine D2 Receptor GeneTaqI Polymorphism
Thomas, G. N., Tomlinson, B., & Critchley, J. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.177 · Cited by 70
The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration
Greenwell, T. N., Walker, B. M., Cottone, P., Zorrilla, E. P., & Koob, G. F. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.07.012 · Cited by 69
Self-citation
Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors
Picciotto, M. R., Brabant, C., Einstein, E. B., Kamens, H. M., & Neugebauer‎, N. M. (2009) · Brain Research · doi:10.1016/j.brainres.2009.08.033 · Cited by 69
ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release
Morris, E. D., Yoder, K. K., Wang, C., Normandin, M. D., Zheng, Q., Mock, B. H., Raymond, F. M., & Froehlich, J. C. (2005) · Molecular Imaging · doi:10.2310/7290.2005.05130 · Cited by 69
Subjective Experience and Dopamine D 2 Receptor Occupancy in Patients Treated with Antipsychotics: Clinical Implications
de Haan, L., Lavalaye, J., van Bruggen, M., van Nimwegen, L. J. M., Booij, J., van Amelsvoort, T., & LINSZEN, D. H. (2004) · The Canadian Journal of Psychiatry · doi:10.1177/070674370404900503 · Cited by 69
Involvement of serotonin in nicotine dependence: Processes relevant to positive and negative regulation of drug intake
Olausson, P., Engel, J. A., & Söderpalm, B. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00673-6 · Cited by 69
Cellular Mechanisms Underlying Reinforcement-Related Processing in the Nucleus Accumbens: Electrophysiological Studies in Behaving Animals
Carelli, R. M., & Deadwyler, S. A. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00442-x · Cited by 69
Dopaminergic Regulation of Striatal Interneurons in Reward and Addiction: Focus on Alcohol
Clarke, R. B. C., & Adermark, L. (2015) · Neural Plasticity · doi:10.1155/2015/814567 · Cited by 68
Drugs of Abuse and Brain Gene Expression
Torres, G., & Horowitz, J. M. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199909000-00007 · Cited by 68
Intraaccumbens injections of substance P, morphine and amphetamine: effects on conditioned place preference and behavioral activity
Schildein, S., Ågmo, A., Huston, J. P., & Schwarting, R. K. W. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00062-6 · Cited by 68
Inactivation of Adenosine A2A Receptors Selectively Attenuates Amphetamine-Induced Behavioral Sensitization
Chen, J., Moratalla, R., Yu, L., Martín, A. B., Xu, K., Bastia, E., Hackett, E., Alberti, I., & Schwarzschild, M. A. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300152 · Cited by 68
Microinjection of CART peptide 55–102 into the nucleus accumbens blocks amphetamine-induced locomotion
Kim, J., Creekmore, E., & Vezina, P. (2003) · Neuropeptides · doi:10.1016/j.npep.2003.10.001 · Cited by 67
Morphine decreases extracellular levels of glutamate in the anterior cingulate cortex: an in vivo microdialysis study in freely moving rats
Hao, Y., Yang, J., Guo, M., Wu, C. F., & Wu, M. F. (2005) · Brain Research · doi:10.1016/j.brainres.2005.01.072 · Cited by 67
Possible Pharmacotherapy of the Opioid κ Receptor Agonist for Drug Dependence
Hasebe, K., Kawai, K., Suzuki, T., Kawamura, K., Tanaka, T., Narita, M., Nagase, H., & Suzuki, T. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1316.050 · Cited by 67
Peroxisome Proliferator-Activated Receptor (PPAR) Agonists as Promising New Medications for Drug Addiction: Preclinical Evidence
Foll, B. L., Ciano, P. D., Panlilio, L. V., Goldberg, S. R., & Ciccocioppo, R. (2013) · Current Drug Targets · doi:10.2174/1389450111314070006 · Cited by 67
Cocaine- and Amphetamine-Regulated Transcript (CART) Peptides Modulate the Locomotor and Motivational Properties of Psychostimulants
Couceyro, P. R., Evans, C. H., McKinzie, A. A., Mitchell, D., Dube, M., Hagshenas, L., White, F. J., Douglass, J., Richards, W. G., & Bannon, A. W. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.091678 · Cited by 67
Effect of imipramine on the expression and acquisition of morphine-induced conditioned place preference in mice
Zarrindast, M., Bahreini, T., & Adl, M. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00951-6 · Cited by 67
Chronic Daily Ethanol and Withdrawal: 3. Forebrain Pro-Opiomelanocortin Gene Expression and Implications for Dependence, Relapse, and Deprivation Effect
Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., & Mitton, D. R. (2002) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02572.x · Cited by 67
Chronic morphine and naltrexone fail to modify μ-opioid receptor mRNA levels in the rat brain
Castelli, M. P., Melis, M., Mameli, M., Fadda, P., Diaz, G., & GESSA, G. L. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(96)00305-1 · Cited by 67
Toluene-Induced Locomotor Activity is Blocked by 6-Hydroxydopamine Lesions of the Nucleus Accumbens and the mGluR2/3 Agonist LY379268
Riegel, A. C., Ali, S. F., & French, E. D. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300193 · Cited by 67
Organization of the ophidian amygdala: Chemosensory pathways to the hypothalamus
Martínez-Marcos, A., Lanuza, E., & Halpern, M. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990913)412:1 · Cited by 45
Localization of the ?-opioid receptor and dopamine transporter in the nucleus accumbens shell: Implications for opiate and psychostimulant cross-sensitization
Svingos, A. L., Clarke, C. L., & Pickel, V. M. (1999) · Synapse · doi:10.1002/(sici)1098-2396(199910)34:1 · Cited by 67
Acute Toluene Induces Biphasic Changes in Rat Spontaneous Locomotor Activity Which Are Blocked by Remoxipride
Riegel, A. C. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00062-8 · Cited by 66
Effects of CB1 receptor antagonist within the nucleus accumbens on the acquisition and expression of morphine-induced conditioned place preference in morphine-sensitized rats
Azizi, P., Haghparast, A., & Hassanpour-Ezatti, M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.08.009 · Cited by 66
Nucleus accumbens cell firing during maintenance, extinction, and reinstatement of cocaine self-administration behavior in rats
Carelli, R. M., & Ijames, S. G. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02217-4 · Cited by 66
Mice selectively bred for high voluntary wheel running have larger midbrains: support for the mosaic model of brain evolution
Kolb, E. M., Rezende, E. L., Holness, L. F., Radtke, A., Lee, S. K., Obenaus, A., & Garland, T. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.076000 · Cited by 66
Effect of acupuncture on behavioral hyperactivity and dopamine release in the nucleus accumbens in rats sensitized to morphine
Kim, M.-R., Kim, S. J., Lyu, Y.-S., Kim, S., Lee, Y. K., Kim, T. H., Shim, I., Zhao, R., Golden, G. T., & Yang, C. H. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.07.007 · Cited by 66
Feedback Control of Mesolimbic Somatodendritic Dopamine Release in Rat Brain
Rahman, S., & McBride, W. J. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740684.x · Cited by 66
The anabolic–androgenic steroid nandrolone induces alterations in the density of serotonergic 5ht1b and 5ht2 receptors in the male rat brain
Kindlundh, A. M. S., Lindblom, J., Bergström, L., & Nyberg, F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00120-9 · Cited by 66
Naltrexone Effects on Ethanol Drinking Acquisition and on Established Ethanol Consumption in C57BL/6J Mice
Phillips, T. J., Wenger, C. D., & Dorow, J. D. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1097/00000374-199706000-00021 · Cited by 66
Encoding and retrieval of episodic memories: Role of cholinergic and GABAergic modulation in the hippocampus
Hasselmo, M. E., Wyble, B., & Wallenstein, G. V. (1998) · Hippocampus · doi:10.1002/(sici)1098-1063(1996)6:6 · Cited by 366
Rewarding brain stimulation induces only sparse Fos-like immunoreactivity in dopaminergic neurons
Hunt, G. E., & McGregor, I. S. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00409-0 · Cited by 66
Locomotor activation and dopamine release produced by nicotine and isoarecolone in rats
Whiteaker, P., Garcha, H. S., Wonnacott, S., & Stolerman, I. P. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb16417.x · Cited by 66
The effects of neonatal paternal deprivation on pair bonding, NAcc dopamine receptor mRNA expression and serum corticosterone in mandarin voles
Yu, P., An, S.-C., Tai, F., Zhang, X., He, F., Wang, J., An, X., & Wu, R. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.028 · Cited by 65
Involvement of the sigma1 receptor in the motivational effects of ethanol in mice
Maurice, T., Casalino, M., Lacroix, M., & Romieu, P. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00002-9 · Cited by 65
Mecamylamine and Ethanol Preference in Healthy Volunteers
Young, E. M., Mahler, S. V., Chi, H., & de Wit, H. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000150007.34702.16 · Cited by 65
Behavioral effects of psychomotor stimulants in rats with dorsal or ventral subiculum lesions: Locomotion, cocaine self-administration, and prepulse inhibition of startle.
Caine, S. B., Humby, T., Robbins, T. W., & Everitt, B. J. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.880 · Cited by 65
Untitled work
(2010) · American journal of play · Cited by 65
Potential association of DRD2 and DAT1 genetic variation with heroin dependence
Hou, Q., & Li, S. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.08.004 · Cited by 64
Molecular Evidence for the Functional Role of Dopamine D3Receptor in the Morphine-Induced Rewarding Effect and Hyperlocomotion
Narita, M., Mizuo, K., Mizoguchi, H., Sakata, M., Narita, M., Tseng, L. F., & Suzuki, T. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-03-01006.2003 · Cited by 64
Prenatal Morphine Enhances Morphine-Conditioned Place Preference in Adult Rats
Gagin, R. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)00281-5 · Cited by 64
Cocaine increases serotonergic activity in the hippocampus and nucleus accumbens in vivo: 5‐HT1a‐receptor antagonism blocks behavioral but potentiates serotonergic activation
Müller, C. P., Carey, R. J., Silva, M. A. D. S., Jocham, G., & Huston, J. P. (2002) · Synapse · doi:10.1002/syn.10083 · Cited by 64
Excitatory amino acid receptor antagonist kynurenic acid attenuates rewarding potential of morphine
Bespalov, A., Думпис, М. А., Piotrovsky, L. B., & Zvartau, E. E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00462-5 · Cited by 64
The “addicted” spine
Spiga, S., Mulas, G., Piras, F., & Diana, M. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00110 · Cited by 63
A bi-directional μ-opioid–opioid connection between the nucleus of the accumbens shell and the central nucleus of the amygdala in the rat
Kim, E., Quinn, J. G., Levine, A. S., & O‘Hare, E. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.001 · Cited by 63
A scale-free systems theory of motivation and addiction
Chambers, R. A., Bickel, W. K., & Potenza, M. N. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.04.005 · Cited by 63
Brain-derived neurotrophic factor in substance use disorders: A systematic review and meta-analysis
Ornell, F. R., Hansen, F., Schuch, F. B., Rebelatto, F. P., Tavares, A. L. J., Scherer, J. N., Valério, A. G., Pechansky, F., Kessler, F. H. P., & DIEMEN, L. V. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.08.036 · Cited by 63
Anatomic Review of the Ventral Capsule/Ventral Striatum and the Nucleus Accumbens to Guide Target Selection for Deep Brain Stimulation for Obsessive-Compulsive Disorder
Park, Y. S., Sammartino, F., Young, N. A., Corrigan, J. D., Krishna, V., & Rezai, A. R. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.01.254 · Cited by 65
Implication of dopaminergic projection from the ventral tegmental area to the anterior cingulate cortex in μ‐opioid‐induced place preference
Narita, M., Matsushima, Y., Niikura, K., Narita, M., Takagi, S., Nakahara, K., Kurahashi, K., ABE, M., Saeki, M., Asato, M., et al. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00249.x · Cited by 63
Effects of estrogen on the number of neurons expressing β‐endorphin in the medial basal hypothalamus of the female guinea pig
Thornton, J. E., Loose, M. D., Kelly, M. J., & Rønnekleiv, O. K. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903410107 · Cited by 63
Molecular evidence for the involvement of NR2B subunit containing N-methyl-d-aspartate receptors in the development of morphine-induced place preference
Narita, M., Aoki, T., & Suzuki, T. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00405-x · Cited by 63
Alterations in Central Preproenkephalin mRNA Expression After Chronic Free-Choice Ethanol Consumption by Fawn-Hooded Rats
Cowen, M. S., & Lawrence, A. J. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02326.x · Cited by 63
Chronic morphine treatment alters expression of N-methyl-D-aspartate receptor subunits in the extended amygdala
Bajo, M., Crawford, E. F., Roberto, M., Madamba, S. G., & Siggins, G. R. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.20756 · Cited by 63
Long-Lasting Increase of Alcohol Relapse by the Cannabinoid Receptor Agonist WIN 55,212-2 during Alcohol Deprivation
López‐Moreno, J. A., González‐Cuevas, G., de Fonseca, F. R., & Navarro, M. A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2179-04.2004 · Cited by 63
ONE HUNDRED YEARS OF ALCOHOLISM: THE TWENTIETH CENTURY
Mann, K. (2000) · Alcohol and Alcoholism · doi:10.1093/alcalc/35.1.10 · Cited by 63
The Cytosolic Acidification in Rat Parotid Cells Is Associated with an Increase in Cytosolic Ca2+ Concentration
Tanimura, A., Tojyo, Y., & Matsumoto, Y. (1993) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.62.15 · Cited by 63
Decreased Presynaptic Sensitivity to Adenosine after Cocaine Withdrawal
Manzoni, O. J., Pujalte, D., Williams, J. T., & Bockaert, J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07996.1998 · Cited by 63
Heroin and its metabolites: relevance to heroin use disorder
Milella, M. S., D’Ottavio, G., Pirro, S. D., Barra, M., Caprioli, D., & Badiani, A. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02406-5 · Cited by 62
Episodic Memories and Their Relevance for Psychoactive Drug Use and Addiction
Müller, C. P. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00034 · Cited by 62
Midbrain functional connectivity and ventral striatal dopamine D2-type receptors: link to impulsivity in methamphetamine users
Kohno, M., Okita, K., Morales, A. M., Robertson, C. L., Dean, A. C., Ghahremani, D. G., Sabb, F. W., Rawson, R. A., Mandelkern, M. A., Bilder, R. M., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.223 · Cited by 62
Role of exercise in the treatment of alcohol use disorders
Manthou, E., Georgakouli, K., Fatouros, I. G., Gianoulakis, C., Theodorakis, Y., & Jamurtas, A. Z. (2016) · Biomedical Reports · doi:10.3892/br.2016.626 · Cited by 62
Circuits, Drugs, and Drug Addiction
Koob, G. F. (1997) · Advances in pharmacology · doi:10.1016/s1054-3589(08)60910-2 · Cited by 62
Self-citation
Cannabinoid-induced Fos expression within A10 dopaminergic neurons
Patel, S., & Hillard, C. J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)03797-6 · Cited by 62
The role of glutamate and its receptors in mesocorticolimbic dopaminergic regions in opioid addiction
Guo, Y., Wang, H., Xiang, X., & Zhao, Y. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.02.005 · Cited by 62
Gabapentin maintenance decreases smoked cocaine-related subjective effects, but not self-administration by humans
Hart, C. L., Ward, A. S., Collins, E. D., Haney, M., & Foltin, R. W. (2003) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2003.10.015 · Cited by 62
Lack of Allelic Association of Dopamine D1 and D2 (TaqIA) Receptor Gene Polymorphisms with Reduced Dopaminergic Sensitivity in Alcoholism
Heinz, A., Sander, T., Harms, H., Finckh, U., Kühn, S., Dufeu, P., Dettling, M., Gräf, K., Rolfs, A., Rommelspacher, H., et al. (1996) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01954.x · Cited by 62
Ethanol Consumption by Fawn‐Hooded Rats Following Abstinence Effect of Naltrexone and Changes in μ‐Opioid Receptor Density
Cowen, M. S., Rezvani, A. H., Jarrott, B., & Lawrence, A. J. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04218.x · Cited by 62
Nicotine and Hippocampus-Dependent Learning: Implications for Addiction
Gould, T. J. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:2:93 · Cited by 61
Exposure to food cues moderates the indirect effect of reward sensitivity and external eating via implicit eating expectancies
Maxwell, A. L., Loxton, N. J., & Hennegan, J. M. (2016) · Appetite · doi:10.1016/j.appet.2016.12.037 · Cited by 61
Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone
Leggio, G. M., Camillieri, G., Platania, C. B. M., Castorina, A., Marrazzo, G., Torrisi, S. A., Nona, C. N., D’Agata, V., Nóbrega, J. N., Stark, H., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.51 · Cited by 61
Effects of High-Dose Methadone Maintenance on Cocaine Place Conditioning, Cocaine Self-Administration, and Mu-Opioid Receptor mRNA Expression in the Rat Brain
Leri, F., Zhou, Y., Goddard, B., Cummins, E., & Kreek, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300927 · Cited by 61
Enhanced sensitivity of the nucleus accumbens proenkephalin system to alcohol in rats selectively bred for alcohol preference
Li, X.-W., Li, T., & Froehlich, J. C. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00191-7 · Cited by 61
Intrauterine cocaine exposure of rabbits: persistent elevation of GABA-immunoreactive neurons in anterior cingulate cortex but not visual cortex
Wang, X.-H., Levitt, P. R., Grayson, D. R., & Murphy, E. H. (1995) · Brain Research · doi:10.1016/0006-8993(95)00528-x · Cited by 61
The diagnostic dilemma of pathological appearance and performance enhancing drug use
Hildebrandt, T., Lai, J. K., Langenbucher, J. W., Schneider, M., Yehuda, R., & Pfaff, D. W. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.09.018 · Cited by 60
Increased dopamine transporter density in the male rat brain following chronic nandrolone decanoate administration
Kindlundh, A. M. S., Rahman, S., Lindblom, J., & Nyberg, F. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2003.11.040 · Cited by 60
Autoradiographic evidence that prenatal morphine exposure sex-dependently alters μ-opioid receptor densities in brain regions that are involved in the control of drug abuse and other motivated behaviors
Vathy, I., Šlamberová, R., Rimanóczy, Á., Riley, M. A., & Bar, N. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00355-x · Cited by 60
Pharmacogenetic insights to monoaminergic dysfunction in alcohol dependence
Heinz, A., Goldman, D. A., Gallinat, J., Schumann, G., & Puls, I. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1903-x · Cited by 60
GABAA receptors in the basolateral amygdala are involved in mediating morphine reward
Zarrindast, M., Ahmadi, S., Haeri-Rohani, A., Rezayof, A., Jafari, M. R., & Jafari‐Sabet, M. (2004) · Brain Research · doi:10.1016/j.brainres.2003.12.048 · Cited by 60
5‐HT Receptor Knockout Mice: Pharmacological Tools or Models of Psychiatric Disorders
Scearce-Levie, K. A., CHEN, J. ‐., Gardner, E. L., & Hen, R. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb11350.x · Cited by 60
Influence of Cocaine on the JAK–STAT Pathway in the Mesolimbic Dopamine System
Berhow, M. T., Hiroi, N., Kobierski, L. A., Hyman, S. E., & Nestler, E. J. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08019.1996 · Cited by 60
Site-specific NMDA receptor antagonists produce differential effects on cocaine self-administration in rats
Hyytiä, P., Bäckström, P., & Liljequist, S. (1999) · European Journal of Pharmacology · doi:10.1016/s0014-2999(99)00446-x · Cited by 60
Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor ε1 subunit
Miyamoto, Y., Yamada, K., Nagai, T., Mori, H., Mishina, M., Furukawa, H., Noda, Y., & Nabeshima, T. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03086.x · Cited by 60
Long-term, low-level adolescent nicotine exposure produces dose-dependent changes in cocaine sensitivity and reward in adult mice
Kelley, B. M., & Rowan, J. D. (2004) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2004.04.002 · Cited by 59
Sex Differences in Mesolimbic Dopamine Responses to Ethanol and Relationship to Ethanol Intake in Rats
Blanchard, B. A., & Glick, S. D. (2002) · Springer eBooks · doi:10.1007/0-306-47138-8_15 · Cited by 59
Dopamine D1 and D3 receptors oppositely regulate NMDA‐ and cocaine‐induced MAPK signaling via NMDA receptor phosphorylation
Jiao, H., Zhang, L., Gao, F., Lou, D., Zhang, J., & Xu, M. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04840.x · Cited by 59
Interaction between Two Independent CNR1 Variants Increases Risk for Cocaine Dependence in European Americans: A Replication Study in Family-Based Sample and Population-Based Sample
Zuo, L., Kranzler, H. R., Luο, X., Yang, B., Weiss, R. D., Brady, K. T., Poling, J. C., Farrer, L. A., & Gelernter, J. E. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.206 · Cited by 59
Association of time-dependent changes in mu opioid receptor mRNA, but not BDNF, TrkB, or MeCP2 mRNA and protein expression in the rat nucleus accumbens with incubation of heroin craving
Theberge, F. R. M., Pickens, C. L., Goldart, E. M., Fanous, S., Hope, B. T., Liu, Q., & Shaham, Y. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2784-z · Cited by 59
Effects of dopaminergic drugs on locomotor activity in teleost fish of the genus Oreochromis (Cichlidae): involvement of the telencephalon
Mok, E. Y.-M., & Munro, A. D. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00038-9 · Cited by 59
Effects of haloperidol in a response-reinstatement model of heroin relapse
Ettenberg, A., MacConell, L., & Geist, T. D. (1996) · Psychopharmacology · doi:10.1007/bf02246658 · Cited by 59
Dextromethorphan reduces intravenous cocaine self-administration in the rat
Pulvirenti, L., Balducci, C., & Koob, G. F. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(96)00970-3 · Cited by 59
Self-citation
µ/δ Cooperativity and opposing κ‐opioid effects in nucleus accumbens‐mediated antinociception in the rat
Schmidt, B. L., Tambeli, C. H., Levine, J. D., & Gear, R. W. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.01915.x · Cited by 59
Reward-quality dependent anticipation in rat nucleus accumbens
Miyazaki, K., Mogi, E., Araki, N., & Matsumoto, G. (1998) · Neuroreport · doi:10.1097/00001756-199812010-00032 · Cited by 59
Neuroimaging reward, craving, learning, and cognitive control in substance use disorders: review and implications for treatment
Tanabe, J., Regner, M. F., Sakai, J. T., Martínez, D., & Gowin, J. L. (2019) · British Journal of Radiology · doi:10.1259/bjr.20180942 · Cited by 58

Authors: Koob, G. F.
Affiliations: Scripps Research Institute (US)
Corresponding author: Koob, George F.
Venue: Trends in Pharmacological Sciences
Publisher: Elsevier BV
Published: 1992-01
Volume: 13
Issue: 5
Pages: 177-184
ISSN: 0165-6147 (ISSN-L)
DOI: 10.1016/0165-6147(92)90060-j
OpenAlex: W2001865657
Cited by: 2,070
References: 73
Citations by year: 2026: 7 · 2025: 10 · 2024: 12 · 2023: 16 · 2022: 17 · 2021: 28 · 2020: 30 · 2019: 28 · 2018: 46 · 2017: 42 · 2016: 43 · 2015: 37 · 2014: 58 · 2013: 53 · 2012: 53
FWCI: 6.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Pharmacological Sciences (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (AA-08459)
National Institute on Drug Abuse (DA04043, DA04398, R01DA004398, R01DA004043)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: drugs of abuse, brain reward system, dopamine, opioid system, GABA, nucleus accumbens, ventral tegmental area, ethanol reward, opioid reward, operant responding
MeSH terms: Animals, Brain, Humans, Reward, Illicit Drugs, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Drugs of abuse: anatomy, pharmacology and function of reward pathways

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks