A novel murine model of aging, Senescence-Accelerated Mouse (SAM)

Longevity, senescence and the genome

(1995) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(95)90026-8 · Cited by 1,403 · see citing works

A new murine model of accelerated senescence

Takeda, T., HOSOKAWA, M., TAKESHITA, S., Irino, M., Higuchi, K., Matsushita, T., Tomita, Y., Yasuhira, K., Hamamoto, H., & Shimizu, K. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90084-1 · Cited by 871 · see citing works

Robbins Pathologic Basis of Disease

Morrison, A. B. (1990) · JAMA · doi:10.1001/jama.1990.03450170141042 · Cited by 616 · see citing works

Age-related changes in learning and memory in the senescence-accelerated mouse (SAM)

Miyamoto, M., Kiyota, Y., Yamazaki, N., Nagaoka, A., Matsuo, T., Nagawa, Y., & Takeda, T. (1986) · Physiology & Behavior · doi:10.1016/0031-9384(86)90112-5 · Cited by 375 · see citing works

Senescence‐Accelerated Mouse (SAM): A Novel Murine Model of Accelerated Senescence

Takeda, T., Hosokawa, M., & Higuchi, K. (1991) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1991.tb04460.x · Cited by 367 · see citing works

Age-related changes in bone mass in the senescence-accelerated mouse (SAM). SAM-R/3 and SAM-P/6 as new murine models for senile osteoporosis.

Matsushita, M., Tsuboyama, T., Kasai, R., Okumura, H., Yamamuro, T., Higuchi, K., Higuchi, K., Kohno, A., Yonezu, T., & Utani, A. (1986) · PubMed Central · Cited by 233 · see citing works

Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)

Hosokawa, M., Kasai, R., Higuchi, K., Takeshita, S., Shimizu, K., Hamamoto, H., Honma, A., Irino, M., Toda, K., Matsumura, A., et al. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90168-4 · Cited by 222 · see citing works

Spontaneous Spongy Degeneration of the Brain Stem in SAM-P/8 Mice, a Newly Developed Memory-Deficient Strain

Yagi, H., Irino, M., Matsushita, T., et al. (1989) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198909000-00008 · Cited by 122 · see citing works

Spontaneous age-associated amyloidosis in senescence-accelerated mouse (SAM)

Takeshita, S., Hosokawa, M., Irino, M., Higuchi, K., Shimizu, K., Yasuhira, K., & Takeda, T. (1982) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(82)90070-7 · Cited by 115 · see citing works

Inbred SAM-P/10 as a Mouse Model of Spontaneous, Inherited Brain Atrophy

Shimada, A., Ohta, A., Akiguchi, I., & Takeda, T. (1992) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199207000-00006 · Cited by 103 · see citing works

Purification and characterization of a senile amyloid-related antigenic substance (apoSASSAM) from mouse serum. apoSASSAM is an apoA-II apolipoprotein of mouse high density lipoproteins.

Higuchi, K., Yonezu, T., Kogishi, K., et al. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67168-6 · Cited by 100 · see citing works

Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice. Relationship between the molecular type of apoA-II and mouse senile amyloidosis

Higuchi, K., Kitagawa, K., Naiki, H., et al. (1991) · Biochemical Journal · doi:10.1042/bj2790427 · Cited by 94 · see citing works

Senescence-Accelerated Mouse (SAM). A novel murine model of aging

Takeda, T. (1994) · Medical Entomology and Zoology · Cited by 78 · see citing works

Immune responses in newly developed short-lived SAM mice. I. Age-associated early decline in immune activities of cultured spleen cells.

Hosokawa, T., Hosono, M., Higuchi, K., et al. (1987) · PubMed · Cited by 69 · see citing works

Age-related changes in the temporomandibular joint of the senescence accelerated mouse. SAM-P/3 as a new murine model of degenerative joint disease.

Chen, W. H., Hosokawa, M., Tsuboyama, T., et al. (1989) · PubMed · Cited by 68 · see citing works

Age-Related Changes In Lung Structure And Function In The Senescence-Accelerated Mouse (Sam): Sam-P/1 As A New Murine Model Of Senile Hyperinflation Of Lung

Kurozumi, M., Matsushita, T., Hosokawa, M., et al. (1994) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.149.3.8118649 · Cited by 66 · see citing works

A novel amyloid fibril protein isolated from senescence-accelerated mice.

Matsumura, A., Higuchi, K., Shimizu, K., et al. (1982) · PubMed · Cited by 60 · see citing works

Localization of atrophy-prone areas in the aging mouse brain: Comparison between the brain atrophy model SAM-P/10 and the normal control SAM-R/1

Shimada, A., Hosokawa, M., Ohta, A., Akiguchi, I., & Takeda, T. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90290-9 · Cited by 60 · see citing works

Mouse senile amyloidosis. ASSAM amyloidosis in mice presents universally as a systemic age-associated amyloidosis.

Higuchi, K., Naiki, H., Kitagawa, K., et al. (1991) · PubMed · Cited by 60 · see citing works

Mouse senile amyloidosis

Higuchi, K., Naiki, H., Kitagawa, K., et al. (1991) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02899551 · Cited by 56 · see citing works

Age-related hearing impairment in senescence-accelerated mouse (SAM)

Saitoh, Y., Hosokawa, M., Shimada, A., et al. (1994) · Hearing Research · doi:10.1016/0378-5955(94)90052-3 · Cited by 51 · see citing works

Acceleration of chromosome aberrations in senescence-accelerated strains of mice

Nisitani, S., Hosokawa, M., Sasaki, M. S., Yasuoka, K., Naiki, H., Matsushita, T., & Takeda, T. (1990) · Mutation Research/DNAging · doi:10.1016/0921-8734(90)90003-a · Cited by 47 · see citing works

Animal Models in Aging Research

Masoro, E. J. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-627870-5.50011-3 · Cited by 40 · see citing works

Immune responses in newly developed short-lived SAM mice. Selectively impaired T-helper cell activity in in vitro antibody response.

Hosokawa, T., Hosono, M., Hanada, K., et al. (1987) · PubMed · Cited by 38 · see citing works

Effects of Dietary Restriction on Age-Related Immune Dysfunction in the Senescence Accelerated Mouse (SAM)

Umezawa, M., Hanada, K., Naiki, H., Wen-Hsi, C. H. E. N., Hosokawa, M., Hosono, M., Hosokawa, T., & Takeda, T. (1990) · Journal of Nutrition · doi:10.1093/jn/120.11.1393 · Cited by 38 · see citing works

Chronic Food Restriction Modulates the Advance of Senescence in the Senescence Accelerated Mouse (SAM)

Kohno, A., Yonezu, T., Matsushita, M., Irino, M., Higuchi, K., Higuchi, K., Takeshita, S., Hosokawa, M., & Takeda, T. (1985) · Journal of Nutrition · doi:10.1093/jn/115.10.1259 · Cited by 33 · see citing works

Genetic analysis of murine senile amyloidosis.

Naiki, H., Higuchi, K., Shimada, A., et al. (1993) · PubMed · Cited by 33 · see citing works

Autoimmune abnormalities in a murine model of accelerated senescence.

Yoshioka, H., Yoshida, H., Doi, T., et al. (1989) · PubMed · Cited by 28 · see citing works

Cross-mating study on bone mass in the spontaneously osteoporotic mouse (SAM-P/6)

Tsuboyama, T., Takahashi, K., Yamamuro, T., et al. (1993) · Bone and Mineral · doi:10.1016/s0169-6009(08)80091-8 · Cited by 28 · see citing works

Accelerated aging of dermal fibroblast-like cells from senescence-accelerated mouse (SAM). 1. Acceleration of population aging in vitro

Hosokawa, M., Ashida, Y., Nishikawa, T., et al. (1994) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(94)90099-x · Cited by 28 · see citing works

Development of congenic strains of mice carrying amyloidogenic apolipoprotein A‐II (Apoa2c)

Higuchi, K., Kitado, H., Kitagawa, K., Kogishi, K., Naiki, H., & Takeda, T. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81277-7 · Cited by 27 · see citing works

Use of congenic mice to study the genetic basis of degenerative disease.

Dm, P. (1978) · PubMed · Cited by 24 · see citing works

Amplification of extrachromosomal small circular DNAs in a murine model of accelerated senescence. A brief note

Yamagishi, H., Kunisada, T., & Takeda, T. (1985) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(85)90051-x · Cited by 23 · see citing works

Dietary Soybean Protein Compared with Casein Retards Senescence in the Senescence Accelerated Mouse

Umezawa, M., Hosokawa, M., Kohno, A., Ishikawa, S., Kitagawa, K., & Takeda, T. (1993) · Journal of Nutrition · doi:10.1093/jn/123.11.1905 · Cited by 21 · see citing works

Effective intervention of low peak bone mass and bone modeling in the spontaneous murine model of senile osteoporosis, SAM-P/6, by Ca supplement and hormone treatment

Takahashi, K., Tsuboyama, T., Matsushita, M., et al. (1994) · Bone · doi:10.1016/8756-3282(94)90710-2 · Cited by 20 · see citing works

A molecular-pathologic approach to murine senile amyloidosis. Serum precursor-apolipoprotein A-II variant (Pro5----Gln) presents only in the senile amyloidosis-prone SAM-P/1 and SAM-P/2 mice.

Yonezu, T., Tsunasawa, S., Higuchi, K., et al. (1987) · PubMed · Cited by 19 · see citing works

Modification of strain-specific femoral bone density by bone marrow chimerism in mice: A study on the spontaneously osteoporotic mouse (SAM-P/6)

Tsuboyama, T., Matsushita, M., Okumura, H., et al. (1989) · Bone · doi:10.1016/8756-3282(89)90064-1 · Cited by 13 · see citing works

HEREDITARY PREMATURE SENESCENCE OF THE RABBIT

Pearce, L., & Brown, W. H. (1960) · The Journal of Experimental Medicine · doi:10.1084/jem.111.4.485 · Cited by 12 · see citing works

Immune responses in newly developed short-lived SAM mice. IV. Chromosomal location of a gene controlling defective helper T-cell activity.

Hanada, K., Katoh, H., Hosokawa, T., Hosono, M., & Takeda, T. (1991) · PubMed Central · Cited by 11 · see citing works

Persistent Hyaloid Vascular System in Age-related Cataract in a SAM Strain of Mouse

Hosokawa, M., Ashida, Y., Matsushita, T., et al. (1993) · Experimental Eye Research · doi:10.1006/exer.1993.1144 · Cited by 10 · see citing works

Animal Models in Aging Research

Masoro, E. J. (1990) · Elsevier eBooks · doi:10.1016/b978-0-12-627871-2.50011-4 · Cited by 7 · see citing works

Glia and their cytokines in progression of neurodegeneration

Mrak, R. E., & Griffin, W. S. T. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.05.010 · Cited by 592 · see citing works

Animal models of age related macular degeneration

Pennesi, M. E., Neuringer, M., & Courtney, R. J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.06.003 · Cited by 391 · see citing works

Senescence-accelerated mouse (SAM): a novel murine model of senescence

Takeda, T., Hosokawa, M., & Higuchi, K. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00036-8 · Cited by 332 · see citing works

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)

Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163 · see citing works

Supplementation with the reduced form of Coenzyme Q₁₀ decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator‐activated receptor‐α gene expression signature in SAMP1 mice

Schmelzer, C., Kubo, H., Mori, M., Sawashita, J., Kitano, M., Hosoe, K., Boomgaarden, I., Döring, F., & Higuchi, K. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900155 · Cited by 53 · see citing works

Hutchinson Gilford progeria syndrome

Sameeraja, V., Kakollu, S., Kancharla, S., et al. (2012) · Journal of Dr. YSR University of Health Sciences. · doi:10.4103/2277-8632.98360

Elevated c-myc expression in progeria fibroblasts

Nakamura, K. D., Turturro, A., & HART, R. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80595-3 · Cited by 12 · see citing works

Proteomic Analysis of the Genetic Premature Aging Disease Hutchinson Gilford Progeria Syndrome Reveals Differential Protein Expression and Glycosylation

Robinson, L. J., Karlsson, N. G., Weiss, A. S., et al. (2003) · Journal of Proteome Research · doi:10.1021/pr034035k · Cited by 23 · see citing works

Isoprenylcysteine carboxylmethyltransferase-based therapy for Hutchinson–Gilford progeria syndromePreprint

Marcos‐Ramiro, B., Gil-Ordóñez, A., Marín‐Ramos, N. I., Ortega-Nogales, F. J., Balabasquer, M., Gonzalo, P., Rolas, L., Barkaway, A., Nourshargh, S., Andrés, V., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.23.217257 · Cited by 2 · see citing works

Progeria-First Case Report from Pakistan -

Iqbal, M., & Iftikhar, A. (2008) · Rawal Medical Journal · Cited by 1 · see citing works