Supplementation with the reduced form of Coenzyme Q10 decelerates phenotypic characteristics of senescence and induces a peroxisome proliferator‐activated receptor‐α gene expression signature in SAMP1 mice

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,285 · see citing works

SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092 · see citing works

Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRα and LXRβPreprint

Repa, J. J., Liang, G., Ou, J., Bashmakov, Y. K., Lobaccaro, J. A., Shimomura, I., Shan, B., Brown, M. S., Goldstein, J. L., & Mangelsdorf, D. J. (2000) · Genes & Development · doi:10.1101/gad.844900 · Cited by 1,693 · see citing works

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

Schoonjans, K., Staels, B., & Auwerx, J. (1996) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)42003-6 · Cited by 1,216 · see citing works

Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammation

Chinetti, G., Fruchart, J.-C., & Staels, B. (2000) · Inflammation Research · doi:10.1007/s000110050622 · Cited by 954 · see citing works

A new murine model of accelerated senescence

Takeda, T., HOSOKAWA, M., TAKESHITA, S., Irino, M., Higuchi, K., Matsushita, T., Tomita, Y., Yasuhira, K., Hamamoto, H., & Shimizu, K. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90084-1 · Cited by 871 · see citing works

Sterol Regulatory Element-binding Proteins (SREBPs): Key Regulators of Nutritional Homeostasis and Insulin Action

Osborne, T. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.r000017200 · Cited by 521 · see citing works

Age‐related changes in the lipid compositions of rat and human tissues

Kalén, A., Appelkvist, E., & Dallner, G. (1989) · Lipids · doi:10.1007/bf02535072 · Cited by 425 · see citing works

Dietary antioxidants in preventing atherogenesis

Kaliora, A. C., Dedoussis, G. V., & Schmidt, H. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.11.001 · Cited by 417 · see citing works

Redox mechanisms in hepatic chronic wound healing and fibrogenesis

Novo, E., & Parola, M. (2008) · Fibrogenesis & Tissue Repair · doi:10.1186/1755-1536-1-5 · Cited by 406 · see citing works

Peroxisome Proliferator-activated Receptor α-Isoform Deficiency Leads to Progressive Dyslipidemia with Sexually Dimorphic Obesity and Steatosis

Costet, P., Legendre, C., Moré, J., Edgar, A. D., Galtier, P., & Pineau, T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.45.29577 · Cited by 402 · see citing works

Nuclear Sterol Regulatory Element-binding Proteins Activate Genes Responsible for the Entire Program of Unsaturated Fatty Acid Biosynthesis in Transgenic Mouse Liver

Shimomura, I., Shimano, H., Korn, B. S., Bashmakov, Y. K., & Horton, J. D. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35299 · Cited by 383 · see citing works

Effects of antioxidant supplementation on the aging process.

Fusco, D., Colloca, G. A., Monaco, M. R. L., & Cesari, M. (2007) · PubMed Central · Cited by 340 · see citing works

Senescence-accelerated mouse (SAM): a novel murine model of senescence

Takeda, T., Hosokawa, M., & Higuchi, K. (1997) · Experimental Gerontology · doi:10.1016/s0531-5565(96)00036-8 · Cited by 332 · see citing works

The role of DT-diaphorase in the maintenance of the reduced antioxidant form of coenzyme Q in membrane systems.

Beyer, R. E., Segura‐Aguilar, J., Bernardo, S. D., Cavazzoni, M., Fato, R., Fiorentini, D., Galli, M. C., Setti, M., Landi, L., & Lenaz, G. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2528 · Cited by 327 · see citing works

Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13

Hua, X., Wu, J., Goldstein, J. L., Brown, M. S., & Hobbs, H. H. (1995) · Genomics · doi:10.1016/0888-7543(95)80009-b · Cited by 302 · see citing works

Regulation of Lipid and Lipoprotein Metabolism by PPAR Activators

Gervois, P. P., Pineda‐Torra, I., Fruchart, J., & Staels, B. (2000) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2000.002 · Cited by 289 · see citing works

Aging: An important factor for the pathogenesis of neurodegenerative diseases

Farooqui, T., & Farooqui, A. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.11.006 · Cited by 244 · see citing works

Grading score system: A method for evaluation of the degree of senescence in Senescence Accelerated Mouse (SAM)

Hosokawa, M., Kasai, R., Higuchi, K., Takeshita, S., Shimizu, K., Hamamoto, H., Honma, A., Irino, M., Toda, K., Matsumura, A., et al. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90168-4 · Cited by 222 · see citing works

Simultaneous Detection of Ubiquinol and Ubiquinone in Human Plasma as a Marker of Oxidative Stress

Yamashita, S., & Yamamoto, Y. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2187 · Cited by 220 · see citing works

Cross-Talk between Peroxisome Proliferator-Activated Receptor (PPAR) α and Liver X Receptor (LXR) in Nutritional Regulation of Fatty Acid Metabolism. II. LXRs Suppress Lipid Degradation Gene Promoters through Inhibition of PPAR Signaling

Ide, T., Shimano, H., Yoshikawa, T., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Nakakuki, M., Yatoh, S., Iizuka, Y., Tomita, S., et al. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0191 · Cited by 199 · see citing works

Coenzyme Q10 affects expression of genes involved in cell signalling, metabolism and transport in human CaCo-2 cells

Groneberg, D. A., Kindermann, B., Althammer, M., Klapper, M., Vormann, J., Littarru, G. P., & Döring, F. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.11.017 · Cited by 195 · see citing works

Coenzyme Q10 and statins: Biochemical and clinical implications

Littarru, G. P., & Langsjoen, P. (2007) · Mitochondrion · doi:10.1016/j.mito.2007.03.002 · Cited by 188 · see citing works

Update of the NAD(P)H:Quinone oxidoreductase (NQO) gene family

Vasiliou, V., Ross, D., & Nebert, D. W. (2006) · Human Genomics · doi:10.1186/1479-7364-2-5-329 · Cited by 178 · see citing works

Modulation of Hepatic Inflammatory Risk Markers of Cardiovascular Diseases by PPAR–α Activators

Zambon, A., Gervois, P. P., Pauletto, P., Fruchart, J., & Staels, B. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000204327.96431.9a · Cited by 162 · see citing works

Cosupplementation With Coenzyme Q Prevents the Prooxidant Effect of α-Tocopherol and Increases the Resistance of LDL to Transition Metal–Dependent Oxidation Initiation

Thomas, S. R., Neužil, J., & Stocker, R. (1996) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.16.5.687 · Cited by 159 · see citing works

Dietary Cosupplementation With Vitamin E and Coenzyme Q 10 Inhibits Atherosclerosis in Apolipoprotein E Gene Knockout Mice

Thomas, S. R., Leichtweis, S. B., Pettersson, K. S., Croft, K. D., Mori, T. A., Brown, A. J., & Stocker, R. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.585 · Cited by 138 · see citing works

Vitamin E and selenium deficiency induces expression of the ubiquinone‐dependent antioxidant system at the plasma membrane

Navarro, F., Navas, P., Burgess, J. R., Bello, R. I., de Cabo, R., Arroyo, A., & Villalba, J. M. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.15.1665 · Cited by 128 · see citing works

A novel murine model of aging, Senescence-Accelerated Mouse (SAM)

Takeda, T., Hosokawa, M., Higuchi, K., Hosono, M., Akiguchi, I., & Katoh, H. (1994) · Archives of Gerontology and Geriatrics · doi:10.1016/0167-4943(94)90039-6 · Cited by 122 · see citing works

A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice

Hosokawa, M. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(02)00091-x · Cited by 120 · see citing works

Activation of PPARα lowers synthesis and concentration of cholesterol by reduction of nuclear SREBP-2

König, B., Koch, A. H., Spielmann, J., Hilgenfeld, C., Stangl, G. I., & Eder, K. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.10.027 · Cited by 112 · see citing works

Coenzyme Q10: Absorption, Antioxidative Properties, Determinants, and Plasma Levels

Kaikkonen, J., Tuomainen, T., Nyyssönen, K., & Salonen, J. T. (2002) · Free Radical Research · doi:10.1080/10715760290021234 · Cited by 107 · see citing works

The role of the peroxisome proliferator-activated receptor-α (PPAR-α) in the regulation of acute inflammation

Cuzzocrea, S., Mazzon, E., Paola, R. D., Peli, A., Bonato, A., Britti, D., Genovese, T., Muià, C., Crisafulli, C., & Caputi, A. P. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0605341 · Cited by 103 · see citing works

The next generation of literature analysis: Integration of genomic analysis into text mining

Scherf, M., Epple, A., & Werner, T. A. (2005) · Briefings in Bioinformatics · doi:10.1093/bib/6.3.287 · Cited by 101 · see citing works

PPARα downregulates airway inflammation induced by lipopolysaccharide in the mouse

Delayre‐Orthez, C., Becker, J., Guénon, I., Lagente, V., Auwerx, J. H., Frossard, N., & Pons, F. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-91 · Cited by 96 · see citing works

Beneficial Effect of Coenzyme Q10 on Increased Oxidative and Nitrative Stress and Inflammation and Individual Metabolic Components Developing in a Rat Model of Metabolic Syndrome

Kunitomo, M., Yamaguchi, Y., Kagota, S., & Otsubo, K. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0072365 · Cited by 95 · see citing works

Less Extrahepatic Induction of Fatty Acid β-Oxidation Enzymes by PPARα

Cook, W. S., Yeldandi, A. V., Rao, M. S., Hashimoto, T., & Reddy, J. K. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3739 · Cited by 87 · see citing works

A Phospholipid-Dependent NADH-Coenzyme Q Reductase from Liver Plasma Membrane

Navarro, F., Villalba, J. M., Crane, F. L., MacKellar, W. C., & Navas, P. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1947 · Cited by 82 · see citing works

In Vitro Effects of the Reduced Form of Coenzyme Q10 on Secretion Levels of TNF-α and Chemokines in Response to LPS in the Human Monocytic Cell Line THP-1

Schmelzer, C., Lorenz, G., Rimbach, G. H., & Döring, F. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.08-182 · Cited by 81 · see citing works

Mechanisms of oxidative modification of low density lipoproteins under conditions of oxidative and carbonyl stress

Lankin, V. Z., Tikhaze, A. K., Kapelko, V. I., Сергеевна, Ш. Г., Шумаев, К. Б., Panasenko, O. M., Георгиевна, К. Г., & Belenkov, Y. N. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907100069 · Cited by 67 · see citing works

Effect of age and caloric restriction on coenzyme Q and α-tocopherol levels in the rat

Kamzalov, S., & Sohal, R. S. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.04.007 · Cited by 61 · see citing works

Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet

Bello, R. I., Gómez-Dı́az, C., Burón, M. I., Alcain, F. J., Navas, P., & Villalba, J. M. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.07.003 · Cited by 59 · see citing works

The Senescence-accelerated Mouse (SAM): A Higher Oxidative Stress and Age-dependent Degenerative Diseases Model

Chiba, Y., Shimada, A., Kumagai, N., Yoshikawa, K., Ishii, S., Furukawa, A., Takei, S., Sakura, M., Kawamura, N., & Hosokawa, M. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9812-8 · Cited by 59 · see citing works

Effects of Coenzyme Q10 on TNF‐α secretion in human and murine monocytic cell lines

Schmelzer, C., Lorenz, G., Lindner, I., Rimbach, G. H., Niklowitz, P., Menke, T., & Döring, F. (2007) · BioFactors · doi:10.1002/biof.5520310104 · Cited by 54 · see citing works

Influence of Coenzyme Q10 on release of pro‐inflammatory chemokines in the human monocytic cell line THP‐1

Schmelzer, C., Lorenz, G., Rimbach, G. H., & Döring, F. (2007) · BioFactors · doi:10.1002/biof.5520310308 · Cited by 52 · see citing works

Biological validation of coenzyme Q redox state by HPLC‐EC measurement: relationship between coenzyme Q redox state and coenzyme Q content in rat tissues

Galinier, A., Carrière, A., Fernandez, Y., Bessac, A. M., Caspar‐Bauguil, S., Périquet, B., Comtat, M., Thouvenot, J. P., & Casteilla, L. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.10.067 · Cited by 49 · see citing works

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins

Lankin, V. Z., Tikhaze, A. K., Kukharchuk, V. V., Георгиевна, К. Г., Pisarenko, O. I., Каминный, А. И., Шумаев, К. Б., & Belenkov, Y. N. (2003) · Springer eBooks · doi:10.1007/978-1-4419-9236-9_17 · Cited by 47 · see citing works

Coadministration of Coenzyme Q prevents Rosiglitazone-induced adipogenesis in ob/ob mice

Carmona, M. C., Lefèbvre, P., Lefebvre, B., Galinier, A., Bénani, A., Jeanson, Y., Louche, K., Flajollet, S., Ktorza, A., Dacquet, C., et al. (2009) · International Journal of Obesity · doi:10.1038/ijo.2008.265 · Cited by 46 · see citing works

Reduced Coenzyme Q10 Supplementation Decelerates Senescence in SAMP1 Mice

Yan, J., Fujii, K., Yao, J., Kishida, H., Hosoe, K., Sawashita, J., Takeda, T., Mori, M., & Higuchi, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.11.007 · Cited by 45 · see citing works

Protective effect of exogenous coenzyme Q against damage by adriamycin in perfused rat liver.

Valls, V., Castelluccio, C., Fato, R., Ml, G., Bovina, C., Sáez, G. T., Marchetti, M., Castelli, G. P., & Lenaz, G. (1994) · PubMed · Cited by 40 · see citing works

Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo

Schmelzer, C., Kitano, M., Rimbach, G. H., Niklowitz, P., Menke, T., Hosoe, K., & Döring, F. (2009) · Mediators of Inflammation · doi:10.1155/2009/415437 · Cited by 39 · see citing works

Liver X receptors and cholesterol homoeostasis: spotlight on the adrenal gland

Cummins, C. L., & Mangelsdorf, D. J. (2006) · Biochemical Society Transactions · doi:10.1042/bst0341110 · Cited by 39 · see citing works

Antioxidants decreases the intensification of low density lipoprotein in vivo peroxidation during therapy with statins

Lankin, V. Z., Tikhaze, A. K., Kukharchuk, V. V., Георгиевна, К. Г., Pisarenko, O. I., Каминный, А. И., Шумаев, К. Б., & Belenkov, Y. N. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024742907379 · Cited by 38 · see citing works

PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia

Lee, J. H., Joe, E.-H., & Jou, I. (2005) · Neuroreport · doi:10.1097/00001756-200505310-00010 · Cited by 35 · see citing works

PPAR-α Expression Inversely Correlates with Inflammatory Cytokines IL-1β and TNF-α in Aging Rats

Gélinas, D. S., & McLaurin, J. (2005) · Neurochemical Research · doi:10.1007/s11064-005-8341-y · Cited by 33 · see citing works

Ubiquinol and a Coenzyme Q Reducing System Protect Platelet Mitochondrial Function of Transfusional Buffy Coats from Oxidative Stress

Pich, M. M., Castagnoli, A., Biondi, A., Bernacchia, A., Tazzari, P. L., D’Aurelio, M., Castelli, G. P., Formiggini, G., Conte, R., Bovina, C., et al. (2002) · Free Radical Research · doi:10.1080/10715760290021289 · Cited by 25 · see citing works

Coenzyme Q10 Supplementation in Aging and Disease

Hernández‐Camacho, J. D., Bernier, M., López‐Lluch, G., & Navas, P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00044 · Cited by 369 · see citing works

The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence

Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works

Mitochondrial dysfunction: A fatal blow in depression

Song, Y., Cao, H., Zuo, C., Gu, Z., Huang, Y., Miao, J., Fu, Y., Guo, Y., Jiang, Y., & Wang, F. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115652 · Cited by 138 · see citing works

Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice

Tian, G., Sawashita, J., Kubo, H., Nishio, S.-Y., Hashimoto, S., Suzuki, N., Yoshimura, H., Tsuruoka, M., Wang, Y., Liu, Y., et al. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5406 · Cited by 123 · see citing works

CoQ10 and Aging

de Barcelos, I. P., & Haas, R. (2019) · Biology · doi:10.3390/biology8020028 · Cited by 126 · see citing works

Shared pathways for neuroprogression and somatoprogression in neuropsychiatric disorders

Morris, G., Puri, B. K., Walker, A. J., Maes, M. H. J., Carvalho, A. F., Bortolasci, C. C., Walder, K. R., & Berk, M. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.025 · Cited by 112 · see citing works

Age-related mitochondrial dysfunction as a key factor in COVID-19 disease

Fernández‐Ayala, D. J. M., Navas, P., & López‐Lluch, G. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111147 · Cited by 105 · see citing works

Coenzyme Q10 suppresses oxLDL‐induced endothelial oxidative injuries by the modulation of LOX‐1‐mediated ROS generation via the AMPK/PKC/NADPH oxidase signaling pathway

Tsai, K., Chen, L., Chiou, S., Chiou, G., Chen, Y., Chou, H., Chen, L., Chen, H., Chiu, T., Tsai, C., et al. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100147 · Cited by 93 · see citing works

Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome

Alam, M. A., & Rahman, M. (2014) · Journal of Diabetes & Metabolic Disorders · doi:10.1186/2251-6581-13-60 · Cited by 92 · see citing works

The Paradox of Coenzyme Q10 in Aging

Díaz-Casado, M. E., Quiles, J. L., Barriocanal-Casado, E., González-García, P., Battino, M., López, L. C., & Varela-López, A. (2019) · Nutrients · doi:10.3390/nu11092221 · Cited by 81 · see citing works

Increasing Nrf2 Activity as a Treatment Approach in Neuropsychiatry

Morris, G., Walker, A. J., Walder, K. R., Berk, M., Marx, W., Carvalho, A. F., Maes, M. H. J., & Puri, B. K. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02212-w · Cited by 74 · see citing works

Markers of innate immune activity in patients with type 1 and type 2 diabetes mellitus and the effect of the anti-oxidant coenzyme Q10 on inflammatory activity

Brauner, H., Lüthje, P., Grünler, J., Ekberg, N. R., Dallner, G., Brismar, K., & Brauner, A. (2014) · Clinical & Experimental Immunology · doi:10.1111/cei.12316 · Cited by 71 · see citing works

The Potential for Natural Antioxidant Supplementation in the Early Stages of Neurodegenerative Disorders

Oppedisano, F., Maiuolo, J., Gliozzi, M., Musolino, V., Carresi, C., Nucera, S., Scicchitano, M., Scarano, F., Bosco, F., Macrì, R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072618 · Cited by 59 · see citing works

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

Falk, M. J., Polyák, E., Zhang, Z., Peng, M., King, R., Maltzman, J. S., Okwuego, E. Y., Horyn, O., Nakamaru‐Ogiso, E., Ostrovsky, J., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100149 · Cited by 48 · see citing works

Physical activity affects plasma coenzyme Q10 levels differently in young and old humans

del Pozo-Cruz, J., Rodríguez-Bies, E., Ballesteros‐Simarro, M., Navas‐Enamorado, I., Tùng, B. T., Navas, P., & López‐Lluch, G. (2014) · Biogerontology · doi:10.1007/s10522-013-9491-y · Cited by 44 · see citing works

Ubiquinol‐induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans

Schmelzer, C., Niklowitz, P., Okun, J. G., Haas, D., Menke, T., & Döring, F. (2011) · IUBMB Life · doi:10.1002/iub.413 · Cited by 41 · see citing works

Precision toxicology shows that troxerutin alleviates ochratoxin A–induced renal lipotoxicity

Yang, X., Xu, W., Huang, K., Zhang, B., Wang, H., Zhang, X., Gong, L., Luo, Y., & He, X. (2018) · The FASEB Journal · doi:10.1096/fj.201800742r · Cited by 41 · see citing works

Oral administration of Coenzyme Q10 protects mice against oxidative stress and neuro-inflammation during experimental cerebral malaria

Nyariki, J. N., Ochola, L. B., Jillani, N., Nyamweya, N. O., Amwayi, P. W., Yole, D., Azonvide, L., & Isaac, A. O. (2019) · Parasitology International · doi:10.1016/j.parint.2019.04.010 · Cited by 42 · see citing works

The effect of coenzyme Q10 supplementation on inflammatory and endothelial dysfunction markers in overweight/obese polycystic ovary syndrome patients

Taghizadeh, S., Izadi, A., Shirazi, S., Parizad, M., & Gargari, B. P. (2020) · Gynecological Endocrinology · doi:10.1080/09513590.2020.1779689 · Cited by 41 · see citing works

Coenzyme Q10 supplementation improves acute outcomes of stroke in rats pretreated with atorvastatin

Nasoohi, S., Simani, L., Khodagholi, F., Nikseresht, S., Faizi, M., & Naderi, N. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1376928 · Cited by 40 · see citing works

Characterization of bioactive agents in five types of marketed sprouts and comparison of their antihypertensive, antihyperlipidemic, and antidiabetic effects in fructose-loaded SHRs

Nakamura, K., Koyama, M., Ishida, R., Kitahara, T., Nakajima, T., & Aoyama, T. (2015) · Journal of Food Science and Technology · doi:10.1007/s13197-015-2048-0 · Cited by 34 · see citing works

Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury

Zhao, S., Wu, W., Liao, J., Zhang, X., Shen, M., Li, X., Qi, L., & Cao, C. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00361-5 · Cited by 33 · see citing works

The compensatory antioxidant response system with a focus on neuroprogressive disorders

Morris, G., Puri, B. K., Walker, A. J., Berk, M., Walder, K. R., Bortolasci, C. C., Marx, W., Carvalho, A. F., & Maes, M. H. J. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.109708 · Cited by 31 · see citing works

Increased Bioavailability of Ubiquinol Compared to That of Ubiquinone Is Due to More Efficient Micellarization during Digestion and Greater GSH-Dependent Uptake and Basolateral Secretion by Caco-2 Cells

Failla, M. L., Chitchumroonchokchai, C., & Aoki, F. (2014) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf5017829 · Cited by 29 · see citing works

Coenzyme Q homeostasis in aging: Response to non-genetic interventions

López‐Lluch, G. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.024 · Cited by 28 · see citing works

Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts

Fischer, A., Onur, S., Niklowitz, P., Menke, T., Laudes, M., Rimbach, G. H., & Döring, F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167124 · Cited by 26 · see citing works

Determination of coenzyme Q10 tissue status via high-performance liquid chromatography with electrochemical detection in swine tissues (Sus scrofa domestica)

Niklowitz, P., Döring, F., Paulussen, M., & Menke, T. (2013) · Analytical Biochemistry · doi:10.1016/j.ab.2013.02.015 · Cited by 25 · see citing works

The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice

Schmelzer, C., Okun, J. G., Haas, D., Higuchi, K., Sawashita, J., Mori, M., & Döring, F. (2010) · IUBMB Life · doi:10.1002/iub.388 · Cited by 24 · see citing works

Micronutrient special issue: Coenzyme Q10 requirements for DNA damage prevention

Schmelzer, C., & Döring, F. (2011) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2011.09.004 · Cited by 23 · see citing works

Serum paraoxonase 1 status and its association with atherogenic indexes in gentamicin-induced nephrotoxicity in rats treated with coenzyme Q10

Ahmadvand, H., Ghasemi‐Dehnoo, M., Dehghani, A., Bagheri, S., & Cheraghi, R. A. (2013) · Renal Failure · doi:10.3109/0886022x.2013.865154 · Cited by 23 · see citing works

Ubiquinol affects the expression of genes involved in PPARα signalling and lipid metabolism without changes in methylation of CpG promoter islands in the liver of mice

Schmelzer, C., Kitano, M., Hosoe, K., & ring, F. D. O. (2011) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.11-19 · Cited by 19 · see citing works

Coenzyme Q10 and Its Therapeutic Potencies Against COVID-19 and Other Similar Infections: A Molecular Review

Fakhrolmobasheri, M., Hosseini, M. S., Shahrokh, S. G., Mohammadi, Z. S., Kahlani, M.-J., Majidi, S.-E., & Zeinalian, M. (2021) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2023.026 · Cited by 17 · see citing works

Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans

Fischer, A., Onur, S., Schmelzer, C., & Döring, F. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-540 · Cited by 15 · see citing works

Potential Cardiovascular and Renal Protective Effects of Vitamin D and Coenzyme Q 10 in l -NAME-Induced Hypertensive Rats

Shamardl, H. A., Elashmony, S. M., Kamel, H. F. M., & Fatani, S. H. (2017) · The American Journal of the Medical Sciences · doi:10.1016/j.amjms.2017.04.007 · Cited by 13 · see citing works

Effect of Coenzyme Q10 Supplementation on Vascular Endothelial Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Daei, S., Ildarabadi, A., Goodarzi, S., & Mohammadi‐Sartang, M. (2024) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-024-00630-8 · Cited by 12 · see citing works

Micronutrient Metabolism in Hemodialysis Patients

Guo, C.-H., Wang, C.-L., & Che, P.-C. (2011) · InTech eBooks · doi:10.5772/22788 · Cited by 12 · see citing works

Targeting Mitochondrial Defects to Increase Longevity in Animal Models of Neurodegenerative Diseases

Casajús-Pelegay, E., Puzzo, F., Yılmazer, A., & Cagin, U. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-12668-1_5 · Cited by 12 · see citing works

Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice

Clark, Y. Y., Wold, L. E., Szalacha, L. A., & McCarthy, D. O. (2014) · Biological Research For Nursing · doi:10.1177/1099800414543822 · Cited by 10 · see citing works

The effect of dietary coenzyme Q10 on plasma metabolites and hepatic gene expression in broiler breeder hens

Sharideh, H., Zhandi, M., Zeinoaldini, S., Zaghari, M., & Sadeghi, M. (2020) · British Poultry Science · doi:10.1080/00071668.2020.1720908 · Cited by 9 · see citing works

Lipid Regulatory Element Interact with CD44 on Mitochondrial Bioenergetics in Bovine Adipocyte Differentiation and Lipometabolism

Li, G., Fang, X., Liu, Y., Lu, X., Liu, Y., Li, Y., Zhao, Z., Liu, B., & Yang, R. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c02434 · Cited by 8 · see citing works

Determination of the coenzyme Q 10 status in a large C aucasian study population

Onur, S., Niklowitz, P., Fischer, A., Jacobs, G., Lieb, W., Laudes, M., Menke, T., & Döring, F. (2015) · BioFactors · doi:10.1002/biof.1216 · Cited by 7 · see citing works

Reduced Coenzyme Q10 Decreases Urinary 8-Oxo-7,8-Dihydro-2′-Deoxyguanosine Concentrations in Healthy Young Female Subjects

Ito, K., Watanabe, C., Nakamura, A., Tada‐Oikawa, S., & Murata, M. (2015) · Journal of Medicinal Food · doi:10.1089/jmf.2014.3302 · Cited by 5 · see citing works

Facing challenges in an ageing world

López‐Lluch, G., & Rattan, S. I. S. (2015) · Biogerontology · doi:10.1007/s10522-015-9597-5 · Cited by 5 · see citing works

Coenzyme Q regulates the expression of essential genes of the pathogen- and xenobiotic-associated defense pathway in C. elegans

Fischer, A., Niklowitz, P., Menke, T., & Döring, F. (2015) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.15-46 · Cited by 2 · see citing works

Importance of CoQ10-dependent Redox Activity in Aging

López‐Lluch, G. (2021) · Healthy ageing and longevity · doi:10.1007/978-3-030-84965-8_9 · Cited by 2 · see citing works

Loss of a novel striated muscle-enriched mitochondrial protein Coq10a enhances postnatal cardiac hypertrophic growthPreprint

Hirose, K., Chang, S., Yu, H., Wang, J., Barca, E., Chen, X. L., Khyeam, S., Tajima, K., Yoneshiro, T., Kajimura, S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/755793 · Cited by 2 · see citing works

Ubiquinol ameliorates social disruption-induced behavioral changes via modulating inflammatory responses and PPARα activation

Chen, C., Huang, B., Yeh, W.-L., Huang, S.-S., Charoensaensuk, V., Yang, L., Wang, Y., Lin, C.-Y., Chen, Y.-C., Cheng, H.-T., et al. (2026) · Behavioural Brain Research · doi:10.1016/j.bbr.2026.116215 · Cited by 1 · see citing works

Fenofibrate: Panacea for Aging-Related Conditions?

Goto, M. (2012) · InTech eBooks · doi:10.5772/28328 · Cited by 1 · see citing works

Reduced Coenzyme Q10 Decelerates Senescence and Age-Related Hearing Loss in Senescence-Accelerated Mice by Activating Mitochondrial Functions.

Sawashita, J., Xu, Z., & Higuchi, K. (2020) · Springer eBooks · doi:10.1007/978-3-030-45642-9_9 · Cited by 1 · see citing works

An in vivo system for the identification of ligands for peroxisome proliferatoractivated receptors

Lee, R. H. (2015) · TSpace (University of Toronto)

Effects of lifetime supplementation with ubiquinol 10 on the lifespan and progression of aging in female C57BL/6 mice

Igarashi, Y., Hamada, S., Dai, J. M., Mori, M., Miyahara, H., Sawashita, J., & Higuchi, K. (2025) · Experimental Gerontology · doi:10.1016/j.exger.2025.112924

CoQ10 Supplementation for Healthy Longevity

López‐Lluch, G. (2026) · Healthy ageing and longevity · doi:10.1007/978-3-032-11608-6_6

Reduced Coenzyme Q10 Decelerates Senescence and Age-Related Hearing Loss in Senescence-Accelerated Mice by Activating Mitochondrial Functions.

Sawashita, J., Xu, Z., & Higuchi, K. (2020) · Springer eBooks · doi:10.1007/978-3-030-45642-9_9 · Cited by 1 · see citing works

Reduced Coenzyme Q10 Supplementation Decelerates Senescence in SAMP1 Mice

Yan, J., Fujii, K., Yao, J., Kishida, H., Hosoe, K., Sawashita, J., Takeda, T., Mori, M., & Higuchi, K. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.11.007 · Cited by 45 · see citing works

The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice

Schmelzer, C., Okun, J. G., Haas, D., Higuchi, K., Sawashita, J., Mori, M., & Döring, F. (2010) · IUBMB Life · doi:10.1002/iub.388 · Cited by 24 · see citing works

Effects of coenzyme Q10 on gene expression and inflammation : \nresults from in silico, in vitro and in vivo studies

Schmelzer, C. (2010) · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)

Effects of coenzyme Q10 on gene expression and inflammation :results from in silico, in vitro and in vivo studies

Schmelzer, C. (2010) · Multimedialen Archiv und Publikationsserver der Christian-Albrechts-Universität zu Kiel (Christian-Albrechts-Universität zu Kiel)