Cited by 101Immune cells in cancerImmune Response and InflammationPhagocytosis and Immune Regulation

Molecular interactions in macrophage activation

Adams, Dolph O.·1989·Immunology Today

Abstract

Macrophage activation, broadly defined as the acquisition of competence to execute a complex function, continues to intrigue biologists, because of its fundamental importance to the host and the fascinating scientific challenges it poses. A recent meeting* emphasized the considerable progress made in this area since the topic was last considered in such a workshop. The workshop focused sharply on one aspect of the field: the molecular basis of macrophage activation, and covered the multiple, specific signals that induce and suppress activation, how these signals are transduced and thus affect macrophage behaviour and how induced function, in turn, is effected.

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Crossref · 10.1016/0167-5699(89)90298-3

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  • DAMPs and PAMPs, as well as interferon-γ released from natural killer cells, polarize macrophages into a pro-inflammatory phenotype.

    “DAMPs and PAMPs (released from necrotic tissue and pathogens, respectively), as well as interferon-γ [(IFN-γ), released from natural killer cells] polarize macrophages into a pro-inflammatory phenotype [64].”

    From Immunology of Wound Healing (2018) · cites this paper as [64]

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Authors
Adams, D. O.
Affiliations
Duke Medical Center (US)
Corresponding author
Adams, Dolph O.
Venue
Immunology Today
Publisher
Elsevier BV
Published
1989-02
Volume
10
Issue
2
Pages
33-35
ISSN
0167-5699 (ISSN-L)
OpenAlex
W2066854915
Cited by
101
References
1
Citations by year
2025: 3 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 1 · 2012: 5
FWCI
2.96
Type
journal article
Language
en
Open access
closed
Locations
  • Immunology Today (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords
macrophage activation, molecular signaling, signal transduction, macrophage function, host defense
MeSH terms
Antigen-Presenting Cells, Histocompatibility Antigens Class II, Calcium, Chemotaxis, Leukocyte, Humans, Lipopolysaccharides, Lymphokines, Macrophage Activation, Macrophages, Phagocytosis, Signal Transduction

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