Cited by 254Immune cells in cancerPhagocytosis and Immune RegulationNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Aging and cancer: The role of macrophages and neutrophils

Jackaman, Connie, Tomay, Federica, Duong, Lelinh, Abdol Razak, Norbaini Bintu, Pixley, Fiona J., Metharom, Pat, Nelson, Delia J.·2017·Ageing Research Reviews

Abstract

Impaired immune function has been implicated in the declining health and higher incidence of cancer in the elderly. However, age-related changes to immunity are not completely understood. Neutrophils and macrophages represent the first line of defence yet their ability to phagocytose pathogens decrease with aging. Cytotoxic T lymphocytes are critical in eliminating tumors, but T cell function is also compromised with aging. T cell responses can be regulated by macrophages and may depend on the functional phenotype macrophages adopt in response to microenvironmental signals. This can range from pro-inflammatory, anti-tumorigenic M1 to anti-inflammatory, pro-tumorigenic M2 macrophages. Macrophages in healthy elderly adipose and hepatic tissue exhibit a more pro-inflammatory M1 phenotype compared to young hosts whilst immunosuppressive M2 macrophages increase in elderly lymphoid tissues, lung and muscle. These M2-like macrophages demonstrate altered responses to stimuli. Recent studies suggest that neutrophils also regulate T cell function and, like macrophages, neutrophil function is modulated with aging. It is possible that age-modified tissue-specific macrophages and neutrophils contribute to chronic low-grade inflammation that is associated with dysregulated macrophage-mediated immunosuppression, which together are responsible for development of multiple pathologies, including cancer. This review discusses recent advances in macrophage and neutrophil biology in healthy aging and cancer.

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Crossref · 10.1016/j.arr.2017.03.008

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Authors
Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J.
Affiliations
  • Curtin University (AU)
  • The University of Western Australia (AU)
Corresponding author
Jackaman, Connie
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2017-07
Volume
36
Pages
105-116
ISSN
1568-1637 (ISSN-L)
OpenAlex
W2604554752
Cited by
251
References
218
Citations by year
2026: 13 · 2025: 33 · 2024: 37 · 2023: 31 · 2022: 39 · 2021: 30 · 2020: 19 · 2019: 22 · 2018: 20 · 2017: 7
FWCI
1.91
Type
journal article
Language
en
Open access
closed
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • eSpace (Curtin University) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
aging, cancer, macrophages, neutrophils, immunosenescence, macrophage polarization, low-grade inflammation, T cell function, phagocytosis, immunosuppression, tumor microenvironment, tissue-specific macrophages
MeSH terms
Aging, Animals, Anti-Inflammatory Agents, Humans, Macrophages, Neoplasms, Neutrophils, Obesity, T-Lymphocytes, Inflammation Mediators

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