Aging and cancer: The role of macrophages and neutrophils
Abstract
Impaired immune function has been implicated in the declining health and higher incidence of cancer in the elderly. However, age-related changes to immunity are not completely understood. Neutrophils and macrophages represent the first line of defence yet their ability to phagocytose pathogens decrease with aging. Cytotoxic T lymphocytes are critical in eliminating tumors, but T cell function is also compromised with aging. T cell responses can be regulated by macrophages and may depend on the functional phenotype macrophages adopt in response to microenvironmental signals. This can range from pro-inflammatory, anti-tumorigenic M1 to anti-inflammatory, pro-tumorigenic M2 macrophages. Macrophages in healthy elderly adipose and hepatic tissue exhibit a more pro-inflammatory M1 phenotype compared to young hosts whilst immunosuppressive M2 macrophages increase in elderly lymphoid tissues, lung and muscle. These M2-like macrophages demonstrate altered responses to stimuli. Recent studies suggest that neutrophils also regulate T cell function and, like macrophages, neutrophil function is modulated with aging. It is possible that age-modified tissue-specific macrophages and neutrophils contribute to chronic low-grade inflammation that is associated with dysregulated macrophage-mediated immunosuppression, which together are responsible for development of multiple pathologies, including cancer. This review discusses recent advances in macrophage and neutrophil biology in healthy aging and cancer.
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The ability of neutrophils to phagocytose pathogens decreases with age.
“The ability of neutrophils to phagocytose pathogens decreases with age [147].”
From Immunosenescence: a key player in cancer development (2020) · cites this paper as [147]
Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Myeloid-derived-suppressor cells as regulators of the immune system
Gabrilovich, D. I., & Nagaraj, S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2506 · Cited by 6,753 · see citing works
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · see citing works
Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337 · see citing works
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189 · see citing works
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
Protective and pathogenic functions of macrophage subsets
Murray, P. J., & Wynn, T. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3073 · Cited by 5,269 · see citing works
Macrophage Diversity Enhances Tumor Progression and Metastasis
Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175 · see citing works
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151 · see citing works
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622 · see citing works
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197 · see citing works
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840 · see citing works
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Fridlender, Z. G., Sun, J., Kim, S., Kapoor, V., Cheng, G., Ling, L. E., Worthen, G. S., & Albelda, S. Μ. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.06.017 · Cited by 3,382 · see citing works
M-1/M-2 Macrophages and the Th1/Th2 Paradigm
Mills, C. D., Kincaid, K., Alt, J. M., Heilman, M. J., & Hill, A. M. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6166 · Cited by 3,287 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards
Bronte, V., Brandau, S., Chen, S.-H., Colombo, M. P., Frey, A. B., Greten, T. F., Mandruzzato, S., Murray, P. J., Ochoa, A., Ostrand-Rosenberg, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12150 · Cited by 2,751 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
Macrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · see citing works
Cancer and the chemokine network
Balkwill, F. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1388 · Cited by 2,343 · see citing works
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · see citing works
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works
Franceschi, C., Capri, M., Monti, D., Giunta, S., Olivieri, F., Sevini, F., Panourgia, M. P., Invidia, L., Celani, L., Scurti, M., et al. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.016 · Cited by 2,087 · see citing works
IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis
Coffelt, S. B., Kersten, K., Doornebal, C. W., Weiden, J., Vrijland, K., Hau, C.-S., Verstegen, N. J. M., Ciampricotti, M., Hawinkels, L. J. A. C., Jonkers, J., et al. (2015) · Nature · doi:10.1038/nature14282 · Cited by 1,703 · see citing works
Meraz, M. A., White, J. M., Sheehan, K. C. F., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81288-x · Cited by 1,656 · see citing works
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Neutrophils, from marrow to microbes.
Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,550 · see citing works
Sica, A., Schioppa, T., Mantovani, A., & Allavena, P. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.003 · Cited by 1,451 · see citing works
Jenkins, S., Ruckerl, D., Cook, P., Jones, L., Finkelman, F., van Rooijen, N., MacDonald, A., & Allen, J. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,427 · see citing works
The cellular and molecular origin of tumor-associated macrophages
Franklin, R. A., Liao, W., Sarkar, A., Kim, M. V., Bivona, M. R., Liu, K., Pamer, E. G., & Li, M. O. (2014) · Science · doi:10.1126/science.1252510 · Cited by 1,399 · see citing works
IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
Krausgruber, T., Blazek, K. D., Smallie, T., Alzabin, S., Lockstone, H. E., Sahgal, N., Hussell, T., Feldmann, M., & Udalova, I. A. (2011) · Nature Immunology · doi:10.1038/ni.1990 · Cited by 1,296 · see citing works
Movahedi, K., Laoui, D., Gysemans, C. A., Baeten, M., Stangé, G. M., den Bossche, J. V., Mack, M., PIPELEERS, D. G., Veld, P. I. '., BAETSELIER, P. D., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4672 · Cited by 1,229 · see citing works
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
Leek, R., Lewis, C. E., Whitehouse, R. M., Greenall, M. J., Clarke, J., & Harris, A. L. (1996) · PubMed · Cited by 1,187 · see citing works
Dai, X.-M., Ryan, G. R., Hapel, A. J., Dominguez, M. G., Russell, R. G., Kapp, S., Sylvestre, V., & Stanley, E. R. (2002) · Blood · doi:10.1182/blood.v99.1.111 · Cited by 1,184 · see citing works
Immune cell promotion of metastasis
Kitamura, T., Qian, B.-Z., & Pollard, J. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3789 · Cited by 1,158 · see citing works
Satoh, T., Takeuchi, O., Vandenbon, A., Yasuda, K., Tanaka, Y., Kumagai, Y., Miyake, T., Matsushita, K., Okazaki, T., Saitoh, T., et al. (2010) · Nature Immunology · doi:10.1038/ni.1920 · Cited by 1,156 · see citing works
M1 and M2 Macrophages: Oracles of Health and Disease
Mills, C. D. (2012) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v32.i6.10 · Cited by 1,145 · see citing works
Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135 · see citing works
Sindrilaru, A., Peters, T., Wieschalka, S., Baican, C., Baican, A., Peter, H., Hainzl, A., Schatz, S., Qi, Y., Schlecht, A., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44490 · Cited by 1,100 · see citing works
Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E., & Charo, I. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119798 · Cited by 1,096 · see citing works
Cancer immunoediting from immune surveillance to immune escape
Kim, R., Emi, M., & Tanabe, K. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02587.x · Cited by 1,078 · see citing works
Macrophages Regulate the Angiogenic Switch in a Mouse Model of Breast Cancer
Lin, E. Y., Li, J.-F., Gnatovskiy, L., Deng, Y., Zhu, L., Grzesik, D. A., Qian, H., Xue, X.-N., & Pollard, J. W. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1278 · Cited by 1,074 · see citing works
Age-dependent dysregulation of innate immunity
Shaw, A. C., Goldstein, D. R., & Montgomery, R. R. (2013) · Nature Reviews Immunology · doi:10.1038/nri3547 · Cited by 1,061 · see citing works
Zhang, Q., Liu, L., Gong, C., Shi, H., Zeng, Y., Wang, X., Zhao, Y., & Wei, Y.-Q. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050946 · Cited by 1,041 · see citing works
Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works
Zhou, W., Ke, S. Q., Huang, Z., Flavahan, W., Fang, X., Paul, J., Wu, L., Sloan, A. E., McLendon, R. E., Li, X., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3090 · Cited by 940 · see citing works
Sinha, P., Clements, V. K., Bunt, S. K., Albelda, S. M., & Ostrand-Rosenberg, S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.2.977 · Cited by 847 · see citing works
Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
Jetten, N., Verbruggen, S. E. L., Gijbels, M. J., Post, M. J., de Winther, M. P. J., & Donners, M. M. P. C. (2013) · Angiogenesis · doi:10.1007/s10456-013-9381-6 · Cited by 841 · see citing works
Schoppmann, S. F., Birner, P., Stöckl, J., Kalt, R., Ullrich, R., Caucig, C., Kriehuber, E., Nagy, K., Alitalo, K., & Kerjaschki, D. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64255-1 · Cited by 794 · see citing works
(2000) · PubMed · Cited by 706 · see citing works
Age Influence on the Immune System
Makinodan, T., & Kay, M. M. B. (1980) · Advances in Immunology · doi:10.1016/s0065-2776(08)60047-4 · Cited by 699 · see citing works
Origins of tumor-associated macrophages and neutrophils
Cortez‐Retamozo, V., Etzrodt, M., Newton, A., Rauch, P. J., Chudnovskiy, A., Berger, C., Ryan, R. J. H., Iwamoto, Y., Marinelli, B. S., Gorbatov, R., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113744109 · Cited by 680 · see citing works
Tumor microenvironment: The role of the tumor stroma in cancer
Li, H., Fan, X., & Houghton, J. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21159 · Cited by 646 · see citing works
Cutting edge: impaired toll-like receptor expression and function in aging
Renshaw, M., Rockwell, J., Engleman, C., Gewirtz, A., Katz, J., & Sambhara, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.9.4697 · Cited by 626 · see citing works
Cecchini, M. G., Dominguez, M. G., Mocci, S., Wetterwald, A., Felix, R., Fleisch, H. A., Chisholm, O., Hofstetter, W., Pollard, J. W., & Stanley, E. R. (1994) · Development · doi:10.1242/dev.120.6.1357 · Cited by 557 · see citing works
Targeting tumor-associated macrophages as a novel strategy against breast cancer
Luo, Y. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27648 · Cited by 554 · see citing works
Leuschner, F., Rauch, P. J., Ueno, T., Gorbatov, R., Marinelli, B. S., Lee, W. W., Dutta, P., Wei, Y., Robbins, C. S., Iwamoto, Y., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111009 · Cited by 519 · see citing works
MacDonald, K. P. A., Palmer, J. S., Cronau, S. L., Seppanen, E. J., Olver, S. D., Raffelt, N. C., Kuns, R. D., Pettit, A. R., Clouston, A. D., Wainwright, B. J., et al. (2010) · Blood · doi:10.1182/blood-2010-02-266296 · Cited by 507 · see citing works
Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions
Robbins, C. S., Chudnovskiy, A., Rauch, P. J., Figueiredo, J., Iwamoto, Y., Gorbatov, R., Etzrodt, M., Weber, G. F., Ueno, T., van Rooijen, N., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.061986 · Cited by 483 · see citing works
Innate immunity and inflammation in ageing: a key for understanding age-related diseases
Licastro, F., Candore, G., Lio, D., Porcellini, E., Colonna-Romano, G., Franceschi, C., & Caruso, C. (2005) · Immunity & Ageing · doi:10.1186/1742-4933-2-8 · Cited by 453 · see citing works
Effect of age on human neutrophil function
Wenisch, C., Patruta, S., Daxböck, F., Krause, R., & Hörl, W. H. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.40 · Cited by 452 · see citing works
Neutrophil heterogeneity: implications for homeostasis and pathogenesis
Silvestre-Roig, C., Hidalgo, A., & Soehnlein, O. (2016) · Blood · doi:10.1182/blood-2016-01-688887 · Cited by 452 · see citing works
The immune system and aging: A review
Castelo-Branco, C., & Soveral, I. (2014) · Gynecological Endocrinology · doi:10.3109/09513590.2013.852531 · Cited by 449 · see citing works
The ageing immune system: is it ever too old to become young again?
Dorshkind, K., Montecino-Rodriguez, E., & Signer, R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2471 · Cited by 445 · see citing works
Butcher, S. K., Chahal, H., Nayak, L., Sinclair, A., Henriquez, N. V., Sapey, E., O'Mahony, D., & Lord, J. M. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.70.6.881 · Cited by 436 · see citing works
Biswas, S. K., Sica, A., & Lewis, C. E. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2011 · Cited by 434 · see citing works
Age-Related Alterations in the Inflammatory Response to Dermal Injury
Swift, M. E., Burns, A. L., Gray, K. L., & DiPietro, L. A. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01539.x · Cited by 398 · see citing works
Pillay, J., Tak, T., Kamp, V. M., & Koenderman, L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1286-4 · Cited by 376 · see citing works
Altered antigen expression of microglia in the aged rodent CNS
Perry, V. H., Matyszak, M. K., & Fearn, S. (1993) · Glia · doi:10.1002/glia.440070111 · Cited by 364 · see citing works
Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., NAKAYAMA, J., Nishioka, Y., Sone, S., & Kuwano, M. (2000) · PubMed · Cited by 363 · see citing works
Multiparameter flow cytometric analysis of CD4 and CD8 T cell subsets in young and old people
Koch, S. D., Larbi, A., Derhovanessian, E., Özcelik, D., Naumova, E. J., & Pawelec, G. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-6 · Cited by 360 · see citing works
Sapey, E., Greenwood, H., Walton, G., Mann, E., Love, A., Aaronson, N., Insall, R. H., Stockley, R. A., & Lord, J. M. (2014) · Blood · doi:10.1182/blood-2013-08-519520 · Cited by 358 · see citing works
Mantovani, A., Sica, A., Allavena, P., Garlanda, C., & Locati, M. (2009) · Human Immunology · doi:10.1016/j.humimm.2009.02.008 · Cited by 350 · see citing works
Human T Cell Aging and the Impact of Persistent Viral Infections
Fülöp, T., Larbi, A., & Pawelec, G. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00271 · Cited by 347 · see citing works
Janssen, W. J., Barthel, L., Muldrow, A., Oberley‐Deegan, R. E., Kearns, M. T., Jakubzick, C., & Henson, P. M. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201011-1891oc · Cited by 339 · see citing works
From mice to humans: developments in cancer immunoediting
Teng, M. W. L., Galon, J., Fridman, W.-H., & Smyth, M. J. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80004 · Cited by 337 · see citing works
Signal transduction and functional changes in neutrophils with aging
Fülöp, T., Larbi, A., Douziech, N., Fortin, C. F., Guérard, K., Lesur, O., Khalil, A., & Dupuis, G. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00110.x · Cited by 331 · see citing works
Gómez, C. R., Nomellini, V., Faunce, D. E., & Kovacs, E. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.016 · Cited by 328 · see citing works
Lumeng, C. N., Liu, J., Geletka, L., Delaney, C., Delproposto, J., Desai, A., Oatmen, K., Martinez-Santibanez, G., Julius, A., Garg, S., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1102188 · Cited by 328 · see citing works
Sambrano, G. R., & Steinberg, D. I. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1396 · Cited by 294 · see citing works
Inflamm-aging does not simply reflect increases in pro-inflammatory markers
Morrisette-Thomas, V., Cohen, A. A., Fülöp, T., Riesco, É., Legault, V., Li, Q., Milot, E., Dusseault-Bélanger, F., & Ferrucci, L. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.06.005 · Cited by 283 · see citing works
Malyshev, I. Y., & Malyshev, Y. (2015) · BioMed Research International · doi:10.1155/2015/341308 · Cited by 276 · see citing works
Boehmer, E. D., Góral, J., Faunce, D. E., & Kovacs, E. J. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0803389 · Cited by 266 · see citing works
Tsai, C.-S., Chen, G. T. Y., Wang, C., Huang, H.-L., Jung, S., Wu, C., Lee, C.-C., McBride, W. H., Chiang, C., & Hong, J. (2007) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2007.01.041 · Cited by 257 · see citing works
Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway
Bowers, N. L., Helton, E. S., Huijbregts, R. P. H., Goepfert, P., Heath, S. L., & Hel, Z. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1003993 · Cited by 256 · see citing works
Rey-Giraud, F., Hafner, M., & Ries, C. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042656 · Cited by 256 · see citing works
Torisu, H., Ono, M., Kiryu, H., Furue, M., Ohmoto, Y., NAKAYAMA, J., Nishioka, Y., Sone, S., & Kuwano, M. (2000) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(20000115)85:2%3c182::aid-ijc6%3e3.0.co;2-m · Cited by 254 · see citing works
Senescence regulates macrophage activation and angiogenic fate at sites of tissue injury in mice
Kelly, J., Khan, A. A., Yin, J., Ferguson, T. A., & Apte, R. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci32430 · Cited by 249 · see citing works
How Neutrophils Shape Adaptive Immune Responses
Leliefeld, P. H. C., Koenderman, L., & Pillay, J. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00471 · Cited by 247 · see citing works
High Accumulation of T Regulatory Cells Prevents the Activation of Immune Responses in Aged Animals
Sharma, S., Dominguez, A. L., & Lustgarten, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.12.8348 · Cited by 240 · see citing works
Ojalvo, L. S., Whittaker, C. A., Condeelis, J. S., & Pollard, J. W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902360 · Cited by 239 · see citing works
Traynor, T. R., Kuziel, W. A., Toews, G. B., & Huffnagle, G. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.4.2021 · Cited by 235 · see citing works
Ogawa, T., Kitagawa, M., & Hirokawa, K. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00137-8 · Cited by 224 · see citing works
Advanced Age Impairs Macrophage Polarization
Mahbub, S., Deburghgraeve, C. R., & Kovacs, E. J. (2012) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2011.0058 · Cited by 222 · see citing works
Neutrophil ageing and immunesenescence
Lord, J. M., Butcher, S. K., Killampalli, V. V., Lascelles, D., & Salmon, M. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00285-8 · Cited by 218 · see citing works
Schutyser, E., Struyf, S., Proost, P., Opdenakker, G., Laureys, G., Verhasselt, B., Peperstraete, L., de Putte, I. V., Saccani, A., Allavena, P., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m112275200 · Cited by 207 · see citing works
Wang, Y., Wehling‐Henricks, M., Samengo, G., & Tidball, J. G. (2015) · Aging Cell · doi:10.1111/acel.12350 · Cited by 205 · see citing works
RORC1 Regulates Tumor-Promoting “Emergency” Granulo-Monocytopoiesis
Strauss, L., Sangaletti, S., Consonni, F. M., Szebeni, G. J., Morlacchi, S., Totaro, M. G., Porta, C., Anselmo, A., Tartari, S., Doni, A., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.07.006 · Cited by 204 · see citing works
Niwa, Y., Kasama, T., Miyachi, Y., & KANOH, T. (1989) · Life Sciences · doi:10.1016/0024-3205(89)90482-7 · Cited by 204 · see citing works
(1998) · PubMed · Cited by 203 · see citing works
Jackaman, C., Bundell, C. S., Kinnear, B. F., McDonnell, A. M., Filion, P. R., van Hagen, D., Robinson, B. W. S., & Nelson, D. J. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5051 · Cited by 202 · see citing works
Self-citationCao, J., Wronski, T. J., Iwaniec, U. T., Phleger, L., Kurimoto, P., Boudignon, B. M., & Halloran, B. P. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.050503 · Cited by 195 · see citing works
vel Szic, K. S., Declerck, K., Vidaković, M., & Vanden Berghe, W. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0068-2 · Cited by 192 · see citing works
Macrophage arginine metabolism and the inhibition or stimulation of cancer
Mills, C. D., Shearer, J. D., Evans, R. L., & Caldwell, M. D. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.8.2709 · Cited by 191 · see citing works
Szebeni, G. J., Vízler, C., Kitajka, K., & Puskás, L. G. (2017) · Mediators of Inflammation · doi:10.1155/2017/9294018 · Cited by 190 · see citing works
Overmeire, E. V., Laoui, D., Keirsse, J., Ginderachter, J. A. V., & Sarukhan, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00127 · Cited by 182 · see citing works
Tracking of intertissue migration reveals the origins of tumor-infiltrating monocytes
Shand, F. H. W., Ueha, S., Otsuji, M., Koid, S., Shichino, S., Tsukui, T., Kosugi-Kanaya, M., Abe, J., Tomura, M., Ziogas, J., et al. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1402914111 · Cited by 173 · see citing works
Aging Affects Human B Cell Responses
Frasca, D., & Blomberg, B. B. (2011) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9501-7 · Cited by 172 · see citing works
Aging impairs peritoneal but not bone marrow‐derived macrophage phagocytosis
Linehan, E., Dombrowski, Y., Snoddy, R., Fallon, P. G., Kissenpfennig, A., & Fitzgerald, D. C. (2014) · Aging Cell · doi:10.1111/acel.12223 · Cited by 169 · see citing works
Ageing is associated with diminished apoptotic cell clearancein vivo
Aprahamian, T. R., Takemura, Y., Goukassian, D. A., & Walsh, K. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03658.x · Cited by 168 · see citing works
The monocyte-macrophage axis in the intestine
Bain, C. C., & Mowat, A. M. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.03.012 · Cited by 166 · see citing works
Sridharan, A., Esposo, M., Kaushal, K., Tay, J., Osann, K., Agrawal, S., Gupta, S., & Agrawal, A. (2011) · AGE · doi:10.1007/s11357-010-9191-3 · Cited by 165 · see citing works
Frank, M. G., Wieseler‐Frank, J., Watkins, L. R., & Maier, S. F. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2005.06.026 · Cited by 164 · see citing works
Pawelec, G., & Solana, R. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01145-6 · Cited by 164 · see citing works
Targeting macrophages rescues age‐related immune deficiencies in C57<scp>BL</scp>/6J geriatric mice
Jackaman, C., Radley‐Crabb, H. G., Soffe, Z., Shavlakadze, T., Grounds, M. D., & Nelson, D. J. (2013) · Aging Cell · doi:10.1111/acel.12062 · Cited by 162 · see citing works
Self-citationIFN-γ–dependent transcription of MHC class II IA is impaired in macrophages from aged mice
Herrero, C., Marqués, L., Lloberas, J., & Celada, A. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11696 · Cited by 162 · see citing works
Ohmori, Y., & Hamilton, T. A. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.11.5474 · Cited by 161 · see citing works
van Duin, D., Allore, H. G., Mohanty, S., Ginter, S., Newman, F. K., Belshe, R. B., Medzhitov, R., & Shaw, A. C. (2007) · The Journal of Infectious Diseases · doi:10.1086/516788 · Cited by 159 · see citing works
Potential role of immunosenescence in cancer development
Fülöp, T., Kotb, R. R., Fortin, C. F., Pawelec, G., Angelis, F. D., & Larbi, A. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05370.x · Cited by 158 · see citing works
Protumor and antitumor functions of neutrophil granulocytes
Brandau, S., Dumitru, C. A., & Lang, S. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-012-0344-6 · Cited by 158 · see citing works
Wiktor-Jędrzejczak, W., & Gordon, S. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.4.927 · Cited by 154 · see citing works
Molecular basis of age-associated cytokine dysregulation in LPS-stimulated macrophages
Chelvarajan, R. L., Liu, Y., Popa, D., Getchell, M. L., Getchell, T. V., Stromberg, A. J., & Bondada, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0106024 · Cited by 151 · see citing works
A Critical Role for Macrophages in Promotion of Urethane-Induced Lung Carcinogenesis
Zaynagetdinov, R., Sherrill, T. P., Polosukhin, V. V., Han, W., Ausborn, J. A., McLoed, A. G., McMahon, F. B., Gleaves, L. A., Degryse, A. L., Stathopoulos, G. T., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100558 · Cited by 147 · see citing works
Chandra, D., Jahangir, A., Quispe‐Tintaya, W., Einstein, M. H., & Gravekamp, C. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.206 · Cited by 146 · see citing works
Unique versus redundant functions of IL-1α and IL-1β in the tumor microenvironment
Voronov, E. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00177 · Cited by 143 · see citing works
Changes in apoptosis of human polymorphonuclear granulocytes with aging
Fülöp Jr, T., Fouquet, C., Allaire, P., Perrin, N., Lacombe, G., Stankova, J., Rola-Pleszczynski, M., Gagné, D., Wagner, J. R., Khalil, A., et al. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(96)01881-7 · Cited by 141 · see citing works
Chatta, G., Andrews, R. G., Rodger, E., Schrag, M., Hammond, W., & Dale, D. (1993) · Journal of Gerontology · doi:10.1093/geronj/48.5.m207 · Cited by 139 · see citing works
Lio, D., Candore, G., Crivello, A., Scola, L., Colonna‐Romano, G., Cavallone, L. F., Hoffmann, E., Caruso, M., Licastro, F., Caldarera, C. M., et al. (2004) · Journal of Medical Genetics · doi:10.1136/jmg.2004.019885 · Cited by 138 · see citing works
Effect of aging on macrophage function
Lloberas, J., & Celada, A. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00125-0 · Cited by 136 · see citing works
Bellingan, G. J., Xu, P., Cooksley, H., Cauldwell, H., Shock, A., Bottoms, S. E., Haslett, C., Mutsaers, S. E., & Laurent, G. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011794 · Cited by 131 · see citing works
Martinis, M. D., Modesti, M., & Ginaldi, L. (2004) · Immunology and Cell Biology · doi:10.1111/j.0818-9641.2004.01242.x · Cited by 127 · see citing works
Aging promotes the development of diet-induced murine steatohepatitis but not steatosis
Fontana, L., Zhao, E., Amir, M., Dong, H., Tanaka, K. E., & Czaja, M. J. (2012) · Hepatology · doi:10.1002/hep.26099 · Cited by 127 · see citing works
Gon, Y., Hashimoto, S., Hayashi, S., Koura, T., Matsumoto, K., & Horie, T. (1996) · PubMed · Cited by 127 · see citing works
Aging of the Innate Immune System: An Update
Mahbub, S., Brubaker, A. L., & Kovacs, E. J. (2011) · Current Immunology Reviews · doi:10.2174/157339511794474181 · Cited by 125 · see citing works
Carrieri, G., Marzi, E., Olivieri, F., Marchegiani, F., Cavallone, L., Cardelli, M., Giovagnetti, S., Stecconi, R., Molendini, C., Trapassi, C., et al. (2004) · Aging Cell · doi:10.1111/j.1474-9728.2004.00129.x · Cited by 124 · see citing works
Davila, D. R., Edwards, C. K., Arkins, S., Simon, J., & Kelley, K. W. (1990) · The FASEB Journal · doi:10.1096/fasebj.4.11.2165948 · Cited by 123 · see citing works
Hufford, M. M., Richardson, G., Zhou, H., Manicassamy, B., García‐Sastre, A., Enelow, R. I., & Braciale, T. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046581 · Cited by 121 · see citing works
Grizzle, W. E., Xu, X., Zhang, S., Stockard, C. R., Liu, C., Yu, S., Wang, J., Mountz, J. D., & Zhang, H. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.10.003 · Cited by 120 · see citing works
Peralbo, E., Alonso, C., & Solana, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.002 · Cited by 118 · see citing works
Butcher, M. J., & Galkina, E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00044 · Cited by 114 · see citing works
Basal Activity of Kupffer Cells Increases With Old Age
Hilmer, S. N., Cogger, V. C., & Couteur, D. G. L. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.9.973 · Cited by 113 · see citing works
Mocchegiani, E., Muzzioli, M., Giacconi, R., Cipriano, C., Gasparini, N., Franceschi, C., Gaetti, R., Cavalieri, E., & Suzuki, H. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00023-x · Cited by 112 · see citing works
Advanced age exacerbates the pulmonary inflammatory response after lipopolysaccharide exposure
Gómez, C. R., Hirano, S. A., Cutro, B. T., Birjandi, S. Z., Baila, H., Nomellini, V., & Kovacs, E. J. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000251639.05135.e0 · Cited by 111 · see citing works
Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice
Hurez, V. J., Daniel, B. J., Sun, L., Liu, A., Ludwig, S. M., Kious, M. J., Thibodeaux, S. R., Pandeswara, S., Murthy, K., Livi, C. B., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3019 · Cited by 109 · see citing works
Zhang, J., Yan, Y., Yang, Y. J., Wang, L., Li, M., Wang, J., Liu, X., Duan, X., & Wang, J. (2016) · Medicine · doi:10.1097/md.0000000000002636 · Cited by 109 · see citing works
A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics
Cao, C., Lawrence, D. A., Strickland, D. K., & Zhang, L. (2005) · Blood · doi:10.1182/blood-2005-03-1288 · Cited by 108 · see citing works
Tymoszuk, P., Evens, H., Marzola, V., Wachowicz, K., Wasmer, M.-H., Datta, S., Müller‐Holzner, E., Fiegl, H., Böck, G., van Rooijen, N., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201344304 · Cited by 104 · see citing works
Nikolich‐Žugich, J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050341 · Cited by 103 · see citing works
Molecular interactions in macrophage activation
Adams, D. O. (1989) · Immunology Today · doi:10.1016/0167-5699(89)90298-3 · Cited by 101 · see citing works
Neutrophils of Centenarians Show Function Levels Similar to Those of Young Adults
Alonso‐Fernández, P., Puerto, M., Maté, I., Ribera, J. M., & De La Fuente, M. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02018.x · Cited by 100 · see citing works
Meghari, S., Bechah, Y., Capo, C., Lépidi, H., Raoult, D., Murray, P. J., & Mège, J. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.0040023 · Cited by 100 · see citing works
Plowden, J., Renshaw-Hoelscher, M., Gangappa, S., Engleman, C., Katz, J. M., & Sambhara, S. (2004) · Cellular Immunology · doi:10.1016/j.cellimm.2004.07.001 · Cited by 98 · see citing works
Tumour‐educated macrophages display a mixed polarisation and enhance pancreatic cancer cell invasion
Karnevi, E., Andersson, R. E., & Rosendahl, A. H. (2014) · Immunology and Cell Biology · doi:10.1038/icb.2014.22 · Cited by 97 · see citing works
Aging and Neutrophils: There Is Still Much To Do
Fortin, C. F., McDonald, P. P., Lesur, O., & Fülöp, T. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0750 · Cited by 94 · see citing works
Fortin, C. F., Larbi, A., Dupuis, G., Lesur, O., & Fülöp, T. (2006) · Biogerontology · doi:10.1007/s10522-006-9067-1 · Cited by 94 · see citing works
Ogawa, K., Suzuki, K., Okutsu, M., Yamazaki, K., & Shinkai, S. (2008) · Immunity & Ageing · doi:10.1186/1742-4933-5-13 · Cited by 93 · see citing works
Immunosenescence of Polymorphonuclear Neutrophils
Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89 · see citing works
T-Cell Biology in Aging, With a Focus on Lung Disease
Lee, N., Shin, M. S., & Kang, I. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr237 · Cited by 89 · see citing works
Harnessing the immune response to treat cancer
Steer, H. J., Lake, R., Nowak, A. K., & Robinson, B. W. S. (2010) · Oncogene · doi:10.1038/onc.2010.437 · Cited by 83 · see citing works
Crane, M. J., Hokeness-Antonelli, K. L., & Salazar‐Mather, T. P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900205 · Cited by 83 · see citing works
Liang, S., Domon, H., Hosur, K. B., Wang, M., & Hajishengallis, G. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2009.06.006 · Cited by 81 · see citing works
Vignaud, J.-M. (1995) · Lung Cancer · doi:10.1016/0169-5002(95)98740-2 · Cited by 80 · see citing works
Effects of age, sex and physical exercise on the phagocytic process of murine peritoneal macrophages
Ferrandez, & Fuente (1999) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1999.00535.x · Cited by 80 · see citing works
Trebilcock, G. U., & Ponnappan, U. (2009) · Gerontology · doi:10.1159/000213785 · Cited by 79 · see citing works
Phenotypic Skewing of Macrophages In Vitro by Secreted Factors from Colorectal Cancer Cells
Edin, S., Wikberg, M. L., Rutegård, M., Oldenborg, P., & Palmqvist, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074982 · Cited by 78 · see citing works
Nomellini, V., Faunce, D. E., Gómez, C. R., & Kovacs, E. J. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1007672 · Cited by 78 · see citing works
Neutrophil migration, oxidative metabolism, and adhesion in elderly and young subjects
Biasi, D., Carletto, A., Dell’Agnola, C., Caramaschi, P., Montesanti, F., Zavateri, G., Zeminian, S., Bellavite, P., & Bambara, L. M. (1996) · Inflammation · doi:10.1007/bf01488803 · Cited by 76 · see citing works
Yoon, P., Keylock, K. T., Hartman, M. E., Freund, G. G., & Woods, J. A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2003.11.010 · Cited by 76 · see citing works
Lustgarten, J., Dominguez, A. L., & Cuadros, C. (2004) · European Journal of Immunology · doi:10.1002/eji.200324427 · Cited by 71 · see citing works
Tasat, D. R., Mancuso, R., O'Connor, S., & Molinari, B. L. (2003) · Aging Cell · doi:10.1046/j.1474-9728.2003.00051.x · Cited by 71 · see citing works
Neutrophil Function in Elderly Persons Assessed by Flow Cytometry
Esparza, B., Sanchez, H., Ruiz, M., Barranquero, M., Sabino, É. C., & Merino, F. (1996) · Immunological Investigations · doi:10.3109/08820139609059301 · Cited by 71 · see citing works
Varga, Z., Kovács, É. M., Paragh, G., Jacob, M., Robert, L., & Fülöp, T. (1988) · Clinical Biochemistry · doi:10.1016/s0009-9120(88)80101-2 · Cited by 70 · see citing works
Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer
Boström, M., Irjala, H., Mirtti, T., Taimen, P., Kauko, T., Ålgars, A., Jalkanen, S., & Boström, P. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133552 · Cited by 68 · see citing works
Age-related differences in the neutrophil response to pulmonary pseudomonas infection
Chen, M. M., Palmer, J. L., Plackett, T. P., Deburghgraeve, C. R., & Kovacs, E. J. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2013.12.010 · Cited by 68 · see citing works
Mancuso, P., McNish, R. W., Peters-Golden, M. L., & Brock, T. G. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00322-0 · Cited by 67 · see citing works
Li, C., Liu, B., Dai, Z., & Tao, Y. (2011) · Cancer Biology & Therapy · doi:10.4161/cbt.12.10.17672 · Cited by 66 · see citing works
Provinciali, M., Argentati, K., & Tibaldi, A. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301131 · Cited by 66 · see citing works
Deliberately provoking local inflammation drives tumors to become their own protective vaccine site
Jackaman, C., Lew, A. M., Zhan, Y., Allan, J. E., Koloska, B., Graham, P. T., Robinson, B. W. S., & Nelson, D. J. (2008) · International Immunology · doi:10.1093/intimm/dxn104 · Cited by 65 · see citing works
Self-citationAge‐Related Decline in Murine Macrophage Production of Nitric Oxide
Kissin, E. Y., Tomasi, M., McCartney-Francis, N. L., Gibbs, C. L., & Smith, P. D. (1997) · The Journal of Infectious Diseases · doi:10.1086/513959 · Cited by 63 · see citing works
Aged Mice Develop Protective Antitumor Immune Responses with Appropriate Costimulation
Lustgarten, J., Dominguez, A. L., & Thoman, M. L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.7.4510 · Cited by 61 · see citing works
Jackaman, C., Yeoh, T. L., Acuil, M. L., Gardner, J. K., & Nelson, D. J. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1173299 · Cited by 61 · see citing works
Self-citationLeng, S. X., Xue, Q., Huang, Y., Ferrucci, L., Fried, L. P., & Walston, J. D. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.08.006 · Cited by 60 · see citing works
Sidler, C. L., Wóycicki, R. K., Ilnytskyy, Y., Metz, G. A. S., Kovalchuk, I., & Kovalchuk, O. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00211 · Cited by 59 · see citing works
Sharma, S., LUCIADOMINGUEZ, A., & Lustgarten, J. (2005) · Experimental Gerontology · doi:10.1016/j.exger.2005.10.002 · Cited by 58 · see citing works
Smallwood, H. S., López‐Ferrer, D., & Squier, T. C. (2011) · Biochemistry · doi:10.1021/bi2011866 · Cited by 56 · see citing works
Age-Induced Reprogramming of Mast Cell Degranulation
Nguyen, M., Pace, A. J., & Koller, B. H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5701 · Cited by 55 · see citing works
Tortorella, C., Simone, O., Piazzolla, G., Stella, I., Cappiello, V., & Antonaci, S. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.11.1111 · Cited by 51 · see citing works
Neutrophils of healthy aged humans are normal
Corberand, J. X., Laharrague, P. F., & Fillola, G. (1986) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(86)90138-7 · Cited by 46 · see citing works
Age-associated changes of neutrophil responsiveness in a human healthy elderly population.
Polignano, A., Tortorella, C., Venezia, A., Jirillo, E., & Antonaci, S. (1994) · PubMed · Cited by 45 · see citing works
Regulatory role of extracellular matrix proteins in neutrophil respiratory burst during aging
Tortorella, C., Piazzolla, G., Spaccavento, F., Vella, F., Pace, L., & Antonaci, S. (2000) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00171-8 · Cited by 43 · see citing works
Failure of aged rats to accumulate eosinophils in allergic inflammation of the airway
Yagi, T., Sato, A., Hayakawa, H., & Ide, K. (1997) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(97)70298-7 · Cited by 43 · see citing works
Effect of age on marrow macrophage number and function
Wang, C. Q., Udupa, K. B., Xiao, H., & Lipschitz, D. A. (1995) · Aging Clinical and Experimental Research · doi:10.1007/bf03324349 · Cited by 42 · see citing works
Ortega, E., Forner, M. A., Barriga, C., & la Fuente, M. D. (1993) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(93)90059-z · Cited by 40 · see citing works
Influence of Age on Oxidative Bursts (Chemiluminescence) of Polymorphonuclear Neutrophil Leukocytes
Braga, P. C., Sala, M. T., Sasso, M. D., Mancini, L., Sandrini, M. C., & Annoni, G. A. (1998) · Gerontology · doi:10.1159/000022009 · Cited by 40 · see citing works
Guo, Z., Tilburgs, T., Wong, B., & Strominger, J. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414780111 · Cited by 40 · see citing works
Baëhl, S., Garneau, H., Page, A. Y. L., Lorrain, D., Viens, I., Svotelis, A., Lord, J. M., Phillips, A. C., Cabana, F., Larbi, A., et al. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.03.009 · Cited by 39 · see citing works
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Macrophages in immunoregulation and therapeutics
Chen, S., Saeed, A. F. U. H., Liu, Q., Jiang, Q., Xu, H., Xiao, G. G., Rao, L., & Duo, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01452-1 · Cited by 2,348 · see citing works
Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape
Jiang, X., Wang, J., Deng, X., Xiong, F., Ge, J., Xiang, B., Wu, X., Ma, J., Zhou, M., Li, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-018-0928-4 · Cited by 1,465 · see citing works
The role of microenvironment in tumor angiogenesis
Jiang, X., Wang, J., Deng, X., Xiong, F., Zhang, S., Gong, Z., Li, X., Cao, K., Deng, H., He, Y., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01709-5 · Cited by 767 · see citing works
Immunosenescence: a key player in cancer development
Lian, J., Yue, Y., Yu, W., & Zhang, Y. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00986-z · Cited by 510 · see citing works
Bajaj, V., Gadi, N., Spihlman, A. P., Wu, S. C., Choi, C. H., & Moulton, V. R. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2020.571416 · Cited by 476 · see citing works
Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging
Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.008 · Cited by 349 · see citing works
Metabolic reprogramming and therapeutic resistance in primary and metastatic breast cancer
Liu, S., Zhang, X., Wang, W., Li, X., Sun, X., Zhao, Y., Wang, Q., Li, Y., Hu, F., & Ren, H. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02165-x · Cited by 279 · see citing works
Sellami, M., Gasmi, M., Denham, J., Hayes, L. D., Stratton, D., Padulo, J., & Bragazzi, N. L. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02187 · Cited by 224 · see citing works
LncRNA: Shedding light on mechanisms and opportunities in fibrosis and aging
Yang, Z. P., Jiang, S., Shang, J., Jiang, Y., Dai, Y., Xu, B., Yu, Y., Liang, Z., & Yang, Y. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.04.001 · Cited by 219 · see citing works
Dual Role of Reactive Oxygen Species and their Application in Cancer Therapy
Huang, R., Chen, H., Liang, J., Li, Y., Yang, J., Luo, C., Tang, Y., Ding, Y., Liu, X., Yuan, Q., et al. (2021) · Journal of Cancer · doi:10.7150/jca.54699 · Cited by 218 · see citing works
Origin and ontogeny of lung macrophages: from mice to humans
Evren, E., Ringqvist, E. E., & Willinger, T. (2019) · Immunology · doi:10.1111/imm.13154 · Cited by 170 · see citing works
Role of the peripheral innate immune system in the development of Alzheimer's disease
Page, A. Y. L., Dupuis, G., Frost, E. H., Larbi, A., Pawelec, G., Witkowski, J. M., & Fülöp, T. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.12.019 · Cited by 158 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03048-x · Cited by 156 · see citing works
Activation of immunosuppressive network in the aging process
Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 153 · see citing works
Traditional Chinese medicine in lung cancer treatment
Xi, Z., Dai, R., Ze, Y., Jiang, X., Liu, M., & Xu, H. (2025) · Molecular Cancer · doi:10.1186/s12943-025-02245-6 · Cited by 143 · see citing works
AMPK orchestrates an elaborate cascade protecting tissue from fibrosis and aging
Jiang, S., Li, T. X., Yang, Z. P., Yi, W., Di, S., Sun, Y., Wang, D., & Yang, Y. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.07.001 · Cited by 136 · see citing works
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Fan, X., Cui, L., Zeng, Y. Y., Song, W., Gaur, U., & Yang, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20143518 · Cited by 136 · see citing works
Next frontier in tumor immunotherapy: macrophage-mediated immune evasion
Qiu, Y., Chen, T., Hu, R., Zhu, R., Li, C., Ruan, Y., Xie, X., & Li, Y. (2021) · Biomarker Research · doi:10.1186/s40364-021-00327-3 · Cited by 134 · see citing works
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Alimirah, F., Pulido, T., Valdovinos, A., Alptekin, S., Chang, E., Jones, E., Diaz, D. A., Flores, J., Velarde, M. C., Demaria, M., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-0108 · Cited by 128 · see citing works
Basheer, A. S., Abas, F., Othman, I., & Naidu, R. (2021) · Cancers · doi:10.3390/cancers13164226 · Cited by 118 · see citing works
Macrophage senescence in health and diseases
Wang, L., Hong, W., Zhu, H., He, Q., Yang, B., Wang, J., & Weng, Q. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.01.008 · Cited by 115 · see citing works
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Bian, X., Wang, W., Abudurexiti, M., Zhang, X., Ma, W., Shi, G., Du, L., Xu, M., Wang, X., Tan, C., et al. (2024) · Advanced Science · doi:10.1002/advs.202305724 · Cited by 106 · see citing works
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Elder, S. S., & Emmerson, E. (2020) · Open Biology · doi:10.1098/rsob.200309 · Cited by 109 · see citing works
Classification, History, and Future Prospects of Maxillofacial Prosthesis
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Fan, Y., Li, S., Ding, X., Yue, J., Jiang, J., Zhao, H., Hao, R., Qiu, W., Liu, K., Li, Y., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-5471-1 · Cited by 100 · see citing works
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Yu, Q., Wang, Y., Lin, D., He, Y., Liu, R., Yang, Q., Cao, Y., Wang, Y., Jia, A., Bi, Y., et al. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.00287 · Cited by 100 · see citing works
Aging, immune senescence, and immunotherapy: a comprehensive review
Elias, R., Hartshorn, K., Rahma, O., Lin, N., & Snyder-Cappione, J. E. (2018) · Seminars in Oncology · doi:10.1053/j.seminoncol.2018.08.006 · Cited by 96 · see citing works
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Liu, S., Yang, J., & Wu, Z.-F. (2021) · Mediators of Inflammation · doi:10.1155/2021/5577577 · Cited by 79 · see citing works
Morgillo, F., Dallio, M., Corte, C. M. D., Gravina, A. G., Viscardi, G., Loguercio, C., Ciardiello, F., & Federico, A. (2018) · Neoplasia · doi:10.1016/j.neo.2018.05.002 · Cited by 94 · see citing works
The origins and non-canonical functions of macrophages in development and regeneration
Théret, M., Mounier, R., & Rossi, F. M. V. (2019) · Development · doi:10.1242/dev.156000 · Cited by 85 · see citing works
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9762-8 · Cited by 84 · see citing works
Immunotherapy of targeting MDSCs in tumor microenvironment
Sui, H., Dongye, S., Liu, X., Xu, X., Wang, L., Jin, C. Q., Yao, M., Gong, Z., Jiang, D., Zhang, K., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.990463 · Cited by 80 · see citing works
The fibrotic and immune microenvironments as targetable drivers of metastasis
Boulter, L., Bullock, E., Mabruk, Z., & Brunton, V. G. (2020) · British Journal of Cancer · doi:10.1038/s41416-020-01172-1 · Cited by 78 · see citing works
Epigenomic drivers of immune dysfunction in aging
Keenan, C. R., & Allan, R. S. (2018) · Aging Cell · doi:10.1111/acel.12878 · Cited by 76 · see citing works
Yan, J., Han, Z., Qu, Y., Yao, C., Shen, D., Tai, G., Cheng, H., & Zhou, Y. (2017) · Food Chemistry · doi:10.1016/j.foodchem.2017.07.154 · Cited by 68 · see citing works
Zhu, G., Shi, R., Li, Y., Zhang, Z., Xu, S., Chen, C., Cao, P., Zhang, H., Liu, M., Pan, Z., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.670040 · Cited by 67 · see citing works
Liu, R., Cui, J., Sun, Y., Xu, W., Wang, Z., Wu, M., Dong, H., Yang, C., Hong, S., Yin, S., et al. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00797-2 · Cited by 68 · see citing works
Deng, Y., Chen, Q., Yang, X., Sun, Y., Zhang, B., Wei, W., Deng, S., Meng, J., Hu, Y., Wang, Y., et al. (2024) · Theranostics · doi:10.7150/thno.91119 · Cited by 70 · see citing works
Wang, H., Wei, Q., Yang, Y., Lu, T., Yan, Y., & Wang, F. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02856-3 · Cited by 64 · see citing works
Pan, X., You, H., Wang, L., Bi, Y., Yang, Y., Meng, H., Meng, X., Ma, T., Huang, C., & Li, J. (2019) · Theranostics · doi:10.7150/thno.32710 · Cited by 65 · see citing works
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Wu, Q., Chen, X., Li, J., & Sun, S. (2020) · Aging and Disease · doi:10.14336/ad.2020.0314 · Cited by 62 · see citing works
The evolving view of thermogenic fat and its implications in cancer and metabolic diseases
Yin, X., Chen, Y., Ruze, R., Xu, R., Song, J., Wang, C., & Xu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01178-6 · Cited by 68 · see citing works
Salminen, A. (2024) · Journal of Molecular Medicine · doi:10.1007/s00109-024-02444-6 · Cited by 61 · see citing works
Senescence in the Development and Response to Cancer with Immunotherapy: A Double-Edged Sword
Battram, A. M., Bachiller, M., & Martín-Antonio, B. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124346 · Cited by 63 · see citing works
Yang, Y.-T., Jiang, J., Yang, H., Wu, Z., Xiao, Z., & Xiang, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-20199-2 · Cited by 61 · see citing works
Zhou, T.-Y., Zhou, Y.-L., Qian, M.-J., Fang, Y.-Z., Ye, S., Xin, W.-X., Yang, X.-C., & Wu, H.-H. (2018) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2018.07.013 · Cited by 54 · see citing works
Rabhi, N., Desevin, K., Belkina, A. C., Tilston-Lünel, A., Varelas, X., Layne, M. D., & Farmer, S. R. (2022) · Life Science Alliance · doi:10.26508/lsa.202101286 · Cited by 54 · see citing works
Bone marrow adipose tissue in metabolic health
Pachón-Peña, G., & Bredella, M. A. (2022) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2022.03.003 · Cited by 52 · see citing works
Tomay, F., Wells, K., Duong, L., Tsu, J. W., Dye, D. E., Radley‐Crabb, H. G., Grounds, M. D., Shavlakadze, T., Metharom, P., Nelson, D. J., et al. (2018) · Immunology and Cell Biology · doi:10.1111/imcb.12046 · Cited by 53 · see citing works
Self-citationDuong, L., Radley‐Crabb, H. G., Gardner, J. K., Tomay, F., Dye, D. E., Grounds, M. D., Pixley, F. J., Nelson, D. J., & Jackaman, C. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00526 · Cited by 54 · see citing works
Self-citationAging hampers neutrophil extracellular traps (NETs) efficacy
Sabbatini, M., Bona, E., Novello, G., Migliario, M., & Renò, F. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02201-0 · Cited by 51 · see citing works
Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells
Oh, J., Magnuson, A., Benoist, C., Pittet, M. J., & Weissleder, R. (2018) · JCI Insight · doi:10.1172/jci.insight.122961 · Cited by 51 · see citing works
Keller, A., Maeß, M. B., Michael Schnoor, A., Scheiding, B., & Stefan Lorkowski, A. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7837-3_18 · Cited by 49 · see citing works
Du, M., Sun, L., Guo, J. J., & Lv, H. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107198 · Cited by 49 · see citing works
Ageing, immune fitness and cancer
Dolan, M., Libby, K. A., Ringel, A. E., van Galen, P., & McAllister, S. S. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00858-z · Cited by 50 · see citing works
Wu, L., Pan, X., Zhang, C., Ye, B., & Song, J. (2023) · Cancer Control · doi:10.1177/10732748231152322 · Cited by 47 · see citing works
Ferroptosis and immunosenescence in colorectal cancer
Wang, Y., Cao, X., Yang, C., Fan, J., Zhang, X., Wu, X., Guo, W., Sun, S., Liu, M., Zhang, L., et al. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.10.003 · Cited by 47 · see citing works
Considerations for successful cancer immunotherapy in aged hosts
Hurez, V. J., Padron, A. S., Svatek, R. S., & Curiel, T. J. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.002 · Cited by 46 · see citing works
Common Pathogenetic Mechanisms Underlying Aging and Tumor and Means of Interventions
Shen, W., He, J., Hou, T., Si, J., & Chen, S. (2022) · Aging and Disease · doi:10.14336/ad.2021.1208 · Cited by 45 · see citing works
Hua, L., Yang, Z., Li, W., Zhang, Q., Ren, Z., Ye, C., Zheng, X. W., Li, D., Long, Q., Bai, H., et al. (2021) · Advanced Materials · doi:10.1002/adma.202103923 · Cited by 45 · see citing works
Stem cells and anti-aging genes: double-edged sword—do the same job of life extension
Ullah, M., & Sun, Z. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0746-4 · Cited by 45 · see citing works
ABC Transporters in T Cell-Mediated Physiological and Pathological Immune Responses
Thurm, C., Schraven, B. L., & Kahlfuß, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179186 · Cited by 44 · see citing works
Functional genomics of inflamm-aging and immunosenescence
Lu, R. J., Wang, E. K., & Benayoun, B. A. (2021) · Briefings in Functional Genomics · doi:10.1093/bfgp/elab009 · Cited by 43 · see citing works
Altered glucocorticoid metabolism represents a feature of macroph‐aging
Perez, J. V. V., Linnenberger, R., Dembek, A., Bruscoli, S., Riccardi, C., Schulz, M. H., Meyer, M. R., Kiemer, A. K., & Hoppstädter, J. (2020) · Aging Cell · doi:10.1111/acel.13156 · Cited by 42 · see citing works
Huang, L., Wang, F., Wang, X., Su, C., Wu, S., Yang, C., Luo, M., Zhang, J., & Fu, L. (2022) · MedComm · doi:10.1002/mco2.191 · Cited by 40 · see citing works
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Otsuka, I. (2019) · Cancers · doi:10.3390/cancers11091292 · Cited by 39 · see citing works
Guan, Y., Du, Y., Wang, G., Gou, H., Xue, Y., Xu, J., Li, E., Chan, D. W., Wu, D., Xu, P., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.673295 · Cited by 37 · see citing works
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Li, Y., Wang, C., & Peng, M. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.735151 · Cited by 40 · see citing works
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Gao, H., Nepovimová, E., Adam, V., Heger, Z., Valko, M., Wu, Q., & Kuča, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1421062 · Cited by 37 · see citing works
Yu, D., Yang, X. N., Lin, J., Cao, Z., Lu, C., Yang, Z., Zheng, M., Pan, R., & Cai, W. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.724655 · Cited by 36 · see citing works
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Fu, Z., Xu, H., Yue, L., Zheng, W., Pan, L., Gao, F., & Liu, X. (2023) · Medicine · doi:10.1097/md.0000000000036045 · Cited by 36 · see citing works
Cutaneous Metastasis after Surgery, Injury, Lymphadenopathy, and Peritonitis: Possible Mechanisms
Otsuka, I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133286 · Cited by 35 · see citing works
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Lü, X., Yang, Y.-M., & Lu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.917293 · Cited by 35 · see citing works
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Margotti, W., Goldim, M. P. D. S., Machado, R. S., Bagio, É., Perin, C. H. D., Bernades, G. C., Lanzzarin, E., Stork, S. D. S., Cidreira, T., Denicol, T. L., et al. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111705 · Cited by 32 · see citing works
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Fernandez, D. M., Clemente, J. C., & Giannarelli, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00763 · Cited by 33 · see citing works
Qiu, J., Fan, Q., Xu, S., Wang, D., Chen, J., Wang, S., Hu, T., Ma, X., Cheng, Y., & Xu, L. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121541 · Cited by 32 · see citing works
Cruz‐Ramos, M., del Puerto‐Nevado, L., Zheng-Lin, B., Bajo, R. L., Cebrián, A., Rodríguez‐Remírez, M., García‐García, L., Casado, S. S., & García‐Foncillas, J. (2018) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2018.10.002 · Cited by 30 · see citing works
Li, C., Xu, W. L., Li, L., Zhou, Y., Yao, G., Chen, G., Xu, L., Yang, N., Yan, Z., Chen, Z., et al. (2024) · Advanced Science · doi:10.1002/advs.202408044 · Cited by 29 · see citing works
Immunosenescence promotes cancer development: from mechanisms to treatment strategies
Wang, L., & Tang, D. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02082-6 · Cited by 30 · see citing works
Elalfy, H., Besheer, T. A., El-Maksoud, M., Farid, K., Elegezy, M., Nakib, A. E., El-Aziz, M., El-Khalek, A., El-Morsy, A., Elmokadem, A. H., et al. (2018) · British Journal of Biomedical Science · doi:10.1080/09674845.2018.1494769 · Cited by 29 · see citing works
Trained Immunity Enhances Human Monocyte Function in Aging and Sepsis
Gill, P. S., Ozment, T. R., Lewis, N. H., Sherwood, E. R., & Williams, D. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872652 · Cited by 29 · see citing works
Mutsaers, S., Pixley, F., Prêle, C., & Hoyne, G. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.04.005 · Cited by 21 · see citing works
Self-citationImmunosenescence and macrophages: From basics to therapeutics
Zhu, H., Shen, F., Liao, T., Qian, H., & Liu, Y. (2023) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2023.106479 · Cited by 28 · see citing works
Shao, Y., Han, S., Hou, Z., Chen, Y., & Zhao, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e36839 · Cited by 25 · see citing works
Xu, X., Lu, J., Xu, Q., Hua, H., Xu, L., & Chen, L. (2020) · Supportive Care in Cancer · doi:10.1007/s00520-020-05483-0 · Cited by 25 · see citing works
Li, B., Yang, Q., Li, Z., Xu, Z., Sun, S., Wu, Q., & Sun, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.574787 · Cited by 25 · see citing works
Innate immunity and immunotherapy for hemorrhagic shock
Huang, Q., Gao, S., Yao, Y., Wang, Y., Li, J., Chen, J., Chen, G., Zhao, D., & Li, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.918380 · Cited by 25 · see citing works
Huang, Z., Xiao, Z., Yu, L., Liu, J., Yang, Y., & Ouyang, W. (2024) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2024.104284 · Cited by 25 · see citing works
Zhang, S., & Tang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1291840 · Cited by 24 · see citing works
Aging-related genes are potential prognostic biomarkers for patients with gliomas
Xiao, G., Zhang, X., Zhang, X., Chen, Y., Xia, Z., Cao, H., Huang, J. X., & Cheng, Q. (2021) · Aging · doi:10.18632/aging.203008 · Cited by 24 · see citing works
Zhang, L., Yi, H., Chen, J., Li, H., Luo, Y., Cheng, T., Yang, H., Jiang, Z., & Pan, C. (2022) · BioMed Research International · doi:10.1155/2022/8316525 · Cited by 24 · see citing works
Chu, P., Tzeng, Y. T., Tsui, K., Chu, C.-Y., & Li, C. (2022) · Aging · doi:10.18632/aging.203933 · Cited by 24 · see citing works
Immunotherapy for metastatic prostate cancer
Laccetti, A. L., & Subudhi, S. K. (2017) · Current Opinion in Urology · doi:10.1097/mou.0000000000000433 · Cited by 25 · see citing works
Immune senescence and periodontitis: From mechanism to therapy
Liu, J., Dan, R., Zhou, X., Wang, J., Wang, J., & Liu, J. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0822-645rr · Cited by 23 · see citing works
Owyong, M., Efe, G., Owyong, M., Abbasi, A. J., Sitarama, V., & Plaks, V. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00019 · Cited by 23 · see citing works
The roles of neutrophils in cardiovascular diseases
Lian, Y., Lai, X., Wu, C., Wang, L., Shang, J., Zhang, H., Jia, S., Xing, W., & Liu, H. (2025) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2025.1526170 · Cited by 22 · see citing works
de Cedrón, M. G., Laparra, J. M., Loria‐Kohen, V., Molina, S., Moreno‐Rubio, J., Montoya, J. J., Torres, C. F., Casado, E., Reglero, G., & de Molina, A. R. (2019) · Nutrients · doi:10.3390/nu11092001 · Cited by 22 · see citing works
Barbosa, J. D. S., Sabry, D. A., Silva, C. H. F., Gomes, D. L., Santana-Filho, A. P., Sassaki, G. L., & Rocha, H. A. O. (2020) · Marine Drugs · doi:10.3390/md18050234 · Cited by 22 · see citing works
Wang, X., Undi, R. B., Ali, N., & Huycke, M. M. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048793 · Cited by 19 · see citing works
- Authors
- Jackaman, C., Tomay, F., Duong, L., Abdol Razak, N. B., Pixley, F. J., Metharom, P., & Nelson, D. J.
- Affiliations
- Curtin University (AU)
- The University of Western Australia (AU)
- Corresponding author
- Jackaman, Connie
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 36
- Pages
- 105-116
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W2604554752
- Cited by
- 251
- References
- 218
- Citations by year
- 2026: 13 · 2025: 33 · 2024: 37 · 2023: 31 · 2022: 39 · 2021: 30 · 2020: 19 · 2019: 22 · 2018: 20 · 2017: 7
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- eSpace (Curtin University) (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Keywords
- aging, cancer, macrophages, neutrophils, immunosenescence, macrophage polarization, low-grade inflammation, T cell function, phagocytosis, immunosuppression, tumor microenvironment, tissue-specific macrophages
- MeSH terms
- Aging, Animals, Anti-Inflammatory Agents, Humans, Macrophages, Neoplasms, Neutrophils, Obesity, T-Lymphocytes, Inflammation Mediators
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