The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Genomic imprinting in mammalian development: a parental tug-of-war
Abstract
Genomic imprinting in mammals is increasingly being implicated in developmental and pathological processes, but without a clear understanding of its function in normal development. We believe that imprinting has evolved in mammals because of the conflicting interests of maternal and paternal genes in relation to the transfer of nutrients from the mother to her offspring. We present an hypothesis that accounts for many of the observed effects of imprinting in mammals and relates them to similar observations in plants. This hypothesis has implications for studies of X-chromosome inactivation and a range of human diseases.
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“This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion (305, 391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [391]
In the citing paper
“In evolutionary terms the role of imprinting has been explained as a means by which the male optimises the spread of his genome through the population (391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [391]
Citations
Cites
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Insulin-like growth factor II receptor as a multifunctional binding protein
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Role of paternal and maternal genomes in mouse development
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Differential activity of maternally and paternally derived chromosome regions in mice
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Parent-Specific Gene Expression and the Triploid Endosperm
Haig, D., & Westoby, M. (1989) · The American Naturalist · doi:10.1086/284971 · Cited by 529
Familial Wiedemann-Beckwith syndrome and a second Wilms tumor locus both map to 11p15.5.
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DIFFERENTIAL IMPRINTING AND EXPRESSION OF MATERNAL AND PATERNAL GENOMES
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DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Placental-specific IGF-II is a major modulator of placental and fetal growth
Constância, M., Hemberger, M., Hughes, J., Dean, W., Ferguson-Smith, A., Fundele, R., Stewart, F., Kelsey, G., Fowden, A., Sibley, C., et al. (2002) · Nature · doi:10.1038/nature00819 · Cited by 1,054
Genomic imprinting: the emergence of an epigenetic paradigm
Ferguson-Smith, A. C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3032 · Cited by 838
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Jansson, T., & Powell, T. L. (2007) · Clinical Science · doi:10.1042/cs20060339 · Cited by 542
Metadata
- Authors
- Moore, T.
- Affiliations
- St George's, University of London (GB)
- Corresponding author
- Moore, T
- ORCID
- Moore, T
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 7
- Issue
- 2
- Pages
- 45-49
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W1985467296
- Cited by
- 1,281
- References
- 29
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 31 · 2023: 32 · 2022: 41 · 2021: 36 · 2020: 27 · 2019: 46 · 2018: 40 · 2017: 33 · 2016: 34 · 2015: 53 · 2014: 61 · 2013: 47 · 2012: 57
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- genomic imprinting, mammalian development, nutrient transfer, X chromosome inactivation, human disease
- MeSH terms
- Animals, Biological Evolution, Embryonic and Fetal Development, Humans, X Chromosome, Gene Expression
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