The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Genomic imprinting in mammalian development: a parental tug-of-war
Abstract
Genomic imprinting in mammals is increasingly being implicated in developmental and pathological processes, but without a clear understanding of its function in normal development. We believe that imprinting has evolved in mammals because of the conflicting interests of maternal and paternal genes in relation to the transfer of nutrients from the mother to her offspring. We present an hypothesis that accounts for many of the observed effects of imprinting in mammals and relates them to similar observations in plants. This hypothesis has implications for studies of X-chromosome inactivation and a range of human diseases.
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“This leads to differential selection pressures on maternally and paternally inherited alleles in the conceptus with respect to resource allocation and is manifested as genomic imprinting, a mechanism for monoallelically regulating gene dosage in a parent-of-origin fashion (305, 391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [391]
In the citing paper
“In evolutionary terms the role of imprinting has been explained as a means by which the male optimises the spread of his genome through the population (391).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [391]
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Cites
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Dominguez-Salas, P., Cox, S. E., Prentice, A. M., Hennig, B. J., & Moore, S. E. (2012) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111003338 · Cited by 163
The role and interaction of imprinted genes in human fetal growth
Moore, G. E., Ishida, M., Demetriou, C., Al-Olabi, L., Leon, L. J., Thomas, A. C., Abu-Amero, S., Frost, J. M., Stafford, J. L., Chaoqun, Y., et al. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0074 · Cited by 155
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Primate brain evolution : genetic and functional considerations
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Maternal-fetal resource allocation: Co-operation and conflict
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Self-citationMaternally-inherited Grb10 reduces placental size and efficiency
Charalambous, M., Cowley, M., Geoghegan, F., Smith, F. M., Radford, E. J., Marlow, B. P., Graham, C. F., Hurst, L. D., & Ward, A. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.10.011 · Cited by 101
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A review of inter- and intraspecific variation in the eutherian placenta
Gundling, W. E., & Wildman, D. E. (2015) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2014.0072 · Cited by 58
Uterine blood flow as a determinant of fetoplacental development
Moore, L. G. (2010) · The Placenta and Human Developmental Programming · doi:10.1017/cbo9780511933806.012 · Cited by 9
Metadata
- Authors
- Moore, T.
- Affiliations
- St George's, University of London (GB)
- Corresponding author
- Moore, T
- ORCID
- Moore, T
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 7
- Issue
- 2
- Pages
- 45-49
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W1985467296
- Cited by
- 1,281
- References
- 29
- Citations by year
- 2026: 16 · 2025: 18 · 2024: 31 · 2023: 32 · 2022: 41 · 2021: 36 · 2020: 27 · 2019: 46 · 2018: 40 · 2017: 33 · 2016: 34 · 2015: 53 · 2014: 61 · 2013: 47 · 2012: 57
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Syndromes and Imprinting
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- genomic imprinting, mammalian development, nutrient transfer, X chromosome inactivation, human disease
- MeSH terms
- Animals, Biological Evolution, Embryonic and Fetal Development, Humans, X Chromosome, Gene Expression
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