The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Wnt-3a regulates somite and tailbud formation in the mouse embryo
Open accessAbstract
Amphibian studies have implicated Wnt signaling in the regulation of mesoderm formation, although direct evidence is lacking. We have characterized the expression of 12 mammalian Wnt-genes, identifying three that are expressed during gastrulation. Only one of these, Wnt-3a, is expressed extensively in cells fated to give rise to embryonic mesoderm, at egg cylinder stages. A likely null allele of Wnt-3a was generated by gene targeting. All Wnt-3a-/Wnt-3a- embryos lack caudal somites, have a disrupted notochord, and fail to form a tailbud. Thus, Wnt-3a may regulate dorsal (somitic) mesoderm fate and is required, by late primitive steak stages, for generation of all new embryonic mesoderm. Wnt-3a is also expressed in the dorsal CNS. Mutant embryos show CNS dysmorphology and ectopic expression of a dorsal CNS marker. We suggest that dysmorphology is secondary to the mesodermal and axial defects and that dorsal patterning of the CNS may be regulated by inductive signals arising from surface ectoderm.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Thomas, K. R., & Capecchi, M. R. (1990) · Nature · doi:10.1038/346847a0 · Cited by 896
Cited by
Luo, G., Hofmann, C., Bronckers, A. L., Sohocki, M., Bradley, A., & Karsenty, G. (1995) · Genes & Development · doi:10.1101/gad.9.22.2808 · Cited by 1,021
Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
Miller, J. R., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.20.2527 · Cited by 656
Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies
ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477
Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice
Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R. (1999) · Genes & Development · doi:10.1101/gad.13.6.709 · Cited by 462
Hamblet, N. S., Lijam, N., Ruiz-Lozano, P., Wang, J., Yang, Y., Luo, Z., Mei, L., Chien, K. R., Sussman, D. J., & Wynshaw-Boris, A. (2002) · Development · doi:10.1242/dev.00164 · Cited by 441
Metadata
- Authors
- Takada, S.
- Venue
- Trends in Genetics
- Publisher
- Elsevier BV
- Published
- 1994-05
- Volume
- 10
- Issue
- 5
- Pages
- 151
- ISSN
- 0168-9525 (ISSN-L)
- OpenAlex
- W2038763845
- Cited by
- 789
- References
- 1
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Wnt-3a regulates somite and tailbud formation in the mouse embryo. https://app.cochat.ai/papers/10.1016/0168-9525(94)90090-6
- The paper
- Takada, S. (1994). Wnt-3a regulates somite and tailbud formation in the mouse embryo. Trends in Genetics. https://doi.org/10.1016/0168-9525(94)90090-6
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
