The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice
Open accessAbstract
Members of the LEF-1/TCF family of transcription factors have been implicated in the transduction of Wnt signals. However, targeted gene inactivations of Lef1, Tcf1, or Tcf4 in the mouse do not produce phenotypes that mimic any known Wnt mutation. Here we show that null mutations in both Lef1 and Tcf1, which are expressed in an overlapping pattern in the early mouse embryo, cause a severe defect in the differentiation of paraxial mesoderm and lead to the formation of additional neural tubes, phenotypes identical to those reported for Wnt3a-deficient mice. In addition, Lef1(-/-)Tcf1(-/-) embryos have defects in the formation of the placenta and in the development of limb buds, which fail both to express Fgf8 and to form an apical ectodermal ridge. Together, these data provide evidence for a redundant role of LEF-1 and TCF-1 in Wnt signaling during mouse development.
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Cites
Functional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Self-citationDistinct WNT Pathways Regulating AER Formation and Dorsoventral Polarity in the Chick Limb Bud
Kengaku, M., Capdevila, J., Rodriguez-Esteban, C., De La Peña, J., Johnson, R. L., Belmonte, J. C. I., & Tabin, C. J. (1998) · Science · doi:10.1126/science.280.5367.1274 · Cited by 411
Cited by
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
Self-citationThe Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
WNT signaling in bone homeostasis and disease: From human mutations to treatments
Baron, R., & Kneissel, M. (2013) · Nature Medicine · doi:10.1038/nm.3074 · Cited by 2,093
The many faces and functions of β‐catenin
Valenta, T., Hausmann, G., & Basler, K. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.150 · Cited by 1,598
WNT Signals Are Required for the Initiation of Hair Follicle Development
Andl, T., Reddy, S. T., Gaddapara, T., & Millar, S. E. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00167-3 · Cited by 1,088
Metadata
- Authors
- Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1999-03-15
- Volume
- 13
- Issue
- 6
- Pages
- 709-717
- ISSN
- 0890-9369 (ISSN-L)
- OpenAlex
- W2066078074
- Cited by
- 462
- References
- 2
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice. https://app.cochat.ai/papers/10.1101/gad.13.6.709
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- Galceran, J., Farinas, I., Depew, M. J., Clevers, H., & Grosschedl, R. (1999). Wnt3a-/--like phenotype and limb deficiency in Lef1-/-Tcf1-/- mice. Genes & Development. https://doi.org/10.1101/gad.13.6.709
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