Signal transduction through beta-catenin and specification of cell fate during embryogenesis.
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β-Catenin translocates into the nucleus, where it forms a complex with HMG box transcription factors including LEF-1 and TCF, and activates transcription of target genes.
“β-Catenin then translocates into the nucleus, where it forms a complex with the HMG box class of transcription factors, including lymphoid enhancer factor 1 (LEF-1) and T-cell factor (TCF), and activates the transcription of its target genes (5, 17, 20).”
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- Authors
- Miller, J. R., & Moon, R. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Washington (US)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1996-10-15
- Volume
- 10
- Issue
- 20
- Pages
- 2527-2539
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2144300167
- Cited by
- 656
- References
- 1
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 8 · 2022: 2 · 2021: 4 · 2020: 8 · 2019: 9 · 2018: 3 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 10 · 2013: 10 · 2012: 11
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- β-catenin, signal transduction, cell fate specification, embryonic development, Wnt signaling, transcriptional regulation
- MeSH terms
- Animals, Cell Adhesion, Cell Differentiation, Cell Membrane, Cell Nucleus, Cytoplasm, Cytoskeletal Proteins, Embryonic and Fetal Development, High Mobility Group Proteins, Humans, Proto-Oncogene Proteins, Transcription Factors, Zygote, Signal Transduction, Trans-Activators, Gene Expression, Drosophila Proteins, Wnt1 Protein, beta Catenin
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