The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
The Plasmodium digestive Vacuole: Metabolic Headquarters and Choice Drug Target
Abstract
The Plasmodium digestive (food) vacuole is an acidic proteolytic compartment central to the metabolism of the parasite. Here haemoglobin is degraded, haem is polymerized, amino acid are transported, oxygen radicals are detoxified, drugs are accumulated, acidification is maintained and free iron may be generated. Despite these crucial roles in parasite development, a number of questions about the digestive vacuole and the haemoglobin ingestion pathway remain unanswered; in consequence, a number of attractive drug targets remain to be exploited. Piero Olliaro and Daniel Goldberg here review the morphology, metabolism and pharmacological disruption of this specialized organelle.
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“During Plasmodium infection of erythrocytes, hemoglobin is digested into amino acids and heme (80).”
From Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens (2010) · cites this paper as [80]
Citations
Cites
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Cited by
Overcoming the Heme Paradox: Heme Toxicity and Tolerance in Bacterial Pathogens
Anzaldi, L. L., & Skaar, E. P. (2010) · Infection and Immunity · doi:10.1128/iai.00613-10 · Cited by 295
Iron and innate antimicrobial immunity-depriving the pathogen, defending the host
Nairz, M., Dichtl, S., Schroll, A., Haschka, D., Tymoszuk, P., Theurl, I., & Weiss, G. (2018) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2018.03.007 · Cited by 123
(1998) · PubMed Central
Metadata
- Authors
- Olliaro, P. L., & Goldberg, D. E.
- Venue
- Parasitology Today
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 11
- Issue
- 8
- Pages
- 294-297
- ISSN
- 0169-4758
- Cited by
- 139
- References
- 65
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
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