Haemozoin: Identification and quantification
Abstract
Haemozoin (malaria pigment) is a haem polymer resulting from the breakdown of haemoglobin by Plasmodium spp. This refractory substance has been the focus of many studies and of much debate, mainly because of its role in the pharmacological activity of certain antimalarials. Haemozoin is also important because its presence in tissues serves as an indicator of malaria infections, and may itself be a mediator of malaria pathogenesis. In this article, Amy Sullivan and Steven Meshnick review the structure and synthesis of haemozoin, and then focus on methods of haemozoin identification in tissue. This latter aspect has implications for the study of haemozoin both as an indicator of malaria infection and as a possible mediator of malaria pathogenesis.
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Hemozoin can be detected by polarized light, by fluorescent properties allowing quantification in tissue, and by laser desorption mass spectrometry.
“Hemozoin can be detected by polarized light [48], by the fluorescent properties of hemozoin which allows quantification in tissue [49], and by laser desorption mass spectrometry (LDMS) that identifies distinct spectral features [50].”
From Diagnosing malaria in pregnancy: An update (2012) · cites this paper as [49]
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- Authors
- Sullivan, A. D., & Meshnick, S. R.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Sullivan, A.D.
- ORCID
- Sullivan, A.D.
- Venue
- Parasitology Today
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 12
- Issue
- 4
- Pages
- 161-163
- ISSN
- 0169-4758 (ISSN-L)
- OpenAlex
- W2020912135
- Cited by
- 19
- References
- 28
- Citations by year
- 2020: 1 · 2017: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Parasitology Today (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Phytochemical compounds biological activities
- Keywords
- hemozoin, Plasmodium, hemoglobin degradation, malaria pathogenesis, antimalarial drugs
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