Neuroimmunology of Alzheimer's disease: A conference report
Abstract
A multidisciplinary group met under the auspices of the National Institute on Aging and the Dell Foundation at the Princess Resort in San Diego, CA on April 5-6, 1991. The meeting was organized by Dr. Caleb E. Finch, University of Southern California, Dr. Zaven Khachaturian, National Institute on Aging, Dr. William Markesbery, University of Kentucky, Dr. Patrick McGeer, University of British Columbia, and Dr. Joseph Rogers, Institute for Biogerontology Research, and covered recent data suggesting neuroimmune correlates of Alzheimer's disease (AD). These findings span many of the major immune system phenomena, from major histocompatibility complex (MHC) antigens through cytokines and the complement cascade and suggest that some facets of AD pathogenesis may be immune related.
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Although B lymphocytes were detected in AD brains, their number was limited, with significantly fewer B cells observed compared to T cells.
“Although B lymphocytes were detec ted in AD brains, their number was limited, with significantly fewer B cells observed compared to T cells [80].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [80]
The earliest mention of the presence of B cells in AD brain tissue appears in a 1992 conference report exploring immune-related aspects of AD pathogenesis.
“The earliest mention of the presence of B cells in AD brain tissue appears in a 1992 conference report exploring immune-related aspects of AD pathogenesis [80].”
From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [80]
Cites
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Brain microglia constitutively express β-2 integrins
Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430 · see citing works
Activation of the classical complement pathway in brain tissue of Alzheimer patients
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90843-4 · Cited by 383 · see citing works
Styren, S. D., Civin, W. H., & Rogers, J. (1990) · Experimental Neurology · doi:10.1016/0014-4886(90)90054-v · Cited by 191 · see citing works
Increased senile plaques without microglia in Alzheimer's disease
Ohgami, T., Kitamoto, T., Shin, R. W., Kaneko, Y., Ogomori, K., & Tateishi, J. (1991) · Acta Neuropathologica · doi:10.1007/bf00305864 · Cited by 64 · see citing works
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Neuropathology of Alzheimer's Disease
Perl, D. P. (2010) · Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20157 · Cited by 825 · see citing works
Inflammatory process in Alzheimer's Disease
Meraz-Ríos, M. A., Toral-Rios, D., Franco-Bocanegra, D., Villeda-Hernández, J., & Campos-Peña, V. (2013) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2013.00059 · Cited by 427 · see citing works
Blazer, L. L., & Neubig, R. R. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.151 · Cited by 197 · see citing works
Blood levels of histamine, IL-1β, and TNF-α in patients with mild to moderate alzheimer disease
Alvarez, X. A., Franco, A., Fernández-Novoa, L., & Cacabelos, R. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815005 · Cited by 139 · see citing works
Is there a role for B cells in Alzheimer's disease?
Charavner, E.-L., Fillatreau, S., & El Behi, M. (2026) · Cellular Immunology · doi:10.1016/j.cellimm.2026.105154
- Authors
- Dickson, D. W., & Rogers, J.
- Affiliations
- Albert Einstein College of Medicine (US)
- Banner Sun Health Research Institute (US)
- Corresponding author
- Rogers, Joseph
- ORCID
- Dickson, Dennis W.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1992-11
- Volume
- 13
- Issue
- 6
- Pages
- 793-798
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2022931361
- Cited by
- 44
- References
- 5
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 2 · 2021: 2 · 2017: 1 · 2013: 1
- FWCI
- 2.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, neuroimmunology, immune system, major histocompatibility complex, cytokines, complement system, pathogenesis, neuroinflammation
- MeSH terms
- Alzheimer Disease, Humans
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