Effects of thyroid hormone(s) on mean wall thickness of trabecular bone packets
Abstract
The mean wall thickness of iliac trabecular bone packets was determined in undecalcified iliac crest bone specimens from 14 hypothyroid patients, 14 hyperthyroid patients and 28 age- and sex-matched normal controls. Calcification rate and fractional resorption, formation and labeled surfaces in trabecular bone from the patients were measured by conventional histomorphometric methods after double-labeling with tetracycline. The mean wall thickness was increased in the hypothyroid patients (58,9 microns), while no change was demonstrated in the hyperthyroid group (52,5 microns) as compared to the controls (54,0 microns). Calculated estimates of trabecular bone remodeling at the "Basic Multicellular Unit" level showed longer periods of resorption, formation and total remodeling in the hypothyroid than in the hyperthyroid patients.
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Although increased mean wall thickness has been reported in hypothyroidism, there does not appear to be increased resorption depth with a corresponding reduction in mean wall thickness in isolated hyperthyroidism; however, biopsy studies have not been large.
“thus although increased mean wall thickness has been reported in hypothyroidism there does not appear to be increased resorption depth with a corresponding reduction in mean wall thickness in isolated hyperthyroidism; however, biopsy studies have not been large.(43)”
The classical effect of thyroid hormone excess in adults is increased activation frequency leading to reversible bone loss.
“The classical effect on thyroid hormone excess in adults is essentially one of increased activation frequency leading to a reversible bone loss”
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- Authors
- Kragstrup, J., Melsen, F., & Mosekilde, L.
- ORCID
- Kragstrup, J.
- Venue
- Metabolic Bone Disease and Related Research
- Publisher
- Elsevier BV
- Published
- 1981-01
- Volume
- 3
- Issue
- 3
- Pages
- 181-185
- ISSN
- 0221-8747 (ISSN-L)
- OpenAlex
- W2083552955
- Cited by
- 28
- References
- 14
- Citations by year
- 2020: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Metabolic Bone Disease and Related Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- thyroid hormones, hypothyroidism, hyperthyroidism, trabecular bone, bone remodeling, basic multicellular unit, bone resorption, bone formation, tetracycline double labeling, iliac crest bone, bone histomorphometry
- MeSH terms
- Adult, Aged, Bone and Bones, Bone Resorption, Calcification, Physiologic, Female, Humans, Hyperthyroidism, Hypothyroidism, Ilium, Male, Middle Aged, Osteogenesis, Thyroid Hormones
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