Trabecular bone remodeling and bone balance in hyperthyroidism
Abstract
In vivo tetracycline double-labeled iliac crest bone biopsies from 15 hyperthyroid patients were used for the reconstruction of curves describing the variation of resorption depth and formation thickness with time. The curves emerging were compared to curves reconstructed from 13 age- and sex-matched normal individuals (mean age 44 years). The median function period for resorptive cells in hyperthyroid patients (16 days) was about one-third the resorptive period in normals (51 days). No significant difference between the osteoclast-, mononuclear-, or preosteoblast-like cell resorption depths could be demonstrated between the two groups. Consequently, the median resorption rate in hyperthyroid patients (3.8 microns/day) was more than 3 times higher than the value in the control group (1.1 micron/day). Median Sigma, was shorter in the hyperthyroid group (109 days) than in the control group (151 days, P less than 0.05), as was the median initial mineralization lag time (5 and 16 days, respectively, P less than 0.01). No significant difference between the measured mean completed wall thickness (mcwT) values in the hyperthyroid groups and the control group could be demonstrated (58.1 and 60.5 micron respectively). Median initial mineralization rate in the hyperthyroid group (1.2 micron3/micron2 per day) was not significantly higher than the value calculated in the control group (0.9 micron3/micron2 per day), but median initial matrix appositional rate in hyperthyroid (4.8 microns3/micron2 per day) was 3 times higher than the value calculated for normals (1.6 micron3/micron2 per day) (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
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Iatrogenic hyperthyroidism can decrease bone quality and bone mineral density, leading to a higher risk of fracture.
“which can decrease bone quality22 and bone mineral density,60 leading to a higher risk of fracture.”
From Levothyroxine dose and risk of fractures in older adults: nested case-control study (2011) · cites this paper as [60]
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Self-citationSkeletal responsiveness to thyroid hormone is not altered at menopause
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Self-citationThyroid Hormone Signaling in the Development of the Endochondral Skeleton
Lindsey, R. C., Aghajanian, P., & Mohan, S. (2017) · Vitamins and hormones · doi:10.1016/bs.vh.2017.06.003 · Cited by 16 · see citing works
Superscan Pattern on Bone Scintigraphy: A Comprehensive Review
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Association of the Vitamin D Receptor Genotype BB with Low Bone Density in Hyperthyroidism
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Utility of C-terminal Telopeptide in Evaluating Levothyroxine Replacement Therapy-Induced Bone Loss
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Self-citationA novel mathematical model of bone remodelling cycles for trabecular bone at the cellular level
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A 64-Year-Old Woman With Primary Hyperparathyroidism
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Effects of electromagnetic fields on bone loss in hyperthyroidism rat model
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- Authors
- Eriksen, E. F., Mosekilde, L., & Melsen, F.
- Corresponding author
- Eriksen, E.F.
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 6
- Issue
- 6
- Pages
- 421-428
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2051022943
- Cited by
- 172
- References
- 17
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- hyperthyroidism, trabecular bone remodeling, bone balance, tetracycline double labeling, iliac crest bone biopsy, bone resorption rate, bone formation rate, formation thickness, mineralization lag time, osteoclasts, bone turnover markers
- MeSH terms
- Adult, Aged, Bone Matrix, Bone Resorption, Female, Humans, Hyperthyroidism, Male, Middle Aged, Minerals, Osteogenesis, Regression Analysis, Time Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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