Stochastics of HZE-induced mulesions
Abstract
Fundamental biological experiments with bacteria, yeast, and mammalian cells irradiated with ions heavier than helium indicate that maximal probability of single-hit inactivation does not occur when the ion has LET below about 100-200 keV/micrometer. Theoretical treatments of cell inactivation data and the radiation chemistry in particle tracks are consistent with this finding. If a "microlesion" is defined as a linear array, within a tissue, of cells inactivated with maximum probability, surrounded by non-lethally damaged cells, then, by this definition, there must be an LET below which "microlesion" damage cannot be expected. In a retrospective survey of experimental literature in which single-particle effects in tissues were sought, it was found that little or no evidence has been reported supporting single-particle effects in tissues when LET was below 200 keV/micrometer, while some experimenters who irradiated tissues with particles having LET greater than 200 keV/micrometer reported effects that could be attributed to single-particle tracks.
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Highly ionizing HZE nuclei can easily penetrate space vehicle structures and still have sufficient energy capable of heavily damaging cells or creating micro-lesions along their tracks through tissues.
“Highly ionizing HZE nuclei can easily penetrate space vehicle structures and still have sufficient energy capable of heavily damaging cells or creating micro-lesions along their tracks through tissues [54].”
From Space Radiation: The number one risk to astronaut health beyond low earth orbit (2014) · cites this paper as [54]
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- Authors
- Todd, P.
- Corresponding author
- Todd, P.
- ORCID
- Todd, P.
- Venue
- Advances in Space Research
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 9
- Issue
- 10
- Pages
- 31-34
- ISSN
- 0273-1177 (ISSN-L)
- OpenAlex
- W2021826353
- Cited by
- 21
- References
- 12
- Citations by year
- 2022: 1 · 2020: 1 · 2016: 1 · 2014: 3
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Space Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Radiation Therapy and Dosimetry
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Keywords
- HZE radiation, microlesions, single-particle effects, linear energy transfer, cell inactivation, space radiation biology
- MeSH terms
- Animals, Bone Marrow, Cell Nucleus, Cells, Cultured, Cosmic Radiation, Dose-Response Relationship, Radiation, Intestines, Ions, Radiation Injuries, Experimental, Stochastic Processes, Cell Death, Linear Energy Transfer, Mice
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