Isolation and characterization of DNA from the plasma of cancer patients

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

Rigby, P. W. J., Dieckmann, M., Rhodes, C., & Berg, P. R. (1977) · Journal of Molecular Biology · doi:10.1016/0022-2836(77)90052-3 · Cited by 11,400 · see citing works

Untitled work

(1977) · PubMed · Cited by 1,801 · see citing works

Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease

Shapiro, B., Chakrabarty, M., Cohn, E. M., & Leon, S. A. (1983) · Cancer · doi:10.1002/1097-0142(19830601)51:11 · Cited by 398 · see citing works

Spontaneous release of DNA by human blood lymphocytes as shown in an in vitro system.

Anker, P., Stroun, M., & Maurice, P. A. (1975) · PubMed · Cited by 234 · see citing works

Excretion of Deoxyribonucleic Acid by Lymphocytes Stimulated with Phytohemagglutinin or Antigen

ROGERS, J. C., Boldt, D. H., Kornfeld, S. A., Skinner, S. A. M., & VALERI, C. R. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.7.1685 · Cited by 158 · see citing works

Circulating Nucleic Acids in Higher Organisms

Stroun, M., Anker, P., Maurice, P. A., & Gahan, P. B. (1977) · International review of cytology · doi:10.1016/s0074-7696(08)60225-9 · Cited by 106 · see citing works

Circulating DNA in systemic lupus erythematosus. Isolation and characterization.

Steinman, C. R. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111278 · Cited by 99 · see citing works

Isolation and characterization of an RNA-proteolipid complex associated with the malignant state in humans.

Wieczorek, A. J., Rhyner, C., & Block, L. H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.10.3455 · Cited by 97 · see citing works

Circulating DNA in systemic lupus erythematosus

Steinman, C. R. (1979) · The American Journal of Medicine · doi:10.1016/0002-9343(79)90789-7 · Cited by 95 · see citing works

Cell-surface-associated nucleic acid in tumorigenic cells made visible with platinum-pyrimidine complexes by electron microscopy.

Aggarwal, S. K., Wagner, R. W., McAllister, P. K., & Rosenberg, B. H. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.928 · Cited by 79 · see citing works

Nucleic acids spontaneously released by living frog auricles

Stroun, M., & Anker, P. (1972) · Biochemical Journal · doi:10.1042/bj1280100pb · Cited by 69 · see citing works

Actions of cis-diamminedichloroplatinum on cell surface nucleic acids in cancer cells as determined by cell electrophoresis techniques.

Juckett, D. A., & Rosenberg, B. (1982) · PubMed · Cited by 38 · see citing works

The DNA extruded by rat spleen cells in culture

Adams, D., & Gahan, P. B. (1983) · International Journal of Biochemistry · doi:10.1016/0020-711x(83)90129-5 · Cited by 22 · see citing works

Leukemia in AKR mice: A defined suppressor cell population expressing membrane-associated DNA

Russell, J. L., & Golub, E. S. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.12.6211 · Cited by 21 · see citing works

Purification of DNA by affinity chromatography: Removal of polysaccharide contaminants

Edelman, M. (1975) · Analytical Biochemistry · doi:10.1016/0003-2697(75)90512-6 · Cited by 15 · see citing works

Spontaneous release of newly synthesized DNA from frog auricles

Stroun, M., Anker, P., & Gahan, P. (1977) · E-Periodica · doi:10.5169/seals-739823 · Cited by 13 · see citing works

Strategies for detection of transfusion-transmitted viruses eluding identification by conventional serologic tests II. Detection of host DNA in human plasmas with elevated alanine aminotransferase

NEURATH, A. R., Strick, N., Miller, K., & Waldman, A. A. (1984) · Journal of Virological Methods · doi:10.1016/0166-0934(84)90042-9 · Cited by 9 · see citing works

A view on drug resistance in cancer

Vasan, N., Baselga, J., & Hyman, D. M. (2019) · Nature · doi:10.1038/s41586-019-1730-1 · Cited by 2,770 · see citing works

Direct detection of early-stage cancers using circulating tumor DNA

Phallen, J. A., Sausen, M., Adleff, V., Leal, A., Hruban, C., White, J. R., Anagnostou, V., Fiksel, J., Cristiano, S., Papp, E., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aan2415 · Cited by 1,129 · see citing works

Origins, structures, and functions of circulating DNA in oncology

Thierry, A. R., El Messaoudi, S., Gahan, P. B., Anker, P., & Stroun, M. (2016) · Cancer and Metastasis Reviews · doi:10.1007/s10555-016-9629-x · Cited by 818 · see citing works

High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants

Razavi, P., Li, B. T., Brown, D. N., Jung, B., Hubbell, E. A., Shen, R., Abida, W. M., Juluru, K., de Bruijn, I., Hou, C., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0652-7 · Cited by 795 · see citing works

Advances in bladder cancer biology and therapy

Tran, L. L., Xiao, J.-F., Agarwal, N., Duex, J. E., & Theodorescu, D. (2020) · Nature reviews. Cancer · doi:10.1038/s41568-020-00313-1 · Cited by 742 · see citing works

Analytical and clinical validation of a digital sequencing panel for quantitative, highly accurate evaluation of cell-free circulating tumor DNA

Lanman, R. B., Mortimer, S. A., Zill, O. A., Sebisanovic, D., Lopez, R., Blau, S., Collisson, E. A., Divers, S. G., Hoon, D. S. B., Kopetz, E. S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140712 · Cited by 695 · see citing works

Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA

Haber, D. A., & Velculescu, V. E. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-1014 · Cited by 697 · see citing works

Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA

Thierry, A. R., Mouliere, F. C., Messaoudi, S. E., Mollévi, C., Lopez‐Crapez, E., Rolet, F., Gillet, B., Gongora, C., Dechelotte, P., Robert, B., et al. (2014) · Nature Medicine · doi:10.1038/nm.3511 · Cited by 681 · see citing works

Microsatellite alterations in serum DNA of head and neck cancer patients

Nawroz, H., Koch, W. M., Anker, P., Stroun, M., & Sidransky, D. (1996) · Nature Medicine · doi:10.1038/nm0996-1035 · Cited by 656 · see citing works

Circulating cell free DNA: Preanalytical considerations

Messaoudi, S. E., Rolet, F., Mouliere, F. C., & Thierry, A. R. (2013) · Clinica Chimica Acta · doi:10.1016/j.cca.2013.05.022 · Cited by 560 · see citing works

Enhancing the accuracy of next-generation sequencing for detecting rare and subclonal mutations

Salk, J. J., Schmitt, M. W., & Loeb, L. A. (2018) · Nature Reviews Genetics · doi:10.1038/nrg.2017.117 · Cited by 536 · see citing works

Detection and Clinical Importance of Micrometastatic Disease

Pantel, K., Côté, R. J., & Fodstad, Ø. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.13.1113 · Cited by 493 · see citing works

Comparison of microfluidic digital PCR and conventional quantitative PCR for measuring copy number variation

Whale, A. S., Huggett, J. F., Cowen, S., Speirs, V., Shaw, J., Ellison, S., Foy, C. A., & Scott, D. J. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks203 · Cited by 453 · see citing works

Detection of Circulating Tumour DNA in the Blood (Plasma/Serum) of Cancer Patients

Anker, P., Mulcahy, H. E., Chen, X. Q., & Stroun, M. (1999) · Cancer and Metastasis Reviews · doi:10.1023/a:1006260319913 · Cited by 451 · see citing works

Circulating free DNA in plasma or serum as biomarker of carcinogenesis: Practical aspects and biological significance

Gormally, E., Caboux, É., Vineis, P., & Hainaut, P. L. (2007) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2006.11.002 · Cited by 444 · see citing works

Point mutations of the N‐ras gene in the blood plasma DNA of patients with myelodysplastic syndrome or acute myelogenous leukaemia

Vasioukhin, V. I., Anker, P., Maurice, P. A., Lyautey, J., Lederrey, C., & Stroun, M. (1994) · British Journal of Haematology · doi:10.1111/j.1365-2141.1994.tb04828.x · Cited by 413 · see citing works

Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.

Rosas, S. L. B., Koch, W. M., Carvalho, M. D. G., Wu, L., Califano, J. A., Westra, W. H., Jen, J., & Sidransky, D. (2001) · PubMed · Cited by 409 · see citing works

Nucleic Acid-Based Methods for the Detection of Cancer

Sidransky, D. (1997) · Science · doi:10.1126/science.278.5340.1054 · Cited by 405 · see citing works

The Origin and Mechanism of Circulating DNA

Stroun, M., Maurice, P. A., Vasioukhin, V. I., Lyautey, J., Lederrey, C., Lefort, F., ROSSIER, A., Chen, X. Q., & Anker, P. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06608.x · Cited by 395 · see citing works

Cell-free DNA in the blood as a solid tumor biomarker–a critical appraisal of the literature

Jung, K., Fleischhacker, M., & Rabien, A. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.07.032 · Cited by 337 · see citing works

The diverse origins of circulating cell‐free DNA in the human body: a critical re‐evaluation of the literature

Aucamp, J., Bronkhorst, A. J., Badenhorst, C. P. S., & Pretorius, P. J. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12413 · Cited by 325 · see citing works

Circulating nucleic acids (CNAs) and cancer—A survey

Fleischhacker, M., & Schmidt, B. (2007) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2006.10.001 · Cited by 851 · see citing works

The Long and Short of Circulating Cell-Free DNA and the Ins and Outs of Molecular Diagnostics

Jiang, P., & Lo, Y. M. D. (2016) · Trends in Genetics · doi:10.1016/j.tig.2016.03.009 · Cited by 309 · see citing works

Quantitation of genomic DNA in plasma and serum samples: higher concentrations of genomic DNA found in serum than in plasma

Lee, T., Montalvo, L., Chrebtow, V., & Busch, M. P. (2001) · Transfusion · doi:10.1046/j.1537-2995.2001.41020276.x · Cited by 311 · see citing works

Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients

Zhang, Y., Yao, Y., Xu, Y., Li, L., Gong, Y., Zhang, K., Zhang, M., Guan, Y., Chang, L., Xia, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20162-8 · Cited by 306 · see citing works

Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts

Thierry, A. R., Mouliere, F. C., Gongora, C., Ollier, J., Robert, B., Ychou, M., Rio, M. D., & Molina, F. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq421 · Cited by 299 · see citing works

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification

Devonshire, A. S., Whale, A. S., Gutteridge, A., Jones, G. M., Cowen, S., Foy, C. A., & Huggett, J. F. (2014) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-014-7835-3 · Cited by 299 · see citing works

Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology

Deveson, I. W., Gong, B., Lai, K., LoCoco, J. S., Richmond, T., Schageman, J. J., Zhang, Z., Novoradovskaya, N., Willey, J. C., Jones, W. D., et al. (2021) · Nature Biotechnology · doi:10.1038/s41587-021-00857-z · Cited by 280 · see citing works

An electrochemical clamp assay for direct, rapid analysis of circulating nucleic acids in serum

Das, J., Ivanov, I., Montermini, L., Rak, J. W., Sargent, E. H., & Kelley, S. O. (2015) · Nature Chemistry · doi:10.1038/nchem.2270 · Cited by 274 · see citing works

Guidelines for the Preanalytical Conditions for Analyzing Circulating Cell-Free DNA

Meddeb, R., Pisareva, E., & Thierry, A. R. (2019) · Clinical Chemistry · doi:10.1373/clinchem.2018.298323 · Cited by 263 · see citing works

Droplet-based digital PCR and next generation sequencing for monitoring circulating tumor DNA: a cancer diagnostic perspective

Postel, M., Roosen, A., Laurent‐Puig, P., Taly, V., & Renault, S. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2018.1400384 · Cited by 255 · see citing works

Genomic Medicine–Progress, Pitfalls, and Promise

Shendure, J., Findlay, G. M., & Snyder, M. W. (2019) · Cell · doi:10.1016/j.cell.2019.02.003 · Cited by 253 · see citing works

Quantitative Cell-Free Circulating BRAFV600E Mutation Analysis by Use of Droplet Digital PCR in the Follow-up of Patients with Melanoma Being Treated with BRAF Inhibitors

Sanmamed, M. F., Landazuri, S. F., Rodríguez, C., Zárate, R., Lozano, M. D., Zubiri, L., Perez‐Gracia, J. L., Martín‐Algarra, S., & González, Á. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2014.230235 · Cited by 245 · see citing works

Quantifying circulating cell-free DNA in humans

Meddeb, R., Dache, Z. A. A., Thézenas, S., Otandault, A., Tanos, R., Pastor, B., Sánchez, C., Azzi, J., Tousch, G., Azan, S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41593-4 · Cited by 242 · see citing works

Human Urine Contains Small, 150 to 250 Nucleotide-Sized, Soluble DNA Derived from the Circulation and May Be Useful in the Detection of Colorectal Cancer

Su, Y., Wang, M., Brenner, D. E., Ng, A. K. L., Melkonyan, H. S., Umansky, S. R., Syngal, S., & Block, T. M. (2004) · Journal of Molecular Diagnostics · doi:10.1016/s1525-1578(10)60497-7 · Cited by 240 · see citing works

Multi‐marker analysis of circulating cell‐free DNA toward personalized medicine for colorectal cancer

Mouliere, F. C., Messaoudi, S. E., Pang, D., Dritschilo, A., & Thierry, A. R. (2014) · Molecular Oncology · doi:10.1016/j.molonc.2014.02.005 · Cited by 228 · see citing works

Cell-free DNA: measurement in various carcinomas and establishment of normal reference range

Wu, T., Zhang, D., Chia, J., Tsao, K., Sun, C., & Wu, J. T. (2002) · Clinica Chimica Acta · doi:10.1016/s0009-8981(02)00091-8 · Cited by 231 · see citing works

Circulating DNA: a new diagnostic gold mine?

Ziegler, A., Zangemeister‐Wittke, U., & Stahel, R. A. (2002) · Cancer Treatment Reviews · doi:10.1016/s0305-7372(02)00077-4 · Cited by 229 · see citing works

Putative Origins of Cell-Free DNA in Humans: A Review of Active and Passive Nucleic Acid Release Mechanisms

Grabuschnig, S., Bronkhorst, A. J., Holdenrieder, S., Rodriguez, I. R., Schliep, K. P., Schwendenwein, D., Ungerer, V., & Sensen, C. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21218062 · Cited by 223 · see citing works

Extracellular DNA and histones: double‐edged swords in immunothrombosis

Gould, T. J., Lysov, Z., & Liaw, P. C. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12977 · Cited by 218 · see citing works

Circulating Cell-Free DNA

Breitbach, S. A., Tug, S., & Simon, P. D. (2012) · Sports Medicine · doi:10.2165/11631380-000000000-00000 · Cited by 209 · see citing works

A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.

Mulcahy, H. E., Lyautey, J., Lederrey, C., Chen, X. Q., Anker, P., Alstead, E. M., Ballinger, A., Farthing, M. J. G., & Stroun, M. (1998) · PubMed · Cited by 205 · see citing works

Clinical use of circulating nucleosomes

Holdenrieder, S., & Stieber, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360802485875 · Cited by 200 · see citing works

The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells

Choi, J., Reich, C. F., & Pisetsky, D. S. (2005) · Immunology · doi:10.1111/j.1365-2567.2005.02130.x · Cited by 199 · see citing works

Detecting tumor-related alterations in plasma or serum DNA of patients diagnosed with breast cancer.

Chen, X., Bonnefoi, H. R., Diebold‐Berger, S., Lyautey, J., Lederrey, C., Faltin-Traub, E. F., Stroun, M., & Anker, P. (1999) · PubMed · Cited by 193 · see citing works

Circulating DNA

van der Vaart, M., & Pretorius, P. J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1448.022 · Cited by 190 · see citing works

Ser-249 p53 Mutations in Plasma DNA of Patients With Hepatocellular Carcinoma From The Gambia

Kirk, G. D., Camus-Randon, A.-M., Mendy, M. E., Goedert, J. J., Merle, P., TREPO, C. G., Bréchot, C., Hainaut, P. L., & Montesano, R. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.2.148 · Cited by 190 · see citing works

Extracellular nucleic acids

Vlassov, V. V., Laktionov, P. P., & RYKOVA, E. Y. (2007) · BioEssays · doi:10.1002/bies.20604 · Cited by 182 · see citing works

Detection of Solid Tumor Molecular Residual Disease (MRD) Using Circulating Tumor DNA (ctDNA)

Chin, R.-I., Chen, K., Usmani, A., Chua, C., Harris, P. K., Binkley, M. S., Azad, T. D., Dudley, J. C., & Chaudhuri, A. A. (2019) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-019-00390-5 · Cited by 191 · see citing works

Genomic analysis of circulating cell-free DNA infers breast cancer dormancyPreprint

Shaw, J., Page, K., Blighe, K., Hava, N., Guttery, D. S., Ward, B., Brown, J., Ruangpratheep, C., Stebbing, J., Payne, R., et al. (2011) · Genome Research · doi:10.1101/gr.123497.111 · Cited by 180 · see citing works

Detection of mutant K-ras DNA in plasma or serum of patients with colorectal cancer

KOPRESKI, M. S., Benko, F. A., Kwee, C., Leitzel, K. E., Eskander, E., Lipton, A., & Gocke, C. D. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.551 · Cited by 172 · see citing works

Plasma cell‐free DNA in ovarian cancer

Kamat, A. A., Baldwin, M., Urbauer, D. L., Dang, D. H., Han, L. Y., Godwin, A. K., Karlan, B. Y., Simpson, J. L., Gershenson, D. M., Coleman, R. L., et al. (2010) · Cancer · doi:10.1002/cncr.24997 · Cited by 169 · see citing works

The Origin of Highly Elevated Cell-Free DNA in Healthy Individuals and Patients with Pancreatic, Colorectal, Lung, or Ovarian Cancer

Mattox, A. K., Douville, C. B., Wang, Y., Popoli, M., Ptak, J., Silliman, N., Dobbyn, L., Schaefer, J., Lu, S., Pearlman, A. H., et al. (2023) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1252 · Cited by 166 · see citing works

Potential clinical utility of liquid biopsies in ovarian cancer

Zhu, J. W., Charkhchi, P., & Akbari, M. R. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01588-8 · Cited by 161 · see citing works

Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.

Yamada, T., Nakamori, S., Ohzato, H., Oshima, S., Aoki, T., HIGAKI, N., Sugimoto, K., Akagi, K., Fujiwara, Y., Nishisho, I., et al. (1998) · PubMed · Cited by 159 · see citing works

Circulating Cell-Free DNA in Plasma/Serum of Lung Cancer Patients as a Potential Screening and Prognostic Tool

Kumar, S. (2006) · Clinical Chemistry · doi:10.1373/clinchem.2005.062893 · Cited by 154 · see citing works

Use of Liquid Biopsies in Clinical Oncology: Pilot Experience in 168 Patients

Schwaederle, M. C., Husain, H., Fanta, P. T., Piccioni, D. E., Kesari, S., Schwab, R. B., Patel, S. P., Harismendy, O., Ikeda, M., Parker, B. A., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0318 · Cited by 152 · see citing works

Blood‐based detection of RAS mutations to guide anti‐ EGFR therapy in colorectal cancer patients: concordance of results from circulating tumor DNA and tissue‐based RAS testing

Schmiegel, W., Scott, R. J., Dooley, S., Lewis, W., Meldrum, C. J., Pockney, P. G., Draganic, B. D., Smith, S., Hewitt, C., Phillimore, H., et al. (2017) · Molecular Oncology · doi:10.1002/1878-0261.12023 · Cited by 152 · see citing works

Cell‐free DNA as a biomarker of aging

Teo, Y. V., Capri, M., Morsiani, C., Pizza, G., Faria, A. M. C., Franceschi, C., & Neretti, N. (2018) · Aging Cell · doi:10.1111/acel.12890 · Cited by 152 · see citing works

The aflatoxin-induced TP53 mutation at codon 249 (R249S): Biomarker of exposure, early detection and target for therapy

Gouas, D. A., Shi, H., & Hainaut, P. L. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.057 · Cited by 151 · see citing works

Circulating biomarkers to monitor cancer progression and treatment

Rapisuwon, S., Vietsch, E. E., & Wellstein, A. (2016) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2016.05.004 · Cited by 138 · see citing works

Application of liquid biopsy in precision medicine: opportunities and challenges

Wang, J., Chang, S., Li, G., & Sun, Y. (2017) · Frontiers of Medicine · doi:10.1007/s11684-017-0526-7 · Cited by 138 · see citing works

Utility of Genomic Analysis In Circulating Tumor DNA from Patients with Carcinoma of Unknown Primary

Kato, S., Krishnamurthy, N., Banks, K. C., De, P. K., Williams, K. A., Williams, C. B., Leyland-Jones, B. R., Lippman, S. M., Lanman, R. B., & Kurzrock, R. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0628 · Cited by 134 · see citing works

Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer

Paci, M., Maramotti, S., Bellesia, E., Formisano, D., Albertazzi, L., Ricchetti, T., Ferrari, G., Annessi, V., Lasagni, D., Carbonelli, C. M., et al. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.07.012 · Cited by 133 · see citing works

Biomarkers for early detection of breast cancer: What, when, and where?

LEVENSON, V (2007) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2007.01.017 · Cited by 131 · see citing works

Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients

Silva, J. M., Domínguez, G., Villanueva, M. J., Gonzalez, R., Garcia, J. M., Corbacho, C., Provencio, M., España, P., & Bonilla, F. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690495 · Cited by 129 · see citing works

Liquid biopsy for cancer screening, patient stratification and monitoring

Brock, G., Castellanos-Rizaldos, E., Hu, L., Coticchia, C. M., & Skog, J. (2018) · Translational Cancer Research · doi:10.21037/4546 · Cited by 131 · see citing works

An Overview on the Isolation and Analysis of Circulating Tumor DNA in Plasma and Serum

Jen, J., Wu, L. J., & Sidransky, D. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06581.x · Cited by 128 · see citing works

Measurement of an apoptotic product in the sera of breast cancer patients

Ueno, T., Toi, M., Bivén, K., Bando, H., Ogawa, T., & Linder, S. T. (2003) · European Journal of Cancer · doi:10.1016/s0959-8049(02)00865-1 · Cited by 127 · see citing works

Circulating cell-free DNA: A novel biomarker for response to therapy in ovarian carcinoma

Kamat, A. A., Bischoff, F. Z., Dang, D., Baldwin, M. R., Han, L. Y., Lin, Y. G., Merritt, W. M., Landen, C. N., Lu, C., Gershenson, D. M., et al. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.10.3240 · Cited by 127 · see citing works

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients

Marzese, D. M., Hirose, H., & Hoon, D. S. �. (2013) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.2013.845088 · Cited by 123 · see citing works

Circulating DNA fragmentomics and cancer screening

Thierry, A. R. (2023) · Cell Genomics · doi:10.1016/j.xgen.2022.100242 · Cited by 125 · see citing works

Circulating Nucleic Acids in Plasma and Serum

Gahan, P. B., & Swaminathan, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1448.050 · Cited by 120 · see citing works

Circulating Mitochondrial Nucleic Acids Have Prognostic Value for Survival in Patients with Advanced Prostate Cancer

Mehra, N., Penning, M. T., Maas, J., van Daal, N., Giles, R. H., & Voest, E. E. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1087 · Cited by 115 · see citing works

Mutation-based detection and monitoring of cell-free tumor DNA in peripheral blood of cancer patients

Benešová, L., Belšánová, B., Suchánek, Š., Kopeckova, M., Mináriková, P., Lipská, L., Levý, M., Visokai, V., Zavoral, M., & Minárik, M. (2012) · Analytical Biochemistry · doi:10.1016/j.ab.2012.06.018 · Cited by 109 · see citing works

Plasma DNA microsatellites as tumor-specific markers and indicators of tumor progression in melanoma patients.

Fujiwara, Y., Chi, D. D., Wang, H., Keleman, P., Morton, D. L., Turner, R. R., & Hoon, D. S. �. (1999) · PubMed · Cited by 108 · see citing works

Recovering circulating extracellular or cell-free RNA from bodily fluids

Tzimagiorgis, G., Michailidou, E. Z., Κritis, A., Markopoulos, A. K., & Kouidou, S. (2011) · Cancer Epidemiology · doi:10.1016/j.canep.2011.02.016 · Cited by 107 · see citing works

The epigenetics of oral cancer

Shaw, R. (2005) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2005.06.014 · Cited by 107 · see citing works

Cell-Free DNA Fragmentomics: The Novel Promising Biomarker

Qi, T., Pan, M., Shi, H., Wang, L., Bai, Y., & Ge, Q. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021503 · Cited by 102 · see citing works

Microsatellite alterations plasma DNA of primary breast cancer patients.

Shaw, J., Smith, B., Walsh, T., Johnson, S., Primrose, L., Slade, M. J., Walker, R. A., & Coombes, R. C. (2000) · PubMed · Cited by 99 · see citing works

Release of DNA from Dead and Dying Lymphocyte and Monocyte Cell Lines In Vitro

Choi, J. ‐., Reich, C. F., & Pisetsky, D. S. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01470.x · Cited by 97 · see citing works

Molecular characterisation and liquid biomarkers in Carcinoma of Unknown Primary (CUP): taking the ‘U’ out of ‘CUP’

Conway, A., Mitchell, C. L., Kilgour, E., Brady, G., Dive, C., & Cook, N. (2018) · British Journal of Cancer · doi:10.1038/s41416-018-0332-2 · Cited by 96 · see citing works

Cell free DNA as a diagnostic and prognostic marker for cardiovascular diseases

Polina, I. A., Ilatovskaya, D. V., & DeLeon‐Pennell, K. Y. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.01.013 · Cited by 95 · see citing works

At the dawn: cell-free DNA fragmentomics and gene regulation

Liu, Y. (2021) · British Journal of Cancer · doi:10.1038/s41416-021-01635-z · Cited by 98 · see citing works

Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells

Jiang, N., Reich, C. F., & Pisetsky, D. S. (2003) · Blood · doi:10.1182/blood-2002-10-3312 · Cited by 94 · see citing works

Cell-free DNA approaches for cancer early detection and interception

Medina, J. E., Dracopoli, N. C., Bach, P. B., Lau, A., Scharpf, R. B., Meijer, G. A., Andersen, C. L., & Velculescu, V. E. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006013 · Cited by 93 · see citing works

Quantification of Circulating DNA in the Plasma and Serum of Cancer Patients

Taback, B., O'Day, S. J., & Hoon, D. S. �. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1318.004 · Cited by 91 · see citing works

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection

Bruhm, D. C., Vulpescu, N. A., Foda, Z. H., Phallen, J. A., Scharpf, R. B., & Velculescu, V. E. (2025) · Nature reviews. Cancer · doi:10.1038/s41568-025-00795-x · Cited by 99 · see citing works

Increased Plasma Circulating Cell-Free DNA Could Be a Potential Marker for Oral Cancer

Lin, L.-H., Chang, K., Kao, S., Cheng, H.-W., & Liu, C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113303 · Cited by 87 · see citing works

Detection of mutated KRAS2 sequences as tumor markers in plasma/serum of patients with gastrointestinal cancer.

Sorenson, G. D. (2000) · PubMed · Cited by 85 · see citing works

Real-Time Genomic Characterization Utilizing Circulating Cell-Free DNA in Patients with Anaplastic Thyroid Carcinoma

Sandulache, V. C., Williams, M. D., Lai, S. Y., Lu, C., William, W. N., Busaidy, N. L., Cote, G. J., Singh, R. R., Luthra, R., & Cabanillas, M. E. (2016) · Thyroid · doi:10.1089/thy.2016.0076 · Cited by 84 · see citing works

Increased integrity of circulating cell-free DNA in plasma of patients with acute leukemia

Gao, Y., He, Y., Yang, Z., Shao, H.-Y., Zuo, Y., Bai, Y., Chen, H., Chen, X., Qin, F., Tan, S., et al. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2010.311 · Cited by 83 · see citing works

Clinical Impact of Hybrid Capture–Based Next-Generation Sequencing on Changes in Treatment Decisions in Lung Cancer

Rozenblum, A. B., Ilouze, M., Dudnik, E., Dvir, A., Soussan‐Gutman, L., Geva, S., & Peled, N. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2016.10.021 · Cited by 80 · see citing works

Validation of a blood plasma separation system by biomarker detection

Kersaudy-Kerhoas, M., Kavanagh, D. M., Dhariwal, R. S., Campbell, C. J., & Desmulliez, M. P. Y. (2010) · Lab on a Chip · doi:10.1039/b926834k · Cited by 80 · see citing works

Dielectrophoretic isolation and detection of cfc‐ DNA nanoparticulate biomarkers and virus from blood

Sonnenberg, A., Marciniak, J. Y., McCanna, J. P., Krishnan, R., Rassenti, L. Z., Kipps, T. J., & Heller, M. J. (2013) · Electrophoresis · doi:10.1002/elps.201200444 · Cited by 79 · see citing works

Liquid biopsy and non-small cell lung cancer: are we looking at the tip of the iceberg?

Bonanno, L., Maso, A. D., Pavan, A., Zulato, E., Calvetti, L., Pasello, G., Guarneri, V., Conte, P., & Indraccolo, S. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01777-8 · Cited by 79 · see citing works

Alternating current electrokinetic separation and detection of DNA nanoparticles in high‐conductance solutions

Krishnan, R., Sullivan, B. D., Mifflin, R. L., Esener, S. C., & Heller, M. J. (2008) · Electrophoresis · doi:10.1002/elps.200800037 · Cited by 79 · see citing works

Measurement of Circulating Cell-Free DNA Levels by a New Simple Fluorescent Test in Patients With Primary Colorectal Cancer

Czeiger, D., Shaked, G., Eini, H., Vered, I., Belochitski, O., Avriel, A., Ariad, S., & Douvdevani, A. (2011) · American Journal of Clinical Pathology · doi:10.1309/ajcp4rk2ihvkttzv · Cited by 77 · see citing works

Circulating cell-free DNA and circulating tumor cells, the “liquid biopsies” in ovarian cancer

Cheng, X., Zhang, L., Chen, Y., & Qing, C. (2017) · Journal of Ovarian Research · doi:10.1186/s13048-017-0369-5 · Cited by 76 · see citing works

Nucleic acid-based biomarkers in body fluids of patients with urologic malignancies

Ralla, B., Stephan, C., Meller, S., Dietrich, D., Kristiansen, G., & Jung, K. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.914888 · Cited by 75 · see citing works

Neoplastic Characteristics of the DNA Found in the Plasma of Cancer Patients

Stroun, M., Anker, P., Maurice, P. A., Lyautey, J., Lederrey, C., & Beljanski, M. (2009) · Oncology · doi:10.1159/000226740 · Cited by 732 · see citing works

Quantification of Circulating DNA in the Plasma and Serum of Cancer Patients

Taback, B., O'Day, S. J., & Hoon, D. S. �. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1318.004 · Cited by 91 · see citing works

Plasma DNA of Cancer Patients

Jaiwang, W., Tangvarasittichai, S., Potup, P., & Tangvarasittichai, O. (2011) · The Public Health Journal of Burapha University

DNA fragments in plasma of cancer patients

Jahr, S. (2001) · KOPS (University of Konstanz)

The Importance of Careful Blood Processing in Isolation of Cell‐Free DNA

PAGE, K., Powles, T., Slade, M. J., Bella, M. T. D., Walker, R. A., Coombes, R. C., & Shaw, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1368.042 · Cited by 71 · see citing works