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Cited by 84Aluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and ToxicityAlzheimer's disease research and treatments

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Neurotoxic effect of enteral aluminium

Bilkei-Gorzó, A.·1993·Food and Chemical Toxicology
DOI 10.1016/0278-6915(93)90191-z
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Abstract

Long Evans rats were treated for 90 days with water-soluble, insoluble or chelated aluminium compounds. The daily treatments given were as follows: controls, NaCl (100 mg/kg body weight) plus citric acid (30 mg/kg); AlCl3 (30 or 100 mg/kg); Al(OH)3 (100 mg/kg) plus citric acid (30 mg/kg); Al(OH)3 (300 mg/kg). Their learning ability was determined in the labyrinth test at day 90, and the choline-acetyltransferase, acetylcholinesterase activity and aluminium content of the brains were measured. Soluble and chelated aluminium compounds seriously worsened the learning ability, and the aluminium content of the brain was elevated. Acetylcholinesterase activity increased and choline-acetyltransferase activity decreased, resulting in a diminished cholinergic activity, which is a characteristic of Alzheimer's disease.

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Research works printed but not linked: 22

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Metadata

Authors
Bilkei-Gorzó, A.
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
1993-05
Volume
31
Issue
5
Pages
357-361
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/0278-6915(93)90191-z
OpenAlex
W2120649643
Cited by
84
References
0
Citations by year
2026: 1 · 2025: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
FWCI
1.46
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Keywords
aluminum neurotoxicity, aluminum chloride, aluminum hydroxide, learning disabilities, choline acetyltransferase, acetylcholinesterase, cholinergic activity, Alzheimer's disease model, Long-Evans rats
MeSH terms
Aluminum Chloride, Acetylcholinesterase, Administration, Oral, Aluminum, Aluminum Hydroxide, Animals, Brain, Chelating Agents, Chlorides, Choline O-Acetyltransferase, Female, Male, Motor Activity, Solubility, Aluminum Compounds, Rats

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CoChat. (2026). Citation check: Neurotoxic effect of enteral aluminium. https://app.cochat.ai/papers/10.1016/0278-6915(93)90191-z
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Bilkei-Gorzó, A. (1993). Neurotoxic effect of enteral aluminium. Food and Chemical Toxicology. https://doi.org/10.1016/0278-6915(93)90191-z