Molecular and cellular biology of cholinesterases

A new and rapid colorimetric determination of acetylcholinesterase activity

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A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASES

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Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

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The α / β hydrolase fold

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Progress in Clinical and Biological Research

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CELL-SURFACE ANCHORING OF PROTEINS VIA GLYCOSYL-PHOSPHATIDYLINOSITOL STRUCTURES

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The Molecular Basis of Muscular Dystrophy in the mdx Mouse: a Point Mutation

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Structure of human pancreatic lipase

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A serine protease triad forms the catalytic centre of a triacylglycerol lipase

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Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

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Environmental fate and toxicity of ionic liquids: A review

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DEVELOPMENT OF THE VERTEBRATE NEUROMUSCULAR JUNCTION

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Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

Inestrosa, N. C., Alvarez, A. R., Pérez, C. A., Moreno, R. D., Vicente, M., Linker, C., Casanueva, O. I., Soto, C. A., & Garrido, J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80108-7 · Cited by 1,117

Microplastics in Wild Fish from North East Atlantic Ocean and Its Potential for Causing Neurotoxic Effects, Lipid Oxidative Damage, and Human Health Risks Associated with Ingestion Exposure

Barboza, L. G. A., Lopes, C., Oliveira, P., Bessa, F., Otero, V., Henriques, B., Raimundo, J., Caetano, M., Vale, C., & Guilhermino, L. (2020) · Science of The Total Environment · doi:10.1016/j.scitotenv.2019.134625 · Cited by 951

Neurobiology of butyrylcholinesterase

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Acetylcholinesterase: From 3D structure to function

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Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment

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The use of biomarkers in biomonitoring: A 2-tier approach assessing the level of pollutant-induced stress syndrome in sentinel organisms

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The Cholinesterases: From Genes to Proteins

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Micro- and nano-plastics activation of oxidative and inflammatory adverse outcome pathways

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Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment

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Ecotoxicological effects of microplastics: Examination of biomarkers, current state and future perspectives

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Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

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Phlorotannins as bioactive agents from brown algae

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Acetylcholinesterase in Alzheimer's disease

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Serine peptidases: Classification, structure and function

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Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo

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A Structural Motif of Acetylcholinesterase That Promotes Amyloid β-Peptide Fibril Formation

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Diffuse transmission by acetylcholine in the CNS

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“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”

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Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease:

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Enzymes involved in the bioconversion of ester-based prodrugs

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The X-ray Structure of a Transition State Analog Complex Reveals the Molecular Origins of the Catalytic Power and Substrate Specificity of Acetylcholinesterase

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Structural roles of acetylcholinesterase variants in biology and pathology

Grisaru, D., Sternfeld, M., Eldor, A., Glick, D., & Soreq, H. (1999) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1999.00693.x · Cited by 359

Abundant Tissue Butyrylcholinesterase and Its Possible Function in the Acetylcholinesterase Knockout Mouse

Li, B., Stribley, J. A., Ticu, A., Xie, W., Schopfer, L. M., HAMMOND, P. I., Brimijoin, S., Hinrichs, S. H., & Lockridge, O. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.751320.x · Cited by 354

Acetylcholinesterase inhibition by fasciculin: Crystal structure of the complex

Bourne, Y., Taylor, P., & Marchot, P. (1995) · Cell · doi:10.1016/0092-8674(95)90128-0 · Cited by 356

The biological significance of substrate inhibition: A mechanism with diverse functions

Reed, M. C., Lieb, A. M., & Nijhout, H. F. (2010) · BioEssays · doi:10.1002/bies.200900167 · Cited by 336

Modification of acetylcholinesterase as a mechanism of resistance to insecticides

Fournier, D. D., & Mutero, A. (1994) · Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology · doi:10.1016/1367-8280(94)90084-1 · Cited by 327

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

Alvarez, A. R., Alarcón, R., Opazo, C., Campos, E. O., Muñoz, F. J., Calderón, F. H., Dajas, F., Gentry, M. K., Doctor, B. P., Mello, F. G. D., et al. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03213.1998 · Cited by 320

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis

Kang, T. S., Georgieva, D. N., Genov, N. C., Murakami, M. T., Sinha, M., Kumar, R. P., Kaur, P., Kumar, S., Dey, S., Sharma, S., et al. (2011) · FEBS Journal · doi:10.1111/j.1742-4658.2011.08115.x · Cited by 316

Revisiting the role of acetylcholinesterase in Alzheimer’s disease: cross-talk with P-tau and β-amyloid

García‐Ayllón, M. (2011) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2011.00022 · Cited by 303

Effects of polystyrene microbeads in marine planktonic crustaceans

Gambardella, C., Morgana, S., Ferrando, S., Bramini, M., Piazza, V., Costa, E., Garaventa, F., & Faimali, M. (2017) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2017.07.036 · Cited by 296

A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non–homologous to theacegeneDrosophila

Weill, M., Fort, P., Berthomieu, A., Dubois, M. P., Pasteur, N., & Michel Raymond, A. (2002) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2002.2122 · Cited by 284

The Origin of the Molecular Diversity and Functional Anchoring of Cholinesterases

Massoulié, J. (2002) · Neurosignals · doi:10.1159/000065054 · Cited by 281

Selectivity of Cholinesterase Inhibition

Weinstock, M. (1999) · CNS Drugs · doi:10.2165/00023210-199912040-00005 · Cited by 283

Involvement of oxidative stress in the enhancement of acetylcholinesterase activity induced by amyloid beta-peptide

Melo, J. B., Agostinho, P. M., & Oliveira, C. R. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(02)00201-8 · Cited by 277

A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba

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Butyrylcholinesterase reactivity differentiates the amyloid plaques of aging from those of dementia

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Human endplate acetylcholinesterase deficiency caused by mutations in the collagen-like tail subunit (ColQ) of the asymmetric enzyme

Ohno, K., Brengman, J. M., Tsujino, A., & Engel, A. G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.16.9654 · Cited by 255

Effects of ionic liquids on the acetylcholinesterase – a structure–activity relationship consideration

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Novel Functions of Cholinesterases in Development, Physiology and Disease

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PRiMA

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Congenital Myasthenic Syndromes

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A molecular approach in drug development for Alzheimer’s disease

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Ion channels: molecular targets of neuroactive insecticides

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Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

Li, Q., He, S., Chen, Y., Feng, F., Qu, W., & Sun, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.031 · Cited by 217

Acetylcholinesterase Clustering at the Neuromuscular Junction Involves Perlecan and Dystroglycan

Peng, H. B., Xie, H. M., Rossi, S. G., & Rotundo, R. L. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.911 · Cited by 207

Antioxidant and anticholinesterase evaluation of selected Turkish Salvia species

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Micro/Nano-Plastics Cause Neurobehavioral Toxicity in Discus Fish (Symphysodon aequifasciatus): Insight from Brain-Gut-Microbiota Axis

Huang, J.-N., Wen, B., Xu, L., Ma, H.-C., Li, X.-X., Gao, J.-Z., & Chen, Z.-Z. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2021.126830 · Cited by 202

The Dystroglycan Complex Is Necessary for Stabilization of Acetylcholine Receptor Clusters at Neuromuscular Junctions and Formation of the Synaptic Basement Membrane

Jacobson, C., Côté, P. D., Rossi, S. G., Rotundo, R. L., & Carbonetto, S. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.3.435 · Cited by 199

Acetylcholinesterase Enhances Neurite Growth and Synapse Development through Alternative Contributions of Its Hydrolytic Capacity, Core Protein, and Variable C Termini

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Qualitative and quantitative structure activity relationships for the inhibitory effects of cationic head groups, functionalised side chains and anions of ionic liquids on acetylcholinesterase

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Structural and Functional Mutations of the Perlecan Gene Cause Schwartz-Jampel Syndrome, with Myotonic Myopathy and Chondrodysplasia

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Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.

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Cholinesterases of marine teleost fish: enzymological characterization and potential use in the monitoring of neurotoxic contamination

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Non-classical actions of cholinesterases: Role in cellular differentiation, tumorigenesis and Alzheimer's disease

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Protein synthesis in axons and terminals: significance for maintenance, plasticity and regulation of phenotype

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Diagnostic aspects of organophosphate poisoning

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Exposure to polystyrene microplastics induced gene modulated biological responses in zebrafish (Danio rerio)

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Micro and Nano Plastics Distribution in Fish as Model Organisms: Histopathology, Blood Response and Bioaccumulation in Different Organs

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Conformational Flexibility of the Acetylcholinesterase Tetramer Suggested by X-ray Crystallography

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Genetic Analysis of Collagen Q: Roles in Acetylcholinesterase and Butyrylcholinesterase Assembly and in Synaptic Structure and Function

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Toxic effects of naturally-aged microplastics on zebrafish juveniles: A more realistic approach to plastic pollution in freshwater ecosystems

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The Mammalian Gene of Acetylcholinesterase-associated Collagen

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Sleuthing molecular targets for neurological diseases at the neuromuscular junction

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Brain Regional Heterogeneity and Toxicological Mechanisms of Organophosphates and Carbamates

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In vivo and in vitro effects of aluminum on the activity of mouse brain acetylcholinesterase

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The Relationship between Perlecan and Dystroglycan and its Implication in the Formation of the Neuromuscular Junction

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Evaluating the hazardous impact of ionic liquids – Challenges and opportunities

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Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

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Absence of acetylcholinesterase at the neuromuscular junctions of perlecan-null mice

Arikawa‐Hirasawa, E., Rossi, S. G., Rotundo, R. L., & Yamada, Y. (2002) · Nature Neuroscience · doi:10.1038/nn801 · Cited by 166

Mutation in the Human Acetylcholinesterase-Associated Collagen Gene, COLQ, Is Responsible for Congenital Myasthenic Syndrome with End-Plate Acetylcholinesterase Deficiency (Type Ic)

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Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015)

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Rapid assessment of organophosphorous/carbamate exposure in the bivalve mollusc Mytilus edulis using combined esterase activities as biomarkers

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RNA interference: Applications and advances in insect toxicology and insect pest management

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Novel Diterpenoid Acetylcholinesterase Inhibitors fromSalvia miltiorhiza

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The Pharmacology of Physostigmine

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Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months

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The key role of butyrylcholinesterase during neurogenesis and neural disorders: an antisense-5′butyrylcholinesterase-DNA study

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Chapter 15: Structure and functions of acetylcholinesterase and butyrylcholinesterase

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Amperometric detection of triazophos pesticide using acetylcholinesterase biosensor based on multiwall carbon nanotube–chitosan matrix

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Design and Synthesis of Chemiluminescent Probes for the Detection of Cholinesterase Activity

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Serum Butyrylcholinesterase is Strongly Associated with Adiposity, the Serum Lipid Profile and Insulin Resistance

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Role of Aspartate 70 and Tryptophan 82 in Binding of Succinyldithiocholine to Human Butyrylcholinesterase

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Transgenic expression of human acetylcholinesterase induces progressive cognitive deterioration in mice

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Crystal Structure of Mouse Acetylcholinesterase

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Phlorotannins are Polyphenolic Metabolites of Brown Algae

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Carbonic anhydrase and acetylcholinesterase inhibitory effects of carbamates and sulfamoylcarbamates

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Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin

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Cholinesterase activity as potential biomarker in two bivalves

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Increased acetylcholinesterase activities in specimens of Sparus auratus exposed to sublethal copper concentrations

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Molecular Dynamics of Acetylcholinesterase

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Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer’s disease (1998–2018)

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tanandebonyGenes Regulate a Novel Pathway for Transmitter Metabolism at Fly Photoreceptor Terminals

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Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase

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Synthesis, in vitro bio-evaluation, and molecular docking study of thiosemicarbazone-based isatin/bis-Schiff base hybrid analogues as effective cholinesterase inhibitors

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Synthesis, molecular docking, and bioactivity study of isoquinoline-sulfonamide hybrid analogues: A promising acetylcholinesterase and butyrylcholinesterase inhibitor candidate

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In vitro and in silico correlation of bis-thiazole based Schiff base hybrids analogues: A computational approach develop to promising acetylcholinesterase and butyrylcholinesterase inhibitors

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New Cholinesterase inhibitors based on 1,2,4-triazole bearing benzenesulfonohydrazide skeleton: Synthesis, in vitro and in silico studies

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