Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

Ullmann's Encyclopedia of Industrial Chemistry

(2012) · Choice Reviews Online · doi:10.5860/choice.50-1224 · Cited by 3,067 · see citing works

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

Sussman, J. L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L., & Silman, I. (1991) · Science · doi:10.1126/science.1678899 · Cited by 2,711 · see citing works

Antioxidant enzymes and human diseases

MatÉs, J. M., Pérez-Gómez, C., & De Castro, I. N. (1999) · Clinical Biochemistry · doi:10.1016/s0009-9120(99)00075-2 · Cited by 2,099 · see citing works

Cholinesterase inhibitors for Alzheimer's disease

Birks, J. S. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005593 · Cited by 1,906 · see citing works

Role of oxygen radicals in DNA damage and cancer incidence

Valko, M., Izakovic, M., Mazur, M., Rhodes, C. J., & Telser, J. (2004) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000049134.69131.89 · Cited by 1,820 · see citing works

Molecular and cellular biology of cholinesterases

Massoulié, J., Pezzementi, L., Bon, S., Krejci, E., & Vallette, F.-M. (1993) · Progress in Neurobiology · doi:10.1016/0301-0082(93)90040-y · Cited by 1,214 · see citing works

Management of acute organophosphorus pesticide poisoning

Eddleston, M., Buckley, N. A., Eyer, P., & Dawson, A. H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61202-1 · Cited by 1,189 · see citing works

Integrated Risk Information System

Ord, Ncea, & Irisd (2013) · Cited by 1,172 · see citing works

Acetylcholinesterase: Enzyme structure, reaction dynamics, and virtual transition states

Quinn, D. M. (1987) · Chemical Reviews · doi:10.1021/cr00081a005 · Cited by 1,072 · see citing works

Pesticides and oxidative stress: a review.

Abdollahi, M. R., Ranjbar, A., Shadnia, S., Nikfar, S., & Rezaie, A. R. (2004) · PubMed · Cited by 1,010 · see citing works

Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial

(2004) · The Lancet · doi:10.1016/s0140-6736(04)16499-4 · Cited by 892 · see citing works

Acetylcholine beyond neurons: the non‐neuronal cholinergic system in humans

Wessler, I. K., & Kirkpatrick, C. J. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.185 · Cited by 855 · see citing works

Hepatotoxic Effects of Tacrine Administration in Patients With Alzheimer's Disease

Watkins, P. B. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370044030 · Cited by 829 · see citing works

Acetylcholine in mind: a neurotransmitter correlate of consciousness?

Perry, E. K., Walker, M. P., Grace, J., & Perry, R. H. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01361-7 · Cited by 764 · see citing works

Genotoxicity of pesticides: a review of human biomonitoring studies

Bolognesi, C. (2003) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(03)00015-2 · Cited by 711 · see citing works

Medical Aspects of Chemical and Biological Warfare

Sidell, F. R., Takafuji, E. T., & Franz, D. R. (1997) · doi:10.21236/ada398241 · Cited by 702 · see citing works

Organophosphates⧸Nerve Agent Poisoning: Mechanism of Action, Diagnosis, Prophylaxis, And Treatment

Bajgar, J. (2004) · Advances in clinical chemistry · doi:10.1016/s0065-2423(04)38006-6 · Cited by 701 · see citing works

Current issues in organophosphate toxicology

Costa, L. G. (2005) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.10.008 · Cited by 700 · see citing works

The Cholinesterases: From Genes to Proteins

Taylor, P., & Radić, Z. (1994) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.34.040194.001433 · Cited by 669 · see citing works

Targeting acetylcholinesterase and butyrylcholinesterase in dementia

Lane, R. M., Potkin, S. G., & Enz, A. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145705005833 · Cited by 654 · see citing works

Basic and Clinical Pharmacology

Wingard, L. B. (1983) · Anesthesia & Analgesia · doi:10.1213/00000539-198308000-00015 · Cited by 636 · see citing works

The Peripheral Nervous System

(1974) · Springer eBooks · doi:10.1007/978-1-4615-8699-9 · Cited by 627 · see citing works

Medical Aspects of Chemical and Biological Warfare

Wilde, H. D. (1998) · JAMA · doi:10.1001/jama.280.13.1199 · Cited by 576 · see citing works

Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis

Sogorb, M. A., & Vilanova, E. (2002) · Toxicology Letters · doi:10.1016/s0378-4274(01)00543-4 · Cited by 566 · see citing works

Cholinesterase inhibitors: new roles and therapeutic alternatives

Giacobini, E. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2003.11.017 · Cited by 559 · see citing works

The histochemical localization of cholinesterases in the central nervous system of the rat

Koelle, G. B. (1954) · The Journal of Comparative Neurology · doi:10.1002/cne.901000108 · Cited by 559 · see citing works

Rivastigmine for Alzheimer’s disease.

Birks, J. S., Chong, L.-Y., & Grimley Evans, J. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001191.pub4 · Cited by 534 · see citing works

Some properties of specific cholinesterase with particular reference to the mechanism of inhibition by diethyl p-nitrophenyl thiophosphate (E 605) and analogues

Aldridge, W. N. (1950) · Biochemical Journal · doi:10.1042/bj0460451 · Cited by 481 · see citing works

The Role of Oximes in the Management of Organophosphorus Pesticide Poisoning

Eyer, P. (2003) · Toxicological Reviews · doi:10.2165/00139709-200322030-00004 · Cited by 460 · see citing works

Occupational exposure to pesticides increases the risk of incident AD

Hayden, K. M., Norton, M. C., Darcey, D. J., Østbye, T., Zandi, P. P., Breitner, J. C. S., & Welsh-Bohmer, K. A. (2010) · Neurology · doi:10.1212/wnl.0b013e3181dd4423 · Cited by 387 · see citing works

CHOLINESTERASES, A TARGET OF PHARMACOLOGY AND TOXICOLOGY

Pohanka, M. (2011) · Biomedical Papers · doi:10.5507/bp.2011.036 · Cited by 377 · see citing works

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

Taylor, P., & Lappi, S. (1975) · Biochemistry · doi:10.1021/bi00680a029 · Cited by 367 · see citing works

Pyridostigmine brain penetration under stress enhances neuronal excitability and induces early immediate transcriptional response

Friedman, A., Kaufer, D., Shemer, J., Hendler, I., Soreq, H., & Tur-Kaspa, I. (1996) · Nature Medicine · doi:10.1038/nm1296-1382 · Cited by 360 · see citing works

Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocket

Ordentlich, A., Barak, D., Kronman, C., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85305-x · Cited by 349 · see citing works

Toxicology of organophosphate and carbamate compounds

Gupta, R. C. (2006) · Cited by 341 · see citing works

Biochemical evidence for free radicalinduced lipid peroxidation as a mechanism for subchronic toxicity of malathion in blood and liver of rats

Akhgari, M., Abdollahi, M. R., Kebryaeezadeh, A., Hosseini, R., & Sabzevari, O. (2003) · Human & Experimental Toxicology · doi:10.1191/0960327103ht346oa · Cited by 329 · see citing works

The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer’s disease (review of Technology Appraisal No. 111): a systematic review and economic model.

Bond, M., Rogers, G., Peters, J., Anderson, R., Hoyle, M., Miners, A. H., Moxham, T., Davis, S., Thokala, P., Wailoo, A., et al. (2012) · Health Technology Assessment · doi:10.3310/hta16210 · Cited by 308 · see citing works

Anti-Alzheimer and Antioxidant Activities of Coptidis Rhizoma Alkaloids

Jung, H. A., Min, B.-S., Yokozawa, T., Lee, J.-H., Kim, Y. S., & Choi, J. S. (2009) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.32.1433 · Cited by 308 · see citing works

The Pathogenesis of Organophosphate Polyneuropathy

Lotti, M. (1992) · Critical Reviews in Toxicology · doi:10.3109/10408449209089884 · Cited by 300 · see citing works

Rivastigmine for Alzheimer's disease

Birks, J., Evans, J. G., Iakovidou, V., & Tsolaki, M. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001191.pub2 · Cited by 295 · see citing works

Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls

Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 276 · see citing works

Catalytic mechanisms for phosphotriesterases

Bigley, A. N., & Raushel, F. M. (2012) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2012.04.004 · Cited by 253 · see citing works

Ap endonucleases and dna glycosylases that recognize oxidative dna damage

Wallace, S. S. (1988) · Environmental Mutagenesis · doi:10.1002/em.2860120411 · Cited by 252 · see citing works

The potential for toxic effects of chronic, low-dose exposure to organophosphates

Ray, D. E., & Richards, P. G. (2001) · Toxicology Letters · doi:10.1016/s0378-4274(01)00266-1 · Cited by 243 · see citing works

Pharmacotherapies for Alzheimer's disease: Beyond cholinesterase inhibitors

Tayeb, H. O., Yang, H. D., Price, B. H., & Tarazi, F. I. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.12.002 · Cited by 231 · see citing works

The Degradation of Organophosphorus Pesticides in Natural Waters: A Critical Review

Pehkonen, S. O., & Zhang, Q. (2002) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380290813444 · Cited by 226 · see citing works

Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study

Farlow, M. R., Salloway, S., Tariot, P. N., Yardley, J., Moline, M. L., Wang, Q., Brand‐Schieber, E., Zou, H., Hsu, T., & Satlin, A. (2010) · Clinical Therapeutics · doi:10.1016/j.clinthera.2010.06.019 · Cited by 214 · see citing works

Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning

Huang, Y., Huang, Y., Baldassarre, H., Wang, B., Lazaris, A., Leduc, M., Bilodeau, A. S., Bellemare, A., Côté, M., Herskovits, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702756104 · Cited by 214 · see citing works

Effects of acute dimethoate administration on antioxidant status of liver and brain of experimental rats

Sharma, Y., Bashir, S., Irshad, M., et al. (2004) · Toxicology · doi:10.1016/j.tox.2004.06.062 · Cited by 211 · see citing works

Soman and Sarin: Clinical Manifestations and Treatment of Accident of Accidental Poisoning by Organophosphates

Sidell, F. R. (1974) · Clinical Toxicology · doi:10.3109/15563657408987971 · Cited by 208 · see citing works

Current opinion on the science of organophosphate pesticides and toxic stress: a systematic review.

Soltaninejad, K., & Abdollahi, M. R. (2009) · PubMed · Cited by 207 · see citing works

Targeting beta-amyloid pathogenesis through acetylcholinesterase inhibitors

Castro, A., & Martinez, A. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206778792985 · Cited by 207 · see citing works

Mode of Action

Maxwell, A., & Critchlow, S. E. (1998) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-80364-2_4 · Cited by 200 · see citing works

Bioremediation and Phytoremediation of Pesticides: Recent Advances

Hussain, S., Siddique, T., Arshad, M., & Saleem, M. (2009) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643380801910090 · Cited by 199 · see citing works

Plantation Work and Risk of Parkinson Disease in a Population-Based Longitudinal Study

Petrovitch, H., Ross, G. W., Abbott, R. D., Sanderson, W. T., Sharp, D. S., Tanner, C. M., Masaki, K., Blanchette, P. L., Popper, J. S., Foley, D. J., et al. (2002) · Archives of Neurology · doi:10.1001/archneur.59.11.1787 · Cited by 186 · see citing works

IDEAL

Winblad, B. G., Grossberg, G. T., Frölich, L., Farlow, M. R., Zechner, S., Nagel, J., & Lane, R. M. (2007) · Neurology · doi:10.1212/01.wnl.0000281847.17519.e0 · Cited by 186 · see citing works

Acetylcholinesterase: Mechanism of Catalysis and Inhibition

Tõugu, V. (2001) · Central Nervous System Agents in Medicinal Chemistry · doi:10.2174/1568015013358536 · Cited by 184 · see citing works

Donepezil for vascular cognitive impairment

Malouf, R. S., & Birks, J. (2004) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004395.pub2 · Cited by 182 · see citing works

The tolerability and safety of cholinesterase inhibitors in the treatment of dementia.

Inglis, F. (2002) · PubMed · Cited by 181 · see citing works

Degradation and by-product formation of diazinon in water during UV and UV/H2O2 treatment

Shemer, H., & Linden, K. G. (2006) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2005.12.028 · Cited by 177 · see citing works

Neuroprotective Effects of Huperzine A

Wang, R., & Tang, X. C. (2005) · Neurosignals · doi:10.1159/000085387 · Cited by 175 · see citing works

Sittig's Handbook of Pesticides and Agricultural Chemicals

(2015) · Elsevier eBooks · doi:10.1016/c2012-0-02568-9 · Cited by 165 · see citing works

Oxidative stress after acute and sub-chronic malathion intoxication in Wistar rats

Possamai, F. P., Fortunato, J. J., Feier, G., et al. (2006) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2006.09.003 · Cited by 164 · see citing works

Oxidative stress in acute human poisoning with organophosphorus insecticides; a case control study

Ranjbar, A., Solhi, H., Mashayekhi, F. J., et al. (2004) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2004.10.007 · Cited by 162 · see citing works

Donepezil–tacrine hybrid related derivatives as new dual binding site inhibitors of AChE

Alonso, D. A., Dorronsoro, I., Rubio, L., Muñoz, P., García‐Palomero, E., del Monte, M., Bidon‐Chanal, A., Orozco, M., Luque, F. J., Castro, A., et al. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.09.029 · Cited by 157 · see citing works

Prostate cancer risk and exposure to pesticides in British Columbia Farmers

Band, P. R., Abanto, Z. U., Bert, J. L., et al. (2010) · The Prostate · doi:10.1002/pros.21232 · Cited by 154 · see citing works

Carbamates with Differential Mechanism of Inhibition Toward Acetylcholinesterase and Butyrylcholinesterase

Darvesh, S., Darvesh, K. V., McDonald, R. S., Mataija, D., Walsh, R., Mothana, S., Lockridge, O., & Martin, E. V. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm8002075 · Cited by 154 · see citing works

Evidence for genotoxicity of pesticides in pesticide applicators: a review

Bull, S., Fletcher, K., Boobis, A. R., et al. (2006) · Mutagenesis · doi:10.1093/mutage/gel011 · Cited by 144 · see citing works

Treatment of Organophosphate Intoxication Using Cholinesterase Reactivators:Facts and Fiction

Bajgar, J., Fusek, J., Kuča, K., et al. (2007) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707780619581 · Cited by 143 · see citing works

Expression of recombinant acetylcholinesterase in a baculovirus system: kinetic properties of glutamate 199 mutants

Radić, Z., Gibney, G., Kawamoto, S., MacPhee-Quigley, K., Bongiorno, C., & Taylor, P. (1992) · Biochemistry · doi:10.1021/bi00155a032 · Cited by 133 · see citing works

Design, evaluation and structure—Activity relationship studies of the AChE reactivators against organophosphorus pesticides

Musílek, K., Doležal, M., Gunn‐Moore, F. J., & Kuča, K. (2009) · Medicinal Research Reviews · doi:10.1002/med.20192 · Cited by 126 · see citing works

Contribution of Aromatic Moieties of Tyrosine 133 and of the Anionic Subsite Tryptophan 86 to Catalytic Efficiency and Allosteric Modulation of Acetylcholinesterase

Ordentlich, A., Barak, D., Kronman, C., Ariel, N., Segall, Y., Velan, B., & Avigdor Shafferman, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.5.2082 · Cited by 126 · see citing works

Recent advances in the treatment of organophosphorous poisonings.

Balali‐Mood, M., & Saber, H. (2012) · PubMed · Cited by 124 · see citing works

Comparison of photocatalysis and photolysis of malathion, isomalathion, malaoxon, and commercial malathion—Products and toxicity studies

Kralj, M. B., Černigoj, U., Franko, M., et al. (2007) · Water Research · doi:10.1016/j.watres.2007.06.016 · Cited by 123 · see citing works

Cholinesterase Inhibitors Stabilize Alzheimer's Disease

Giacobini, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06942.x · Cited by 122 · see citing works

Cholinesterases : structure, function, mechanism, genetics, and cell biology

Massoulié, J. (1991) · HAL (Le Centre pour la Communication Scientifique Directe) · Cited by 122 · see citing works

Investigations of the determination and transformations of diazinon and malathion under environmental conditions using gas chromatography coupled with a flame ionisation detector

Kralj, M. B., Trebše, P., & Zupančič‐Kralj, L. (2002) · Chemosphere · doi:10.1016/s0045-6535(02)00643-4 · Cited by 118 · see citing works

Pharmacological Aspects of the Acetylcholinesterase Inhibitor Galantamine

Ago, Y., Koda, K., Takuma, K., & Matsuda, T. (2011) · Journal of Pharmacological Sciences · doi:10.1254/jphs.11r01cr · Cited by 116 · see citing works

Acetylcholinesterase studies on molecular complementariness

Wilson, I. B., & Quan, C. (1958) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(58)90248-0 · Cited by 115 · see citing works

Prostate cancer and exposure to pesticides in agricultural settings

Settimi, L., Masina, A., Andrion, A., & Axelson, O. (2003) · International Journal of Cancer · doi:10.1002/ijc.10955 · Cited by 115 · see citing works

Increased morbidity and mortality in acute human organophosphate-poisoned patients treated by oximes: a meta-analysis of clinical trials

Rahimi, R., Nikfar, S., & Abdollahi, M. R. (2006) · Human & Experimental Toxicology · doi:10.1191/0960327106ht602oa · Cited by 112 · see citing works

Ligand binding properties of acetylcholinesterase determined with fluorescent probes

Mooser, G., & Sigman, D. S. (1974) · Biochemistry · doi:10.1021/bi00708a010 · Cited by 111 · see citing works

Acetylcholinesterase engineering for detection of insecticide residues

Boublik, Y., Saint-Aguet, P., Lougarre, A., et al. (2002) · Protein Engineering Design and Selection · doi:10.1093/protein/15.1.43 · Cited by 110 · see citing works

Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease

Watkins, P. B. (1994) · JAMA · doi:10.1001/jama.271.13.992 · Cited by 110 · see citing works

Neuroprotective and Cholinergic Properties of Multifunctional Glutamic Acid Derivatives for the Treatment of Alzheimer’s Disease

Arce, M. P., Rodrı́guez-Franco, M. I., González-Muñoz, G. C., Pérez, C., López, B., Villarroya, M., López, M. G., Garcı́a, A. G., & Conde, S. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm900628z · Cited by 109 · see citing works

The Enzymic Hydrolysis and Synthesis of Acetylcholine

Nachmansohn, D. A., & Wilson, I. B. (1951) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122570.ch5 · Cited by 107 · see citing works

Toxic effects of diazinon and its photodegradation products

Čolović, M. B., Krstic, D. Z., Petrović, S. Ž., Leskovac, A. R., Joksiċ, G., Savić, J., Franko, M., Trebše, P., & Vasić, V. (2009) · Toxicology Letters · doi:10.1016/j.toxlet.2009.11.022 · Cited by 106 · see citing works

Alteration of hepatic cells glucose metabolism as a non-cholinergic detoxication mechanism in counteracting diazinon-induced oxidative stress

Teimouri, F., Amirkabirian, N., Esmaily, H., Mohammadirad, A., Aliahmadi, A., & Abdollahi, M. R. (2006) · Human & Experimental Toxicology · doi:10.1177/0960327106075064 · Cited by 105 · see citing works

Organophosphorus pesticide ozonation and formation of oxon intermediates

Wu, J., Lan, C., & Chan, Y. S. G. (2009) · Chemosphere · doi:10.1016/j.chemosphere.2009.04.060 · Cited by 105 · see citing works

Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide

Gao, X., Zheng, C. Y., Yang, L., Tang, X. C., & Zhang, H. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.028 · Cited by 103 · see citing works

Opportunities for nutritional amelioration of radiation-induced cellular damage

Turner, N. D., Braby, L. A., Ford, J. R., & Lupton, J. R. (2002) · Nutrition · doi:10.1016/s0899-9007(02)00945-0 · Cited by 98 · see citing works

Beneficial Effect of N-Acetylcysteine against Organophosphate Toxicity in Mice

Yürümez, Y., Cemek, M., Yavuz, Y., Bırdane, Y. O., & Büyükokuroğlu, M. E. (2007) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.30.490 · Cited by 97 · see citing works

Efficient electrostatic solvation model for protein-fragment docking

Majeux, N., Scarsi, M., & Caflisch, A. (2000) · Proteins Structure Function and Bioinformatics · doi:10.1002/1097-0134(20010201)42:2 · Cited by 97 · see citing works

Evolution of the evidence on the effectiveness and cost-effectiveness of acetylcholinesterase inhibitors and memantine for Alzheimer's disease: systematic review and economic model†

Hyde, C., Peters, J., Bond, M., Rogers, G., Hoyle, M., Anderson, R., Jeffreys, M., Davis, S., Thokala, P., & Moxham, T. (2012) · Age and Ageing · doi:10.1093/ageing/afs165 · Cited by 96 · see citing works

Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer’s disease

Farlow, M., Veloso, F., Moline, M., Yardley, J., Brand-Schieber, E., Bibbiani, F., Zou, H., Hsu, T., & Satlin, A. (2011) · BMC Neurology · doi:10.1186/1471-2377-11-57 · Cited by 95 · see citing works

The ‘aromatic patch’ of three proximal residues in the human acetylcholinesterase active centre allows for versatile interaction modes with inhibitors

Ariel, N., Ordentlich, A., Barak, D., et al. (1998) · Biochemical Journal · doi:10.1042/bj3350095 · Cited by 89 · see citing works

Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase

Catto, M., Pisani, L., Leonetti, F., Nicolotti, O., Pesce, P., Stefanachi, A., Cellamare, S., & Carotti, A. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.10.045 · Cited by 88 · see citing works

Block of Neuronal Nicotinic Acetylcholine Receptors by Organophosphate Insecticides

Smulders, C. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh269 · Cited by 86 · see citing works

The Role of Phosphotriesterases in the Detoxication of Organophosphorus Compounds

Vilanova, E., & Sogorb, M. A. (1999) · Critical Reviews in Toxicology · doi:10.1080/10408449991349177 · Cited by 81 · see citing works

Biodegradation of Carbaryl by a Micrococcus Species

Doddamani, H. P., & Ninnekar, H. Z. (2001) · Current Microbiology · doi:10.1007/s002840010262 · Cited by 80 · see citing works

Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates

Worek, F., Aurbek, N., Koller, M., et al. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.02.008 · Cited by 79 · see citing works

Complementary and Alternative Medicine for Glaucoma

Rhee, D. J., Katz, L. J., Spaeth, G. L., & Myers, J. S. (2001) · Survey of Ophthalmology · doi:10.1016/s0039-6257(01)00233-8 · Cited by 79 · see citing works

Cholinesterase Inhibitors Stabilize Alzheimer Disease

Giacobini, E. (2000) · Neurochemical Research · doi:10.1023/a:1007679709322 · Cited by 78 · see citing works

Myasthenia gravis requiring pyridostigmine treatment in a national population cohort

Andersen, J. B., Engeland, A., Owe, J. F., et al. (2010) · European Journal of Neurology · doi:10.1111/j.1468-1331.2010.03089.x · Cited by 74 · see citing works

Lipid peroxidative damage on malathion exposure in rats

Fortunato, J. J., Agostinho, F. R., Réus, G. Z., et al. (2006) · Neurotoxicity Research · doi:10.1007/bf03033304 · Cited by 70 · see citing works

Comparative effect of pesticides on brain acetylcholinesterase in tropical fish

Assis, C. R. D., Linhares, A. G., Oliveira, V. D. M., et al. (2012) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2012.09.058 · Cited by 70 · see citing works

Investigation of the Heterogeneously Catalyzed Hydrolysis of Organophosphorus Pesticides

Dannenberg, A., & Pehkonen, S. O. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf970368o · Cited by 69 · see citing works

Oxidative damage in intermediate syndrome of acute organophosphorous poisoning.

Dandapani, M., Zachariah, A., Kavitha, M. R., et al. (2003) · PubMed · Cited by 69 · see citing works

Hybrids of oxoisoaporphine-tacrine congeners: Novel acetylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation inhibitors

Tang, H., Zhao, L.-Z., Zhao, H., Huang, S., Zhong, S., Qin, J., Chen, Z., Huang, Z., & Liang, H. (2011) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2011.08.002 · Cited by 68 · see citing works

Antioxidative role of melatonin in organophosphate toxicity in rats

Büyükokuroğlu, M. E., Cemek, M., Yürümez, Y., et al. (2007) · Cell Biology and Toxicology · doi:10.1007/s10565-007-9024-z · Cited by 67 · see citing works

The Metabolism of Organophosphorus Insecticides

Chambers, J. E., Meek, E. C., & Chambers, H. W. (2009) · Elsevier eBooks · doi:10.1016/b978-0-12-374367-1.00065-3 · Cited by 65 · see citing works

Design, Synthesis, and Biological Evaluation of Coumarin Derivatives Tethered to an Edrophonium‐like Fragment as Highly Potent and Selective Dual Binding Site Acetylcholinesterase Inhibitors

Pisani, L., Catto, M., Giangreco, I., Leonetti, F., Nicolotti, O., Stefanachi, A., Cellamare, S., & Carotti, A. (2010) · ChemMedChem · doi:10.1002/cmdc.201000210 · Cited by 64 · see citing works

We have a new publisher: John Wiley & Sons

Voet, J. G., & Voet, D. (2007) · Biochemistry and Molecular Biology Education · doi:10.1002/bmb.20 · Cited by 63 · see citing works

Serum Albumin is as Efficient as Paraxonase in the Detoxication of Paraoxon at Toxicologically Relevant Concentrations

Sogorb, M. A., García-Argüelles, S., Carrera, V., et al. (2008) · Chemical Research in Toxicology · doi:10.1021/tx800075x · Cited by 62 · see citing works

Diazepam in the Treatment of Organophosphorus Ester Pesticide Poisoning

Marrs, T. C. (2003) · Toxicological Reviews · doi:10.2165/00139709-200322020-00002 · Cited by 62 · see citing works

Accurate prediction of the bound conformation of galanthamine in the active site of torpedo californica acetylcholinesterase using molecular docking

Pilger, C., Bartolucci, C., Lamba, D., Tropsha, A., & Fels, G. (2001) · Journal of Molecular Graphics and Modelling · doi:10.1016/s1093-3263(00)00056-5 · Cited by 61 · see citing works

Genotoxicity induced by pesticide mixtures: in-vitro studies on human peripheral blood lymphocytes

Das, P., Shaik, A. P., & Jamil, K. (2007) · Toxicology and Industrial Health · doi:10.1177/0748233708089040 · Cited by 61 · see citing works

Adverse reaction to atropine and the treatment of organophosphate intoxication.

Robenshtok, E., Luria, S., Tashma, Z., et al. (2002) · PubMed · Cited by 60 · see citing works

Inhibition of AChE by malathion and some structurally similar compounds

Krstic, D. Z., Čolović, M. B., Kralj, M. B., et al. (2008) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756360701632031 · Cited by 59 · see citing works

Organophosphate hydrolases as catalytic bioscavengers of organophosphorus nerve agents

Trovaslet-Leroy, M., Musilová, L., Renault, F., et al. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.05.1041 · Cited by 57 · see citing works

Rivastigmine for Alzheimer’s disease

Desai, A. K., & Grossberg, G. T. (2005) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.5.5.563 · Cited by 57 · see citing works

Activated transformations of organophosphorus insecticides in the case of non‐AChE inhibitory oxons

Kasagami, T., Miyamoto, T., & YAMAMOTO, I. (2002) · Pest Management Science · doi:10.1002/ps.546 · Cited by 56 · see citing works

Detection and repair of DNA base damages produced by ionizing radiation

Wallace, S. S. (1983) · Environmental Mutagenesis · doi:10.1002/em.2860050514 · Cited by 55 · see citing works

Efficacy of Metrifonate in Improving the Psychiatric and Behavioral Disturbances of Patients with Alzheimer's Disease

Cummings, J. L., Nadel, A., Masterman, D. L., et al. (2001) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198870101400211 · Cited by 55 · see citing works

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

Hemmert, A., Otto, T. C., Wierdl, M., et al. (2010) · Molecular Pharmacology · doi:10.1124/mol.109.062356 · Cited by 55 · see citing works

Donepezil for vascular cognitive impairment

Malouf, R. S., & Birks, J. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd004395 · Cited by 54 · see citing works

Histochemical localization of cholinesterase in the amphibian spinal cord and alterations following ventral root section.

Chacko, L. W., & Cerf, J. A. (1960) · PubMed · Cited by 52 · see citing works

Five oximes (K‐27, K‐48, obidoxime, HI‐6 and trimedoxime) in comparison with pralidoxime: survival in rats exposed to methyl‐paraoxon

Petroianu, G. A., Nurulain, S. M., Nagelkerke, N., et al. (2007) · Journal of Applied Toxicology · doi:10.1002/jat.1224 · Cited by 52 · see citing works

Successful Use of Donepezil for the Treatment of Dementia with Lewy Bodies

Rojas‐Fernandez, C. H. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.10192 · Cited by 52 · see citing works

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

Tsurkan, L. G., Hatfield, M. J., Edwards, C. C., Hyatt, J. L., & Potter, P. M. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.10.018 · Cited by 51 · see citing works

Single and simultaneous exposure of acetylcholinesterase to diazinon, chlorpyrifos and their photodegradation products

Čolović, M. B., Krstic, D. Z., Uščumlić, G., et al. (2011) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2011.01.010 · Cited by 51 · see citing works

Understanding the Toxic Actions of Organophosphates

Savolainen, K. (2001) · Elsevier eBooks · doi:10.1016/b978-012426260-7.50053-7 · Cited by 51 · see citing works

The New Cholinesterase Inhibitors for Alzheimer's Disease, Part 2: Illustrating Their Mechanisms of Action

Stahl, S. M. (2000) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v61n1101 · Cited by 47 · see citing works

Serum albumins and detoxication of anti-cholinesterase agents

Sogorb, M. A., & Vilanova, E. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.03.001 · Cited by 45 · see citing works

Pesticides and prostate cancer: a review of epidemiologic studies with specific agricultural exposure information

Mink, P. J., Adami, H., Trichopoulos, D., et al. (2008) · European Journal of Cancer Prevention · doi:10.1097/cej.0b013e3280145b4c · Cited by 43 · see citing works

Preparation and in vitro screening of symmetrical bispyridinium cholinesterase inhibitors bearing different connecting linkage—initial study for Myasthenia gravis implications

Musílek, K., Komlóová, M., Zavadova, V., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.01.034 · Cited by 42 · see citing works

Applications of bioanalytical techniques in evaluating advanced oxidation processes in pesticide degradation

Kralj, M. B., Trebše, P., & Franko, M. (2007) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2007.09.006 · Cited by 41 · see citing works

Kinetic and physicochemical properties of brain acetylcholinesterase from the peacock bass (Cichla ocellaris) and in vitro effect of pesticides and metal ions

Silva, K. C. C., Assis, C. R. D., Oliveira, V. D. M., et al. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.11.001 · Cited by 41 · see citing works

Exaggerated levothyroxine malabsorption due to calcium carbonate supplementation in gastrointestinal disorders

Csako, G., McGriff, N. J., Rotman-Pikielny, P., Sarlis, N. J., & Pucino, F. (2001) · Annals of Pharmacotherapy · doi:10.1345/aph.1a031 · Cited by 40 · see citing works

Circular dichroism studies of acetylcholine sterase conformation. Comparison of the 11 S and 5.6 S species and the differences induced by inhibitory ligands

Manavalan, P., Taylor, P., & Johnson, W. C. (1985) · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · doi:10.1016/0167-4838(85)90246-8 · Cited by 37 · see citing works

Promotion of organophosphate induced delayed polyneuropathy by certain esterase inhibitors

Lotti, M., & Moretto, A. (1999) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(99)00066-6 · Cited by 37 · see citing works

Statistical analysis, trial design and duration in Alzheimer's disease clinical trials: a review

Thompson, P. A., Wright, D. E., Counsell, C. E., et al. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211001116 · Cited by 36 · see citing works

Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597

Crow, J. A., Bittles, V., Borazjani, A., et al. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.08.017 · Cited by 35 · see citing works

Binding of huperzine A and galanthamine to acetylcholinesterase, based on ONIOM method

Kitisripanya, N., Saparpakorn, P., Wolschann, P., & Hannongbua, S. (2010) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.08.004 · Cited by 34 · see citing works

Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer’s disease

Roy, K. K., Tota, S., Tripathi, T., Chander, S., Nath, C., & Saxena, A. K. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.09.005 · Cited by 34 · see citing works

Chromosomal composition of micronuclei in mouse bone marrow treated with rifampicin and nicotine, analyzed by multicolor fluorescence in situ hybridization with pancentromeric DNA probe

Attia, S. M. (2007) · Toxicology · doi:10.1016/j.tox.2007.03.011 · Cited by 32 · see citing works

Donepezil for severe Alzheimer's disease

Hogan, D. B. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68395-5 · Cited by 31 · see citing works

In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species

Herkert, N. M., Thiermann, H., & Worek, F. (2011) · Toxicology Letters · doi:10.1016/j.toxlet.2011.03.004 · Cited by 30 · see citing works

Rivastigmine in Parkinson's disease dementia

Chitnis, S., & Rao, J. (2009) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425250903105420 · Cited by 29 · see citing works

Electrochemical Biosensors for Determination of Organophosphorus Compounds: Review

Gahlaut, A., Gothwal, A., Chhillar, A. K., et al. (2012) · Open Journal of Applied Biosensor · doi:10.4236/ojab.2012.11001 · Cited by 28 · see citing works

Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R)

Kanamori‐Kataoka, M., & Seto, Y. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.09.044 · Cited by 28 · see citing works

Cholinesterase inhibitors: new roles and therapeutic alternatives

Giacobini, E. (2004) · Pharmacological Research · doi:10.1016/s1043-6618(04)00085-4 · Cited by 28 · see citing works

Pesticides: A Toxic Time Bomb in Our Midst

Schecter, A. J. (2008) · JAMA · doi:10.1001/jama.299.13.1613 · Cited by 27 · see citing works

New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate Paraoxon

Petroianu, G. A., Hasan, M. Y., Nurulain, S. M., et al. (2007) · Toxicology Mechanisms and Methods · doi:10.1080/15376510601131362 · Cited by 27 · see citing works

The Cholinesterases: From Genes to Proteins

Taylor, P. (1994) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.34.1.281 · Cited by 27 · see citing works

Pesticides: a toxic time bomb in our midst

(2007) · Choice Reviews Online · doi:10.5860/choice.44-6882 · Cited by 25 · see citing works

Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives

Yan, J., Sun, L., Wu, G., et al. (2009) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2009.08.017 · Cited by 24 · see citing works

Assessing the prospect of donepezil in improving cognitive impairment in patients with schizophrenia

Thakurathi, N., Vincenzi, B., & Henderson, D. C. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.750650 · Cited by 24 · see citing works

Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase

Herkert, N. M., Freude, G., Kunz, U., et al. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2011.12.015 · Cited by 23 · see citing works

Protection by pyridostigmine bromide of marmoset hemi-diaphragm acetylcholinesterase activity after soman exposure

Haigh, J. R., Adler, M., Apland, J. P., et al. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.02.003 · Cited by 22 · see citing works

Identification and characterization of novel catalytic bioscavengers of organophosphorus nerve agents

Otto, T. C., Scott, J. R., Kauffman, M. A., et al. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.09.009 · Cited by 21 · see citing works

H-7 Effect on Outflow Facility after Trabecular Obstruction Following Long-Term Echothiophate Treatment in Monkeys

Gabelt, B. T., Hennes, E. A., Seeman, J. L., et al. (2004) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0083 · Cited by 21 · see citing works

The effect of exposure to chlorfenvinphos on lipid metabolism and apoptotic and necrotic cells death in the brain of rats

Roszczenko, A., Rogalska, J., Moniuszko-Jakoniuk, J., & Brzoska, M. M. (2012) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2012.03.002 · Cited by 19 · see citing works

Esterase metabolism of cholinesterase inhibitors using rat liver in vitro

MOSER, V. C., & Padilla, S. (2011) · Toxicology · doi:10.1016/j.tox.2011.01.002 · Cited by 18 · see citing works

The Metabolism of Organophosphorus Insecticides

Chambers, J. E., Carr, R. L., Boone, J. S., et al. (2001) · Elsevier eBooks · doi:10.1016/b978-012426260-7.50048-3 · Cited by 16 · see citing works

New performance of biosensor technology for Alzheimer's disease drugs: in vitro comparison of tacrine and 7-methoxytacrine.

Pohanka, M., Kuča, K., & Kassa, J. (2008) · PubMed · Cited by 15 · see citing works

Inhibition of AChE by single and simultaneous exposure to malathion and its degradation products.

Krstic, D. Z., Čolović, M. B., Krinulović, K., et al. (2007) · PubMed · Cited by 13 · see citing works

Elimination of lymphatic filariasis

Michael, E., Malecela‐Lazaro, M. N., & Kazura, J. W. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69100-9 · Cited by 10 · see citing works

Tabun-inhibited rat tissue and blood cholinesterases and their reactivation with the combination of trimedoxime and HI-6 in vivo

Bajgar, J., Karasová, J. Ž., Kassa, J., et al. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.02.009 · Cited by 10 · see citing works

Donepezil for severe Alzheimer's disease

Allsop, D., Martin, F. L., Moore, S., & Fullwood, N. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69097-1 · Cited by 10 · see citing works

In vitro investigation of efficacy of new reactivators on OPC inhibited rat brain acetylcholinesterase

Atanasov, V. N., Petrova, I., & Dishovsky, C. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.11.020 · Cited by 9 · see citing works

Progress in Antidotes (Acetylcholinesterase Reactivators) Against Organophosphorus Pesticides

Musílek, K., Holas, O., Horova, A., et al. (2011) · InTech eBooks · doi:10.5772/17287 · Cited by 7 · see citing works

Antioxidative role of melatonin in organophosphate toxicity in rats

Büyükokuroğlu, M. E., Cemek, M., Yürümez, Y., et al. (2007) · Toxicology Letters · doi:10.1016/j.toxlet.2007.05.524 · Cited by 7 · see citing works

Donepezil for severe Alzheimer's disease

Opie, L. H. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69098-3 · Cited by 6 · see citing works

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

Cerasoli, D. M., Wierdl, M., Fleming, C. D., et al. (2020) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/2pdx-xf67 · Cited by 3 · see citing works

Microplastics effects in Scrobicularia plana

Ribeiro, F., Garcia, A. R., Pereira, B. P., Fonseca, M., Mestre, N. C., Fonseca, T. G., Ilharco, L. M., & Bebianno, M. J. (2017) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2017.06.078 · Cited by 492 · see citing works

Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

Sharma, P., Srivastava, P., Seth, A., Tripathi, P. N., Banerjee, A. G., & Shrivastava, S. K. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.006 · Cited by 331 · see citing works

Cognitive remission: a novel objective for the treatment of major depression?

Bortolato, B., Miskowiak, K. W., Köhler, C. A., Maes, M., Fernandes, B. S., Berk, M., & Carvalho, A. F. (2016) · BMC Medicine · doi:10.1186/s12916-016-0560-3 · Cited by 252 · see citing works

Controversies over human health and ecological impacts of glyphosate: Is it to be banned in modern agriculture?

Meftaul, I. M., Venkateswarlu, K., Dharmarajan, R., Annamalai, P., Asaduzzaman, M., Parven, A., & Megharaj, M. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114372 · Cited by 218 · see citing works

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges

Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C.-S., & Lee, K.-J. (2021) · Molecules · doi:10.3390/molecules26175327 · Cited by 182 · see citing works

Anticholinergics: theoretical and clinical overview

Nishtala, P. S., Salahudeen, M. S., & Hilmer, S. N. (2016) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2016.1165664 · Cited by 167 · see citing works

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665031 · Cited by 165 · see citing works

Phlorotannins: A review on biosynthesis, chemistry and bioactivity

Shrestha, S., Zhang, W., & Smid, S. D. (2021) · Food Bioscience · doi:10.1016/j.fbio.2020.100832 · Cited by 155 · see citing works

Plants-derived neuroprotective agents: cutting the cycle of cell death through multiple mechanisms

Elufioye, T. O., Berida, T. I., & Habtemariam, S. (2017) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2017/3574012 · Cited by 107 · see citing works

Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals

Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103 · see citing works

Pharmacotherapy Evolution in Alzheimer’s Disease: Current Framework and Relevant Directions

Miculas, D. C., Negru, P. A., Bungau, S. G., Behl, T., Hassan, S. S. U., & Tit, D. M. (2022) · Cells · doi:10.3390/cells12010131 · Cited by 96 · see citing works

Amyloid-β Oligomers May Impair SNARE-Mediated Exocytosis by Direct Binding to Syntaxin 1a

Yang, Y., Kim, J., Kim, H. Y., Ryoo, N., Lee, S., Kim, Y., Rhim, H., & Shin, Y.-K. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.044 · Cited by 88 · see citing works

Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR)

Ferreira, J. P. S., Albuquerque, H. M. T., Cardoso, S. M., Silva, A. M. S., & Silva, V. L. M. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113492 · Cited by 96 · see citing works

Fenugreek Seed Powder Attenuated Aluminum Chloride-Induced Tau Pathology, Oxidative Stress, and Inflammation in a Rat Model of Alzheimer’s Disease1

Prema, A., Justin Thenmozhi, A., Manivasagam, T., Mohamed Essa, M., & Guillemin, G. J. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161103 · Cited by 90 · see citing works

Drug Delivery Systems as a Strategy to Improve the Efficacy of FDA-Approved Alzheimer’s Drugs

Nunes, D., Loureiro, J. A., & Pereira, M. C. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14112296 · Cited by 68 · see citing works

Memantine Derivatives as Multitarget Agents in Alzheimer’s Disease

Marotta, G., Basagni, F., Rosini, M., & Minarini, A. (2020) · Molecules · doi:10.3390/molecules25174005 · Cited by 61 · see citing works

<i>Prunella vulgaris</i> L., an Edible and Medicinal Plant, Attenuates Scopolamine-Induced Memory Impairment in Rats

Qu, Z., Zhang, J., Yang, H., Gao, J., Chen, H., Liu, C., & Gao, W. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04597 · Cited by 46 · see citing works

Novel Rivastigmine Derivatives as Promising Multi-Target Compounds for Potential Treatment of Alzheimer’s Disease

Vicente-Zurdo, D., Rosales-Conrado, N., León-González, M. E., Brunetti, L., Piemontese, L., Pereira-Santos, A. R., Cardoso, S. M., Madrid, Y., Chaves, S., & Santos, M. A. (2022) · Biomedicines · doi:10.3390/biomedicines10071510 · Cited by 47 · see citing works

Anti-Cholinesterase Combination Drug Therapy as a Potential Treatment for Alzheimer’s Disease

Amat-ur-Rasool, H., Ahmed, M., Hasnain, S., & Carter, W. G. (2021) · Brain Sciences · doi:10.3390/brainsci11020184 · Cited by 43 · see citing works

Neuroprotective effects of quercetin produced by an endophytic fungus <i>Nigrospora oryzae</i> isolated from <i>Tinospora cordifolia</i>

Vig, R., Bhadra, F., Gupta, S. K., Sairam, K., & Vasundhara, M. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15174 · Cited by 40 · see citing works

Metformin and Its Sulfenamide Prodrugs Inhibit Human Cholinesterase Activity

Markowicz-Piasecka, M., Sikora, J., Mateusiak, Ł., Mikiciuk-Olasik, E., & Huttunen, K. M. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/7303096 · Cited by 32 · see citing works

Metallic, metal oxide, and metalloid nanoparticles toxic effects on freshwater microcrustaceans: An update and basis for the use of new test species

Gutierrez, M. F., Ale, A., Andrade, V., Bacchetta, C., Rossi, A., & Cazenave, J. (2021) · Water Environment Research · doi:10.1002/wer.1637 · Cited by 29 · see citing works

Is It the Twilight of BACE1 Inhibitors?

Hrabinova, M., Pejchal, J., Kucera, T., Jun, D., Schmidt, M., & Soukup, O. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200503023323 · Cited by 28 · see citing works

Natural Products from Plants and Algae for Treatment of Alzheimer’s Disease: A Review

Klose, J., Griehl, C., Roßner, S., & Schilling, S. (2022) · Biomolecules · doi:10.3390/biom12050694 · Cited by 23 · see citing works

Evaluation of neuroprotective effects of Canna indica L against aluminium chloride induced memory impairment in rats

Ojha, P. S., Biradar, P. R., Tubachi, S., & Patil, V. S. (2023) · Advances in Traditional Medicine · doi:10.1007/s13596-021-00627-x · Cited by 24 · see citing works

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Choi, S.-H., Lee, N.-E., Cho, H.-J., Lee, R. M., Rhim, H., Kim, H.-C., Han, M., Lee, E.-H., Park, J., Kim, J. N., et al. (2021) · Journal of Ginseng Research · doi:10.1016/j.jgr.2019.12.002 · Cited by 20 · see citing works

Aminoalcoholate-driven tetracopper(II) cores as dual acetyl and butyrylcholinesterase inhibitors: Experimental and theoretical elucidation of mechanism of action

Bondžić, A. M., Senćanski, M. V., Vujačić Nikezić, A. V., Kirillova, M. V., André, V., Kirillov, A. M., & Bondžić, B. P. (2020) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2019.110990 · Cited by 14 · see citing works

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Li, L., Wang, F., Jia, X., Yao, L., & Liu, Y. (2024) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/0113895575263783231009051957 · Cited by 11 · see citing works

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Rethinam, P., & Krishnakumar, V. (2022) · Coconut Water · doi:10.1007/978-3-031-10713-9_4 · Cited by 9 · see citing works

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Raju M, G., Gouthami K, G., Reddy V, N. V. L. S., & Nicholas, M. (2020) · Journal of Young Pharmacists · doi:10.5530/jyp.2020.12s.54 · Cited by 7 · see citing works

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Ye, X., Roberts, C., Dl, H., et al. (2009) · Value in Health · doi:10.1016/s1098-3015(10)74745-8

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Li, D., Zhang, Y.-H., Zhang, W., & Zhao, P. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00472 · Cited by 183 · see citing works

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Feng, J. X., Huang, R., & Pwee, K. (2010) · Value in Health · doi:10.1016/s1098-3015(11)73351-4 · Cited by 2 · see citing works

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Sakya, S. M., & Karki, K. (2010) · doi:10.1002/9780470768594.ch17 · Cited by 3 · see citing works

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Ohta, Y., Darwish, M., Hishikawa, N., et al. (2017) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.12971 · Cited by 19 · see citing works