Oxytocin release is inhibited by opiates from the neural lobe, not those from the intermediate lobe
Abstract
Previous experiments have shown that the amount of oxytocin released by electrical stimulation from an isolated rat neurointermediate lobe is about doubled in the presence of the opiate antagonist naloxone. To test whether the opiates from the intermediate lobe inhibit the release of oxytocin, we performed similar experiments on the isolated neural lobe, after almost total removal of intermediate lobe tissue. The potentiating effect of naloxone upon oxytocin release was undiminished, suggesting that the endogenous opiate responsible for inhibiting oxytocin secretion comes from the neural lobe itself.
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Opioids suppress the functional activity of oxytocin neurons via opioid action on their cell bodies in the hypothalamus.
“Opioids not only inhibit OT release from the axon terminal in the posterior pituitary but also suppress the functional activity of OT neurons via opioid action on their cell bodies in the hypothalamus (23, 24).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [24]
Cites
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The effects of opioids and opioid analogs on animal and human endocrine systems
Vuong, C., Van Uum, S. H. M., O'Dell, L. E., Lutfy, K., & Friedman, T. C. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0009 · Cited by 564 · see citing works
Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte, O., Piva, M., Anderson, K. M., Tringides, M., Holmes, A. J., & Chang, S. W. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702725114 · Cited by 55 · see citing works
- Authors
- Bicknell, R. J., Ingram, C. D., & Leng, G.
- ORCID
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1983-12
- Volume
- 43
- Issue
- 2-3
- Pages
- 227-230
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2082579409
- Cited by
- 35
- References
- 15
- Citations by year
- 2025: 1 · 2022: 2 · 2019: 1 · 2018: 1 · 2017: 1
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- oxytocin release, opiates, neural lobe, intermediate lobe, naloxone, opioid antagonism, neurosecretion, pituitary gland, electrical stimulation
- MeSH terms
- Animals, Electric Stimulation, Endorphins, Male, Oxytocin, Pituitary Gland, Posterior, Rats, Inbred Strains, Receptors, Opioid, Vasopressins, Rats
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