Endogenous opiates regulate oxytocin but not vasopressin secretion from the neurohypophysis
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The potential benefit of coadministering oxytocin with naloxone is supported by the mechanistic link between inhibition of opioid processing and increase in oxytocin release from the posterior pituitary, as well as the colocalization of the expressed oxytocin receptor and μ-opioid and κ-opioid receptor genes at the primary oxytocin-releasing sites in the human brain.
“The potential benefit of coadministering OT with NAL is supported by the mechanistic link between the inhibition of opioid processing and increase in OT release from the posterior pituitary (22), as well as the colocalization of the expressed OT receptor and μ-opioid and κ-opioid receptor genes at the primary OT-releasing sites in the human brain.”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [22]
Opioids directly inhibit oxytocin secretion in mammals through action in the posterior pituitary and the hypothalamus.
“Opioids directly inhibit OT secretion in mammals through action in the posterior pituitary and the hypothalamus (21, 22).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [22]
The high-affinity μ-opioid receptor antagonist naloxone strongly drives oxytocin, but not vasopressin, release from the posterior pituitary.
“the high-affinity μ-opioid receptor antagonist NAL strongly drives OT, but not vasopressin, release from the posterior pituitary (22).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [22]
Opioids selectively regulate release of oxytocin rather than vasopressin.
“opioids selectively regulate release of OT rather than vasopressin (22).”
From Oxytocin under opioid antagonism leads to supralinear enhancement of social attention (2017) · cites this paper as [22]
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The neurobiology of attachment
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A neurobiological basis of social attachment.
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Oxytocin under opioid antagonism leads to supralinear enhancement of social attention
Dal Monte, O., Piva, M., Anderson, K. M., Tringides, M., Holmes, A. J., & Chang, S. W. C. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1702725114 · Cited by 55 · see citing works
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Oxytocin release is inhibited by opiates from the neural lobe, not those from the intermediate lobe
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- Authors
- Bicknell, R. J., & Leng, G.
- ORCID
- Leng, G.
- Venue
- Nature
- Published
- 1982-07
- Volume
- 298
- Issue
- 5870
- Pages
- 161-162
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2016433933
- Cited by
- 229
- References
- 11
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 1 · 2022: 5 · 2021: 3 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 36.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- endogenous opioids, oxytocin secretion, vasopressin release, neurohypophysis, dopamine, spiperone, naloxone, electrical stimulation, presynaptic inhibition, hypothalamic neurons, neurosecretion regulation
- MeSH terms
- Animals, Butyrophenones, Electric Stimulation, Kinetics, Male, Naloxone, Oxytocin, Pituitary Gland, Posterior, Rats, Inbred Strains, Spiperone, Vasopressins, Rats, In Vitro Techniques
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