Effects of estradiol treatment on responses of rat preoptic warm sensitive neurons to progesterone in vitro
Abstract
Single unit activity was recorded extracellularly in preoptic slice preparations from ovariectomized female rats. The rats were pretreated daily with (1) estradiol benzoate (20 micrograms/0.1 ml sesame oil) for 3 consecutive days just prior to the experiment (OVX+E72h), (2) sesame oil (OVX+Oil), or (3) untreated (OVX). In the preparations from OVX rats, 12 (50%) of 24 warm-sensitive neurons were inhibited and 2 (8%) were excited by the application of progesterone (P) in perfusion medium (30 ng/ml). In OVX+Oil preparations, 4 (40%) of 10 warm-sensitive neurons were inhibited and none was excited by P. In OVX+E72h preparations, however, only 4 (10%) were inhibited by P and 16 (38%) of 42 warm-sensitive neurons were excited. When Ru38486, a P-receptor antagonist, was applied together with P, no excitation was observed in warm-sensitive neurons in OVX+E72h preparations. These findings suggest that the P-induced excitation of preoptic warm sensitive neurons is mediated through the estrogen-induced P-receptors.
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Both these mechanisms may coexist.
“Both these mechanisms may coexist [156].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [156]
In preparations taken from ovariectomized rats treated with estrogen 72 h previously, progesterone excited warm-sensitive neurons.
“In contrast, in preparations taken from ovariectomized rats treated with estrogen 72 h previously, progesterone excited warm-sensitive neurons [156].”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [156]
Taken together, these data support a rapid inhibitory effect of progesterone (not via progesterone receptors) on heat-loss and/or heat-production mechanisms in the POA.
“Taken together, these data support a rapid inhibitory effect of progesterone (not via progesterone receptors) on heat-loss and/or heat-production mechanisms in the POA.”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [156]
A second study by the same authors found that, similar to their earlier findings, progesterone alone tended to inhibit warm-sensitive neurons.
“A second study by these same authors considered the priming effect of estrogen [156] and found that, similar to their earlier findings, progesterone alone tended to inhibit warm-sensitive neurons (Table 2).”
From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [156]
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Temperature regulation in women: Effects of the menstrual cycle
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- Authors
- Tsai, C. L., Kanosue, K., & Matsumura, K.
- Affiliations
- National Sun Yat-sen University (TW)
- The University of Osaka (JP)
- Corresponding author
- Tsai, Ching Lin
- ORCID
- Kanosue, Kazuyuki
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1992-02
- Volume
- 136
- Issue
- 1
- Pages
- 23-26
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2022572528
- Cited by
- 15
- References
- 15
- Citations by year
- 2023: 3 · 2020: 1 · 2019: 1 · 2017: 1 · 2016: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (63304033)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- estradiol benzoate, progesterone, progesterone receptor, mifepristone, ovariectomy, neuronal excitation, neuronal inhibition, thermoregulation
- MeSH terms
- Animals, Body Temperature Regulation, Estradiol, Estrus, Female, Neurons, Ovariectomy, Preoptic Area, Progesterone, Rats, Inbred Strains, Receptors, Progesterone, Sesame Oil, Mifepristone, Rats
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