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Cited by 21Thermoregulation and physiological responsesThermal Regulation in MedicineRegulation of Appetite and Obesity

Effects of progesterone on thermosensitive neurons in preoptic slice preparations

Tsai, Ching Lin, Matsumura, Kiyoshi, Nakayama, Teruo·1988·Neuroscience Letters
DOI 10.1016/0304-3940(88)90182-6
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Abstract

Single neuronal activities in preoptic (PO) slice preparations from both male and female rats were recorded and examined for their responses to 3 ng/ml or 30 ng/ml progesterone (P). Of 31 warm-sensitive neurons, 19 (61.3%) were inhibited by P, 5 (16.1%) were excited, and 7 (22.6%) did not respond to P. Of 26 thermally insensitive neurons, 4 (15.4%) were inhibited by P, 3 (11.5%) were excited, and 19 (73.1%) did not respond to P. Of 4 cold-sensitive neurons, 3 were inhibited and one was excited. These results demonstrate that P inhibits most warm-sensitive neurons directly or indirectly via local neuronal circuits in the slice.

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  • Taken together, these data support a rapid inhibitory effect of progesterone (not via progesterone receptors) on heat-loss and/or heat-production mechanisms in the POA.

    “Taken together, these data support a rapid inhibitory effect of progesterone (not via progesterone receptors) on heat-loss and/or heat-production mechanisms in the POA.”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [155]

  • In vitro studies using slice preparations showed that a greater proportion of warm-sensitive neurons (61%) than thermally insensitive neurons (15%) in the POA were inhibited by progesterone.

    “Fourth, in vitro studies using slice preparations, which isolate the actions of progesterone on thermosensitive neurons in the POA from other progesterone-sensitive areas, showed that a greater proportion of warm-sensitive neurons (61%) than thermally insensitive neurons (15%) in the POA were inhibited by progesterone [155] (Table 2).”

    From Temperature regulation in women: Effects of the menstrual cycle (2020) · cites this paper as [155]

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Authors
Tsai, C. L., Matsumura, K., & Nakayama, T.
Affiliations
The University of Osaka (JP)
Corresponding author
Nakayama, Teruo
Venue
Neuroscience Letters
Publisher
Elsevier BV
Published
1988-03
Volume
86
Issue
1
Pages
56-60
ISSN
0304-3940 (ISSN-L)
DOI
10.1016/0304-3940(88)90182-6
OpenAlex
W2093942724
Cited by
21
References
13
Citations by year
2023: 3 · 2022: 1 · 2021: 1 · 2020: 2 · 2016: 2 · 2015: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience Letters (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
progesterone, thermosensitive neurons, preoptic area, warm-sensitive neurons, cold-sensitive neurons, neuronal inhibition, neuronal excitation, hypothalamic thermoregulation, sex differences
MeSH terms
Action Potentials, Animals, Cold Temperature, Female, Hot Temperature, Male, Preoptic Area, Progesterone, Rats, Inbred Strains, Reaction Time, Thermoreceptors, Rats, In Vitro Techniques

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