The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased density of cortical apolipoprotein E immunoreactive neurons in rabbit brain after dietary administration of cholesterol
Abstract
Rabbits were fed 2% cholesterol diet for 4, 6 and 8 weeks or control diet for 6 weeks. Frontal cortex and hippocampal formation were stained with apolipoprotein E (Apo-E) antibody using standard immunocytochemical methods. The number of neurons expressing the Apo-E epitope and the intensity of Apo-E immunoreactivity increased with increasing time on the cholesterol diet. Because Apo-E chaperones cholesterol in the brain, the data may suggest that elevated circulating levels of cholesterol eventually cause increased cerebral levels.
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The APOE mRNA trend toward decrease after LDL exposure contrasts with in vivo studies where hypercholesterolemia increased ApoE protein levels in rabbit cortex, underscoring differences between in vitro and in vivo systems.
“In this context, our observation that APOE mRNA expression also tended to decrease is noteworthy, although it contrasts with in vivo studies in which hypercholesterolemia increased ApoE protein levels in rabbit cortex (Sparks et al. 1995), underscoring key differences between simplified in vitro systems and complex in vivo environments.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Sparks et al. 1995
Sparks et al. (1995) showed that amyloid plaques were formed when rabbits were fed a hypercholesterolemic diet.
“Sparks et al. (1995) showed that amyloid plaques were formed when rabbits were fed a hypercholesterolemic diet.”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Sparks et al. (1995)
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Cites
Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study
Wilson, P. W. F. (1994) · JAMA · doi:10.1001/jama.1994.03520210050031 · Cited by 468
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Research works printed but not linked: 18
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Cited by
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Fagan, A. M., Christopher, E., Taylor, J. W., Parsadanian, M., Spinner, M., Watson, M., Fryer, J. D., Wahrle, S., Bales, K. R., Paul, S. M., et al. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63399-8 · Cited by 54
Baumart, G. J., Rodrigues, M. S., Sholl, J. N., de Sousa, A. C., Weber, A. F., Costa‐Beber, L. C., Farias, H. R., Costa, M. V., Peres, A. M., de Camargo, P. R., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70403 · Cited by 2
Metadata
- Authors
- Sparks, D. L., Liu, H., Gross, D. R., & Scheff, S. W.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1995-03
- Volume
- 187
- Issue
- 2
- Pages
- 142-144
- ISSN
- 0304-3940
- Cited by
- 39
- References
- 1
- Language
- en
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