Expression of ionotropic glutamate receptor subunit mRNAs by paraventricular corticotropin-releasing factor (CRF) neurons
Open accessAbstract
To determine whether paraventricular corticotropin-releasing factor (CRF) neurons express NMDA, AMPA or kainate-preferring glutamate receptors, we have colocalized, by in situ hybridization (ISH), transcripts of various glutamate receptor subunit genes with the CRF messenger RNA on doublet adjacent sections of the rat hypothalamus. We found that more than 70% of CRF-positive neurons contain the NMDA receptor subunit NR1 mRNA whereas NR2A and NR2B subunit mRNAs were not detectable in CRF cells. A significant proportion of identified CRF cells express AMPA receptor subunit GluRA (46%), GluRB (21%) as well as the kainate-preferring receptor subunit KA2 (31%) mRNAs. These results support the hypothesis that the excitatory transmitter glutamate may directly influence CRF neurons through NMDA as well as non-NMDA receptors.
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GRIK5 is extensively expressed on parvocellular neurons.
“GRIK5 is extensively expressed on parvocellular neurons (Aubry et al., 1996).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Aubry et al., 1996
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- Authors
- Aubry, J.-M., Bartanusz, V., Pagliusi, S., Schulz, P., & Kiss, J. Z.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Kiss, Jozsef Z.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 205
- Issue
- 2
- Pages
- 95-98
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2060143040
- Cited by
- 42
- References
- 20
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing factor, paraventricular nucleus, NMDA receptor, AMPA receptors, kainate receptors, hypothalamus, excitatory neurotransmission, CRF neurons
- MeSH terms
- Animals, Corticotropin-Releasing Hormone, Male, Neurons, Paraventricular Hypothalamic Nucleus, Rats, Inbred WKY, RNA, Messenger, Oligonucleotide Probes, Gene Expression, Silver Staining, In Situ Hybridization, Receptors, Glutamate, Rats
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