The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
Abstract
Systemic application of lidocaine in rats suppressed ectopic impulse discharge generated both at sites of experimental nerve injury and in axotomized dorsal root ganglion (DRG) cells. ED50 for DRGs was significantly lower than for the injury site. Lidocaine doses effective at blocking ectopic discharge failed to block the initiation or propagation of impulses by electrical stimulation, and only minimally affected normal sensory receptors. This selectivity may account for the effectiveness of systemic local anesthetics and other drugs that share the same mechanism of action (notably certain anticonvulsants and antiarrhythmics), in the management of neuropathic paresthesias and pain. In addition, it may account for the prolonged analgesia sometimes obtained using regional local anesthetic block.
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Cites
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Self-citationMyelinated afferents signal the hyperalgesia associated with nerve injury
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MEXILETINE FOR TREATMENT OF CHRONIC PAINFUL DIABETIC NEUROPATHY
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Self-citationCommon modes of drug action on Na+ channels: local anesthetics, antiarrhythmics and anticonvulsants
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Cited by
The induction of pain: an integrative review
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Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation
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Weibel, S., Jelting, Y., Pace, N. L., Helf, A., Eberhart, L. H., Hahnenkamp, K., Hollmann, M. W., Poepping, D. M., Schnabel, A., & Kranke, P. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009642.pub3 · Cited by 404
Systemic lidocaine for neuropathic pain relief
Mao, J., & Chen, L. L. (2000) · Pain · doi:10.1016/s0304-3959(00)00229-3 · Cited by 375
Perioperative Intravenous Lidocaine Decreases the Incidence of Persistent Pain After Breast Surgery
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Metadata
- Authors
- Devor, M., Wall, P. D., & Catalan, N.
- Venue
- Pain
- Published
- 1992-02
- Volume
- 48
- Issue
- 2
- Pages
- 261-268
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2048656464
- Cited by
- 448
- References
- 27
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
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- Devor, M., Wall, P. D., & Catalan, N. (1992). Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain. https://doi.org/10.1016/0304-3959(92)90067-l
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
