Perioperative Intravenous Lidocaine Decreases the Incidence of Persistent Pain After Breast Surgery

Grigoras, Anca; Lee, Peter; Sattar, Faisal; Shorten, George

doi:10.1097/ajp.0b013e31823b9cc8

Cited by 186Anesthesia and Pain ManagementCancer, Stress, Anesthesia, and Immune ResponsePain Management and Opioid Use

Perioperative Intravenous Lidocaine Decreases the Incidence of Persistent Pain After Breast Surgery

Grigoras, Anca, Lee, Peter, Sattar, Faisal, Shorten, George·2012·The Clinical Journal of Pain

DOI 10.1097/ajp.0b013e31823b9cc8

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Abstract

OBJECTIVES: Breast cancer surgery is associated with a high incidence of persistent postsurgical pain (PPSP). The aim of this study was to evaluate the impact of intravenous (IV) lidocaine on acute and PPSP, analgesic requirements, and sensation abnormalities in patients undergoing surgery for breast cancer. METHODS: Thirty-six patients participated in this randomized, double-blinded study. Before induction of general anesthesia, patients received a bolus of intravenous lidocaine 1.5 mg/kg followed by a continuous infusion of lidocaine 1.5 mg/kgh (lidocaine group) or an equal volume of saline (control group). The infusion was stopped 1 hour after the skin closure. Pain scores and analgesic consumption were recorded at 2, 4, 24 hours, and then daily for 1 week postoperatively. Three months later, patients were assessed for PPSP and secondary hyperalgesia. RESULTS: Two (11.8%) patients in the lidocaine group and 9 (47.4%) patients in the control group reported PPSP at 3 months follow-up (P=0.031). McGill Pain Questionnaire revealed greater present pain intensity-visual analog scale in the control group (14.6 ± 22.5 vs. 2.6 ± 7.5; P=0.025). Secondary hyperalgesia (area of hyperalgesia/length of surgical incision) was significantly less in the lidocaine group compared with control group (0.2 ± 0.8 vs. 3.2 ± 4.5 cm; P=0.002). The 2 groups were similar in terms of analgesic consumption during the early postoperative period. DISCUSSION: Intravenous perioperative lidocaine decreases the incidence and severity of PPSP after breast cancer surgery. Prevention of the induction of central hyperalgesia is a potential mechanism.

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Intraoperative intravenous lidocaine infusion is effective for prevention of CPSP after breast cancer surgery.
“An intraoperative, intravenous, lidocaine infusion has been found to be effective for the prevention of CPSP after breast cancer surgery in a study conducted by Grigoras et al.”
From Chronic postsurgical pain: current evidence for prevention and management (2018) · cites this paper as [41]
In Grigoras et al.'s study, lidocaine significantly reduced the incidence and severity of CPSP at 3 months postoperatively (P = 0.031).
“They found a significant reduction in the incidence and severity of CPSP with lidocaine at 3 months postoperatively (P = 0.031) [41].”
From Chronic postsurgical pain: current evidence for prevention and management (2018) · cites this paper as [41]

The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139 · see citing works
The short-form McGill pain questionnaire
Melzack, R. (1987) · Pain · doi:10.1016/0304-3959(87)91074-8 · Cited by 4,368 · see citing works
Theoretical perspectives on the relation between catastrophizing and pain
Sullivan, M. J. L., Thorn, B., Haythornthwaite, J. A., Keefe, F., Martin, M., Bradley, L. A., & Lefebvre, J. C. (2001) · The Clinical Journal of Pain · doi:10.1097/00002508-200103000-00008 · Cited by 2,472 · see citing works
Chronic Pain as an Outcome of Surgery
Perkins, F. M., & Kehlet, H. (2000) · Anesthesiology · doi:10.1097/00000542-200010000-00038 · Cited by 1,336 · see citing works
Chronic post-surgical pain: 10 years on
Macrae, W. A. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen099 · Cited by 992 · see citing works
Prevalence of and Factors Associated With Persistent Pain Following Breast Cancer Surgery
Gärtner, R., Jensen, M.-B., Nielsen, J., Ewertz, M., Kroman, N., & Kehlet, H. (2009) · JAMA · doi:10.1001/jama.2009.1568 · Cited by 908 · see citing works
Local Anesthetics and the Inflammatory Response
Hollmann, M. W., Durieux, M. E., & Fisher, D. M. (2000) · Anesthesiology · doi:10.1097/00000542-200009000-00038 · Cited by 690 · see citing works
Risk Factors for Chronic Pain Following Breast Cancer Surgery: A Prospective Study
Poleshuck, E. L., Katz, J., Andrus, C. H., Hogan, L. A., Jung, B. F., Kulick, D. I., & Dworkin, R. H. (2006) · Journal of Pain · doi:10.1016/j.jpain.2006.02.007 · Cited by 550 · see citing works
Neuropathic pain following breast cancer surgery: proposed classification and research update
Jung, B. F., Ahrendt, G. M., Oaklander, A. L., & Dworkin, R. H. (2003) · Pain · doi:10.1016/s0304-3959(03)00241-0 · Cited by 476 · see citing works
Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
Devor, M. G., Wall, P. D., & Catalan, N. (1992) · Pain · doi:10.1016/0304-3959(92)90067-l · Cited by 446 · see citing works
Intravenous Lidocaine Infusion Facilitates Acute Rehabilitation after Laparoscopic Colectomy
Kaba, A., Laurent, S., Detroz, B., Sessler, D. I., Durieux, M. E., Lamy, M., & Joris, J. L. (2007) · Anesthesiology · doi:10.1097/00000542-200701000-00007 · Cited by 431 · see citing works
Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery
Marret, E., Rolin, M., Beaussier, M., & Bonnet, F. J. (2008) · British journal of surgery · doi:10.1002/bjs.6375 · Cited by 399 · see citing works
Perioperative Intravenous Lidocaine Has Preventive Effects on Postoperative Pain and Morphine Consumption After Major Abdominal Surgery
Koppert, W., Weigand, M., Neumann, F., Sittl, R., Schüttler, J., Schmelz, M., & Hering, W. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000104582.71710.ee · Cited by 377 · see citing works
Intraoperative Epidural Analgesia Combined with Ketamine Provides Effective Preventive Analgesia in Patients Undergoing Major Digestive Surgery
Lavand'homme, P. M., Kock, M. D., & Waterloos, H. (2005) · Anesthesiology · doi:10.1097/00000542-200510000-00020 · Cited by 354 · see citing works
Systemic Lidocaine Shortens Length of Hospital Stay After Colorectal Surgery
Herroeder, S., Pecher, S., Schönherr, M. E., Kaulitz, G., Hahnenkamp, K., Friess, H., Böttiger, B. W., Bauer, H. W., Dijkgraaf, O. G. W., Durieux, M. E., et al. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e31805dac11 · Cited by 343 · see citing works
Intravenous lidocaine infusion — a new treatment of chronic painful diabetic neuropathy?
Kastrup, J., Petersen, P., Dejgård, A., Angelo, H. R., & Hilsted, J. (1987) · Pain · doi:10.1016/0304-3959(87)91061-x · Cited by 293 · see citing works
The systemic administration of local anaesthetics produces a selective depression of C-afferent fibre evoked activity in the spinal cord
Woolf, C. J., & Wiesenfeld‐Hallin, Z. (1985) · Pain · doi:10.1016/0304-3959(85)90006-5 · Cited by 256 · see citing works
Multimodal Analgesia with Gabapentin and Local Anesthetics Prevents Acute and Chronic Pain After Breast Surgery for Cancer
Fassoulaki, A., Triga, A., Melemeni, A., & Sarantopoulos, C. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000180200.11626.8e · Cited by 255 · see citing works
Low-dose lidocaine reduces secondary hyperalgesia by a central mode of action
Koppert, W., Ostermeier, N., Sittl, R., Weidner, C., & Schmelz, M. (2000) · Pain · doi:10.1016/s0304-3959(99)00268-7 · Cited by 212 · see citing works
Analgesic Effects of Intravenous Lidocaine and Morphine on Postamputation Pain
Wu, C. L., Tella, P. K., Staats, P. S., Vaslav, R., Kazim, D. A., Wesselmann, U., & Raja, S. N. (2002) · Anesthesiology · doi:10.1097/00000542-200204000-00010 · Cited by 197 · see citing works
Pain and Quality of Life after Surgery for Breast Cancer
Caffo, O., Amichetti, M., Ferro, A., Lucenti, A., Valduga, F., & Galligioni, E. (2003) · Breast Cancer Research and Treatment · doi:10.1023/a:1024435101619 · Cited by 188 · see citing works
Experimental incision-induced pain in human skin: effects of systemic lidocaine on flare formation and hyperalgesia
Kawamata, M., Takahashi, T., Kozuka, Y., Nawa, Y., Nishikawa, K., Narimatsu, E., Watanabe, H., & Namiki, A. (2002) · Pain · doi:10.1016/s0304-3959(02)00233-6 · Cited by 133 · see citing works
Chronic post-treatment symptoms in patients with breast cancer operated in different surgical units
Tasmuth, T., BLOMQVIST, C. P., & Kalso, E. A. (1999) · European Journal of Surgical Oncology · doi:10.1053/ejso.1998.0597 · Cited by 124 · see citing works
Effect of Axillary Lymph Node Dissection on Prevalence and Intensity of Chronic and Phantom Pain After Breast Cancer Surgery
Steegers, M. A. H., Wolters, B., Evers, A. W. M., Strobbe, L. J. A., & Wilder‐Smith, O. H. G. (2008) · Journal of Pain · doi:10.1016/j.jpain.2008.04.001 · Cited by 121 · see citing works
Low-dose Lidocaine Suppresses Experimentally Induced Hyperalgesia in Humans
Koppert, W., Zeck, S., Sittl, R., Likar, R., Knoll, R., & Schmelz, M. (1998) · Anesthesiology · doi:10.1097/00000542-199812000-00011 · Cited by 117 · see citing works
Local anaesthetics have different mechanisms and sites of action at the recombinant N‐methyl‐D‐aspartate (NMDA) receptors
Sugimoto, M., Uchida, I., & Mashimo, T. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705107 · Cited by 114 · see citing works
XYLOCAINE for the relief of postoperative pain
Bartlett, E. E., & HUTASERANI, O. (1961) · Anesthesia & Analgesia · doi:10.1213/00000539-196105000-00011 · Cited by 108 · see citing works
Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol–remifentanil-based anaesthesia
Cui, W., Li, Y., Li, S., Wang, R., & Li, J. (2009) · European Journal of Anaesthesiology · doi:10.1097/eja.0b013e32832d5426 · Cited by 102 · see citing works
The Associations Between Severity of Early Postoperative Pain, Chronic Postsurgical Pain and Plasma Concentration of Stable Nitric Oxide Products After Breast Surgery
Iohom, G., Abdalla, H., Brien, J. O., Szarvas, S., Larney, V., Buckley, E., Butler, M. D., & Shorten, G. (2006) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000240415.49180.4a · Cited by 100 · see citing works
Self-citation
The Effect of Systemic Lidocaine on Pain and Secondary Hyperalgesia Associated with the Heat/Capsaicin Sensitization Model in Healthy Volunteers
Dirks, J., Fabricius, P. G., Petersen, K. L., Rowbotham, M. C., & Dahl, J. B. (2000) · Anesthesia & Analgesia · doi:10.1097/00000539-200010000-00037 · Cited by 98 · see citing works
Treatment of intractable painful diabetic neuropathy with intravenous lignocaine
Viola, V., Newnham, H. H., & Simpson, R. (2005) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2005.05.007 · Cited by 90 · see citing works
Inhibition of burn pain by intravenous lignocaine infusion
Cassuto, J., Hanson, B., & Jonsson, A. (1991) · The Lancet · doi:10.1016/0140-6736(91)90139-g · Cited by 84 · see citing works
Receptors, G Proteins, and Their Interactions
Hollmann, M. W., Strümper, D., Herroeder, S., Durieux, M. E., & Warltier, D. C. (2005) · Anesthesiology · doi:10.1097/00000542-200511000-00022 · Cited by 77 · see citing works
Continuous Lidocaine Infusion for the Relief of Refractory Malignant Pain in a Terminally Ill Pediatric Cancer Patient
Massey, G. V., Pedigo, S. A., Dunn, N. L., Grossman, N. J., & Russell, E. C. (2002) · Journal of Pediatric Hematology/Oncology · doi:10.1097/00043426-200210000-00015 · Cited by 59 · see citing works
A CONTROLLED STUDY OF PAIN RELIEF BY INTRAVENOUS PROCAINE
Keats, A. S. (1951) · JAMA · doi:10.1001/jama.1951.73670350005011 · Cited by 56 · see citing works
Intravenous lignocaine in the management of primary fibromyalgia syndrome.
Bennett, M., & Tai, Y. M. (1995) · PubMed · Cited by 27 · see citing works
Effects of systemic administration of lidocaine and QX-314 on hyperexcitability of spinal dorsal horn neurons after incision in the rat
Kawamata, M., Sugino, S., Narimatsu, E., Yamauchi, M., Kiya, T., Furuse, S., & Namiki, A. (2006) · Pain · doi:10.1016/j.pain.2006.01.004 · Cited by 27 · see citing works
A new method to evaluate central sensitization to pain following surgery. Effect of ketamine
Stubhaug, A. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb05540.x · Cited by 24 · see citing works

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Gan, T. J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s144066 · Cited by 1,525 · see citing works
Chronic Opioid Use After Surgery: Implications for Perioperative Management in the Face of the Opioid Epidemic
Hah, J. M., Bateman, B. T., Ratliff, J., Curtin, C., & Sun, E. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002458 · Cited by 728 · see citing works
Persistent Postsurgical Pain
Richebé, P., Capdevila, X., & Rivat, C. (2018) · Anesthesiology · doi:10.1097/aln.0000000000002238 · Cited by 439 · see citing works
Postoperative pain—from mechanisms to treatment
Pogatzki-Zahn, E. M., Segelcke, D., & Schug, S. A. (2017) · PAIN Reports · doi:10.1097/pr9.0000000000000588 · Cited by 421 · see citing works
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults
Weibel, S., Jelting, Y., Pace, N. L., Helf, A., Eberhart, L. H. J., Hahnenkamp, K., Hollmann, M. W., Poepping, D. M., Schnabel, A., & Kranke, P. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009642.pub3 · Cited by 417 · see citing works
Perioperative Use of Intravenous Lidocaine
Beaussier, M., Delbos, A., Maurice-Szamburski, A., Ecoffey, C., & Mercadal, L. (2018) · Drugs · doi:10.1007/s40265-018-0955-x · Cited by 391 · see citing works
Perioperative Use of Intravenous Lidocaine
Dunn, L. K., & Durieux, M. E. (2017) · Anesthesiology · doi:10.1097/aln.0000000000001527 · Cited by 369 · see citing works
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery
Kranke, P., Jokinen, J., Pace, N. L., Schnabel, A., Hollmann, M. W., Hahnenkamp, K., Eberhart, L. H. J., Poepping, D. M., & Weibel, S. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009642.pub2 · Cited by 331 · see citing works
Pharmacotherapy for the prevention of chronic pain after surgery in adults
Chaparro, L. E., Smith, S. A., Moore, A., Wiffen, P. J., & Gilron, I. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008307.pub2 · Cited by 316 · see citing works
The use of intravenous lidocaine for postoperative pain and recovery: international consensus statement on efficacy and safety
Foo, I. T. H., Macfarlane, A. J. R., Srivastava, D., Bhaskar, A., Barker, H., Knaggs, R., Eipe, N., & Smith, A. F. (2020) · Anaesthesia · doi:10.1111/anae.15270 · Cited by 287 · see citing works
Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis
Weibel, S., Jokinen, J., Pace, N. L., Schnabel, A., Hollmann, M. W., Hahnenkamp, K., Eberhart, L. H. J., Poepping, D. M., Afshari, A., & Kranke, P. (2016) · British Journal of Anaesthesia · doi:10.1093/bja/aew101 · Cited by 266 · see citing works
A systematic review of therapeutic interventions to reduce acute and chronic post‐surgical pain after amputation, thoracotomy or mastectomy
Humble, S. R., Dalton, A. J., & Li, L. (2015) · European Journal of Pain · doi:10.1002/ejp.567 · Cited by 220 · see citing works
Mechanisms of action of fascial plane blocks: a narrative review
Chin, K. J., Lirk, P. B., Hollmann, M. W., & Schwarz, S. K. W. (2021) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2020-102305 · Cited by 213 · see citing works
Intravenous lidocaine for acute pain: an evidence-based clinical update
Eipe, N., Gupta, S., & Penning, J. (2016) · BJA Education · doi:10.1093/bjaed/mkw008 · Cited by 206 · see citing works
Local anaesthetics and regional anaesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children
Weinstein, E. J., Levene, J. L., Cohen, M. S., Andreae, D. A., Chao, J. Y., Johnson, M., Hall, C. B., & Andreae, M. H. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007105.pub3 · Cited by 209 · see citing works
Prevalence of pain in patients with breast cancer post-treatment: A systematic review
Wang, K., Yee, C., Tam, S., Drost, L., Chan, S., Zaki, P., Rico, V., Ariello, K., Dasios, M., Lam, H., et al. (2018) · The Breast · doi:10.1016/j.breast.2018.08.105 · Cited by 176 · see citing works
Chronic postsurgical pain: current evidence for prevention and management
Thapa, P., & Euasobhon, P. (2018) · The Korean Journal of Pain · doi:10.3344/kjp.2018.31.3.155 · Cited by 177 · see citing works
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Barreveld, A. M., Witte, J., Chahal, H., Durieux, M. E., & Strichartz, G. R. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318277a270 · Cited by 172 · see citing works
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Chang, Y., Liu, C., Chen, M., Hsu, Y.-W., Chen, S.-N., Lin, C., Chen, C.-M., Yang, F., & Hu, M. (2013) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182a94479 · Cited by 147 · see citing works
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Chamaraux‐Tran, T., & Piegeler, T. (2017) · Frontiers in Medicine · doi:10.3389/fmed.2017.00235 · Cited by 93 · see citing works
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Kandil, E. S., Melikman, E., & Adinoff, B. H. (2017) · Journal of Anesthesia & Clinical Research · doi:10.4172/2155-6148.1000697 · Cited by 91 · see citing works
Intravenous lidocaine
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Local anesthetics and regional anesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children: A Cochrane systematic review and meta-analysis update
Levene, J. L., Weinstein, E. J., Cohen, M. S., Andreae, D. A., Chao, J. Y., Johnson, M., Hall, C. B., & Andreae, M. H. (2019) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2018.12.043 · Cited by 96 · see citing works
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Douleurs chroniques postchirurgicales
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Bailey, M., Corcoran, T. B., Schug, S. A., & Toner, A. (2018) · Pain · doi:10.1097/j.pain.0000000000001273 · Cited by 76 · see citing works
Risk factors for persistent pain after breast and thoracic surgeries: a systematic literature review and meta-analysis
Lim, J., Chen, D., McNicol, E. D., Sharma, L. R., Varaday, G., Sharma, A., Wilson, E., Wright-Yatsko, T., Yaeger, L., Gilron, I., et al. (2021) · Pain · doi:10.1097/j.pain.0000000000002301 · Cited by 71 · see citing works
Risk Factors and Early Pharmacological Interventions to Prevent Chronic Postsurgical Pain Following Cardiac Surgery
Gjeilo, K. H., Stenseth, R., & Klepstad, P. (2014) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-014-0083-2 · Cited by 68 · see citing works
Post-surgical pain syndromes: a review for the non-pain specialist
Rashiq, S., & Dick, B. D. (2013) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-013-0072-y · Cited by 67 · see citing works
An Update of the Systematic Appraisal of the Accuracy and Utility of Lumbar Discography in Chronic Low Back Pain
Manchikanti, L. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/se55 · Cited by 67 · see citing works
Lidocaine infusion adjunct to total intravenous anesthesia reduces the total dose of propofol during intraoperative neurophysiological monitoring
Sloan, T. B., Mongan, P. D., Lyda, C., & Koht, A. H. (2013) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-013-9506-x · Cited by 65 · see citing works
Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta‐Analysis of Randomized Controlled Trials
Chang, Y., Liu, C., Liu, T., Yang, P., Chen, M., & Cheng, S. (2016) · Pain Practice · doi:10.1111/papr.12442 · Cited by 64 · see citing works
Does Regional Analgesia for Major Surgery Improve Outcome? Focus on Epidural Analgesia
Kooij, F. O., Schlack, W. S., Preckel, B., & Hollmann, M. W. (2014) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000245 · Cited by 61 · see citing works
A Review of Postoperative Analgesia for Breast Cancer Surgery
Cheng, G. S., & Ilfeld, B. M. (2016) · Pain Management · doi:10.2217/pmt-2015-0008 · Cited by 58 · see citing works
Percutaneous Lumbar Laser Disc Decompression: An Update of Current Evidence
Singh, V. P. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/se229 · Cited by 63 · see citing works
An Update of the Systematic Assessment of Mechanical Lumbar Disc Decompression with Nucleoplasty
Manchikanti, L. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/se25 · Cited by 58 · see citing works
Effect of Intravenous Lidocaine on Postoperative Recovery of Patients Undergoing Mastectomy
Terkawi, A. S., Durieux, M. E., Gottschalk, A., Brenin, D. R., & Tiouririne, M. (2014) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0000000000000140 · Cited by 56 · see citing works
Factors Associated with the Development of Chronic Pain after Surgery for Breast Cancer: A Prospective Cohort from a Tertiary Center in the United States
Oliveira, G. D. D., Chang, R., Khan, S., Hansen, N., Khan, J. H., McCarthy, R. J., & Apkarian, A. (2014) · The Breast Journal · doi:10.1111/tbj.12207 · Cited by 53 · see citing works
Effects of systemic lidocaine versus magnesium administration on postoperative functional recovery and chronic pain in patients undergoing breast cancer surgery: A prospective, randomized, double-blind, comparative clinical trial
Kim, M. H., Lee, K., Park, S., Kim, S. I., Park, H. S., & Yoo, Y. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173026 · Cited by 55 · see citing works
Non-opioid-based adjuvant analgesia in perioperative care
Ramaswamy, S., Wilson, J. A., & Colvin, L. (2013) · Continuing Education in Anaesthesia Critical Care & Pain · doi:10.1093/bjaceaccp/mkt012 · Cited by 54 · see citing works
Reducing Persistent Postoperative Pain and Disability 1 Year After Breast Cancer Surgery: A Randomized, Controlled Trial Comparing Thoracic Paravertebral Block to Local Anesthetic Infiltration
Chiu, M., Bryson, G. L., Lui, A. C. P., Watters, J. M., Taljaard, M., & Nathan, H. J. (2013) · Annals of Surgical Oncology · doi:10.1245/s10434-013-3334-6 · Cited by 53 · see citing works
An Updated Review of the Diagnostic Utility of Cervical Facet Joint Injections
Datta, S. (2012) · Pain Physician · doi:10.36076/ppj.2012/15/e807 · Cited by 52 · see citing works
Perioperative Pregabalin and Intraoperative Lidocaine Infusion to Reduce Persistent Neuropathic Pain After Breast Cancer Surgery: A Multicenter, Factorial, Randomized, Controlled Pilot Trial
Khan, J. S., Hodgson, N., Choi, S., Reid, S., Paul, J., Hong, N. J. L., Holloway, C. M. B., Busse, J. W., Gilron, I., Buckley, D. N., et al. (2019) · Journal of Pain · doi:10.1016/j.jpain.2019.02.010 · Cited by 53 · see citing works
Diagnosis and management of neuropathic pain: Review of literature and recommendations of the Polish Association for the Study of Pain and the Polish Neurological Society – Part Two
Szczudlik, A., Dobrogowski, J., Wordliczek, J., Stępień, A., Krajnik, M., Leppert, W., Woroń, J., Przeklasa-Muszyńska, A., Kocot-Kępska, M., Zajączkowska, R., et al. (2014) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2014.11.002 · Cited by 48 · see citing works
Intravenous Lidocaine for the Prevention of Postoperative Catheter-Related Bladder Discomfort in Male Patients Undergoing Transurethral Resection of Bladder Tumors: A Randomized, Double-Blind, Controlled Trial
Kim, D.-H., Park, J.-Y., Yu, J., Lee, S., Park, S., Hwang, J., Koh, G.-H., & Kim, Y. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004405 · Cited by 48 · see citing works
“Post Mastectomy Pain Syndrome: A Systematic Review of Prevention Modalities”
Yuksel, S. S., Chappell, A. G., Jackson, B., Wescott, A., & Ellis, M. F. (2021) · JPRAS Open · doi:10.1016/j.jpra.2021.10.009 · Cited by 50 · see citing works
An Evidence-Based Review of the Efficacy of Perioperative Analgesic Techniques for Breast Cancer-Related Surgery
Cheng, G. S., & Ilfeld, B. M. (2016) · Pain Medicine · doi:10.1093/pm/pnw172 · Cited by 47 · see citing works
An update of the effectiveness of therapeutic lumbar facet joint interventions.
Falco, F. J. E., Manchikanti, L., Datta, S., Sehgal, N., Geffert, S., Onyewu, O., Zhu, J., Coubarous, S., Hameed, M., Ward, S. P., et al. (2012) · PubMed · Cited by 46 · see citing works
An Updated Review of Automated Percutaneous Mechanical Lumbar Discectomy for the Contained Herniated Lumbar Disc
Manchikanti, L. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/se151 · Cited by 45 · see citing works
Intravenous Lidocaine for Effective Pain Relief After a Laparoscopic Colectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Study
Ahn, E. J., Kang, H., Choi, G. J., Park, Y., Yang, S. Y., Kim, B. G., & Choi, S. W. (2015) · International Surgery · doi:10.9738/intsurg-d-14-00225.1 · Cited by 46 · see citing works
The Effects of Intravenous Lidocaine Infusions on the Quality of Recovery and Chronic Pain After Robotic Thyroidectomy: A Randomized, Double‐Blinded, Controlled Study
Choi, K. W., Nam, K., Lee, J. R., Chung, W. Y., Kang, S., Joe, Y., & Lee, J. H. (2016) · World Journal of Surgery · doi:10.1007/s00268-016-3842-1 · Cited by 46 · see citing works
A comparison between intravenous lidocaine and ketamine on acute and chronic pain after open nephrectomy: A prospective, double-blind, randomized, placebo-controlled study
Jendoubi, A., Naceur, I. B., Bouzouita, A., Trifa, M., Ghedira, S., Chébil, M., & Houissa, M. (2017) · Saudi Journal of Anaesthesia · doi:10.4103/1658-354x.203027 · Cited by 46 · see citing works
Efficacy of intravenous lidocaine on pain relief in patients undergoing laparoscopic cholecystectomy: A meta-analysis from randomized controlled trials
Li, J., Wang, G., Xu, W., Ding, M., & Yu, W. (2018) · International Journal of Surgery · doi:10.1016/j.ijsu.2018.01.001 · Cited by 46 · see citing works
The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Kendall, M. C., McCarthy, R. J., Panaro, S., Goodwin, E. J., Bialek, J. M., Nader, A., & Oliveira, G. S. D. (2017) · Pain Practice · doi:10.1111/papr.12611 · Cited by 44 · see citing works
Prevention of chronic post-surgical pain: the importance of early identification of risk factors
Tawfic, Q. A., Kumar, K., Pirani, Z., & Armstrong, K. (2017) · Journal of Anesthesia · doi:10.1007/s00540-017-2339-x · Cited by 44 · see citing works
Does the perioperative analgesic/anesthetic regimen influence the prevalence of long-term chronic pain after mastectomy?
Steyaert, A., Forget, P., Dubois, V., Lavand'homme, P. M., & Kock, M. D. (2016) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2015.07.010 · Cited by 39 · see citing works
Intravenous Lidocaine Infusion for the Management of Early Postoperative Pain: A Comprehensive Review of Controlled Trials
Chu, R., Umukoro, N. N., Greer, T., Roberts, J., Adekoya, P., Odonkor, C. A., Hagedorn, J. M., Olatoye, D., Urits, I., Orhurhu, M. S., et al. (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4391 · Cited by 38 · see citing works
Perfusión de lidocaína intravenosa
Soto, G., González, M. N., & Calero, F. (2018) · Revista Española de Anestesiología y Reanimación · doi:10.1016/j.redar.2018.01.004 · Cited by 36 · see citing works
Chronic pain after breast surgery: incidence, associated factors, and impact on quality of life, an observational prospective study
Villa, G., Mandarano, R., Scirè‐Calabrisotto, C., Rizzelli, V., Duca, M. D., Montin, D. P., Paparella, L., Gaudio, A. R. D., & Romagnoli, S. (2021) · Perioperative Medicine · doi:10.1186/s13741-021-00176-6 · Cited by 36 · see citing works
The Efficacy of Systemic Lidocaine in the Management of Chronic Pain: A Literature Review
Yousefshahi, F., Predescu, O., & Asenjo, J. F. (2017) · Anesthesiology and Pain Medicine · doi:10.5812/aapm.44732 · Cited by 35 · see citing works
Chronifizierung postoperativer Schmerzen
Gerbershagen, H. U. (2013) · Der Schmerz · doi:10.1007/s00482-012-1287-5 · Cited by 35 · see citing works
Research design considerations for chronic pain prevention clinical trials: IMMPACT recommendations
Gewandter, J. S., Dworkin, R. H., Turk, D. C., Farrar, J. T., Fillingim, R. B., Gilron, I., Markman, J. D., Oaklander, A. L., Polydefkis, M. J., Raja, S. N., et al. (2021) · PAIN Reports · doi:10.1097/pr9.0000000000000895 · Cited by 34 · see citing works
Lack of association between breast reconstructive surgery and the development of chronic pain after mastectomy: a propensity matched retrospective cohort analysis.
Oliveira, G. D. D., Bialek, J. M., Nicosia, L., McCarthy, R., Chang, R., Fitzgerald, P., & Kim, J. Y. S. (2014) · Breast · doi:10.1016/j.breast.2014.01.003 · Cited by 30 · see citing works
Postoperative pain and the gut microbiome
Brenner, D., Shorten, G., & O’Mahony, S. M. (2021) · Neurobiology of Pain · doi:10.1016/j.ynpai.2021.100070 · Cited by 31 · see citing works
Self-citation
Can Acute Pain Treatment Reduce Postsurgical Comorbidity after Breast Cancer Surgery? A Literature Review
Amaya, F., Hosokawa, T., Okamoto, A., Matsuda, M., Yamaguchi, Y., Yamakita, S., Taguchi, T., & Sawa, T. (2015) · BioMed Research International · doi:10.1155/2015/641508 · Cited by 28 · see citing works
A randomized crossover study of the effects of lidocaine on motor- and sensory-evoked potentials during spinal surgery
Urban, M. K., Fields, K. G., Donegan, S. W., Beathe, J. C., Pinter, D. W., Boachie-Adjei, O., & Emerson, R. G. (2017) · The Spine Journal · doi:10.1016/j.spinee.2017.06.024 · Cited by 27 · see citing works
Intravenous lidocaine infusions in a multidirectional model of treatment of neuropathic pain patients
Przeklasa-Muszyńska, A., Kocot-Kępska, M., Dobrogowski, J., Wiatr, M., & Mika, J. (2016) · Pharmacological Reports · doi:10.1016/j.pharep.2016.06.010 · Cited by 26 · see citing works
Intravenous lidocaine infusion
Soto, G., González, M. N., & Calero, F. (2018) · Revista Española de Anestesiología y Reanimación (English Edition) · doi:10.1016/j.redare.2018.01.015 · Cited by 25 · see citing works
A pilot multicentre randomised controlled trial of lidocaine infusion in women undergoing breast cancer surgery
Toner, A. J., Bailey, M., Schug, S. A., & Corcoran, T. B. (2021) · Anaesthesia · doi:10.1111/anae.15440 · Cited by 25 · see citing works
Effect of Intravenous Lidocaine on Serum Interleukin-17 After Video-Assisted Thoracic Surgery for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Hou, Y.-H., Shi, W.-C., Cai, S., Liu, H., Zheng, Z., Qi, F.-W., Li, C., Feng, X.-M., Peng, K., & Ji, F. (2021) · Drug Design Development and Therapy · doi:10.2147/dddt.s316804 · Cited by 25 · see citing works
Repeated Intravenous Lidocaine Infusions for Patients with Fibromyalgia: Higher Doses of Lidocaine Have a Stronger and Longer-Lasting Effect on Pain Reduction
Wilderman, I., Pugacheva, O., Perelman, V. S., Wansbrough, M. C. T., Voznyak, Y., & Zolnierczyk, L. (2019) · Pain Medicine · doi:10.1093/pm/pnz251 · Cited by 23 · see citing works
The analgesic effectiveness of perioperative lidocaine infusions for acute and chronic persistent postsurgical pain in patients undergoing breast cancer surgery: a systematic review and meta-analysis
Hussain, N., Brull, R., Weber, L. V., Garrett, A. L., Werner, M., D'Souza, R. S., Sawyer, T. R., Weaver, T. E., Iyer, M. H., Essandoh, M. K., et al. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.12.005 · Cited by 23 · see citing works
Intravenous lidocaine to treat postoperative pain
Couceiro, T. C. D. M., Lima, L. C., Burle, L. M. C., & Valênça, M. M. (2014) · Revista Dor · doi:10.5935/1806-0013.20140013 · Cited by 22 · see citing works
Continuous Lidocaine Infusion as Adjunctive Analgesia in Intensive Care Unit Patients
Mo, Y., Thomas, M. C., Antigua, A. D., Ebied, A. M., & Karras, G. E. (2017) · The Journal of Clinical Pharmacology · doi:10.1002/jcph.874 · Cited by 22 · see citing works
Transitional Pain Service: An Update
Klimke, R., Ott, A., Romero, C. S., Berendes, A., Urman, R. D., Luedi, M. M., & Ashok, V. (2024) · Current Pain and Headache Reports · doi:10.1007/s11916-024-01239-1 · Cited by 21 · see citing works
An Update of Evaluation of Intravenous Sedation on Diagnostic Spinal Injection Procedures
Smith, H. S. (2013) · Pain Physician · doi:10.36076/ppj.2013/16/se217 · Cited by 21 · see citing works
Chronifizierung postoperativer Schmerzen: Physiologie, Risikofaktoren und Prävention
Gerbershagen, H. U. (2013) · Der Schmerz · Cited by 19 · see citing works
Anti-Inflammatory and Immunomodulatory Effects of Intravenous Lidocaine in Surgery: A Narrative Review
Fernández-Martínez, A., García, J. G., & Picado, A. L. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14113883 · Cited by 18 · see citing works
Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons
Zhang, L., Tanabe, K., Yanagidate, F., Kawasaki, Y., Chen, G., Dohi, S., & Iida, H. (2014) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.03.048 · Cited by 18 · see citing works
Intravenous lidocaine as a non-opioid adjunct analgesic for traumatic rib fractures
Choi, J., Zamary, K. R., Barreto, N. B., Tennakoon, L., Davis‐Lopez, K. M., Trickey, A. W., & Spain, D. A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239896 · Cited by 18 · see citing works
The Effect of Perioperative Lidocaine Infusion on Postoperative Pain and Postsurgical Recovery Parameters in Gynecologic Cancer Surgery
Yazici, K., Kaya, M., Aksu, B. N., & Ünver, S. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000900 · Cited by 18 · see citing works
Patients with Chronic Pain
Salama-Hanna, J., & Chen, G. L. (2013) · Medical Clinics of North America · doi:10.1016/j.mcna.2013.07.005 · Cited by 17 · see citing works
Perioperative Pregabalin for Preventive Analgesia in Breast Cancer Surgery
Chang, C.-C., Yen, W.-T., Lin, Y., Wang, L., Hung, K., Wu, Z., & Chen, J. (2020) · Clinical Journal of Pain · doi:10.1097/ajp.0000000000000883 · Cited by 17 · see citing works

Effect of intravenous lidocaine on chronic postoperative pain in patients undergoing breast cancer surgery: a prospective, double-blind, randomized, placebo-controlled clinical trial
Xia, M., Wei, Q., Zhang, Q., & Jiang, H. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-3522 · Cited by 11 · see citing works
The analgesic effectiveness of perioperative lidocaine infusions for acute and chronic persistent postsurgical pain in patients undergoing breast cancer surgery: a systematic review and meta-analysis
Hussain, N., Brull, R., Weber, L. V., Garrett, A. L., Werner, M., D'Souza, R. S., Sawyer, T. R., Weaver, T. E., Iyer, M. H., Essandoh, M. K., et al. (2024) · British Journal of Anaesthesia · doi:10.1016/j.bja.2023.12.005 · Cited by 23 · see citing works
The Effect of Intraoperative Systemic Lidocaine on Postoperative Persistent Pain Using Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials Criteria Assessment Following Breast Cancer Surgery: A Randomized, Double‐Blind, Placebo‐Controlled Trial
Kendall, M. C., McCarthy, R. J., Panaro, S., Goodwin, E. J., Bialek, J. M., Nader, A., & Oliveira, G. S. D. (2017) · Pain Practice · doi:10.1111/papr.12611 · Cited by 44 · see citing works
Effect of Perioperative Intravenous Lidocaine Infusion on Acute and Chronic Pain after Breast Surgery: A Meta‐Analysis of Randomized Controlled Trials
Chang, Y., Liu, C., Liu, T., Yang, P., Chen, M., & Cheng, S. (2016) · Pain Practice · doi:10.1111/papr.12442 · Cited by 64 · see citing works
Perioperative intravenous lidocaine for postoperative pain in patients undergoing breast surgery: a meta-analysis with trial sequential analysis of randomized controlled trials
Li, J., Huang, J., Yang, J., & Liu, J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1101582 · Cited by 8 · see citing works

Authors: Grigoras, A., Lee, P., Sattar, F., & Shorten, G.
Affiliations: University College Cork (IE)
ORCID: Lee, Peter
Shorten, George
Venue: The Clinical Journal of Pain
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-09
Volume: 28
Issue: 7
Pages: 567-572
ISSN: 0749-8047 (ISSN-L)
DOI: 10.1097/ajp.0b013e31823b9cc8
OpenAlex: W2059055540
Cited by: 186
References: 38
Citations by year: 2026: 7 · 2025: 5 · 2024: 6 · 2023: 5 · 2022: 11 · 2021: 14 · 2020: 9 · 2019: 12 · 2018: 17 · 2017: 20 · 2016: 15 · 2015: 19 · 2014: 16 · 2013: 24 · 2012: 4
FWCI: 20.52
Type: journal article
Language: en
Open access: closed
Locations: Clinical Journal of Pain (publishedVersion)
PubMed (publishedVersion)
Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
Topics: Health Sciences › Medicine › Surgery › Anesthesia and Pain Management
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
Keywords: intravenous lidocaine, chronic postoperative pain, breast cancer surgery, perioperative analgesia, secondary hyperalgesia, analgesic use, postoperative pain prevention
MeSH terms: Adult, Aged, Anesthetics, Local, Back Pain, Breast Neoplasms, Chronic Disease, Double-Blind Method, Drug Administration Schedule, Female, Humans, Hyperalgesia, Lidocaine, Middle Aged, Pain, Pain Measurement, Postoperative Complications, Prospective Studies, Time Factors, Incidence, Administration, Intravenous

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Perioperative Intravenous Lidocaine Decreases the Incidence of Persistent Pain After Breast Surgery

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