The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man
Abstract
Oral doses of dextromethorphan (DM), a common cough suppressant and N-methyl-D-aspartate (NMDA) receptor antagonist, and their vehicle control were given on a double-blind basis to normal volunteer human subjects who rated intensities of first and second pain in response to repeated painful electric shocks and repeated 52 degrees C heat pulses. Doses of 30 and 45 mg, but not 15 mg, were effective in attenuating temporal summation of second pain, a psychophysical correlate of temporal summation of C afferent-mediated responses of dorsal horn nociceptive neurons, termed 'wind-up'. By contrast, neither first nor second pain evoked by the first stimulus in a train of stimuli were affected by any of these doses of DM. These results further confirm temporal summation of second pain as a psychophysical correlate of wind-up by providing evidence that DM selectively reduces temporal summation of second pain, as has been shown for wind-up.
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Cites
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Anis, N. A., Berry, S. C., Burton, N. R., & Lodge, D. (1983) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1983.tb11031.x · Cited by 1,399
Price, D. D., Bush, F. M., Long, S., & Harkins, S. W. (1994) · Pain · doi:10.1016/0304-3959(94)90097-3 · Cited by 1,174 · cited 4×
“These electrophysiological events are thought to provide the basis for spontaneous pain and hyperalgesia (see Bennett 1991, Mao et al. 1994, and Price et al. 1994a for reviews).”
BackgroundMethodInfluentialSelf-citationPhysiological properties of unmyelinated fiber projection to the spinal cord
Mendell, L. M. (1966) · Experimental Neurology · doi:10.1016/0014-4886(66)90068-9 · Cited by 845
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Painful neuropathy: altered central processing maintained dynamically by peripheral input
Gracely, R. H., Lynch, S. A., & Bennett, G. J. (1992) · Pain · doi:10.1016/0304-3959(92)90259-e · Cited by 785
Davies, S. N., & Lodge, D. (1987) · Brain Research · doi:10.1016/0006-8993(87)91487-9 · Cited by 663
Price, D. D., Hu, J. W., Dubner, R., & Gracely, R. H. (1977) · Pain · doi:10.1016/0304-3959(77)90035-5 · Cited by 589
Self-citationRen, K., Hylden, J. L. K., Williams, G. M., Ruda, M. A., & Dubner, R. (1992) · Pain · doi:10.1016/0304-3959(92)90039-e · Cited by 412
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Cited by
Staud, R., Vierck, C. J., Cannon, R. L., Mauderli, A. P., & Price, D. D. (2001) · Pain · doi:10.1016/s0304-3959(00)00432-2 · Cited by 774
Self-citationWind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Assessment and manifestation of central sensitisation across different chronic pain conditions
Arendt‐Nielsen, L., Morlion, B., Perrot, S., Dahan, A., Dickenson, A., Kress, H. G., Wells, C., Bouhassira, D., & Drewes, A. M. (2018) · European Journal of Pain · doi:10.1002/ejp.1140 · Cited by 695
Danysz, W., & Parsons, C. G. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01382-6 · Cited by 649
Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation
Fields, H. L., Rowbotham, M., & Baron, R. (1998) · Neurobiology of Disease · doi:10.1006/nbdi.1998.0204 · Cited by 561
Metadata
- Authors
- Price, D. D., Mao, J., Frenk, H., & Mayer, D. J.
- Venue
- Pain
- Published
- 1994-11
- Volume
- 59
- Issue
- 2
- Pages
- 165-174
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W1500514965
- Cited by
- 364
- References
- 36
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Price, D. D., Mao, J., Frenk, H., & Mayer, D. J. (1994). The Symbol receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man. Pain. https://doi.org/10.1016/0304-3959(94)90069-8
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
