The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input
Abstract
Hyperactivity of N-methyl D-aspartate (NMDA) receptors may be one of the factors in the maintenance of persistent stump and phantom limb pain. Ketamine (bolus at 0.1 mg/kg/5 min followed by an infusion of 7 micrograms/kg/min) was administered intravenously to 11 patients with established stump and phantom limb pain in a double-blind saline-controlled study. All 11 patients responded with a decrease in the rating of stump and phantom limb pain assessed by visual analogue scale (VAS) and McGill Pain Questionnaire (MPQ). Ketamine increased pressure-pain thresholds significantly. Wind-up like pain (pain evoked by repeatedly tapping the dysaesthetic skin area) was reduced significantly by ketamine. In contrast, no effect was seen on pain evoked by repeated thermal stimuli. Side effects were observed in nine patients. The results support the notion that stump and phantom pain are generated by activity in afferent fibres activated by mechanical but not by thermal stimuli and that the NMDA receptor is involved in the maintenance of postamputation pain states. NMDA receptor antagonists may have a potential in the treatment of stump and phantom limb pain.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
Bennett, G. J., & Xie, Y.-K. (1988) · Pain · doi:10.1016/0304-3959(88)90209-6 · Cited by 5,376
Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R. (1993) · Pain · doi:10.1016/0304-3959(93)90161-h · Cited by 1,966
Cited by
Spared nerve injury: an animal model of persistent peripheral neuropathic pain
Decosterd, I., & Woolf, C. J. (2000) · Pain · doi:10.1016/s0304-3959(00)00276-1 · Cited by 2,307
Katz, J., & Melzack, R. (1999) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70381-9 · Cited by 723
Wind-up of spinal cord neurones and pain sensation: much ado about something?
Herrero, J. F., Laird, J. M. A., & Lopez-Garcia, J. A. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00051-9 · Cited by 714
Assessment and manifestation of central sensitisation across different chronic pain conditions
Arendt‐Nielsen, L., Morlion, B., Perrot, S., Dahan, A., Dickenson, A., Kress, H. G., Wells, C., Bouhassira, D., & Drewes, A. M. (2018) · European Journal of Pain · doi:10.1002/ejp.1140 · Cited by 695
Self-citationSchwenk, E. S., Viscusi, E. R., Buvanendran, A., Hurley, R. W., Wasan, A. D., Narouze, S., Bhatia, A., Davis, F. N., Hooten, W. M., & Cohen, S. P. (2018) · Regional Anesthesia and Pain Medicine · doi:10.1097/aap.0000000000000806 · Cited by 584
Metadata
- Authors
- Nikolajsen, L., Hansen, C. L., Nielsen, J., Keller, J., Arendt-Nielsen, L., & Jensen, T. S.
- Venue
- Pain
- Published
- 1996-09
- Volume
- 67
- Issue
- 1
- Pages
- 69-77
- ISSN
- 0304-3959 (ISSN-L)
- OpenAlex
- W2059441972
- Cited by
- 352
- References
- 2
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. https://app.cochat.ai/papers/10.1016/0304-3959(96)03080-1
- The paper
- Nikolajsen, L., Hansen, C. L., Nielsen, J., Keller, J., Arendt-Nielsen, L., & Jensen, T. S. (1996). The effect of ketamine on phantom pain: a central neuropathic disorder maintained by peripheral input. Pain. https://doi.org/10.1016/0304-3959(96)03080-1
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
