Cited by 5,376Pain Mechanisms and TreatmentsPain Management and TreatmentIon Channels and Receptors

A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man

Bennett, Gary J., Xie, Y.-K.·1988·Pain

Abstract

A peripheral mononeuropathy was produced in adult rats by placing loosely constrictive ligatures around the common sciatic nerve. The postoperative behavior of these rats indicated that hyperalgesia, allodynia and, possibly, spontaneous pain (or dysesthesia) were produced. Hyperalgesic responses to noxious radiant heat were evident on the second postoperative day and lasted for over 2 months. Hyperalgesic responses to chemogenic pain were also present. The presence of allodynia was inferred from the nocifensive responses evoked by standing on an innocuous, chilled metal floor or by innocuous mechanical stimulation, and by the rats' persistence in holding the hind paw in a guarded position. The presence of spontaneous pain was suggested by a suppression of appetite and by the frequent occurrence of apparently spontaneous nocifensive responses. The affected hind paw was abnormally warm or cool in about one-third of the rats. About one-half of the rats developed grossly overgrown claws on the affected side. Experiments with this animal model may advance our understanding of the neural mechanisms of neuropathic pain disorders in humans.

Integrity signals

Registry

Crossref · 10.1016/0304-3959(88)90209-6

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34 of 34 references verified0 citation errors · 0 not checkable

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  • Chronic constriction injury produces mechanical allodynia as well as thermal allodynia and hyperalgesia in the ipsilateral paw as early as two days post-surgery.

    “CCI produces mechanical allodynia as well as thermal allodynia and hyperalgesia in the ipsilateral paw as early as two days post-surgery.37”

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Authors
Bennett, G. J., & Xie, Y.-K.
Affiliations
National Institutes of Health (US)
Corresponding author
Bennett, Gary J.
Venue
Pain
Published
1988-04
Volume
33
Issue
1
Pages
87-107
ISSN
0304-3959 (ISSN-L)
OpenAlex
W2058020736
Cited by
5,376
References
34
Citations by year
2026: 119 · 2025: 161 · 2024: 186 · 2023: 147 · 2022: 194 · 2021: 215 · 2020: 234 · 2019: 197 · 2018: 191 · 2017: 205 · 2016: 198 · 2015: 206 · 2014: 220 · 2013: 222 · 2012: 199
FWCI
16.45
Type
journal article
Language
en
Open access
closed
Locations
  • Pain (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fogarty International Center
Topics
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
peripheral mononeuropathy, sciatic nerve constriction, neuropathic pain, hyperalgesia, allodynia, spontaneous pain, dysesthesia, nocifensive behavior, thermal pain
MeSH terms
Animals, Behavior, Animal, Cold Temperature, Hot Temperature, Hyperalgesia, Hyperesthesia, Ligation, Male, Neurons, Afferent, Pain, Peripheral Nervous System Diseases, Rats, Inbred Strains, Reaction Time, Sciatic Nerve, Skin, Time Factors, Rats

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