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Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

Pazos, A., Probst, A., Palacios, J.M.·1987·Neuroscience

DOI 10.1016/0306-4522(87)90327-7

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Abstract

The anatomical distribution of serotonin-2 receptors in the human brain was studied by light microscopic autoradiography, using [3H]ketanserin as a ligand. The receptor densities were quantified by microdensitometry with the aid of a computer-assisted image-analysis system. A heterogeneous distribution of serotonin-2 receptor densities was found in the human brain. Very high concentrations were localized over layers III and V of several cortical areas, including the frontal, parietal, temporal and occipital lobes, the anterogenual cortex and the entorhinal area, as well as in the corpus mamillare of the hypothalamus. The claustrum, nucleus lateralis of the amygdala and some cortical layers also presented a high density of serotonin-2 receptors. Intermediate concentrations were found over the hippocampus, the caudatus, putamen and accumbens nuclei, and some nuclei of the amygdala, among other structures. Areas such as the thalamus, brain stem, cerebellum and spinal cord contained, in general, only low to very low densities of serotonin-2 receptors. A very high level of non-specific binding, which was not displaceable by any serotonin-2 compound, was found in some areas of the human brain, including the caudatus and putamen nuclei, the substantia nigra and the raphé nuclei. The distribution of serotonin-2 receptors in the human brain described herein is discussed in relation to the distribution of serotonergic innervation, the central effects which have been proposed to be serotonin-2-mediated, and the neuropathological characteristics of the diseases where a modification in the number of serotonin-2 receptors has been reported.

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Authors: Pazos, A., Probst, A., & Palacios, J. M.
Affiliations: University of Basel (CH)
Sandoz Group AG (Switzerland) (CH)
Corresponding author: Palacios, J.M.
ORCID: Palacios, J.M.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1987-04
Volume: 21
Issue: 1
Pages: 123-139
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(87)90327-7
OpenAlex: W4319425390
Cited by: 355
References: 75
Citations by year: 2026: 6 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 14 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 4
FWCI: 4.07
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: serotonin 2 receptor, human brain, receptor distribution, entorhinal area, hippocampus, basal ganglia, substantia nigra, raphe nuclei, non-specific binding, serotonergic innervation, neurodegenerative diseases

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Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors

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