The DOI matches its Crossref record; 71 of the 75 references it cites were found in a registry or an index.
Serotonin receptors in the human brain—IV. Autoradiographic mapping of serotonin-2 receptors
Abstract
The anatomical distribution of serotonin-2 receptors in the human brain was studied by light microscopic autoradiography, using [3H]ketanserin as a ligand. The receptor densities were quantified by microdensitometry with the aid of a computer-assisted image-analysis system. A heterogeneous distribution of serotonin-2 receptor densities was found in the human brain. Very high concentrations were localized over layers III and V of several cortical areas, including the frontal, parietal, temporal and occipital lobes, the anterogenual cortex and the entorhinal area, as well as in the corpus mamillare of the hypothalamus. The claustrum, nucleus lateralis of the amygdala and some cortical layers also presented a high density of serotonin-2 receptors. Intermediate concentrations were found over the hippocampus, the caudatus, putamen and accumbens nuclei, and some nuclei of the amygdala, among other structures. Areas such as the thalamus, brain stem, cerebellum and spinal cord contained, in general, only low to very low densities of serotonin-2 receptors. A very high level of non-specific binding, which was not displaceable by any serotonin-2 compound, was found in some areas of the human brain, including the caudatus and putamen nuclei, the substantia nigra and the raphé nuclei. The distribution of serotonin-2 receptors in the human brain described herein is discussed in relation to the distribution of serotonergic innervation, the central effects which have been proposed to be serotonin-2-mediated, and the neuropathological characteristics of the diseases where a modification in the number of serotonin-2 receptors has been reported.
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“A similar pattern of 5-HT2A receptor expression has been shown in human post-mortem tissue using both autoradiography (211) and in situ hybridization (212).”
From Psychedelics and Other Psychoplastogens for Treating Mental Illness. (2021) · cites this paper as [211]
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Cites
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A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,211
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Metadata
- Authors
- Pazos, A., Probst, A., & Palacios, J. M.
- Affiliations
- University of Basel (CH)
- Sandoz Group AG (Switzerland) (CH)
- Corresponding author
- Palacios, J.M.
- ORCID
- Palacios, J.M.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 1987-04
- Volume
- 21
- Issue
- 1
- Pages
- 123-139
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W4319425390
- Cited by
- 355
- References
- 75
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 6 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 9 · 2017: 14 · 2016: 6 · 2015: 9 · 2014: 10 · 2013: 6 · 2012: 4
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- serotonin 2 receptor, human brain, receptor distribution, entorhinal area, hippocampus, basal ganglia, substantia nigra, raphe nuclei, non-specific binding, serotonergic innervation, neurodegenerative diseases
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