The ontogeny of excitatory amino acid receptors in rat forebrain--I. N-methyl-D-aspartate and quisqualate receptors

Insel, T.R.; Miller, L.P.; Gelhard, R.E.

doi:10.1016/0306-4522(90)90117-m

Cited by 529Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismReceptor Mechanisms and Signaling

The ontogeny of excitatory amino acid receptors in rat forebrain--I. N-methyl-D-aspartate and quisqualate receptors

Insel, T.R., Miller, L.P., Gelhard, R.E.·1990·Neuroscience

DOI 10.1016/0306-4522(90)90117-m

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Abstract

The ontogeny of radioligand binding to N-methyl-D-aspartate and quisqualate receptors in rat forebrain was studied quantitatively using in vitro receptor autoradiography. Specific binding to both receptors could be detected by postnatal day 1 in hippocampus and striatum. The adult pattern of binding to N-methyl-D-aspartate receptors emerged by postnatal day 14 with high densities of binding in CA1 (stratum oriens and stratum radiatum), dentate gyrus (molecular layer) and striatum (caudate-putamen). Binding to the outer laminae of frontal cortex was as much as 45% above adult levels during development. Binding of [3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid to quisqualate receptors showed a similar overshoot during development, but also manifested a unique distribution with CA3 and medial aspects of the amygdala exhibiting transient, intense labeling. Homogenate binding studies with [3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid demonstrated a 73% increase in quisqualate receptors in whole brain at postnatal day 21 compared with adult levels. The selectivity of excitatory amino acid binding to the quisqualate site in development was similar to the selectivity in adult brain. These data taken with other recent reports, suggest that quisqualate receptors may have a role in development distinct from their function in the adult brain.

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In rats, AMPA/Kainate receptor binding sites and GluR2 protein begin to decline between ~P24-P30 and P60.
“In rats, AMPA/Kainate receptor binding sites (Insel et al., 1990) and GluR2 protein (Murphy et al., 2012) begin to decline between ~P24-P30 and P60.”
From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Insel et al., 1990

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Authors: Insel, T. R., Miller, L. P., & Gelhard, R. E.
Affiliations: National Institute of Mental Health (US)
Georgetown University (US)
Corresponding author: Insel, T.R.
ORCID: Insel, T.R.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1990-01
Volume: 35
Issue: 1
Pages: 31-43
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(90)90117-m
OpenAlex: W2011448874
Cited by: 529
References: 46
Citations by year: 2026: 2 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 6 · 2020: 8 · 2019: 17 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 8 · 2014: 9 · 2013: 16 · 2012: 10
FWCI: 11.05
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords: glutamate receptors, NMDA receptor, quisqualate receptors, receptor development, ontogeny, forebrain, hippocampus, striatum, frontal cortex, amygdala, postnatal development, receptor autoradiography, radioligand binding
MeSH terms: Aging, Animals, Frontal Lobe, Glutamates, Ibotenic Acid, Rats, Inbred Strains, Receptors, N-Methyl-D-Aspartate, Receptors, Neurotransmitter, Receptors, AMPA, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Neurotransmitter Agents, Glutamic Acid, Rats

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The ontogeny of excitatory amino acid receptors in rat forebrain--I. N-methyl-D-aspartate and quisqualate receptors

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