Adolescence: booze, brains, and behavior
Abstract
This article represents the proceedings of a symposium at the 2004 Research Society on Alcoholism meeting in Vancouver, British Columbia, Canada, organized and chaired by Peter M. Monti and Fulton T. Crews. The presentations and presenters were (1) Introduction, by Peter M. Monti; (2) Adolescent Binge Drinking Causes Life-Long Changes in Brain, by Fulton T. Crews and Kim Nixon; (3) Functional Neuroimaging Studies in Human Adolescent Drinkers, by Susan F. Tapert; (4) Abnormal Emotional Reactivity as a Risk Factor for Alcoholism, by Robert Miranda, Jr.; (5) Alcohol-Induced Memory Impairments, Including Blackouts, and the Changing Adolescent Brain, by Aaron M. White and H. Scott Swartzwelder; and (6) Discussion, by Kenneth Sher.
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Adolescents are more vulnerable to alcohol-induced neurotoxicity.
“However, they are more vulnerable to alcohol-induced neurotoxicity (Crews et al., 2000; Crews et al., 2006b; Monti et al., 2005).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Monti et al., 2005
Adolescents are less sensitive to the sedative effects of alcohol.
“Adolescents are less sensitive to the sedative effects of alcohol (Monti et al., 2005; Silveri and Spear, 1998), which allows them to stay awake to drink more alcohol.”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Monti et al., 2005
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Adolescent cortical development: A critical period of vulnerability for addiction
Crews, F., He, J., & Hodge, C. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.12.001 · Cited by 1,091 · see citing works
“Adolescents are less sensitive to the sedative effects of alcohol (Silveri and Spear, 1998), which allows them to binge drink, however, they are more vulnerable to alcoholinduced neurotoxicity (Monti et al., 2005).”
BackgroundWiers, R. W., Bartholow, B. D., van den Wildenberg, E., Thush, C., Engels, R. C. M. E., Sher, K. J., Grenard, J., Ames, S. L., & Stacy, A. W. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.09.021 · Cited by 734 · see citing works
“Animal studies have revealed that alcohol exposure (especially at intoxicating dosages) impairs cognitive abilities more in adolescents than in adults (e.g., Monti et al., 2005; White et al., 2000; White and Swartzwelder, 2004) and that this impairment is long-lasting.”
BackgroundThe role of early life stress as a predictor for alcohol and drug dependence
Enoch, M.-A. (2011) · Psychopharmacology · doi:10.1007/s00213-010-1916-6 · Cited by 668 · see citing works
“Heavy drinking during adolescence can impair brain development (Guerri and Pascual 2010; Monti et al. 2005; Witt 2010).”
BackgroundImpulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679 · see citing works
“However, they are more vulnerable to alcohol-induced neurotoxicity (Crews et al., 2000, 2006b; Monti et al., 2005).”
BackgroundAdolescent impulsivity phenotypes characterized by distinct brain networks
the IMAGEN Consortium, Whelan, R., Conrod, P. J., Poline, J.-B., Lourdusamy, A., Banaschewski, T., Barker, G. J., Bellgrove, M. A., Büchel, C., Byrne, M., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3092 · Cited by 420 · see citing works
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“In comparison with adult drinking, however, relatively little is known about adolescent drinking and its prolonged neurobiological impact during this developmental period (Monti et al., 2005).”
BackgroundKing, K. M., & Chassin, L. (2007) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2007.68.256 · Cited by 348 · see citing works
Cannabis use before age 15 and subsequent executive functioning
Fontes, M. A., Bolla, K. I., Cunha, P. J., Almeida, P. P., Jungerman, F. S., Laranjeira, R., Bressan, R. A., & Lacerda, A. L. T. (2011) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.110.077479 · Cited by 300 · see citing works
Lisdahl, K. M., Hanson, K. L., Schweinsburg, A. D., Cohen‐Zion, M., Nagel, B. J., & Tapert, S. F. (2007) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617707071032 · Cited by 296 · see citing works
Lisdahl, K. M., Gilbart, E. R., Wright, N. E., & Shollenbarger, S. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00053 · Cited by 284 · see citing works
“Animal studies have suggested that compared to adults, adolescents may be particularly vulnerable to the neurotoxic effects of early alcohol use onset (AUO) (see Barron et al., 2005; Monti et al., 2005; Spear, 2010 for previous reviews).”
BackgroundLisdahl, K. M., Schweinsburg, A. D., Cohen‐Zion, M., Nagel, B. J., & Tapert, S. F. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.10.010 · Cited by 280 · see citing works
“Adolescents may be particularly vulnerable to the neurotoxic effects of alcohol (see Barron et al., 2005; Monti et al., 2005; Spear, 2000).”
BackgroundAge of onset of marijuana use and executive function.
Gruber, S. A., Sagar, K. A., Dahlgren, M. K., Racine, M. T., & Lukas, S. E. (2011) · Psychology of Addictive Behaviors · doi:10.1037/a0026269 · Cited by 267 · see citing works
“…neuromaturation, with increasing evidence that the adolescent brain may be more vulnerable to the effects of drugs and alcohol than the adult brain (Monti et al., 2005), and those who are at the greatest risk for adverse consequences appear to represent a growing population of consumers of MJ…”
BackgroundDecision making and binge drinking: a longitudinal study
Goudriaan, A. E., Grekin, E. R., & Sher, K. J. (2007) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00378.x · Cited by 257 · see citing works
“Human and animal studies indicate that adolescence is a developmental period during which brain structures and functions have a higher vulnerability to the effects of heavy alcohol use, than during adulthood (Brown et al., 2000; De Bellis et al., 2000; Markwiese et al., 1998; Monti et al., 2005).”
BackgroundVerbal learning and memory in adolescent cannabis users, alcohol users and non-users
Solowij, N., Jones, K. A., Rozman, M. E., Davis, S. M., Ciarrochi, J., Heaven, P. C. L., Lubman, D. I., & Yücel, M. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2203-x · Cited by 227 · see citing works
Effects of home access and availability of alcohol on young adolescents' alcohol use
Komro, K. A., Maldonado‐Molina, M. M., Tobler, A. L., Bonds, J. R., & Muller, K. E. (2007) · Addiction · doi:10.1111/j.1360-0443.2007.01941.x · Cited by 225 · see citing works
Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence
Hanson, K. L., Winward, J. L., Schweinsburg, A. D., Lisdahl, K. M., Brown, S. A., & Tapert, S. F. (2010) · Addictive Behaviors · doi:10.1016/j.addbeh.2010.06.012 · Cited by 229 · see citing works
“Within several hours to days since last use, heavy marijuana users have shown decrements in attention, memory, executive function, time estimation, and psychomotor speed (Pope & Yurgelun-Todd, 1996; Solowij et al., 2002; Varma et al., 1988).”
BackgroundGenetic and Environmental Influences on the Development of Alcoholism
Enoch, M. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1376.019 · Cited by 214 · see citing works
SPEAR, L. P., & Swartzwelder, H. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.04.012 · Cited by 202 · see citing works
Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity
Gruber, S. A., Dahlgren, M. K., Sagar, K. A., Gönenç, A., & Lukas, S. E. (2014) · Psychopharmacology · doi:10.1007/s00213-013-3326-z · Cited by 177 · see citing works
“…is a time of neuromaturation, with increasing evidence that the adolescent brain is more vulnerable to the effects of drugs than the adult brain (Monti et al. 2005), those at the greatest risk for adverse consequences represent a growing population of consumers of MJ (Schneider 2008), posing a…”
BackgroundDoom, J. R., VanZomeren‐Dohm, A., & Simpson, J. A. (2015) · Development and Psychopathology · doi:10.1017/s0954579415001169 · Cited by 170 · see citing works
Neurobiology of the Adolescent Brain and Behavior: Implications for Substance Use Disorders
Casey, B. J., & Jones, R. M. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.08.017 · Cited by 692 · see citing works
Chassin, L., Sher, K. J., Hussong, A. M., & Curran, P. J. (2013) · Development and Psychopathology · doi:10.1017/s0954579413000771 · Cited by 152 · see citing works
“The associated neurocognitive deficits, especially those associated with deficits in prefontal and limbic systems (Monti et al., 2005), could pose added risk for heavier alcohol involvement and engagement in a range of externalizing behaviors (e.g., Bava & Tapert, 2010).”
Substance use and the adolescent brain: A toxic combination?
Lubman, D. I., Yücel, M., & Hall, W. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881107078309 · Cited by 135 · see citing works
Vetreno, R. P., Qin, L., & Crews, F. T. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.07.002 · Cited by 132 · see citing works
“As a consequence of binge drinking and higher blood alcohol contents, there is a greater risk of alcohol-induced neurotoxicity (Crews et al. 2007; Monti et al. 2005) and activation of the innate immune system in the brain that may alter adolescent-typical cortical maturation.”
BackgroundBinge Drinking Affects Attentional and Visual Working Memory Processing in Young University Students
Crego, A., Holguı́n, S. R., Parada, M., Mota, N., Corral, M., & Cadaveira, F. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.01025.x · Cited by 131 · see citing works
“adult brain, particularly those brain structures that mature late on in development, such as the hippocampus and the prefrontal cortex (Hunt, 1993; Monti et al., 2005; White and Swartzwelder, 2004).”
BackgroundResearch on alcohol and adolescent brain development: opportunities and future directions
Witt, E. D. (2010) · Alcohol · doi:10.1016/j.alcohol.2009.08.011 · Cited by 125 · see citing works
“In addition, adult rats exposed to binge alcohol treatment during adolescence exhibit increased serotonin transporter density in several regions including the forebrain, possibly as a result of changes in serotonergic innervation (Monti et al., 2005).”
BackgroundNeurobiology of adolescent substance use and addictive behaviors: treatment implications.
Hammond, C. J., Mayes, L. C., & Potenza, M. N. (2014) · PubMed · Cited by 115 · see citing works
A Prospective Study of Sexual Assault and Alcohol Use Among First-Year College Women
Mouilso, E. R., Fischer, S. F., & Calhoun, K. S. (2012) · Violence and Victims · doi:10.1891/0886-6708.27.1.78 · Cited by 113 · see citing works
“Alcohol researchers have begun to suggest that heavy alcohol use during brain development disrupts critical ongoing processes and results in neurocognitive deficits (Monti et al., 2005; Spear, 2002; Zeigler et al., 2005).”
BackgroundWelch, K. A., Carson, A. J., & Lawrie, S. M. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt037 · Cited by 112 · see citing works
“Specifically, reduced grey matter has been reported in the amygdala, anterior insula and orbitofrontal cortex of adolescents with conduct disorder (Monti et al., 2005; Sterzer et al., 2007; Fairchild et al., 2011).”
Clarke, R. J., Clarke, E. A., Roe-Sepowitz, D. E., & Fey, R. (2012) · Journal of Human Behavior in the Social Environment · doi:10.1080/10911359.2012.655583 · Cited by 109 · see citing works
“Alcohol may have less of a sedative effect on adolescents than adults (Silveri & Spear, 1998), and addictive substance use behavior patterns may be programmed during this period (Monti et al., 2005).”
BackgroundInfluentialAn investigation of the behavioral actions of ethanol across adolescence in mice
Hefner, K. R., & Holmes, A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0646-2 · Cited by 109 · see citing works
“various neuroanatomical and neurophysiological measures (De Bellis et al. 2000, 2005; Monti et al. 2005).”
BackgroundCrego, A., Holguı́n, S. R., Parada, M., Mota, N., Corral, M., & Cadaveira, F. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.11.020 · Cited by 105 · see citing works
The Prospective Association Between Sipping Alcohol by the Sixth Grade and Later Substance Use
Jackson, K. M., Barnett, N. P., Colby, S. M., & Rogers, M. L. (2015) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2015.76.212 · Cited by 105 · see citing works
Balodis, I. M., Potenza, M. N., & Olmstead, M. C. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328330c779 · Cited by 101 · see citing works
“binge drinking) may be particularly detrimental for college-aged students because motivational neurocircuitry underlying risk, reward, and decision making continues to develop during this period (Crews et al., 2000; Chambers et al., 2003; Monti et al., 2005).”
BackgroundVarlinskaya, E. I., & SPEAR, L. P. (2006) · Developmental Psychobiology · doi:10.1002/dev.20124 · Cited by 100 · see citing works
Neurobiological Processes in Adolescent Addictive Disorders
Schepis, T. S., Adinoff, B. H., & Rao, U. (2008) · American Journal on Addictions · doi:10.1080/10550490701756146 · Cited by 95 · see citing works
A model-based cluster analysis approach to adolescent problem behaviors and young adult outcomes
Mun, E., Windle, M. T., & Schainker, L. M. (2008) · Development and Psychopathology · doi:10.1017/s095457940800014x · Cited by 91 · see citing works
“…such as heavy alcohol use, in and of itself, is shown to damage the prefrontal cortex, which is critical for executive functions such as impulse control and goal setting in animal models, and to lead to impaired cognitive functioning in human adolescents (Monti et al., 2005; Reyna & Farley, 2006).”
BackgroundThe role of executive control in human drug addiction
Hester, R., Lubman, D. I., & Yücel, M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_28 · Cited by 83 · see citing works
“, a family history of alcoholism) suggest impairments in frontal functioning are apparent prior to drug use exposure (Monti et al. 2005; Schweinsburg et al. 2005) and can predict later substance use (Deckel and Hesselbrock 1996; see also Ivanov et al.”
BackgroundHaller, M., Handley, E., Chassin, L., & Bountress, K. (2010) · Development and Psychopathology · doi:10.1017/s0954579410000532 · Cited by 101 · see citing works
Evrard, S. G., Vega, M. D., Tagliaferro, P. A., Mirochnic, S., Caltana, L. R., & Brusco, A. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.03.001 · Cited by 78 · see citing works
Fleming, R. L., Wilson, W. A., & Swartzwelder, H. S. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00101.2007 · Cited by 77 · see citing works
The declining trend in Swedish youth drinking: collectivity or polarization?
Norström, T., & Svensson, J. (2014) · Addiction · doi:10.1111/add.12510 · Cited by 75 · see citing works
“In addition to short-term negative outcomes such as injuries and violence, there is evidence that brain development during adolescence may be affected adversely by alcohol [2,3].”
BackgroundImpact of ADHD and cannabis use on executive functioning in young adults
Tamm, L., Epstein, J. N., Lisdahl, K. M., Molina, B. S. G., Tapert, S. F., Hinshaw, S. P., Arnold, L. E., Velanova, K., Abikoff, H., & Swanson, J. M. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.08.001 · Cited by 75 · see citing works
“Thus, adolescence is a particularly vulnerable time for neurocognitive effects of substance use (Monti et al., 2005).”
BackgroundStrandheim, A., Holmen, T. L., Coombes, L., & Bentzen, N. (2009) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-3-18 · Cited by 71 · see citing works
Schulteis, G., Archer, C., Tapert, S. F., & Frank, L. R. (2008) · Alcohol · doi:10.1016/j.alcohol.2008.05.002 · Cited by 71 · see citing works
“Long-term treatment with high doses of ethanol results in increased damage to certain cortical regions in adolescent (PD35) versus adult rats (PD80e90) (Crews et al., 2000; Monti et al., 2005), and also leads to lasting deficits in spatial memory that outlast the period of ethanol treatment (Tomlinson et al.”
Maldonado‐Devincci, A. M., Alipour, K. K., Michael, L. A., & Kirstein, C. L. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.07.008 · Cited by 70 · see citing works
“Moreover, recent work indicates that binge fourday EtOH administration has greater detrimental effects on brain structure and function in adolescent as compared with adult rats (Crews et al., 2000; Monti et al., 2005).”
BackgroundCurrent hypotheses on the mechanisms of alcoholism
Vetreno, R. P., & Crews, F. T. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00027-6 · Cited by 71 · see citing works
“In contrast, they are more vulnerable to alcohol-induced neurotoxicity (Monti et al., 2005; Crews et al., 2007).”
BackgroundPetit, G., Kornreich, C., Maurage, P., Noël, X., Letesson, C., Verbanck, P., & Campanella, S. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.10.042 · Cited by 69 · see citing works
“, 2000, 2006) have suggested that adolescence is a critical stage in the development of the brain, which is particularly sensitive to the neurotoxic effects of alcohol, in particular brain structures that mature during this period, such as the hippocampus and the prefrontal cortex (Hunt, 1993; Monti et al., 2005; Whit…”
BackgroundAssociation of PER2 genotype and stressful life events with alcohol drinking in young adults
Blomeyer, D., Buchmann, A. F., Lascorz, J., Zimmermann, U. S., Esser, G., Desrivieres, S., Schmidt, M. H., Banaschewski, T., Schumann, G., & Laucht, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059136 · Cited by 65 · see citing works
“Adolescence and young adulthood are periods of particular importance for the development of substance use disorders, as the brain is still in a developing phase and thus prone to alcohol related alterations [19,20].”
BackgroundFinn, P., Rickert, M. E., Miller, M. A., Lucas, J., Bogg, T., Bobova, L., & Cantrell, H. (2009) · Journal of Abnormal Psychology · doi:10.1037/a0014656 · Cited by 64 · see citing works
“Research clearly indicates recent substance use does affect brain and neurocognitive function (Medina, Schweinsburg, Cohen-Zion, Nagel, & Tapert, 2007; Monti et al., 2005).”
Bogg, T., & Finn, P. (2010) · Journal of Personality · doi:10.1111/j.1467-6494.2010.00622.x · Cited by 64 · see citing works
Faria, R. R., Rueda, A. V. L., Sayuri, C., Soares, S. L., Malta, M. B., Carrara‐Nascimento, P. F., Alves, A. D. S., Marcourakis, T., Yonamine, M., Scavone, C., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.056 · Cited by 63 · see citing works
SURVEILLANCE REPORT #107 TRENDS IN UNDERAGE DRINKING IN THE UNITED STATES, 1991–2015
Chen, C. M., Yoon, Y., & Faden, V. B. (2017) · doi:10.13140/rg.2.2.22612.19841 · Cited by 62 · see citing works
Neurobiology of Adolescent Substance Use Disorders: Implications for Prevention and Treatment
Rutherford, H., Mayes, L., & Potenza, M. (2010) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2010.03.003 · Cited by 59 · see citing works
“Further, evidence suggests that the adolescent brain is more vulnerable to the effects of substance use [47], with animal studies showing that substance use in adolescent rats disturbs neuroendocrine functioning [48].”
BackgroundAlcohol use across the lifespan: An analysis of adolescent and aged rodents and humans
Novier, A., Diaz‐Granados, J. L., & Matthews, D. B. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.03.015 · Cited by 59 · see citing works
McAlaney, J., Helmer, S. M., Stock, C., Vriesacker, B., Hal, G. F. V., Dempsey, R. C., Akvardar, Y., Salonna, F., Kalina, O., Guillén‐Grima, F., et al. (2015) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2015.76.430 · Cited by 59 · see citing works
“Heavy alcohol use in young adults may result in cognitive and neurological impairments (Hartley et al., 2004; Monti et al., 2005), although these effects may not become permanent if the individual can be encouraged to avoid further episodes of heavy consumption (Mota et al., 2013).”
BackgroundBrain Activation, Response Inhibition, and Increased Risk for Substance Use Disorder
McNamee, R. L., Edelman, K. L., Luna, B., Clark, D. B., Eddy, W. F., & Tarter, R. E. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00604.x · Cited by 59 · see citing works
Chronic tolerance to the social consequences of ethanol in adolescent and adult Sprague-Dawley rats
Varlinskaya, E. I., & SPEAR, L. P. (2006) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2006.08.009 · Cited by 59 · see citing works
“Indeed, there are a number of reports that ethanol-induced damage in these and other brain regions may be more pronounced during adolescence than in adulthood [5,22].”
BackgroundSubstance Use and Substance Use Disorders
Chassin, L., Colder, C. R., Hussong, A. M., & Sher, K. J. (2016) · Wiley eBooks · doi:10.1002/9781119125556.devpsy319 · Cited by 59 · see citing works
Psychopathological Development Across Adolescence
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“There is also some evidence that responses to alcohol change with age (Monti et al., 2005).”
BackgroundAddiction, Adolescence, and Innate Immune Gene Induction
Crews, F. T., & Vetreno, R. P. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00019 · Cited by 52 · see citing works
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“Furthermore, there are some suggestions from recent work that alcohol use may cause long-term structural and functional changes in the developing brains of adolescents (Brown & Tapert, 2004; Monti et al., 2005).”
BackgroundIncreased amplitude of P3 event-related potential in young binge drinkers
Crego, A., Cadaveira, F., Parada, M., Corral, M., Caamaño‐Isorna, F., & Holguı́n, S. R. (2012) · Alcohol · doi:10.1016/j.alcohol.2011.10.002 · Cited by 50 · see citing works
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“This prevalence of heavy drinking occurs during a period when the brain is undergoing rapid changes in structure and function that make it vulnerable to negative consequences of alcohol exposure (Dahl, 2004; Monti et al., 2005; Pfefferbaum et al., 2016).”
Lyvers, M., Duff, H., Basch, V., & Edwards, M. S. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.03.028 · Cited by 49 · see citing works
“(2011) found an inverse relationship between SR and the age at which an individual started drinking weekly (AOD), suggesting that over-responsiveness to reward contingencies influences the drinking-related choices made at younger ages (Crews et al., 2007; Loxton & Dawe, 2001; Monti et al., 2005; Pardo, Aguilar, Molinu…”
BackgroundSpoelder, M., Tsutsui, K. T., Lesscher, H. M. B., Vanderschuren, L. J. M. J., & Clark, J. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.139 · Cited by 48 · see citing works
“…an increasing number of studies have revealed that the adolescent brain is particularly vulnerable to alcohol-induced functional changes (Crews et al, 2007; Guerri and Pascual 2010; Monti et al, 2005; Philpot et al, 2009; Schindler et al, 2014; Squeglia et al, 2012; Zeigler et al, 2005).”
BackgroundValencia, M. L. C., Tran, B. T., Lim, M. K., Choi, K. S., & Oh, J.-K. (2019) · Asia Pacific Journal of Public Health · doi:10.1177/1010539519860732 · Cited by 48 · see citing works
Progression through Early Drinking Milestones in an Adolescent Treatment Sample
Jackson, K. M. (2010) · Addiction · doi:10.1111/j.1360-0443.2009.02800.x · Cited by 46 · see citing works
“Early alcohol consumption is particularly worrisome, as excessive alcohol use has acute, prolonged neurobiological effects specific to the adolescent brain [3].”
Role of central nervous system insulin resistance in fetal alcohol spectrum disorders.
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“Chronic intermittent exposure, an analog of binge drinking, is particularly harmful, leading to reduced neurogenesis (Nixon and Crews 2002) and neurochemical changes (Obernier et al. 2002) in the hippocampus, which can be permanent (Monti et al. 2005).”
Age- and sex-related differences in the acquisition and reinstatement of ethanol CPP in mice
Roger-Sánchez, C., Aguilar, M. A., Rodríguez‐Arias, M., Aragón, C. M. G., & Miñarro, J. (2011) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2011.07.011 · Cited by 42 · see citing works
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Effectiveness of public health programs for decreasing alcohol consumption
Kelly‐Weeder, S., Phillips, K. E., & Rounseville, S. (2011) · Patient Intelligence · doi:10.2147/pi.s12431 · Cited by 42 · see citing works
“Additional maturation processes are underway in the hippocampus and limbic systems.(12) Magnetic resonance imaging studies have suggested that adolescents with alcohol use disorders have reductions in the size of the hippocampus, a part of the brain involved in memory and spatial navigation.”
Distinct cognitive performance and patterns of drug use among early and late onset cocaine users
Lopes, B. M., Gonçalves, P. D., Ometto, M., dos Santos, B., Cavallet, M., Chaim-Avancini, T. M., Serpa, M. H., Nicastri, S., Malbergier, A., Busatto, G. F., et al. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.04.013 · Cited by 41 · see citing works
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Increased vulnerability to ethanol consumption in adolescent maternal separated mice
García‐Gutiérrez, M. S., Navarrete, F., Aracil-Fernández, A., Bartoll, A., Martínez‐Gras, I., Lanciego, J. L., Rubio, G., & Manzanares, J. (2015) · Addiction Biology · doi:10.1111/adb.12266 · Cited by 40 · see citing works
“This period is characterized by neuronal maturation and cortical development with changes in plasticity, neurotransmission and neurogenesis (Monti et al. 2005; Crews, He & Hodge 2007).”
BackgroundDaoura, L., Haaker, J., & Nylander, I. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01367.x · Cited by 40 · see citing works
Sher, K. J., Dick, D. M., Crabbe, J. C., Hutchison, K. E., O’Malley, S. S., & Heath, A. C. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00189.x · Cited by 40 · see citing works
“The associated neurocognitive deficits, especially those associated with deficits in executive functioning (Monti et al. 2005), could pose added risk for a range of externalizing behaviour problems in addition to alcohol dependence.”
BackgroundFleming, R. L., Li, Q., Risher, M., Sexton, H. G., Moore, S. D., Wilson, W. A., Acheson, S. K., & Swartzwelder, H. S. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12087 · Cited by 38 · see citing works
“…M anuscript during adolescence, and binge drinking by adolescents is a major public health concern because this pattern of ethanol exposure is associated with increased risk of neurotoxicity and the development of alcohol abuse disorders (Crews et al., 2000; Hunt 1993; Monti et al., 2005; 2009).”
BackgroundSwartzwelder, H. S., Park, M.-H., & Acheson, S. (2017) · Scientific Reports · doi:10.1038/s41598-017-12956-6 · Cited by 38 · see citing works
Self-citationRocha, A., Hart, N., & Trujillo, K. A. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.04.007 · Cited by 37 · see citing works
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“Thus puberty is a part of adolescence.(27) During puberty, the hormonal surge of the hypothalamic–pituitary–gonadal (HPG) axis precedes and promotes the secondary sexual characteristics and physical development.”
BackgroundSUBSTANCE USE AND ACADEMIC OUTCOMES: SYNTHESIZING FINDINGS AND FUTURE DIRECTIONS
King, K. M., Meehan, B. T., Trim, R. S., & Chassin, L. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01695.x · Cited by 36 · see citing works
“Recent studies have shown that heavy adolescent substance use can lead to problems with working memory and attention due to changes in adolescent brain activity [5].”
BackgroundNeurobiology of the Adolescent Brain and Behavior
Casey, B. J., & Jones, R. M. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-201012000-00005 · Cited by 36 · see citing works
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“Young humans and animals also appear to be more sensitive to the deleterious effects that alcohol has on various neuroanatomical and neurophysiological measures (De Bellis et al. 2005; Monti et al. 2005).”
Adolescent Alcohol Exposure Alters GABA A Receptor Subunit Expression in Adult Hippocampus
Centanni, S. W., Teppen, T. L., Risher, M., Fleming, R. L., Moss, J. L., Acheson, S. K., Mulholland, P. J., Pandey, S. C., Chandler, L. J., & Swartzwelder, H. S. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12562 · Cited by 34 · see citing works
“This prevalence of binge drinking occurs at a developmental period when the brain is undergoing rapid changes in structure and function that make it vulnerable to negative consequences of alcohol exposure (Monti et al., 2005).”
BackgroundA neuroscience perspective on sexual risk behavior in adolescence and emerging adulthood
Victor, E. C., & Hariri, A. R. (2015) · Development and Psychopathology · doi:10.1017/s0954579415001042 · Cited by 34 · see citing works
“…individuals with a positive family history of alcohol dependence) suggest that impairments in PFC-related functioning are present before drug use (Monti et al., 2005; Pulido, Brown, Cummins, Paulus, & Tapert, 2010) and predict later substance abuse (Deckel & Hesselbrock, 1996; Tarter et al.,…”
BackgroundSpanos, M., Besheer, J., & Hodge, C. W. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.02.010 · Cited by 32 · see citing works
“ERK1/2 signaling is critical for neural and behavioral plasticity [32], which may be of special importance to the adolescent response to ethanol [33].”
BackgroundMcMurray, M. S., Amodeo, L. R., & Roitman, J. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100697 · Cited by 32 · see citing works
“Chronic alcohol use has been shown to cause detrimental effects on cognitive processing and prefrontal cortex functioning in adolescent animals [15,16,17,18].”
BackgroundEffects of State Coalitions to Reduce Underage DrinkingA National Evaluation
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“Such lists are known to include a substantial amount of error, which can significantly reduce the validity evaluation studies ( Lafond, Toomey, Rothstein, Manning, & Wagenaar, 2000 ).”
BackgroundAlcohol and Other Contextual Factors of Suicide in Four Aboriginal Communities of Quebec, Canada
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Contextual influences on early drinking: Characteristics of drinking and nondrinking days.
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“Early alcohol consumption is particularly concerning, as alcohol use may have acute and prolonged neurobiological effects specific to the adolescent brain (Monti et al. 2005).”
BackgroundCarrara‐Nascimento, P. F., Lopez, M. F., Becker, H. C., Olive, M. F., & Camarini, R. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12056 · Cited by 29 · see citing works
Effects of intermittent binge alcohol exposure on long-term motor function in young rats
Forbes, A., Cooze, J., Malone, C. D., French, V. M., & Weber, J. T. (2013) · Alcohol · doi:10.1016/j.alcohol.2012.12.007 · Cited by 29 · see citing works
Adolescence, glucocorticoids and alcohol
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- Authors
- Monti, P. M., Miranda, R., Nixon, K., Sher, K. J., Swartzwelder, H. S., Tapert, S. F., White, A., & Crews, F. T.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Monti, Peter M.
- ORCID
- Venue
- Alcoholism: Clinical & Experimental Research
- Publisher
- Wiley
- Published
- 2005-02
- Volume
- 29
- Issue
- 2
- Pages
- 207-220
- ISSN
- 0145-6008 (ISSN-L)
- OpenAlex
- W2101666366
- Cited by
- 206
- References
- 138
- Citations by year
- 2025: 1 · 2024: 2 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 7 · 2018: 7 · 2017: 6 · 2016: 7 · 2015: 13 · 2014: 17 · 2013: 19 · 2012: 18
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Alcoholism Clinical and Experimental Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01aa012478-05)
- National Institute on Alcohol Abuse and Alcoholism (R01 AA12478, 2 R01 AA07850, AA05559, AA011605, R37 AA 07231, R01AA013987, R01 AA13419, R01AA013419, R37AA007231, F31AA005559, R01AA007850, AA06069)
- National Institute on Drug Abuse (R21DA016904)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- adolescent binge drinking, adolescent brain development, functional neuroimaging, emotional reactivity, alcoholism risk, alcohol-induced memory impairment, blackouts
- MeSH terms
- Adolescent, Adolescent Behavior, Alcohol Drinking, Ethanol, Brain, Humans
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