Distribution of choline acetyltransferase-immunoreactive axons in monkey frontal cortex

Lewis, D.A.

doi:10.1016/0306-4522(91)90126-9

Cited by 59Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

Distribution of choline acetyltransferase-immunoreactive axons in monkey frontal cortex

Lewis, D.A.·1991·Neuroscience

DOI 10.1016/0306-4522(91)90126-9

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Abstract

Cholinergic neurons of the nucleus basalis of Meynert project to numerous regions of the cerebral cortex. However, little is known about the regional and laminar distributions of cholinergic axons in monkey frontal cortex. In this study, immunohistochemical techniques were used to identify axons that were immunoreactive for choline acetyltransferase, the enzyme that catalyses the synthesis of acetylcholine, in the frontal cortex of cynomolgus monkeys. Motor cortex contained the greatest density of labeled fibers: the density of labeled fibers was lower in premotor and anterior cingulate cortices and lower still in the association regions of prefrontal cortex. On a laminar basis, choline acetyltransferase-immunoreactive axons were most dense in layer I to superficial layer III. Layer V also contained a distinct band of labeled fibers that was particularly prominent in the agranular regions of frontal cortex. The density of labeled fibers was much lower in the deep portion of layer III to layer IV and in layer VI. These findings demonstrate a specific and regionally distinctive cholinergic innervation of monkey frontal cortex that may reveal the anatomical basis for the influence of acetylcholine on the diverse functions of primate frontal cortex.

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Within the PFC, the cholinergic innervation initially terminates in layers III and IV, slowly losing laminar preference over time.
“Within the PFC, the cholinergic innervation initially terminates in layers III and IV slowly losing laminar preference over time [221–223].”
From Development of prefrontal cortex (2022) · cites this paper as [223]

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Authors: Lewis, D. A.
Affiliations: University of Pittsburgh (US)
Corresponding author: Lewis, D.A.
ORCID: Lewis, D.A.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1991-01
Volume: 40
Issue: 2
Pages: 363-374
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(91)90126-9
OpenAlex: W1973406239
Cited by: 59
References: 46
Citations by year: 2024: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 1
FWCI: 1.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH43784, MH-00519)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: choline acetyltransferase, cholinergic axons, frontal cortex, nucleus basalis of Meynert, acetylcholine, laminar distribution, regional distribution, motor cortex, premotor cortex, anterior cingulate cortex, prefrontal cortex, Macaca fascicularis, cholinergic innervation
MeSH terms: Animals, Axons, Choline O-Acetyltransferase, Frontal Lobe, Immunohistochemistry, Macaca fascicularis, Male, Nerve Fibers, Tissue Distribution

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Distribution of choline acetyltransferase-immunoreactive axons in monkey frontal cortex

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