Cited by 185Cancer Treatment and PharmacologyPain Mechanisms and TreatmentsIon Channels and Receptors

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Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans

Aley, K.O., Reichling, D.B., Levine, J.D.·1996·Neuroscience

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Abstract

To investigate the mechanism of vincristine-induced pain in humans undergoing chemotherapy we have established a model of vincristine-induced hyperalgesia in rat. Vincristine (100 micrograms/kg) was administered daily over a period of two weeks. An acute dose-dependent decrease in mechanical nociceptive threshold and an increased response to non-noxious mechanical stimuli ("hyperalgesia") occurred after the second day of administration. Chronic lowered threshold and increased response to stimuli (determined 24 h after each injection) was first noted during the second week of vincristine administration. Responses gradually returned to baseline during the two weeks following discontinuation of treatment. Vincristine also increased sensitivity to heat stimulation. At a dose that produced hyperalgesia (100 micrograms/kg), vincristine did not cause a significant motor deficit. Peripheral administration of a mu-opioid agonist did not reduce vincristine-induced acute hyperalgesia. Hyperalgesia induced by vincristine in the rat provides a good model for the experimental study of painful peripheral neuropathies in human patients receiving vincristine as a chemotherapeutic agent.

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Authors: Aley, K. O., Reichling, D. B., & Levine, J. D.
Affiliations: University of California, San Francisco (US)
Corresponding author: Levine, J.D.
ORCID: Levine, J.D.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 1996-07
Volume: 73
Issue: 1
Pages: 259-265
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/0306-4522(96)00020-6
OpenAlex: W2004637463
Cited by: 185
References: 48
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 9 · 2016: 1 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 9
FWCI: 1.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer Treatment and Pharmacology
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords: vincristine, chemotherapy-induced peripheral neuropathy, hyperalgesia, peripheral neuropathic pain, mechanical nociception, thermal sensitivity, mu-opioid receptor, animal models
MeSH terms: Analgesics, Animals, Antineoplastic Agents, Phytogenic, Disease Models, Animal, Enkephalins, Hot Temperature, Hyperalgesia, Injections, Intravenous, Male, Neurons, Afferent, Peripheral Nervous System Diseases, Physical Stimulation, Psychomotor Performance, Vincristine, Rats, Sprague-Dawley, Pain Threshold, Enkephalin, Ala(2)-MePhe(4)-Gly(5)-, Rats

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Vincristine hyperalgesia in the rat: A model of painful vincristine neuropathy in humans

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