The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Blockade of the LH surge and ovulation by GABA-T inhibitory drugs that increase brain GABA levels in rats
Abstract
The present experiments were designed to evaluate the effects of GABA increase in the brain on the LH surge and ovulation in female rats. GABA-transaminase (GABA-T) inhibitory drugs were administered intraperitoneally in the early afternoon hours on the day before the expected ovulation. Gamma-acetylenic GABA (GAG) prevented the proestrus LH surge and ovulation in freely moving adult female rats. In a similar manner, GAG blunted the enhanced LH release found at 1800 h on the preovulatory day and the subsequent ovulation in PMSG-treated 32-day-old rats. LH secretion and ovulation in these animals was restored by administration of the selective GABA antagonist, bicuculline. The other GABA-T inhibitors, amino-oxyacetic acid and gamma-vinyl GABA, produced similar effects to GAG in the PMSG-treated rats. These results indicate that the increase of brain GABA levels during the preovulatory day alters LH release and prevents ovulation in rats.
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“and that its occurrence is coincident with a decline of GABAergic transmission to both POA kisspeptin neurons and GnRH neurons [106,107].”
From Fibromyalgia pathogenesis explained by a neuroendocrine multistable model (2024) · cites this paper as [106]
Citations
Cites
Jung, M. J., Lippert, B. J., Metcalf, B. W., Böhlen, P., & Schechter, P. J. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb10721.x · Cited by 481
Barraclough, C. A., & Wise, P. M. (1982) · Endocrine Reviews · doi:10.1210/edrv-3-1-91 · Cited by 371
GABA Neuron Systems in Hypothalamus and the Pituitary Gland
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Progress in Psychoneuroendocrinology
Carroll, B. J. (1982) · Psychoneuroendocrinology · doi:10.1016/0306-4530(82)90058-0 · Cited by 293
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Gamma-Aminobutyric Acid Effects on Pituitary Gonadotropin Secretion
Ondo, J. G. (1974) · Science · doi:10.1126/science.186.4165.738 · Cited by 122
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The Effects of γ-Aminobutyric Acid on Prolactin and Gonadotropin Secretion in the Unanesthetized Rat
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Grant, S., & Heel, R. C. (1991) · Drugs · doi:10.2165/00003495-199141060-00007 · Cited by 311
Neuroendocrine Control of the Ovarian Cycle of the Rat
Freeman, M. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012515400-0/50048-8 · Cited by 287
Chapter 2 Hypothalamic Neural Systems Controlling the Female Reproductive Life Cycle
(2009) · International Review of Cell and Molecular Biology · doi:10.1016/s1937-6448(08)02002-9 · Cited by 93
MASOTTO, C., Wisniewski, G., & Negro-Vilar, A. F. (1989) · Endocrinology · doi:10.1210/endo-125-1-548 · Cited by 64
MASOTTO, C., & Negro-Vilar, A. F. (1987) · Endocrinology · doi:10.1210/endo-121-6-2251 · Cited by 44
Metadata
- Authors
- Donoso, A. O., & Banzan, A. M.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Corresponding author
- Donoso, A.O.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1986-01
- Volume
- 11
- Issue
- 4
- Pages
- 429-435
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W1980560986
- Cited by
- 19
- References
- 26
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- GABA transaminase inhibitors, gamma-acetylenic GABA, brain GABA, luteinizing hormone surge, ovulation, bicuculline, aminooxyacetic acid, vigabatrin, permanent magnet synchronous generator, female reproduction, luteinizing hormone secretion
- MeSH terms
- Alkynes, 4-Aminobutyrate Transaminase, Aminocaproates, Animals, Bicuculline, Brain Chemistry, Estrus, Female, gamma-Aminobutyric Acid, Gonadotropins, Equine, Luteinizing Hormone, Ovulation, Rats
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- The paper
- Donoso, A. O., & Banzan, A. M. (1986). Blockade of the LH surge and ovulation by GABA-T inhibitory drugs that increase brain GABA levels in rats. Psychoneuroendocrinology. https://doi.org/10.1016/0306-4530(86)90004-1
