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Effects of early prenatal dexamethasone on the cognitive and behavioral development of young children: Results of a pilot study
Open accessAbstract
The effect of early prenatal dexamethasone (DEX) exposure on cognitive and behavioral development, behavior problems, and temperament were examined in 26 consecutively identified children aged 6 mo to 5 1/2 years, whose mothers had been DEX-treated during pregnancy because their offspring was at risk for congenital adrenal hyperplasia (CAH), and compared with 14 children from untreated CAH-risk pregnancies. Three children in each group were CAH-affected. Assessments were performed by way of mother-completed standard questionnaires. No significant differences in cognitive abilities or behavior problems were identified. On temperament questionnaires, DEX-exposed children showed more Shyness (p < .004), greater Emotionality (p < .03), less Sociability (p < .04), and a trend for greater Avoiddance (p < .07) than unexposed children. DEX-exposed children also had significantly higher Internalizing (p < .002) and Total Problem scores (p < .05) on the behavior problem measure for 2-3 year olds. The results should be considered preliminary until they have been replicated by the study of a larger sample and direct examination of the children.
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“Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both shortterm and full-term treated cases at risk for CAH (472-474).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [473]
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Metadata
- Authors
- Trautman, P. D., Meyer-Bahlburg, H. F. L., Postelnek, J., & New, M. I.
- Affiliations
- Cornell University (US)
- Corresponding author
- Trautman, Paul D.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 1995
- Volume
- 20
- Issue
- 4
- Pages
- 439-449
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2021131551
- Cited by
- 217
- References
- 45
- Citations by year
- 2024: 9 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 2 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 15
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- prenatal dexamethasone, congenital adrenal hyperplasia, prenatal glucocorticoid exposure, child cognitive development, child behavior problems, temperament, internalizing problems, shyness, sociability, emotionality, avoidance behavior, young children
- MeSH terms
- Adrenal Hyperplasia, Congenital, Child, Child Behavior, Child Development, Child, Preschool, Cognition, Dexamethasone, Female, Humans, Infant, Maternal-Fetal Exchange, Pilot Projects, Pregnancy, Prenatal Exposure Delayed Effects, Surveys and Questionnaires, Risk Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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