Cognitive and motor development of children with and without congenital adrenal hyperplasia after early-prenatal dexamethasone
Abstract
Dexamethasone (DEX) administration to the pregnant woman has become the treatment of choice for the prevention of genital masculinization in female fetuses affected with congenital adrenal hyperplasia (CAH). Although no somatic teratological side effects have been found to date, recent animal research has shown adverse effects of glucocorticoids on brain structures such as the hippocampus, raising concerns about possible functional side effects of DEX on human development. The current survey of 487 children, 1 month to 12 yr of age, focused on cognitive and motor development. The mothers of 174 prenatally DEX-exposed children (including 48 with CAH) and 313 unexposed children (including 195 with CAH) completed four standardized developmental questionnaires about their children. None of the comparisons of prenatally DEX-exposed children and unexposed controls was significant. Among the DEX-exposed children, increased duration of DEX exposure was correlated with significantly fewer developmental delays on three variables of one of the questionnaires, but none of the correlations reached significance, when Bonferroni corrections for multiple correlations were used. With the methods used, we were unable to document any adverse effects of early-prenatal DEX treatment in the doses recommended for the treatment of pregnancies at risk for CAH on motor and cognitive development.
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Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both short-term and full-term treated cases at risk for CAH.
“Other adverse events including failure to thrive, stroke-like events and midline defects have been observed in both shortterm and full-term treated cases at risk for CAH (472-474).”
From Congenital Adrenal Hyperplasia—Current Insights in Pathophysiology, Diagnostics, and Management (2022) · cites this paper as [474]
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Congenital Adrenal Hyperplasia
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Genetic Defects of Female Sexual Differentiation
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- Authors
- Meyer-Bahlburg, H. F. L., Dolezal, C., Baker, S. W., Carlson, A. D., Obeid, J. S., & New, M. I.
- Affiliations
- New York State Psychiatric Institute (US)
- NewYork–Presbyterian Hospital (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2004-02
- Volume
- 89
- Issue
- 2
- Pages
- 610-614
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2119285041
- Cited by
- 123
- References
- 25
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 5 · 2015: 9 · 2014: 4 · 2013: 4 · 2012: 10
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Keywords
- congenital adrenal hyperplasia, prenatal dexamethasone, glucocorticoid exposure, cognitive development, motor development, developmental delay, fetal brain, hippocampus
- MeSH terms
- Adolescent, Adrenal Hyperplasia, Congenital, Child, Child Development, Child, Preschool, Cognition, Dexamethasone, Female, Glucocorticoids, Health Surveys, Humans, Infant, Infant, Newborn, Male, Motor Activity, Pregnancy, Prenatal Exposure Delayed Effects, Surveys and Questionnaires, Case-Control Studies
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