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Cited by 133Neuroendocrine regulation and behaviorObsessive-Compulsive Spectrum DisordersPsychoanalysis and Psychopathology Research

The DOI matches its Crossref record; 210 of the 211 references it cites were found in a registry or an index.

The role of central oxytocin in obsessive compulsive disorder and related normal behavior

Leckman, James F., Goodman, Wayne K., North, William G., Chappell, Phillip B., Price, Lawrence H., Pauls, David L., Anderson, George M., Riddle, Mark A., McDougle, Christopher J., Barr, Linda C., Cohen, Donald J.·1994·Psychoneuroendocrinology
DOI 10.1016/0306-4530(94)90021-3
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Abstract

Oxytocin (OT) is a neurosecretory nonapeptide synthesized in hypothalamic cells, which project to widely distributed sites in the CNS as well as the neurohypophysis. Central OT affects a variety of cognitive, grooming, affiliative, sexual, and reproductive behaviors in animals. Obsessive Compulsive Disorder (OCD) includes a range of cognitive and behavioral symptoms that bear some relationship to dimensions of behavior associated with OT. Anecdotal data and a recently completed cerebrospinal fluid (CSF) study provide evidence that some forms of OCD are related to OT dysfunction. Based on these findings, we hypothesize: 1) that some forms of OCD are at the extreme end of a range of normal behaviors that are mediated by OT and related systems; and that 2) some normal cognitive, affiliative, and sexual behaviors contain elements that are similar to features of OCD. Alternative hypotheses are considered, and a series of predictions are presented concerning the relationship between central OT and the onset, course, treatment response, and response to challenge procedures seen in this form of OCD.

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Citations

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Research works printed but not linked: 5

  1. Charles, 1989, Oxytocin in the treatment of obsessive-compulsive disorder, J Psychiatr Psychol, 4, 111
  2. Leckman JF, Goodman WK, North WG, Chappell PB, Price LH, Pauls DL, Anderson GM, Riddle MA, McSwiggan-Hardin M, McDougle CJ, Barr LC, Cohen DJ (in press) Elevated levels of CSF oxytocin in obsessive-compulsive disorder. Arch Gen Psychiatry.
  3. Pauls, 1991, A family study of Tourette's syndrome, Am J Hum Genet, 48, 154
  4. Rapoport, 1988, Obsessive-compulsive disorder: Is it a basal ganglia dysfunction?, Psychopharmacol Bull, 24, 380
  5. Richter D, Mohr E (in press) Axonal mRNA transport in the hypothalamo-neurohypophyseal tract of rats. In: North WG, Moses AM, Share L (Eds) The Neurohypophysis: A Window on Brain Function—Annals of the New York Academy of Sciences. The New York Academy of Sciences, New York.

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Metadata

Authors
Leckman, J. F., Goodman, W. K., North, W. G., Chappell, P. B., Price, L. H., Pauls, D. L., Anderson, G. M., Riddle, M. A., McDougle, C. J., Barr, L. C., & Cohen, D. J.
Affiliations
  • Yale University (US)
  • University of Florida Health (US)
  • Dartmouth College (US)
  • Connecticut Mental Health Center (US)
  • Johns Hopkins University (US)
Corresponding author
Leckman, James F.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
1994
Volume
19
Issue
8
Pages
723-749
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/0306-4530(94)90021-3
OpenAlex
W2043814644
Cited by
133
References
211
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 1 · 2019: 4 · 2017: 3 · 2016: 11 · 2015: 6 · 2014: 4 · 2013: 5 · 2012: 5
FWCI
1.22
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01mh044843-03)
  • National Institute of Mental Health (MH00508, MH49351, P01MH049351, MH 44843)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords
oxytocin, obsessive-compulsive disorder, affiliative behavior, grooming, sexual behavior, normal behavior, treatment response, hypothalamic neurosecretion
MeSH terms
Animals, Behavior, Animal, Brain, Brain Mapping, Humans, Hypothalamus, Neural Pathways, Neurophysins, Obsessive-Compulsive Disorder, Oxytocin, Stereotyped Behavior

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