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Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutase
Abstract
It seems that superoxide dismutase plays the key role in protecting aerobes against O2 toxicity, but there is a whole range of ancillary mechanisms: enzymes to remove H2O2 (catalase, peroxidases) and hence to control formation of .OH from O2, which requires H2O2; antioxidants (ascorbate, GSH, alpha-tocopherol, carotenoids), which also react with singlet oxygen and/or .OH and often inhibit lipid peroxidation and last, but not least in animals, glutathione peroxidase, which controls the rate of lipid peroxidation. These mechanisms cope well at normal O2 concentrations but are insufficient at higher levels.
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Citations
Cited by
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Free radicals, oxidative stress, and antioxidants in human health and disease
Aruoma, O. I. (1998) · Journal of the American Oil Chemists' Society · doi:10.1007/s11746-998-0032-9 · Cited by 1,682
Halliwell, B., & Gutteridge, J. M. C. (1981) · FEBS Letters · doi:10.1016/0014-5793(81)80114-7 · Cited by 829
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Metadata
- Authors
- HALLIWELL, B.
- Venue
- Cell Biology International Reports
- Publisher
- Wiley
- Published
- 1978-03
- Volume
- 2
- Issue
- 2
- Pages
- 113-128
- ISSN
- 0309-1651 (ISSN-L)
- OpenAlex
- W1988641324
- Cited by
- 245
- References
- 0
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- HALLIWELL, B. (1978). Biochemical mechanisms accounting for the toxic action of oxygen on living organisms: The key role of superoxide dismutase. Cell Biology International Reports. https://doi.org/10.1016/0309-1651(78)90032-2
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