Susceptibility of nosocomial isolates of Candida species to LY121019 and other antifungal agents
Abstract
LY121019 is a novel analog of the polypeptide antifungal antibiotic echinocandin B. We investigated the in vitro activity of LY121019, amphotericin B, ketoconazole and 5-fluorocytosine against 131 nosocomial isolates of Candida species: C. albicans (n = 50), C. tropicalis (n = 30), C. rugosa (n = 12), C. parapsilosis (n = 11), C. lusitaniae (n = 10), C. guillermondii (n = 9), and C. krusei (n = 9). In vitro susceptibility testing was performed using a broth microdilution method. The minimal inhibitory concentrations (MIC) of LY121019 were less than or equal to that of the other antifungal agents against C. albicans and C. tropicalis but were generally higher for the other species of Candida. Paradoxical growth at high concentrations, but not at low concentrations, of LY121019 was observed with isolates of C. albicans and C. tropicalis.
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Multiple studies have emphasized the presence of bacteria and the polymicrobial nature of chronic, non-healing wounds, and the frequency of S. aureus and P. aeruginosa organisms has been shown to be exceedingly high.
“Multiple studies have also emphasized the presence of bacteria and the polymicrobial nature of chronic, non-healing wounds [6], [7], [8], [9], [10], and the frequency of S. aureus and P. aeruginosa organisms has been shown to be exceedingly high [10], [11], [12], [13], [14].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [7]
The polymicrobial nature of non-healing wounds, such as venous, pressure, and diabetic foot ulcers, is well documented and established.
“The polymicrobial nature of non-healing wounds, such as venous, pressure, and diabetic foot ulcers is well documented and established [6], [7], [8], [9], [58], [59].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [7]
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- Authors
- Pfaller, M. A., Wey, S., Gerarden, T., Houston, A., & Wenzel, R. P.
- Affiliations
- Iowa City VA Medical Center (US)
- Venue
- Diagnostic Microbiology and Infectious Disease
- Publisher
- Elsevier BV
- Published
- 1989-01
- Volume
- 12
- Issue
- 1
- Pages
- 1-4
- ISSN
- 0732-8893 (ISSN-L)
- OpenAlex
- W1978602955
- Cited by
- 18
- References
- 16
- Citations by year
- 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Diagnostic Microbiology and Infectious Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Keywords
- Candida, hospital isolates, antifungal susceptibility, Candida albicans, Candida tropicalis, Candida parapsilosis, Candida lusitaniae, Candida guilliermondii, Candida krusei, Candida rugosa, amphotericin B, ketoconazole, 5-fluorocytosine, minimum inhibitory concentration
- MeSH terms
- Amphotericin B, Antifungal Agents, Candida, Candidiasis, Cross Infection, Flucytosine, Humans, Ketoconazole, Microbial Sensitivity Tests, Peptides, Peptides, Cyclic, Echinocandins
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