Cited by 328Infective Endocarditis Diagnosis and ManagementCardiac Valve Diseases and TreatmentsStreptococcal Infections and Treatments

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Echocardiographic assessment of patients with infectious endocarditis: Prediction of risk for complications

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Sanfilippo, Anthony J., Picard, Michael H., Newell, John B., Rosas, Emma, Davidoff, Ravin, Thomas, James D., Weyman, Arthur E.·1991·Journal of the American College of Cardiology

DOI 10.1016/0735-1097(91)90535-h

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Abstract

To enhance the echocardiographic identification of high risk lesions in patients with infectious endocarditis, the medical records and two-dimensional echocardiograms of 204 patients with this condition were analyzed. The occurrence of specific clinical complications was recorded and vegetations were assessed with respect to predetermined morphologic characteristics. The overall complication rates were roughly equivalent for patients with mitral (53%), aortic (62%), tricuspid (77%) and prosthetic valve (61%) vegetations, as well as for those with nonspecific valvular changes but no discrete vegetations (57%), although the distribution of specific complications varied considerably among these groups. There were significantly fewer complications in patients without discernible valvular abnormalities (27%). In native left-sided valve endocarditis, vegetation size, extent, mobility and consistency were all found to be significant univariate predictors of complications. In multivariate analysis, vegetation size, extent and mobility emerged as optimal predictors and an echocardiographic score based on these factors predicted the occurrence of complications with 70% sensitivity and 92% specificity in mitral valve endocarditis and with 76% sensitivity and 62% specificity in aortic valve endocarditis.

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Echocardiography in infective endocarditis: Reassessment of prognostic implications of vegetation size determined by the transthoracic and the transesophageal approach
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Authors: Sanfilippo, A. J., Picard, M. H., Newell, J. B., Rosas, E., Davidoff, R., Thomas, J. D., & Weyman, A. E.
Affiliations: Massachusetts General Hospital (US)
Harvard University (US)
Corresponding author: Sanfilippo, Anthony J.
ORCID: Picard, Michael H.
Newell, John B.
Davidoff, Ravin
Thomas, James D.
Venue: Journal of the American College of Cardiology
Publisher: Elsevier BV
Published: 1991-11
Volume: 18
Issue: 5
Pages: 1191-1199
ISSN: 0735-1097 (ISSN-L)
DOI: 10.1016/0735-1097(91)90535-h
OpenAlex: W2091438055
Semantic Scholar: 77cbe2ef81fa55b216750cf99958a15b75b73716
Cited by: 328
References: 23
Citations by year: 2026: 4 · 2025: 5 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 12 · 2014: 9 · 2013: 13 · 2012: 9
FWCI: 4.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 7928 d)
Locations: Journal of the American College of Cardiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5t32hl007535-08)
National Heart, Lung, and Blood Institute (HL-07535)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
Keywords: infective endocarditis, echocardiographic assessment, vegetation characteristics, complication prediction, vegetation size, mitral valve endocarditis, aortic valve endocarditis, tricuspid valve endocarditis, prosthetic valve endocarditis, risk stratification
MeSH terms: Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Aortic Valve, Echocardiography, Endocarditis, Bacterial, Female, Heart Valve Prosthesis, Humans, Male, Middle Aged, Mitral Valve, Predictive Value of Tests, Regression Analysis, Sensitivity and Specificity, Survival Rate

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Echocardiographic assessment of patients with infectious endocarditis: Prediction of risk for complications

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